Search Thermo Fisher Scientific
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FIGURE: 1 / 3
Recommended positive controls: 293T, A431, Jurkat, Raji.
Predicted reactivity: Mouse (93%), Rat (94%), Bovine (94%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
WDR24, as a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. WDR24 is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GATOR2 complex protein WDR24; WD repeat-containing protein 24
Gene Aliases: BC037651; C16orf21; JFP7; WDR24
UniProt ID: (Human) Q96S15, (Mouse) Q8CFJ9
Entrez Gene ID: (Human) 84219, (Mouse) 268933
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