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            • Primary Antibodies ›
            • ZEB2 Antibodies

            Bethyl Laboratories

            ZEB2/SIP Polyclonal Antibody

            View all (39) ZEB2 antibodies
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            Catalog # A302-473A
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            Preis (EUR)
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            Cite ZEB2/SIP Polyclonal Antibody

            • Antibody Testing Data (2)
            Application
            ZEB2/SIP Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            Group 53 Created with Sketch.

            FIGURE: 1 / 2

            ZEB2/SIP Antibody (A302-473A) in IHC (P)

            Detection of human ZEB2/SIP by immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-ZEB2/SIP (Product # A302-473A) (Lot 1) used at a dilution of 1:1,000 (1 µg/mL). Detection: DAB.
            View Product

            ZEB2/SIP Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            ZEB2/SIP Antibody in Immunoprecipitation (IP)

            Product Details

            A302-473A

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            Assay-dependent
            -

            Immunohistochemistry (IHC)

            1:500-1:2,000
            -

            Immunohistochemistry (Paraffin) (IHC (P))

            1:500-1:2,000
            -

            Immunoprecipitation (IP)

            2-5 µg/mg lysate
            -
            Product Specifications

            Species Reactivity

            Human

            Host/Isotype

            Rabbit / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            Region between residue 750 and 800 of Human Smad interacting-protein 1.
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            1 mg/mL

            Purification

            Antigen affinity chromatography

            Storage buffer

            tris citrate/phosphate, pH 7-8

            Contains

            0.09% sodium azide

            Storage conditions

            4°C

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            Product Specific Information

            The recommended shelf life for this product is 1 year from date of receipt.

            Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

            Target Information

            ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            References (0)

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            Cite this product

            Bioinformatics

            Protein Aliases: SMAD interacting protein 1; Smad-interacting protein 1; SMADIP1; Zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b; Zinc finger homeobox protein 1b

            View more View less

            Gene Aliases: HRIHFB2411; HSPC082; KIAA0569; SIP-1; SIP1; SMADIP1; ZEB2; ZFHX1B; ZFX1B

            View more View less

            UniProt ID: (Human) O60315

            View more View less

            Entrez Gene ID: (Human) 9839

            View more View less

            Function(s)

            transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding protein binding phosphatase regulator activity metal ion binding R-SMAD binding C2H2 zinc finger transcription factor

            Process(es)

            negative regulation of transcription from RNA polymerase II promoter neural crest cell migration somitogenesis neural tube closure transcription from RNA polymerase II promoter nervous system development corpus callosum morphogenesis hippocampus development cell proliferation in forebrain corticospinal tract morphogenesis positive regulation of Wnt signaling pathway positive regulation of JUN kinase activity positive regulation of melanocyte differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of melanin biosynthetic process developmental pigmentation collateral sprouting positive regulation of axonogenesis mammillary axonal complex development melanocyte migration positive regulation of lens fiber cell differentiation regulation of melanosome organization
            It has to be done as per old AB suggested Products section.
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