Bringing Raman Analysis Closer to the Sample

Multi-modal analysis with Raman spectrometers

By simultaneously measuring the Raman spectrum along with mechanical, thermal, and other physical properties, researchers can obtain the broad range of insights they need to improve product quality and performance.

Yet one of the challenges has been the difficulty of obtaining accurate, repeatable data when taking separate measurements under different conditions. Historically, users combining Raman with other techniques such as rheology, hot melt extrusion, and X-ray photoelectron spectroscopy (XPS) have found it challenging to capture measurements under identical conditions

Multiple techniques, one measurement

Our new Thermo Scientific DXR3 Flex Raman Spectrometer addresses these problems by providing a research-grade Raman spectrometer specifically designed for integration with other analytical tools. The open-architecture design makes it ideal for multi-modal analysis and offers minimum signal loss as there are no fiber optics involved for instrument coupling.

By pairing the DXR3 Flex Raman Spectrometer with other analytical tools, users can learn about the physical, chemical, and structural characteristics of their samples as well as how different characteristics affect one another. One measurement provides data from multiple techniques, all taken simultaneously under the same conditions—providing the accurate, fast answers researchers need.

Analyzing samples in their native state with Raman spectrometers

Moreover, the DXR3 Flex Raman Spectrometer can be coupled with a wide range of accessories for use with different types of samples. This allows researchers to bring the instrument closer to the sample in its native state to capture the quick and accurate information they need.

 

By pairing the DXR3 Flex Raman Spectrometer with different accessories, for example, users can measure large samples. They can measure powders and liquids through the walls of glass and plastic containers. They can examine small areas of interest ranging from a few micrometers to 100 micrometers in size. They can employ a camera to visualize the sample or area of interest. And they can take process measurements, while analyzing samples in their native form.

This compact spectrometer uses the same design and optics as advanced spectrometers in the DXR3 Raman Spectrometer product family, making it an effective mobile instrument for forensics specialists, environmental researchers, geologists, and other users who need immediate results. And unlike most compact Raman spectrometers on the market, theDXR3 Flex Raman Spectrometer enables users to change laser frequencies to achieve different wavelengths of excitation, helping them optimize their Raman signal to remove or reduce background fluorescence.

A Raman spectrometer designed for a wide range of applications

As we developed the DXR3 Flex Raman Spectrometer, we worked closely with engineers from different fields to understand their needs, and then built the accessories accordingly. The result is Raman spectrometer that can easily be configured to solve specific customer problems—making it useful for a broad range of industry applications.

For example, researchers in the pharmaceutical industry can analyze polymorphs and particulate contaminants. Geologists can identify colored stones and distinguish natural and synthetic diamonds. Biologists can identify protein structures and biomolecules. Plastics manufacturers can pinpoint inclusions, gel defects, and weathering effects. Art historians can use it to identify specific paint pigments. And cosmetics producers can analyze product dyes and impurities.

These are just a few examples of the diverse industries that can accelerate their research with this new Raman spectrometer. Read more examples here and here.

To learn more about the Thermo Scientific DXR3 Flex Raman Spectrometer, visit  thermofisher.com/flex.

 

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Sudhir Dahal is a product manager for Raman spectroscopy at Thermo Fisher Scientific.