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Bioss

p95 NBS1 Polyclonal Antibody

View all (92) NBS1 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (1)

Application

p95 NBS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 1

p95 NBS1 Antibody (BS-6124R) in IHC (P)

Formalin-fixed and paraffin embedded mouse embryo labeled with Anti-p95 NBS1/Cell cycle regulatory protein p95 Polyclonal Antibody, Unconjugated (bs-6124R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

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Product Details

BS-6124R

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500

Immunocytochemistry (ICC/IF)

1:50-1:200

ELISA (ELISA)

1:500-1:1,000

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human NBS1, amino acids 641-754.

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AT V1; AT V2; Cell cycle regulatory protein p95; FLJ10155; hNbs1; MGC87362; Nibrin; Nijmegen breakage syndrome 1 (nibrin); Nijmegen breakage syndrome protein 1; Nijmegen breakage syndrome protein 1 homolog; OTTHUMP00000204088; p95 protein of the MRE11/RAD50 complex; p95-NBS1

Gene Aliases: AT-V1; AT-V2; ATV; NBN; NBS; NBS1; P95

UniProt ID: (Human) O60934, (Mouse) Q9R207, (Rat) Q9JIL9

Entrez Gene ID: (Human) 4683, (Mouse) 27354, (Rat) 85482

Function(s)

damaged DNA binding ATP-dependent DNA helicase activity protein binding transcription factor binding protein N-terminus binding molecular_function damaged DNA-binding protein

Process(es)

DNA damage checkpoint telomere maintenance double-strand break repair via homologous recombination DNA double-strand break processing DNA synthesis involved in DNA repair strand displacement blastocyst growth DNA replication double-strand break repair double-strand break repair via nonhomologous end joining cell cycle arrest mitotic cell cycle checkpoint mitotic G2 DNA damage checkpoint cell proliferation regulation of DNA-dependent DNA replication initiation DNA damage response, signal transduction by p53 class mediator telomeric 3' overhang formation positive regulation of protein autophosphorylation positive regulation of telomere maintenance DNA duplex unwinding positive regulation of kinase activity isotype switching neuromuscular process controlling balance meiotic cell cycle intrinsic apoptotic signaling pathway regulation of signal transduction by p53 class mediator negative regulation of telomere capping in utero embryonic development DNA repair cellular response to DNA damage stimulus cell cycle positive regulation of cell proliferation negative regulation of neuron differentiation negative regulation of viral entry into host cell regulation of fibroblast proliferation response to drug

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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