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Invitrogen
VPS37A Polyclonal Antibody
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Application
FIGURE: 1 / 1
VPS37A Antibody (PA5-96833) in WB
Western blot analysis of VPS37A in extracts of various cell lines. Samples were incubated with VPS37A Polyclonal antibody (Product # PA5-96833) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 30s.
Product Details
PA5-96833
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 224-397 of human VPS37A (NP_6896282)
Conjugate
Unconjugated
Form
Liquid
Concentration
2.4 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2808635
Product Specific Information
Immunogen sequence: MPDVPDAFPE LSELSVSQLT DMNEQEEVLL EQFLTLPQLK QIITDKDDLV KSIEELARKN LLLEPSLEAK RQTVLDKYEL LTQMKSTFEK KMQRQHELSE SCSASALQAR LKVAAHEAEE ESDNIAEDFL EGKMEIDDFL SSFMEKRTIC HCRRAKEEKL QQAIAMHSQF HAPL; Positive Samples: A-549, Jurkat, HepG2; Cellular Location: Late endosome membrane, Nucleus, Peripheral membrane protein
Target Information
This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ESCRT-I complex subunit VPS37A; Hepatocellular carcinoma-related protein 1; hVps37A; polyglutamine binding protein 2; vacuolar protein sorting 37 homolog A; vacuolar protein sorting 37A; Vacuolar protein sorting-associated protein 37A; Vps37A
Gene Aliases: 2210018P21Rik; 4930592A21Rik; AW261445; D8Ertd531e; HCRP1; PQBP2; SPG53; VPS37A
UniProt ID: (Human) Q8NEZ2, (Mouse) Q8CHS8
Entrez Gene ID: (Human) 137492, (Mouse) 52348, (Rat) 290775
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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