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One of the oldest reactions in organic chemistry, the Fischer Indole synthesis is the condensation of a substituted phenylhydrazine and a carbonyl compound under acidic conditions to produce an aromatic heterocycle indole.
Watch our video to learn more about the Fischer Indole synthesis and its mechanisms.
In 1883, E. Fischer and F. Jourdan treated pyruvic acid 1-methylphenylhydrazone with alcoholic hydrogen chloride and generated 1-methylindole-2-carboxylic acid. Preparing indoles by heating the arylhydrazones of either aldehydes or ketones in the presence of a protic or Lewis acid is now known as the Fischer indole synthesis. Since its discovery, it has remained the most important method of preparing substituted indoles.
Main features of the Fischer indole synthesis:
Other Heterocycle Formation Reactions include:
For other types of reactions, visit our Named Reactions page.
Chemical reactions often involve the use of air- and moisture-sensitive solvents, and pyrophoric or hazardous reagents. Our AcroSeal packaging is a packaging solution designed to enable safe handling of these types of materials which are used in a variety of research and development applications, including NMR analysis and studies in drug discovery, agrochemicals, flavors and fragrances, and more.
Watch our video for more information.