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            • Primary Antibodies ›
            • c-Mpl Antibodies

            Invitrogen

            c-Mpl Polyclonal Antibody

            1 Published Figure
            1 Reference
            View all (17) c-Mpl antibodies
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            Cite c-Mpl Polyclonal Antibody

            • Antibody Testing Data (1)
            • Published Figures (1)
            Application
            c-Mpl Antibody in Western Blot (WB)
            Group 53 Created with Sketch.

            FIGURE: 1 / 2

            c-Mpl Antibody (PA5-47042) in WB

            Western blot analysis of c-Mpl lysates of Daudi human Burkitts lymphoma cell line, loaded at 0.2 mg/mL. A specific band was detected for Thrombopoietin at approximately 73 kDa (as indicated) using 20 µg/mL c-Mpl Polyclonal Antibody (Product # PA5-47042) followed by Goat Anti-Human Thrombopoietin R/Tpo R Antigen Affinity-purified Polyclonal Antibody. This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.
            View Product

            c-Mpl Antibody in Western Blot (WB)
            c-Mpl Antibody in Neutralization (Neu)

            Product Details

            PA5-47042

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            0.1 µg/mL
            -

            Neutralization (Neu)

            0.5-2.5 µg/mL
            View 1 publication 1 publication
            Product Specifications

            Species Reactivity

            Human

            Host/Isotype

            Goat / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            Mouse myeloma cell line NS0-derived recombinant human Thrombopoietin R/Tpo R Gln26-Tyr423
            View immunogen

            Conjugate

            Unconjugated

            Form

            Lyophilized

            Concentration

            0.2 mg/mL

            Purification

            Antigen affinity chromatography

            Storage buffer

            PBS with 5% trehalose

            Contains

            No Preservative

            Storage conditions

            -20°C, Avoid Freeze/Thaw Cycles

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            RRID

            AB_2608846

            Product Specific Information

            In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human Epo R is observed.

            Reconstitute at 0.2 mg/mL in sterile PBS.

            Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

            Target Information

            In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            Bioinformatics

            Protein Aliases: CD110; Myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene; Proto-oncogene c-Mpl; Thrombopoietin receptor; TPO-R

            View more View less

            Gene Aliases: C-MPL; CD110; MPL; MPLV; THCYT2; TPOR

            View more View less

            UniProt ID: (Human) P40238

            View more View less

            Entrez Gene ID: (Human) 4352

            View more View less

            Function(s)

            transmembrane signaling receptor activity protein binding thrombopoietin receptor activity transmembrane signal receptor

            Process(es)

            cell surface receptor signaling pathway cell proliferation thrombopoietin-mediated signaling pathway
            It has to be done as per old AB suggested Products section.
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            If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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