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Antibody detects endogenous levels of total WWP1.
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq].
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Protein Aliases: AIP5; atrophin-1 interacting protein 5; Atrophin-1-interacting protein 5; DKFZp434D2111; HECT-type E3 ubiquitin transferase WWP1; Nedd-4-like ubiquitin-protein ligase; NEDD4-like E3 ubiquitin-protein ligase WWP1; TGIF-interacting ubiquitin ligase 1; Tiul1; WW domain-containing protein 1
Gene Aliases: 8030445B08Rik; AIP5; hSDRP1; SDRP1; Tiul1; WWP1
UniProt ID: (Human) Q9H0M0, (Mouse) Q8BZZ3
Entrez Gene ID: (Human) 11059, (Rat) 297930, (Mouse) 107568
Molecular Function:
ubiquitin-protein ligase
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