Raman Spectroscopy Resources

Pharmaceutical formations are typically complex mixtures that need to be carefully verified and understood. Raman spectroscopy is a proven method for identifying and verifying the presence of a variety of different components and providing detailed information on molecular structure and chemical environments.  Raman imaging adds a spatial dimension to the analysis and extends the power of Raman spectroscopy across the sample.

Some of the applications of Raman imaging relevant to pharmaceutical evaluations include:

• Revealing spatial distribution of components - homogeneity and content uniformity
• Assessing particle size including relative percentages of components
• Differentiating and displaying chemically similar components such as polymorphs
• Quickly surveying larger areas and conducting detailed studies of smaller areas

Raman imaging for life science research offers unique analytical capabilities for cell biology, enabling label-free characterization of biological systems with sub-micron spatial resolution. The ability to visualize living samples spatially and temporally to non-invasively understand molecular composition and dynamics has made Raman imaging a promising tool for cellular analysis. The DXRxi Raman imaging microscope allows the user to study living specimens through chemical imaging of components in their native environment. We will illustrate how this is an effective technique for live human cells, bacteria cells, and model organisms.

Among the topics to be discussed in this webinar:

• Collection of Raman images from live cells showing the distribution of biological components including nucleic acids, cytochrome c, lipids, and proteins.
• Examples of how Raman imaging can be used for chemical analysis of live cells, bacteria cells and model organisms.

In our energy savvy society, we are seeing an increasing demand for renewable energy and new trends in energy storage. Although lithium-ion batteries offer the highest energy density among present commercial rechargeable batteries, the technology is still in need of vast improvements. Researchers seek solutions to understanding a diverse family of materials and chemical effects in lithium-ion batteries. Breaking through the ceiling of technology restraints is critical, and part of understanding the lithium-ion battery in full includes the chemistry inside of the cell.

This webinar illustrates how the lithium-ion battery works, and in effect, what types of problems are investigated within the laboratory. It will be the first part in a series of solution-focused webinars showing how we can help resolve the lithium-ion batteries' complicated mysteries.

What you will learn:

• The lithium-ion battery defined
• Major research pieces in question
• Influential battery components
• Lithium-ion battery problems

The rising demand of energy and the technological transformation of our energy systems require new and better battery materials. The success of the electric vehicle and the introduction of alternative energy sources are highly dependent on new batteries with higher energy density and longer life-time. Lithium-ion batteries are the actual state of technology, with a lot of potential for improvement and research beyond the lithium-ion technology, such as magnesium and sodium. The key for development is in new materials and the improvement of existing materials for better anodes, cathodes, separators, and electrolytes. However, before using these new materials in commercial batteries, it is necessary to characterize and test them in a laboratory environment. 

This webinar introduces the basics of characterizing battery materials and the special equipment required to run these tests. We will specifically cover:

Basics of testing battery materials:

• 2 vs. 3 electrode measurements
• Optical in situ measurements

Exemplary case studies:

• PAT-Series test cells
• An in situ test cell for Raman spectroscopy

This presentation will focus upon what information is present in the Raman spectrum of carbon nanotubes and graphene and how Raman spectroscopy is a critical tool for everyone involved in the development and use of these materials.

This presentation will focus on characterizing graphene, carbon nanotubes, and diamond-like carbon films using Raman spectroscopy.

Learn how to:

• Generate vital qualitative and quantitative data
• Interpret Raman spectra for layer thickness, domain size and more
• Assess efficiency of carbon nanotube separation/purification methods

Raman spectroscopy can characterize nanomaterials at different stages in their development, including guiding new synthetic routes for higher quality materials to assessing the effectiveness of desired chemical modifications and evaluating finished devices. This webinar will present a survey of applications where Raman gives important insight into these quickly evolving materials.

Raman spectroscopy provides important information such as layer thickness, uniformity, quality and functionalization, key parameters that ultimately determines the properties these materials will possess. This webinar will present an overview of recent work where Raman spectroscopy is playing vital role in realizing the development and full potential of these materials, spanning the range of applications from advanced composites, energy storage, transparent electrodes, and sensor technologies.

In our mobile society, we heavily rely on portable energy sources leading to driving improvements in battery technology. Although lithium-ion batteries offer the highest energy density among present commercial rechargeable batteries, the technology is still evolving and improving. Raman spectroscopy is a very versatile analytical tool that can be used to analyze the diverse materials that are used in lithium-ion batteries.

This presentation will illustrate how the structural and chemical information obtained from Raman spectroscopy can be applied to the analysis of components of lithium-ion batteries including cathodes, anodes, and electrolytes.

Good materials characterization is required across all steps in the creation of new graphene devices—from guiding the initial graphene synthesis, transfer to the desired substrate, and understanding chemical modification and analysis of the finished device. Our webinar presentation shows how a multi-technique approach using both Raman spectroscopy and XPS can address the challenges posed at these steps.

Using both techniques together allows analysts to completely characterize carbon nanomaterials. Our webinar demonstrates the utility of these techniques, illustrated by examples from graphene samples created by mechanical exfoliation, chemical reduction and CVD methods.

Areas of Interest:

• Graphene Devices
• Transparent conductive electrode for microelectronics
• Thin film transistors
• Touch Screen Devices
• Graphene-based catalytic systems
• Molecular Sensors

This webinar demonstrates how new tools like enhanced low-pressure diamond cells and micro-ATR produce excellent results on samples important in Forensic investigations.

Topics will include:

• Sampling approaches to improve performance and data reliability for FTIR microscopy in forensic laboratories
• Learning special tools for simplifying micro-FTIR including: diamond cells, micro-ATR, preparation tips, and creating data bases
• Combining FT-IR with an optical microscope to extend analysis power to many small and complex forensic samples such as fibers, paint chips, inks, and other physical evidence
• How IR microscopy can produce excellent results on fibers, paints, inks, and energetic materials samples.
• Using Raman microscopy for some samples to get around certain spatial resolution and sample preparation problems, while supplying equally diagnostic results
• Software tools applicable to both techniques for identifying unknowns and mixtures will also be discussed

Raman spectroscopy can be used for the analysis of prescription, counterfeit, and designer drug tablets in just minutes with little to no sample preparation. As part of the presentation, we will make our debut presentation of the new Law Enforcement and Security (LEnS) spectral library which contains over 8300 unique spectra. Also featured will be the use of our multicomponent spectral search software, OMNIC Specta, for simplifying the analysis of complex tablet data.

Biological tissues pose an analytical challenge because they are compositionally complex and the information, they provide can be difficult to objectively uncover. Raman spectroscopy offers an objective technique for characterization, however information from Raman spectra can be hard to reliably extract. We will explore how Raman microscopy can be utilized as a simple, non-invasive method to biochemically characterize healing wounds, particularly when coupled with multivariate spectral analysis to accurately identify different phases of the healing of wounds with time in clinical research.

Considering wounds as a model biological surface, the webinar will address:

• Challenges associated with collection of Raman spectra from a biological tissue or surface
• The potential of Raman spectroscopy for real-time, in situ biochemical characterization of biological tissues for clinical research 

Raman imaging for life science research offers unique analytical capabilities for cell biology, enabling label-free characterization of biological systems with sub-micron spatial resolution. The ability to visualize living samples spatially and temporally to non-invasively understand molecular composition and dynamics has made Raman imaging a promising tool for cellular analysis. The DXRxi Raman imaging microscope allows the user to study living specimens through chemical imaging of components in their native environment. We will illustrate how this is an effective technique for live human cells, bacteria cells, and model organisms.

Among the topics to be discussed in this webinar:

• Collection of Raman images from live cells showing the distribution of biological components including nucleic acids, cytochrome c, lipids, and proteins.
• Examples of how Raman imaging can be used for chemical analysis of live cells, bacteria cells and model organisms.

The combination of FTIR and Raman spectroscopy with mapping is well-suited for identifying and sizing API domains. Both techniques provide excellent chemical and spatial information about the distribution and concentration of the API in a tablet.

During this webinar, you’ll learn how to:

• Collect area data in FTIR and Raman imaging
• Process and analyze a large mapping/imaging data set
• Understand and interpret the data to communicate to stakeholders