Cell Therapy Learning Center

Accelerate your knowledge, and maximize your time, effort, and clinical outcomes

At Thermo Fisher Scientific, our goal is to support you from initial discovery through clinical trials to commercially viable gene-modified cell therapies. Here, you can find resources for a broad range of techniques and application notes or learn about meeting the demanding needs of clinical research.

Cell type:
Immune cells
Stem cells
Focus area:
Cell isolation and cell activation
Genome editing
Cell processing
Cell culture and expansion
Formulation, fill, finish and cryopreservation
Lot release, characterization
Supply chain and logisitcs
Analytics
Outsourcing strategy
Automation strategy
Collaboration program
Services:
Translational research services
Viral vector CDMO services
Cell therapy CDMO services
Clinical supply services
Clinical trial services (CRO)
Regulatory
Content type:
Application notes
Articles
Brochures
Case studies
eBooks
Infoposters
Protocols
Webinars
Videos
Publications
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Digital connectivity and standardization within cell therapy manufacturing

This article will introduce the importance of digital connectivity solutions to ensure process and data integrity and integration of instruments into your DCS system.
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Scaling nonviral cell therapy approaches for solid tumor treatments

Learn how PACT Pharma Inc. revolutionized a nonviral precision genome engineering process through automation and standardization of the end-to-end cell therapy manufacturing workflow.
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Strategic partnering to enable cell therapy commercialization

In this article, cell therapy manufacturing leaders from ArsenalBio and Thermo Fisher Scientific discuss the benefits of building partnerships between biotech and pharma to optimize and accelerate cel...
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Cell therapy handbook: Considerations for cell therapy development and manufacturing

A review of the latest methodologies, common practices, resources, applications and more, to support every step of your cell therapy manufacturing workflow.
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Raw material considerations for cell therapies

This blog intends to provide a high-level overview of the considerations used to select raw materials that mitigate risk and align with current regulatory guidelines.
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Manufacturing CAR T Cell Therapies: Challenges, Insights and Solutions

Manufacturing autologous CAR T cell therapies presents significant challenges, from patient-specific logistics to rigorous regulatory demands. This blog post highlights Thermo Fisher Scientific’s Cell...
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Strategic raw material selection for cell therapy commercialization

In this webinar, industry leaders share important factors for critical raw materials selection, top considerations when evaluating a raw materials supplies, and how to navigate global regulatory compl...
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Key Considerations for Cell Therapy Trials Beyond Oncology

This webinar explores the key considerations of cell therapy trials, from clinical site readiness to ensuring patient safety, all while meeting trial goals.
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A Journey to Cell Therapy Manufacturing: From R&D to Lot-release

In this webinar, we will discuss considerations when preparing to commercialize a cell therapy including starting/raw material, controlled manufacturing processes and testing safety and quality.
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Enabling development of scalable, personalized cell therapies for solid tumor treatments

Non-viral electroporation is emerging as the method of choice for gene editing of harvested immune cells, as reported in a recent study published in Nature Portfolio and discussed by Thermo Fisher Sci...
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Flexible and scalable nonviral delivery for cGMP cell therapy processing

In this application note, in order to demonstrate a transition from research and discovery to process development and manufacturing, we compare the Invitrogen™ Neon™ Transfection System to the CTS Xen...
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A closed, modular approach to CAR T cell therapy manufacturing

In this video, you'll get a step‑by‑step overview on how to use Thermo Fisher Scientific's digitally compatible, GMP‑compliant manufacturing platform to produce CAR T cells.
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Current and future state of T cell therapy manufacturing

Watch this webinar to learn about the challenges associated with supporting conversion of autologous to allogeneic workflows.
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Maximizing value in cell therapy manufacturing through collaboration

Learn how the strategic collaboration between Thermo Fisher Scientific and ArsenalBio helped accelerate therapeutic development and facilitated the challenging transition of moving therapies through t...
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Maximizing Efficiency in CAR-T Cell Manufacturing with Process Control

This article showcases the significance of automated, controlled processes in increasing efficiency in CAR-T cell manufacturing workflows.
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Wash or no wash: Processing Leukopak cells for CAR T cell therapy

In this blog post, we were interested in learning if washing thawed leukopak cells on the CTS Rotea system before magnetic separation of T cells on the CTS DynaCellect system would affect T cell isola...
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Enabling Instrument Connectivity through Digital Automation

In this webinar, you’ll get an introduction of Thermo Fisher Scientific’s closed, modular end-to-end manufacturing process, as well as a demonstration how cell therapy instruments can be integrated, a...
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Implementing a Closed Cell therapy Manufacturing Process through Strategic Collaboration

In this webinar, cell therapy manufacturing industry leaders discuss solutions for standardizing your manufacturing process and how strategic collaborations can help streamline the transition through ...
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Approaches to Implementing Automation in Cell Therapy Manufacturing

In this webinar, David James from Scinogy, Fred Parietti from Multiply Labs, and Betty Woo from Thermo Fisher Scientific, share valuable insights on the evolution of automation processes, designing or...
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Build vs. Buy Dilemma – Economics of Manufacturing Cell-based Therapies

Our Thermo Fisher Scientific specialists take you through what you need to consider when setting up a commercial strategy for success.
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Strategic Partnering to Enable Cell Therapy Commercialization

Cell therapy manufacturing leaders discuss the challenges of commercializing cell therapies. Learn how manufacturing innovations, industry partnerships, and more can help you optimize your processes a...
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The Digital Revolution—Enabling Automation in Cell Therapy Manufacturing

Learn how emerging technologies in cell therapy manufacturing can enable automation and standardization.
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Decentralized manufacturing: Enabling scalable and cost effective point of care for cell and gene therapies

Tune into this webinar and learn all about the drivers and challenges of decentralized manufacturing from industry leaders.
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Thermo Fisher Scientific and UCSF strategic alliance enables accelerated cell therapy development

Learn how the new state-of-the-art cell therapy manufacturing and collaboration center will empower researchers to scale future clinical campaigns.
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Digital Automation in Cell Therapy Manufacturing

This article reviews the considerations and benefits of an automated closed, modular cell therapy workflow.
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Scaling nonviral cell therapy approaches for solid tumor treatments

In this article, cell therapy manufacturing leaders from PACT Pharma Inc. and Thermo Fisher Scientific discuss safety and regulatory advantages of non-viral transfection for cell therapy and scaling a...
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An innovative approach towards standardizing cell therapy manufacturing

Whether you’re new to cell therapy manufacturing or looking to expand your existing processes and knowledge base, this article highlights emerging technologies for cell therapy manufacturers.
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Cell therapy workflow: Integrated solutions from collection to delivery

The journey of the patient from vein-to-vein is a complex process that requires a multitude of products, instrumentation, equipment and regulatory compliant infrastructure.
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Cell therapy manufacturing workflow

View this infographic for an overview of a genetically modified cell therapy workflow and key considerations at each step from plasmid production through cold chain logistics.
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Overcoming Cell Therapy Manufacturing Challenges

Navigate top manufacturing challenges and solutions across the autologous T-cell therapy workflow.
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Cell therapy: Optimizing the vein-to-vein workflow

The patient is at the center of the cell therapy journey. Discover how a GMP-compliant, semiautomated manufacturing platform can result in consistent, efficacious CAR T cell production.
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Autologous CAR-T cell manufacturing using a semiautomatic, closed, modular workflow

Learn how you can integrate complex workflows to improve the consistency, purity, and safety of your CAR-T cell product.
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Cell Therapy: Streamline the path from discovery to commercialization

From discovery to cell therapy bioprocessing and commercialization, Thermo Fisher Scientific is the partner to support you at every step of the way.
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Closed System Automation for Cell Therapy

Explore the differences between open and closed systems for manufacturing CAR T cell therapies, as well as the benefits of closed system automation.
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Characterization and analysis of cell therapies

Learn about the tools and strategies cell therapy manufacturers use to analyze and accurately characterize their biological products.
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Cell isolation, engineering, and expansion

This blog serves as a high-level overview of common techniques employed in the field for cell isolation, genetic modification and approaches to cell expansion.
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Better together: Accelerating cell therapy development through collaboration

Discover why collaboration matters, what makes a good partnership, and how you can overcome the challenges of cell therapy manufacturing and scaling on your path to clinical and commercial success.
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How to Find the Right Cell Therapy Collaborator For Your Specific Needs

Whether you’re a large biotech company producing blockbuster therapeutics or a startup biotech looking to bring your innovative and disruptive product to market, this blog post will show you how partn...
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Digital automation enhances efficiency in CAR-T cell manufacturing

This white paper describes the significance of Cellmation Software in automating and integrating the CAR-T cell manufacturing workflow.
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Maximizing Process Control and Efficiency in CAR-T Cell Manufacturing

In this webinar cell therapy product application specialists provide a detailed, step‑by‑step walkthrough of the CAR T cell manufacturing process, highlighting crucial data points in the isolation, a...
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Decentralizing Autologous Cell Therapies with Accelerated Manufacturing Workflows

In this blog post, we will highlight a next-generation cell therapy manufacturing process that shortens the time to manufacture autologous CAR-T cells from a typical 7-14-day timeline to a 24-hour pro...
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Overcoming common cell therapy manufacturing challenges with a closed, modular and automated solution

In this blog post, we highlight the modularity of our CTS cell therapy manufacturing instruments and the ability to connect them using automation software. A video is embedded to illustrate the modula...
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Developing scalable solutions for CAR T cell expansion: stirred tank vs static bioreactors

In this study/blog post, we sought to learn the effects of expanding genetically edited T cells in a stirred tank bioreactor, in comparison to expansion in a static bioreactor.
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Efficient CAR T cell manufacturing using a closed and integrated instrument workflow

This application note demonstrates the closed and integrated use of the Gibco CTS Rotea Counterflow Centrifugation System with the Gibco CTS Xenon Electroporation System to edit T cells isolated with ...
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Automating the cell therapy workflow with Gibco CTS Cellmation software

In this video, we provide an overview of how the Gibco CTS Cellmation Software automates and controls the cell therapy manufacturing workflow while ensuring cGMP compliance.
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CAR-T Cell Manufacturing Workflow Video

This new video demonstrates how cells move through our CAR-T manufacturing workflow, with emphasis on CTx instruments including the Gibco CTS DynaCellect, Rotea and Xenon.
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Shorten the CAR T manufacturing process

This article summarizes a recent study successfully shortening a 24‑hour lentivirus‑based method using the Gibco CTS Detachable Dynabeads CD3/CD28 magnetic beads, Gibco CTS Detachable Dynabeads Releas...
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Optimizing the CGT patient journey through integrated CRO/CDMO partnership

This whitepaper highlights the complex CGT patient journey and how working with an integrated CRO/CDMO partner can help improve the patient experience.
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Positioning early cell therapy programs for clinical success

This webinar explores key considerations for early-phase cell therapy developers to help mitigate risk and ensure GMP readiness.
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Leveraging a flexible and efficient Rapid Development Framework™ to accelerate development and manufacturing of CGTs

This webinar explains how our unique and flexible approach to a platform process for cell and gene therapy helps to promote consistency, reduce failure risk, and enhance product quality and patient sa...
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Autologous and allogeneic therapies - Exploring the science, manufacturing and regulatory considerations

In this roundtable discussion, clinical and commercial experts address the complex dynamics associated with allogeneic vs. autologous cell therapies and offer insight into the current and future state...
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Optimize your raw material selection to reach clinical and commercial milestones

In the ever-evolving global landscape of cell therapy development, selecting quality raw materials is crucial for achieving clinical and commercial milestones. In this article, industry leaders share ...
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Automating the cell therapy workflow with Gibco CTS Cellmation software

In this poster, you see an overview of how the Gibco CTS Cellmation Software automates and controls the cell therapy manufacturing workflow while ensuring cGMP compliance.
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Empowering the future of cell therapy: leveraging partnerships to support advancement

In this webinar, speakers from LabCentral, Bayer, Thymmune Therapeutics, Inc., and Thermo Fisher Scientific share insights on how collaborative technical work can facilitate knowledge exchange, fundin...
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Cell and Gene Therapy Institute

Regardless of where your asset is along the drug development journey, our PPD® clinical research solutions help enable you to bring your drug to the clinic quickly and safely. To learn more, read this...
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Advancing Cell Therapy in China

Explore the challenges and opportunities to advance cell therapy clinical trials in China in this European Biopharmaceutical Review article.
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Managing Complex Sample and IP Logistics in Support of Cell and Gene Therapies

Proper logistics management for cell and gene therapies, particularly during clinical trials, is an intense process requiring meticulous planning, execution and oversight. These therapies are exceptio...
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Long-term follow-up considerations for cell and gene therapies

In this webinar, a panel of experts will cover key regulatory, operational, medical and scientific insights when considering long-term follow-up (LTFU) studies in the cell and gene therapy (CGT) space...
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A cell therapy journey from vein-to-vein

Realize your vision of transforming cells into life-saving cell therapies.
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A TaqMan-based PCR Multiplex Mycoplasma Detection Assay for Rapid Lot-Release Testing in Cell Therapeutics

The MycoSEQ Plus Kit is suited as both a release test and as an in-process control test during the manufacturing of cell therapy products.
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Accelerating cell therapy production: Realizing the advantages of rapid analytical testing solutions

Learn more from Tom Heng, Product Manager, BioProduction Group.
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Advancing cell therapy manufacturing: Rapid sterility testing to help ensure the safety and quality of cell therapy products

Discover how to swiftly detect bacteria and fungi in complex cell therapy product matrices within a single well.
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Environmental monitoring: Optimizing microbial control in cell & gene therapy workflows

Discover more about the MicroSEQ System, designed to support the recommended qualification guidelines by regulatory agencies worldwide.
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Environmental monitoring: Optimizing microbial testing in cell and gene therapy

Learn more about a comparison of methods for microbial identification with Nico Chow, Field Application Specialist.
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Guidance for cell and gene therapy manufacturing: Meeting GMP and Regulatory Challenges

Discover more about GMP and regulatory challenges in cell and gene therapy manufacturing.
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Key factors to consider for successful cell therapy manufacturing: A case study

Experts discuss key considerations for successful cell therapy manufacture.
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Lentiviral vector characterization for cell and gene therapy manufacturing using the QuantStudio Absolute Q Digital PCR System

Discover more about the measurement of lentiviral vector titers and provirus copies in transduced cells by digital PCR.
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Leveraging rapid sterility testing to advance cell therapy production

In this webinar you will learn about detecting specific bacterial and fungal species which are commonly associated with cell therapy product contamination, leveraging the SteriSEQ Rapid Sterility Test...
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Mycoplasma detection in cell therapy products

Learn more with this webinar featuring Valentina Becherucci, Senior Scientist, Cell Factory Meyer.
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Mycoplasma testing: Regulatory guidance and strategies for cGMP cell and gene therapy manufacturing

A highly sensitive, specific, and robust method for rapid mycoplasma detection for lot-release and in-process testing.
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Overcoming challenges in cell therapy production: Rapid sterility testing

Featuring Seth Peterson, Senior Manager, Application Scientists, BioProduction Group.
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Pharmaceutical analytics for cell and gene therapy development

Find out how you can quickly evaluate and monitor your lentivirus (LV) and adeno-associated virus (AAV) production processes.
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Regulatory consideration and validation strategies for mycoplasma testing for cell-based therapies

Learn more about regulatory guidance from Mike Brewer, Global Principal Consultant, Regulatory, BioProduction.
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Setting up a cell therapy production facility

Our lab products can help support you from R&D to process development, GMP, clean room, and QC.
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GMP lab equipment to support unique quality control strategies

Thermo Scientific offers GMP lab equipment to support unique quality control strategies.
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Overcome your cell and gene (GMP) challenges

Contamination control strategies play a profound role when creating your unique Good Manufacturing Practice (GMP) production workflow.
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G-Rex bioreactors incubated in Heracell™ Vios™ CR CO₂ Incubators help prevent cross contamination and bacterial contamination in cell and gene modified cell therapy production

Prevent cross contamination and bacterial contamination in cell and gene modified cell therapy production
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Scaling Up Regulatory T Cell Therapy

Hear speakers from the University of British Columbia and the BC Children's Hospital Research Institute and Thermo Fisher Scientific, present compelling data on how CAR-engineered Tregs can induce imm...
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From the Lab to the Bench, Scaling up Regulatory T Cell Therapy

Regulatory T cells (Tregs) play a critical role in maintaining immune balance and preventing autoimmune diseases. In this webinar we discuss a novel technology that provides an optimized activation si...
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Large Scale Expansion of PSCs to support cell therapy manufacturing

In this application note, we demonstrate how the Gibco™ CTS™ StemScale™ PSC Suspension Medium enables large scale production of high-quality PSCs for cell therapy manufacturing applications.
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Advancing CAR T Therapies: The Importance of Closed Processes in Manufacturing and Future Innovations

Find out how T cell therapy is transforming the personalized treatment of autoimmune and rare diseases with two innovative forms of T cell therapy which are at the forefront of research: Chimeric Anti...
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PeproGMP Cytokines: Set your manufacturing up for consistency

PeproGMP products are optimized for use in your cell therapy workflows with exceptional lot-to-lot purifity and bioactivity
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Counterflow Centrifugation (CFC) eBook: An exploration of CFC throughout the cell and gene therapy workflow

Download this eBook to learn how the CTS Rotea system's CFC is useful in cell therapy manufacturing.
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Rapid dissociation of PSC spheroids in a closed environment using the CTS Rotea system

Learn how the CTS Rotea System can be utilized for dissociation of PSC spheroids in a closed-system.
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Autologous CAR T cell manufacturing using a semiautomatic, closed, modular workflow

Learn how the CTS Rotea system can be used with Gibco™ CTS™ reagents for efficacious CAR T cell production.
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Closed, automated wash and concentration of expanded human natural killer (NK) cells

Learn how to improve the efficiency of NK cell processing with the CTS Rotea System and CTS NK-Xpander Medium
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Flexibility and modularity in cell therapy manufacturing: incorporating the CTS Rotea and Xenon systems

Read how the CTS Rotea and CTS Xenon systems support the T cell workflow for cell therapy manufacturing.
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Optimization and scale-up of genetically modified NK cells

Learn how the CTS Rotea system and CTS Xenon system can be used for generation of CAR NK cells.
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Gibco CTS Rotea System Brochure

Download the brochure for the Gibco CTS Rotea Counterflow Centrifugation System
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Gibco CTS Xenon Electroporation System Brochure

Download the brochure for the Gibco CTS Xenon Electroporation System
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Differentiation and characterization of monocyte-derived dendritic cells and macrophages

Learn about dendritic cell and macrophage differentiation with CTS AIM-V Medium and CTS ICSR
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Automated 24-hour CAR T Manufacturing Process

This article summarizes a recent study successfully shortening a 24‑hour lentivirus‑based method using the Gibco CTS Detachable Dynabeads CD3/CD28 magnetic beads, Gibco CTS Detachable Dynabeads Releas...
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For Research Use Only. Not for use in diagnostic procedures.

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