Product References
Large-scale microRNA functional high-throughput screening identifies miR-515-3p and miR-519e-3p as inducers of human cardiomyocyte proliferation.
iScience
Renikunta HV,Lazarow K,Gong Y,Shukla PC,Nageswaran V,Giral H,Kratzer A,Opitz L,Engel FB,Haghikia A,Costantino S,Paneni F,von Kries JP,Streckfuss-Bömeke K,Landmesser U,Jakob P
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Western Blot
Fri May 19 00:00:00 UTC 2023
NFATc1 Regulation of Dexamethasone-Induced TGFB2 Expression Is Cell Cycle Dependent in Trabecular Meshwork Cells.
Cells
Filla MS,Faralli JA,Dunn CR,Khan H,Peters DM
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunohistochemistry (Paraffin)
Fri Feb 03 00:00:00 UTC 2023
NFATc1 Regulation of Dexamethasone-Induced TGFB2 Expression Is Cell Cycle Dependent in Trabecular Meshwork Cells.
Cells
Filla MS,Faralli JA,Dunn CR,Khan H,Peters DM
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunohistochemistry (Paraffin)
Fri Feb 03 00:00:00 UTC 2023
Single Fraction and Hypofractionated Radiation Cause Cochlear Damage, Hearing Loss, and Reduced Viability of Merlin-Deficient Schwann Cells.
Cancers
Dinh CT,Chen S,Nourbakhsh A,Padgett K,Johnson P,Goncalves S,Bracho O,Bas E,Bohorquez J,Monje PV,Fernandez-Valle C,Elsayyad N,Liu X,Welford SM,Telischi F
MA5-14949 was used in Immunocytochemistry to investigate the effects of single fraction and hypofractionated radiation on hearing thresholds in rats, cell death pathways in rat cochleae, and viability of human merlin-deficient Schwann cells (MD-SC).
Thu May 18 00:00:00 UTC 2023
KRT5+/p63+ Stem Cells Undergo Senescence in the Human Lung with Pathological Aging.
Aging and disease
Moreno-Valladares M,Moncho-Amor V,Silva TM,Garcés JP,Álvarez-Satta M,Matheu A
MA5-14949 was used in Immunohistochemistry-immunofluorescence to provide new evidence of the activity of p63+/KRT5+ stem cells on human lung regeneration and point out that regeneration machinery in human lung is activated under stress due to aging, but fails to repair in pathological cases, as stem cells would likely become senescent.
Thu Jun 01 00:00:00 UTC 2023
Cyanidin 3-O-arabinoside suppresses DHT-induced dermal papilla cell senescence by modulating p38-dependent ER-mitochondria contacts.
Journal of biomedical science
Jung YH,Chae CW,Choi GE,Shin HC,Lim JR,Chang HS,Park J,Cho JH,Park MR,Lee HJ,Han HJ
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Western Blot
Mon Mar 07 00:00:00 UTC 2022
Cyanidin 3-O-arabinoside suppresses DHT-induced dermal papilla cell senescence by modulating p38-dependent ER-mitochondria contacts.
Journal of biomedical science
Jung YH,Chae CW,Choi GE,Shin HC,Lim JR,Chang HS,Park J,Cho JH,Park MR,Lee HJ,Han HJ
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Western Blot
Mon Mar 07 00:00:00 UTC 2022
CUDC907, a dual phosphoinositide-3 kinase/histone deacetylase inhibitor, promotes apoptosis of NF2 Schwannoma cells.
Oncotarget
Huegel J,Dinh CT,Martinelli M,Bracho O,Rosario R,Hardin H,Estivill M,Griswold A,Gultekin S,Liu XZ,Fernandez-Valle C
MA5-14949 was used in Immunohistochemistry to screened PI3K pathway inhibitors for efficacy in reducing viability of human schwannoma cells.
Thu Aug 10 00:00:00 UTC 2023
Senolysis-Based Elimination of Chemotherapy-Induced Senescent Breast Cancer Cells by Quercetin Derivative with Blocked Hydroxy Groups.
Cancers
Lewińska A,Przybylski P,Adamczyk-Grochala J,Błoniarz D,Litwinienko G,Wnuk M
MA5-14949 was used in Immunocytochemistry-immunofluorescence to study targeted elimination of senescent cells using synthesized quercetin derivatives which were tested for improved senolytic action against etoposide-induced senescent human normal mammary epithelial cells and triple-negative breast cancer cells in vitro.
Tue Jan 25 00:00:00 UTC 2022
Decreased p53 is associated with a decline in asymmetric stem cell self-renewal in aged human epidermis.
Aging cell
Charruyer A,Weisenberger T,Li H,Khalifa A,Schroeder AW,Belzer A,Ghadially R
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Mon Feb 01 00:00:00 UTC 2021
Decreased p53 is associated with a decline in asymmetric stem cell self-renewal in aged human epidermis.
Aging cell
Charruyer A,Weisenberger T,Li H,Khalifa A,Schroeder AW,Belzer A,Ghadially R
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Mon Feb 01 00:00:00 UTC 2021
Interleukin-6 neutralization ameliorates symptoms in prematurely aged mice.
Aging cell
Squarzoni S,Schena E,Sabatelli P,Mattioli E,Capanni C,Cenni V,D'Apice MR,Andrenacci D,Sarli G,Pellegrino V,Festa A,Baruffaldi F,Storci G,Bonafè M,Barboni C,Sanapo M,Zaghini A,Lattanzi G
MA5-14949 was used in Western Blot to show that tocilizumab counteracts aberrant differentiation of adipocytes and osteoblasts, improves adipose tissue dystrophy, aorta histological lesions, and skeletal deterioration, and positively impacts the overall condition of progeroid mice, while reducing progerin accumulation and its deleterious effects in mouse and human progeria cells.
Fri Jan 01 00:00:00 UTC 2021
Interleukin-6 neutralization ameliorates symptoms in prematurely aged mice.
Aging cell
Squarzoni S,Schena E,Sabatelli P,Mattioli E,Capanni C,Cenni V,D'Apice MR,Andrenacci D,Sarli G,Pellegrino V,Festa A,Baruffaldi F,Storci G,Bonafè M,Barboni C,Sanapo M,Zaghini A,Lattanzi G
MA5-14949 was used in Western Blot to show that tocilizumab counteracts aberrant differentiation of adipocytes and osteoblasts, improves adipose tissue dystrophy, aorta histological lesions, and skeletal deterioration, and positively impacts the overall condition of progeroid mice, while reducing progerin accumulation and its deleterious effects in mouse and human progeria cells.
Fri Jan 01 00:00:00 UTC 2021
Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes.
Aging
Schwartz RE,Shokhirev MN,Andrade LR,Gutkind JS,Iglesias-Bartolome R,Shadel GS
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Fri Feb 12 00:00:00 UTC 2021
Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes.
Aging
Schwartz RE,Shokhirev MN,Andrade LR,Gutkind JS,Iglesias-Bartolome R,Shadel GS
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Fri Feb 12 00:00:00 UTC 2021
Baricitinib, a JAK-STAT Inhibitor, Reduces the Cellular Toxicity of the Farnesyltransferase Inhibitor Lonafarnib in Progeria Cells.
International journal of molecular sciences
Arnold R,Vehns E,Randl H,Djabali K
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Mon Jul 12 00:00:00 UTC 2021
Baricitinib, a JAK-STAT Inhibitor, Reduces the Cellular Toxicity of the Farnesyltransferase Inhibitor Lonafarnib in Progeria Cells.
International journal of molecular sciences
Arnold R,Vehns E,Randl H,Djabali K
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Mon Jul 12 00:00:00 UTC 2021
Palbociclib-mediated cell cycle arrest can occur in the absence of the CDK inhibitors p21 and p27.
Open biology
Pennycook BR,Barr AR
MA5-14949 was used in Immunocytochemistry and Western Blotting to clarify the mechanism of action of CDK4/6 inhibitors and has implications for cancer treatment and patient stratification.
Mon Nov 01 00:00:00 UTC 2021
Palbociclib-mediated cell cycle arrest can occur in the absence of the CDK inhibitors p21 and p27.
Open biology
Pennycook BR,Barr AR
MA5-14949 was used in Immunocytochemistry and Western Blotting to clarify the mechanism of action of CDK4/6 inhibitors and has implications for cancer treatment and patient stratification.
Mon Nov 01 00:00:00 UTC 2021
Palbociclib-mediated cell cycle arrest can occur in the absence of the CDK inhibitors p21 and p27.
Open biology
Pennycook BR,Barr AR
MA5-14949 was used in Immunocytochemistry and Western Blotting to clarify the mechanism of action of CDK4/6 inhibitors and has implications for cancer treatment and patient stratification.
Mon Nov 01 00:00:00 UTC 2021
Palbociclib-mediated cell cycle arrest can occur in the absence of the CDK inhibitors p21 and p27.
Open biology
Pennycook BR,Barr AR
MA5-14949 was used in Immunocytochemistry and Western Blotting to clarify the mechanism of action of CDK4/6 inhibitors and has implications for cancer treatment and patient stratification.
Mon Nov 01 00:00:00 UTC 2021
The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence.
Aging
Bloniarz D,Adamczyk-Grochala J,Lewinska A,Wnuk M
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Thu Jun 17 00:00:00 UTC 2021
AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts.
Redox biology
Lewinska A,Adamczyk-Grochala J,Bloniarz D,Olszowka J,Kulpa-Greszta M,Litwinienko G,Tomaszewska A,Wnuk M,Pazik R
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunofluorescence
Wed Jan 01 00:00:00 UTC 2020
AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts.
Redox biology
Lewinska A,Adamczyk-Grochala J,Bloniarz D,Olszowka J,Kulpa-Greszta M,Litwinienko G,Tomaszewska A,Wnuk M,Pazik R
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunofluorescence
Wed Jan 01 00:00:00 UTC 2020
AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts.
Redox biology
Lewinska A,Adamczyk-Grochala J,Bloniarz D,Olszowka J,Kulpa-Greszta M,Litwinienko G,Tomaszewska A,Wnuk M,Pazik R
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunofluorescence
Wed Jan 01 00:00:00 UTC 2020
Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin-BAF Interaction and BAF Nuclear Localization.
Cells
Cenni V,Squarzoni S,Loi M,Mattioli E,Lattanzi G,Capanni C
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Western Blot
Sat Jun 06 00:00:00 UTC 2020
Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin-BAF Interaction and BAF Nuclear Localization.
Cells
Cenni V,Squarzoni S,Loi M,Mattioli E,Lattanzi G,Capanni C
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Western Blot
Sat Jun 06 00:00:00 UTC 2020
Sodium butyrate inhibits high cholesterol-induced neuronal amyloidogenesis by modulating NRF2 stabilization-mediated ROS levels: involvement of NOX2 and SOD1.
Cell death & disease
Kim SY,Chae CW,Lee HJ,Jung YH,Choi GE,Kim JS,Lim JR,Lee JE,Cho JH,Park H,Park C,Han HJ
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Western Blot
Thu Jun 18 00:00:00 UTC 2020
Modulated Electro-Hyperthermia-Induced Tumor Damage Mechanisms Revealed in Cancer Models.
International journal of molecular sciences
Krenacs T,Meggyeshazi N,Forika G,Kiss E,Hamar P,Szekely T,Vancsik T
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Sat Aug 29 00:00:00 UTC 2020
Modulated Electro-Hyperthermia-Induced Tumor Damage Mechanisms Revealed in Cancer Models.
International journal of molecular sciences
Krenacs T,Meggyeshazi N,Forika G,Kiss E,Hamar P,Szekely T,Vancsik T
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Sat Aug 29 00:00:00 UTC 2020
Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells.
Cells
Liu C,Arnold R,Henriques G,Djabali K
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Western Blot
Fri Oct 18 00:00:00 UTC 2019
Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells.
Cells
Liu C,Arnold R,Henriques G,Djabali K
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Western Blot
Fri Oct 18 00:00:00 UTC 2019
Snake venoms promote stress-induced senescence in human fibroblasts.
Journal of cellular physiology
Lewinska A,Bocian A,Petrilla V,Adamczyk-Grochala J,Szymura K,Hendzel W,Kaleniuk E,Hus KK,Petrillova M,Wnuk M
MA5-14949 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to investigate snake-venom-induced adaptive response at a relatively noncytotoxic concentration (0.01 µg/ml) in two human fibroblast cell lines of different origin, namely WI-38 fetal lung fibroblasts and BJ foreskin fibroblasts.
Wed May 01 00:00:00 UTC 2019
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS.
Aging cell
Mattioli E,Andrenacci D,Garofalo C,Prencipe S,Scotlandi K,Remondini D,Gentilini D,Di Blasio AM,Valente S,Scarano E,Cicchilitti L,Piaggio G,Mai A,Lattanzi G
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Western Blot
Mon Oct 01 00:00:00 UTC 2018
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS.
Aging cell
Mattioli E,Andrenacci D,Garofalo C,Prencipe S,Scotlandi K,Remondini D,Gentilini D,Di Blasio AM,Valente S,Scarano E,Cicchilitti L,Piaggio G,Mai A,Lattanzi G
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Western Blot
Mon Oct 01 00:00:00 UTC 2018
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS.
Aging cell
Mattioli E,Andrenacci D,Garofalo C,Prencipe S,Scotlandi K,Remondini D,Gentilini D,Di Blasio AM,Valente S,Scarano E,Cicchilitti L,Piaggio G,Mai A,Lattanzi G
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Western Blot
Mon Oct 01 00:00:00 UTC 2018
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS.
Aging cell
Mattioli E,Andrenacci D,Garofalo C,Prencipe S,Scotlandi K,Remondini D,Gentilini D,Di Blasio AM,Valente S,Scarano E,Cicchilitti L,Piaggio G,Mai A,Lattanzi G
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Western Blot
Mon Oct 01 00:00:00 UTC 2018
Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation-related miRNA expression.
Redox biology
Lewinska A,Adamczyk-Grochala J,Kwasniewicz E,Deregowska A,Semik E,Zabek T,Wnuk M
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Western Blot
Sun Apr 01 00:00:00 UTC 2018
Preclinical Efficacy of the MDM2 Inhibitor RG7112 in MDM2-Amplified and TP53 Wild-type Glioblastomas.
Clinical cancer research : an official journal of the American Association for Cancer Research
Verreault M,Schmitt C,Goldwirt L,Pelton K,Haidar S,Levasseur C,Guehennec J,Knoff D,Labussière M,Marie Y,Ligon AH,Mokhtari K,Hoang-Xuan K,Sanson M,Alexander BM,Wen PY,Delattre JY,Ligon KL,Idbaih A
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Tue Mar 01 00:00:00 UTC 2016
Preclinical Efficacy of the MDM2 Inhibitor RG7112 in MDM2-Amplified and TP53 Wild-type Glioblastomas.
Clinical cancer research : an official journal of the American Association for Cancer Research
Verreault M,Schmitt C,Goldwirt L,Pelton K,Haidar S,Levasseur C,Guehennec J,Knoff D,Labussière M,Marie Y,Ligon AH,Mokhtari K,Hoang-Xuan K,Sanson M,Alexander BM,Wen PY,Delattre JY,Ligon KL,Idbaih A
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Tue Mar 01 00:00:00 UTC 2016
Disentangling the aneuploidy and senescence paradoxes: a study of triploid breast cancers non-responsive to neoadjuvant therapy.
Histochemistry and cell biology
Gerashchenko BI,Salmina K,Eglitis J,Huna A,Grjunberga V,Erenpreisa J
MA5-14949 was used in immunohistochemistry to analyze triploid breast cancers non-responsive to neoadjuvant therapy by study of aneuploidy and senescence paradoxes
Fri Apr 01 00:00:00 UTC 2016
Detection of mesenchymal stem cells senescence by prelamin A accumulation at the nuclear level.
SpringerPlus
Bellotti C,Capanni C,Lattanzi G,Donati D,Lucarelli E,Duchi S
MA514949 was used in immunocytochemistry to correlate lamin A maturation and cellular senescence
Wed Sep 14 00:00:00 UTC 2016
Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide.
Cell cycle (Georgetown, Tex.)
Huna A,Salmina K,Erenpreisa J,Vazquez-Martin A,Krigerts J,Inashkina I,Gerashchenko BI,Townsend PA,Cragg MS,Jackson TR
MA5-14949 was used in western blot to elucidate the mechanism of p53-dependent upregulation of OCT4A and p21Cip1.
Wed Aug 03 00:00:00 UTC 2016
Sp1 acetylation is associated with loss of DNA binding at promoters associated with cell cycle arrest and cell death in a colon cell line.
Molecular cancer
Waby JS,Chirakkal H,Yu C,Griffiths GJ,Benson RS,Bingle CD,Corfe BM
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Fri Oct 15 00:00:00 UTC 2010
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.jpg?time=20220826?time=20220826 "p21 Antibody (MA5-14949) in WB")
.jpg?time=20220826?time=20220826 "p21 Antibody (MA5-14949) in WB")
