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WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. WDFY1 positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. WDFY1 Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines. WDFY2 acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. WDFY2 positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1.
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Protein Aliases: FENS-1; FYVE domain-containing protein localized to endosomes 1; Phosphoinositide-binding protein 1; phosphoinositide-binding protein SR1; WD repeat and FYVE domain-containing protein 1; WD40 and FYVE domain containing 1; WD40- and FYVE domain-containing protein 1; Zinc finger FYVE domain-containing protein 17
Gene Aliases: 1700013B03Rik; 1700120F24Rik; FENS-1; FENS1; Jr1; KIAA1435; mKIAA1435; WDF1; WDFY1; ZFYVE17
UniProt ID: (Human) Q8IWB7, (Mouse) E9Q4P1
Entrez Gene ID: (Human) 57590, (Rat) 301549, (Mouse) 69368
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