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Invitrogen

c-Fos Monoclonal Antibody (2H2)

Name: c-Fos Monoclonal Antibody (2H2)
Brand: Invitrogen
SKU: MA547406
Price: 504.0 USD

View all (106) c-Fos antibodies

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Catalog # MA5-47406

Price (USD)

504.00

Estimated availability date: 16-Jun-2025

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Datasheet

Protocols

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Antibody Testing Data (2)

Application

c-Fos Antibody in Immunohistochemistry (IHC)

FIGURE: 1 / 2

c-Fos Antibody (MA5-47406) in IHC

Immunohistochemistry analysis of c-Fos in rat hippocampus section. Samples were stained with c-Fos monoclonal antibody (Product # MA5-47406) using a dilution of 1:200 (red). Costained with rabbit pAb to FOX3/NeuN (Product # PA5-143605) dilution 1:3,000, in green. The blue is Hoechst staining of nuclear DNA. The c-fos antibody labels nuclei of spontaneously activated neurons, while FOX3/NeuN antibody stains nuclei and distal perikarya of most neurons.

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Product Details

MA5-47406

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500

Immunohistochemistry (IHC)

1:1,000-1:2,000

Immunocytochemistry (ICC/IF)

1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

2H2

Immunogen

Full length recombinant human protein expressed in and purified from E. coli.

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 50% glycerol

Contains

5mM sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2942388

Target Information

FBJ murine osteosarcoma viral oncogene homolog is commonly known as Cellular protooncogene Fos (c-Fos). It belongs to the fos transcription factor family and is encoded by the C-FOS gene located on chromosome 14. c-Fos heterodimerizes with c-Jun to form the Activator Protein -1 (AP-1) transcription factor which regulates transcription of several genes that play an important role in cellular signal transduction, cell proliferation and differentiation. c-Fos has been shown to be phosphorylated by various stimuli including growth factors and insulin at atleast seven different sites. The best known upstream kinase for phosphorylation at Threonine 232 is ERK MAPK which regulates localization of c-Fos to the nucleus and is thus important for c-Fos induced transcriptional activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activator protein 1; c-fos oncogene; cellular oncogene c-fos; Cellular oncogene fos; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS); FBJ murine osteosarcoma viral oncogene homolog; FBJ osteosarcoma oncogene; Fos proto-oncogene, AP-1 trancription factor subunit; Fos proto-oncogene, AP-1 transcription factor subunit; G0/G1 switch regulatory protein 7; Protein c-Fos; Proto-oncogene c-Fos; proto-oncogene cFOS; proto-oncogene protein c-fos; Transcription factor AP-1 subunit c-Fos; v-fos FBJ murine osteosarcoma viral oncogene homolog

Gene Aliases: AP-1; C-FOS; cFos; D12Rfj1; FOS; G0S7; p55

UniProt ID: (Human) P01100, (Mouse) P01101, (Rat) P12841

Entrez Gene ID: (Human) 2353, (Mouse) 14281, (Rat) 314322

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding transcription regulatory region DNA binding protein heterodimerization activity R-SMAD binding DNA binding double-stranded DNA binding sequence-specific DNA binding basic leucine zipper transcription factor

Process(es)

conditioned taste aversion DNA methylation regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter inflammatory response transforming growth factor beta receptor signaling pathway nervous system development female pregnancy aging response to cold response to light stimulus response to gravity response to toxic substance sleep cellular response to extracellular stimulus response to lipopolysaccharide response to progesterone cellular response to hormone stimulus response to cytokine cellular response to reactive oxygen species response to immobilization stress skeletal muscle cell differentiation response to muscle stretch Fc-epsilon receptor signaling pathway response to drug positive regulation of osteoclast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of sequence-specific DNA binding transcription factor activity response to corticosterone response to cAMP SMAD protein signal transduction cellular response to calcium ion positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of transcription, DNA-templated response to mechanical stimulus response to organic cyclic compound

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