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Improve biotech processes with mass spectrometry gas analysis
What if you could achieve faster off-gas composition analysis without sacrificing precision and quality? With our Prima mass spectrometers, you can. As the standard in gas analysis, our robust instruments provide improved precision, accuracy, long intervals between calibration, and resistance to contamination, so you can optimize industrial processes across many applications – from biopharma to biofuels.
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Thermo Scientific Gas Analysis Mass Spectrometers have been used successfully for over 30 years on bacterial and microbial processes. More recently, there has been increasing interest in mammalian cell culture because they offer the prospect of radical advances in vaccines, monoclonal antibodies, and gene therapy. Although the requirements of mammalian cell fermentation processes provide challenges to the off-gas analyzer, our mass spectrometers for bioreactor monitoring have already proved invaluable in improving understanding and increasing yields of mammalian cell cultures.
In mammalian cell fermentations, the feed gas composition is a frequently changing mixture of several compounds. The feed gas concentration ranges also vary dramatically. The implementation of real-time, off-gas analysis using Mass Spectrometry in mammalian cell culture can help identify process deviations during bioreactor runs and evaluate batch to batch variation, within predefined specifications, for robust manufacturing.
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Applications of off-gas mass spectrometry in fed-batch mammalian cell culture
Why use mass spectrometers for mammalian cell fermentations?
Improving biotech processes with process mass spectrometry gas analysis
5 reasons to use process mass spectrometry in biotechnology
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Laboratory quality gas analysis for fermentation processes
Analysis of respiratory gases is an ideal way of fermentation monitoring. It’s non-invasive and provides invaluable information on the physiological state of the culture, including growth kinetics and substrate consumption. It also helps determine the optimum point to halt the process for maximum yield. Many fermentations are characterized by small changes in oxygen and carbon dioxide concentrations. The speed of our Thermo Scientific Prima PRO Process Mass Spectrometer makes it ideal for fermentation process control, but speed must not be at the expense of precision. It is equally important that precise data is acquired; otherwise, small changes in concentration will be lost.
Over 30 years of industrial experience have shown that magnetic sector analyzers offer the best performance for fermentation off-gas analysis. Key advantages include improved precision, accuracy, long intervals between calibration, and resistance to contamination. Typically, analytical precision is between 2 and 10 times better than a quadrupole mass spectrometer.
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Improving biotech processes with process mass spectrometry gas analysis
5 reasons to use process mass spectrometry in biotechnology
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Use magnetic sector mass spectrometry to control the solvent drying process with fast, precise, quantitative data
A key stage in many pharmaceutical processes is the complete or partial removal of a solvent or solvents from a product or intermediate. This solvent recovery process can occur in a variety of process vessels, including vacuum dryers, tray dryers and rotary dryers.
In the past, the success of the solvent drying process was simply measured at the end by taking a sample for laboratory analysis and the amount of residual solvent was defined by the Loss on Drying (LOD). If the sample failed the LOD test for one or more of the solvents then the drying process had to be restarted. If the drying took place under vacuum this provided additional complications in terms of both sampling the active pharmaceutical ingredient (API) and re-starting the dryer.
Mass spectrometers have been used to monitor solvent levels in the headspace above the API during drying processes but they have typically only produced qualitative or semi-quantitative data. If the Prima PRO Process Mass Spectrometer is to be used as part of a PAT solvent drying process control project, it must produce accurate, reliable quantitative data, even for multi-dryer, multi-solvent systems.
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Improving biotech processes with process mass spectrometry gas analysis
5 reasons to use process mass spectrometry in biotechnology
Additional resources
Thermo Scientific GasWorks Process MS software provides the unique and powerful interface for the Thermo Scientific Prima PRO, Prima BT, Sentinel PRO and APIX δQ Mass Spectrometers. The software has been designed to ensure that the process analyzer is simple to configure, operate, and maintain without any prior mass spectrometer experience for better process analytics.
The suite includes a wide range of functions and features. Whether the requirement is for a simple alarm indication in the event of a manufacturing process failure, or for complex data presentation for process understanding and control, Gasworks Software is well equipped to offer an effective solution.
- Supports stand-alone analyzer operation
- Sets no limits to the number of sample streams or analytical methods
- Includes rigorous mathematical equations to deconvolute complex mixtures
- Multi-layered security with expiring passwords and audit trail
- Supports the integration of third-party analytical data
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Gain process understanding and control
GasWorks Process Analysis Software FAQs
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Pharmaceutical & biotech manufacturing processes & production methods
Article: Harnessing lab power on the pharma plant floor
Process Analytical Technology
Process Analytical Technology (PAT) is a regulatory framework initiated by the United States Food and Drug Administration (FDA) that encourages pharmaceutical manufacturers to improve the process of pharmaceutical development, manufacturing, and quality control.
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Prima BT Bench Top Process Mass Spectrometer
Prima PRO Process Mass Spectrometer
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Thermo Scientific Prima PRO mass spectrometer delivering over 30 years of proven process performanceWith over 30 years of proven performance and more than 1500 installations worldwide, the Thermo Scientific Prima PRO mass spectrometer delivers precise, reliable gas analysis for petrochemical, biofuel, clean energy, and beyond.
Streamlining Process Monitoring in Cell Culture Analysis & SpectrometryOn-demand webinar for Biopharma, focused on cell culture analysis and the use of Prima BT.
Streamlining process monitoring in cell culture analysis and spectrometry (Chinese subtitle version)Streamlining process monitoring in cell culture analysis and spectrometry (Chinese subtitle version)
GasWorks How To Video Series: Analysis and Calibration ConfigurationLearn how to: Add Gases and Amend Analysis Configuration, Add Gases to Calibration Configuration and Schedule a Report
GasWorks How To Video Series: Analysis and Calibration Configuration (Chinese subtitle)Gasworks how to video series analysis and calibration configuration (Chinese subtitle version)
Off-Gas Monitoring in Fermentations with Prima Mass SpectrometersDiscover how the Thermo Scientific™ Prima family of mass spectrometers allows for monitoring of off-gases present in fermentations in real time, regardless of scale.
Process Development Tools : Thermo Scientific Prima BT Bench Top Mass SpectrometerThe high scanning speeds and reproducible measurements of the Thermo Scientific Prima BT Bench Top Mass Spectrometer make it ideal for process development laboratories that require a highly precise, multi-port magnetic sector gas analyzer.
A Collaboration Built for BioPharma: NIBRT x Thermo Fisher ScientificLearn about the collaboration between NIBRT and Thermo Fisher Scientific for biopharmaceutical research and training.
Featured resources
A Guide to Improving Biotech Processes
Gas Analysis Mass Spectrometry Applications in Fermentation
How online process analytics are assisting the biofoods industrys
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