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Immunogen sequence: MTSATSPII LKWDPKSLEI RTLTVERLLE PLVTQVTTLV NTSNKGPSGK KKGRSKKAHV LAASVEQATQ NFLEKGEQIA KESQDLKEEL VAAVEDVRKQ GETMRIASSE FADDPCSSVK RGTMVRAARA LLSAVTRLLI LADMADVMRL LSHLKIVEEA LEAVKNATNE QDLANRFKEF GKEMVKLNYV AARRQQELKD PHCRDEMAAA RGALKKNATM LYTASQAFLR HPDVAATRAN RDYVFKQVQE AIAGISNAAQ ATSPTDEAKG HTGIGELAAA LNEFDNKIIL DPMTFSEARF RPSLEERLES IISGAALMAD SSCTRDDRRE RIVAECNAVR QALQDLLSEY M (1-350 aa encoded by BC052996)
The catenins (alpha, beta, and gamma) are cytoplasmic proteins found in varying abundance in many developing and adult tissues. Catenins bind directly or indirectly to the conserved cytoplasmic tail domain of the cell adhesion cadherins. The association of catenins to cadherins produces a complex, which is linked to the actin filament network. Catenins/cadherin complexes play an important role in mediating cell adhesion, transduction of cell-cell contact positional signals to the cell interior, and may play a crucial role in cell differentiation. Alpha-Catenin (CAP102, 102 kDa), originally described as an E-cadherin associated protein, has been shown to associate with other members of the cadherin family members, N-cadherin and P-cadherin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Alpha N-catenin; alpha(N)-catenin; Alpha-catenin-related protein; alpha-N-catenin; cadherin associated protein; cadherin-associated protein, related; cancer/testis antigen 114; catenin (cadherin-associated protein), alpha 2; catenin alpha 2; Catenin alpha-2; cerebellar deficient folia; DKFZp686H02198; OTTHUMP00000216460; OTTHUMP00000216462
Gene Aliases: AI481747; CAP-R; CAPR; Catna; Catna2; cdf; chp; CT114; CTNNA2; CTNR
UniProt ID: (Human) P26232, (Mouse) Q61301
Entrez Gene ID: (Human) 1496, (Mouse) 12386, (Rat) 297357
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