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Proteintech

PRDM5 Polyclonal Antibody

View all (7) PRDM5 antibodies

Questions & Answers

Questions & Answers

Antibody Testing Data (4)

Application

PRDM5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 4

PRDM5 Antibody (14126-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using 14126-1-AP ( PRDM5 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

PRDM5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PRDM5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PRDM5 Antibody in Western Blot (WB)

PRDM5 Antibody in Western Blot (WB)

Product Image Gallery

PRDM5 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using 14126-1-AP ( PRDM5 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

PRDM5 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using 14126-1-AP (PRDM5 Antibody) at dilution of 1:200 (under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

PRDM5 Antibody in Western Blot (WB) — Mouse ovary tissue were subjected to SDS PAGE followed by western blot with 14126-1-AP ( PRDM5 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

PRDM5 Antibody in Western Blot (WB) — Mouse colon tissue were subjected to SDS PAGE followed by western blot with 14126-1-AP (PRDM5 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

Product Details

14126-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PRDM5 Fusion Protein Ag5277 (1-111 aa encoded by BC066942)

Conjugate

Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLGMYVPDR FSLKSSRVQD GMGLYTARRV RKGEKFGPFA GEKRMPEDLD ENMDYRLMWE VRGSKGEVLY ILDATNPRHS NWLRFVHEAP SQEQKNLAAI QDKNLGPAEW RG (1-111 aa encoded by BC066942)

Target Information

PRDM5, a novel member of PR domain protein family, contains a PR-domain at the -NH2 terminus followed by 16 zinc finger motifs. It is found to have a role in cell differentiation and tumorigenesis. Reports suggest PRDM5 causes G2/M arrest and apoptosis upon infection of tumor cells and has been found to be silenced in breast, ovarian and lung cancers, suggesting a potential clinical significance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: PR domain containing 5; PR domain zinc finger protein 5; PR domain-containing protein 5

Gene Aliases: 4432417F03Rik; 6530401I24Rik; AI197291; BCS2; E130112L17Rik; PFM2; PRDM5

UniProt ID: (Human) Q9NQX1, (Mouse) Q9CXE0

Entrez Gene ID: (Human) 11107, (Mouse) 70779, (Rat) 689788

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding protein binding methyltransferase activity sequence-specific DNA binding transcription regulatory region DNA binding metal ion binding repressing transcription factor binding rRNA (adenine-N6,N6-)-dimethyltransferase activity transcription regulatory region sequence-specific DNA binding nucleic acid binding DNA binding protein C-terminal carboxyl O-methyltransferase activity tRNA (guanine-N2-)-methyltransferase activity C-methyltransferase activity N-methyltransferase activity O-methyltransferase activity S-methyltransferase activity RNA methyltransferase activity mRNA methyltransferase activity tRNA methyltransferase activity protein methyltransferase activity 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity rRNA methyltransferase activity rRNA (uridine-2'-O-)-methyltransferase activity rRNA (adenine-N6-)-methyltransferase activity DNA-methyltransferase activity tRNA (guanine-N1-)-methyltransferase activity rRNA (cytosine-C5-)-methyltransferase activity selenocysteine methyltransferase activity arginine N-methyltransferase activity protein-arginine N-methyltransferase activity lysine N-methyltransferase activity protein-lysine N-methyltransferase activity tRNA (uracil) methyltransferase activity tRNA (guanine) methyltransferase activity tRNA (adenine) methyltransferase activity tRNA (cytosine) methyltransferase activity tRNA (cytosine-5-)-methyltransferase activity tRNA (adenine-N1-)-methyltransferase activity rRNA (adenine) methyltransferase activity rRNA (cytosine) methyltransferase activity rRNA (guanine) methyltransferase activity rRNA (uridine) methyltransferase activity transferase activity protein C-terminal leucine carboxyl O-methyltransferase activity 1-phenanthrol methyltransferase activity protein-arginine N5-methyltransferase activity methylarsonite methyltransferase activity dimethylarsinite methyltransferase activity 4,5-dihydroxybenzo(a)pyrene methyltransferase activity 1-hydroxypyrene methyltransferase activity 1-hydroxy-6-methoxypyrene methyltransferase activity demethylmenaquinone methyltransferase activity cobalt-precorrin-6B C5-methyltransferase activity cobalt-precorrin-7 C15-methyltransferase activity cobalt-precorrin-5B C1-methyltransferase activity cobalt-precorrin-3 C17-methyltransferase activity dimethylamine methyltransferase activity hydroxyneurosporene-O-methyltransferase activity tRNA (adenine-57, 58-N(1)-) methyltransferase activity methylamine-specific methylcobalamin:coenzyme M methyltransferase activity trimethylamine methyltransferase activity methanol-specific methylcobalamin:coenzyme M methyltransferase activity monomethylamine methyltransferase activity P-methyltransferase activity Se-methyltransferase activity 2-phytyl-1,4-naphthoquinone methyltransferase activity tRNA (uracil-2'-O-)-methyltransferase activity tRNA (cytosine-2'-O-)-methyltransferase activity phosphomethylethanolamine N-methyltransferase activity tRNA (cytosine-3-)-methyltransferase activity rRNA (cytosine-2'-O-)-methyltransferase activity rRNA (cytosine-N4-)-methyltransferase activity trihydroxyferuloyl spermidine O-methyltransferase activity C2H2 zinc finger transcription factor

Process(es)

negative regulation of transcription from RNA polymerase II promoter mitotic cell cycle transcription, DNA-templated histone deacetylation negative regulation of transcription, DNA-templated histone H3-K9 methylation regulation of transcription, DNA-templated transcription from RNA polymerase II promoter chromatin modification methylation

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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