Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: GSLILVSASR DKTLRVWDLK DDGNMMKVLR GHQNWVYSCA FSPDSSMLCS VGASKAVFLW NMDKYTMIRK LEGHHHDVVA CDFSPDGALL ATASYDTRVY IWDPHNGDIL MEFGHLFPPP TPIFAGGAND RWVRSVSFSH DGLHVASLAD DKMVRFWRID EDYPVQVAPL SNGLCCAFST DGSVLAAGTH DGSVYFWATP RQVPSLQHLC RMSIRRVMPT QEVQELPIPS KLLEFLSYRI; Positive Samples: HT-29, A-549, HeLa, HepG2, SGC-7901
WSB1 (WD repeat and SOCS box-containing 1), also known as SWIP1, is a 421 amino acid protein that contains one SOCS box domain and six WD repeats. Expressed as multiple alternatively spliced isoforms, WSB1 is thought to function as part of an SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as DIO2. Overexpression of WSB1 is implicated in pancreatic cancer progression, suggesting a role for WSB1 in carcinogenesis.
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Protein Aliases: SOCS box-containing WD protein SWiP-1; WD repeat and SOCS box-containing 1; WD repeat and SOCS box-containing protein 1; WSB-1
Gene Aliases: SWIP1; WSB-1; WSB1
UniProt ID: (Human) Q9Y6I7
Entrez Gene ID: (Human) 26118
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