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Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.
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Protein Aliases: ADD2; ADDB; Adducin beta; Adducin-1; Adducin-alpha; Adducin-beta; Adducin1; Alpha adducin; Alpha-adducin; beta Adducin; Erythrocyte adducin subunit alpha
Gene Aliases: Add1; AI256389
UniProt ID: (Mouse) Q9QYC0
Entrez Gene ID: (Mouse) 11518
Molecular Function: non-motor actin binding protein
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