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Invitrogen
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants.
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Protein Aliases: CEA receptor; Heterogeneous nuclear ribonucleoprotein M; heterogenous nuclear ribonucleoprotein M4; hnRNA-binding protein M4; hnRNP M; M4 protein; N-acetylglucosamine receptor 1
Gene Aliases: 2610023M21Rik; AA409009; CEAR; hnRNP M; HNRNPM; HNRNPM4; HNRPM; HNRPM4; HTGR1; mKIAA4193; NAGR1
UniProt ID: (Human) P52272, (Rat) Q62826, (Mouse) Q9D0E1
Entrez Gene ID: (Human) 4670, (Rat) 116655, (Mouse) 76936
Molecular Function:
RNA metabolism protein
RNA processing factor
RNA splicing factor
nucleic acid metabolism protein
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