Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
MA5-31755 has been tested in indirect ELISA.
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ41058; glutamate receptor; glutamate receptor, metabotropic 8; M mGlu8; Metabotropic glutamate receptor 8; MGC126724; mGluR8
Gene Aliases: GLUR8; GPRC1H; GRM8; mGlu8; MGLUR8
UniProt ID: (Human) O00222
Entrez Gene ID: (Human) 2918
Molecular Function:
G-protein coupled receptor
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