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Product Details
PA5-118599
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GRM4(Accession Q14833), corresponding to amino acid residues R856-T906.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2903099
Product Specific Information
Antibody detects endogenous levels of total mGluR4.
Target Information
The Metabotropic Glutamate Receptor mGluR4/GRM4 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G protein-coupled receptor GRM4; G protein-coupled receptor, family C, group 1, member D; glutamate receptor; glutamate receptor, metabotropic 4; Metabotropic glutamate receptor 4; mGluR4
Gene Aliases: GPRC1D; GRM4; mGlu4; MGLUR4
UniProt ID: (Human) Q14833, (Rat) P31423, (Mouse) Q68EF4
Entrez Gene ID: (Human) 2914, (Rat) 24417, (Mouse) 268934
activation of MAPK activity
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
chemical synaptic transmission
neurotransmitter secretion
positive regulation of MAPK cascade
regulation of neuron apoptotic process
regulation of synaptic transmission, glutamatergic
learning
negative regulation of cell proliferation
gamma-aminobutyric acid secretion
neuron projection development
synaptic transmission, glutamatergic
negative regulation of apoptotic process
negative regulation of synaptic transmission
synaptic transmission, GABAergic
signal transduction
G-protein coupled receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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