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Product Details
23082-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
alpha Actin Fusion Protein Ag19482 (1-50 aa encoded by BC009978)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MCDDEETTA LVCDNGSGLV KAGFAGDDAP RAVFPSIVGR PRHQGVMVGM G (1-50 aa encoded by BC009978)
Target Information
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: actin alpha cardiac; Actin, alpha cardiac muscle 1; Actin, alpha skeletal muscle; Alpha-actin-1; Alpha-cardiac actin; alphac-actin; nemaline myopathy type 3
Gene Aliases: AA959943; ACTA; Acta-2; ACTA1; ACTC; Actc-1; ACTC1; Acts; Actsk-1; ASD5; ASMA; CFTD; CFTD1; CFTDM; CMD1R; CMH11; LVNC4; MPFD; NEM1; NEM2; NEM3; SHPM
UniProt ID: (Human) P68133, (Human) P68032, (Mouse) P68134, (Mouse) P68033
Entrez Gene ID: (Human) 58, (Human) 70, (Mouse) 11459, (Mouse) 11464
muscle contraction
response to mechanical stimulus
response to extracellular stimulus
response to lithium ion
positive regulation of gene expression
cell growth
muscle filament sliding
skeletal muscle thin filament assembly
skeletal muscle fiber adaptation
response to steroid hormone
skeletal muscle fiber development
mesenchyme migration
apoptotic process
actin filament-based movement
actomyosin structure organization
actin-myosin filament sliding
response to drug
negative regulation of apoptotic process
response to ethanol
cardiac myofibril assembly
cardiac muscle tissue morphogenesis
heart contraction
cardiac muscle contraction
metabolic process
actin-mediated cell contraction
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