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Ouabain octahydrate, 96%
Ouabain octahydrate, CAS # 11018-89-6, (synonym: gamma-Strophanthin), is a plant-derived organic compound that inhibits the Na+/K+ ATPase pump present in all animal cell membranes.
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Catalog number 161730050
Price (USD)/ Each
439.65
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Online exclusive
Ends: 31-Dec-2024
517.00 Save 77.35 (15%)
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Quantity:
5 g
Packaging:
Glass bottle
Price (USD)/ Each
439.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
517.00 Save 77.35 (15%)
Ouabain octahydrate, 96%
Catalog number161730050
Price (USD)/ Each
439.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
517.00 Save 77.35 (15%)
-
Chemical Identifiers
CAS11018-89-6
IUPAC Name4-[(1R,7S,9R,9bS,10R)-3a,5a,9,10-tetrahydroxy-9a-(hydroxymethyl)-11a-methyl-7-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-2,5-dihydrofuran-2-one octahydrate
Molecular FormulaC29H60O20
InChI KeyTYBARJRCFHUHSN-HMNHGHQSSA-N
SMILESO.O.O.O.O.O.O.O.CC1OC(O[C@H]2C[C@@H](O)C3(CO)[C@H]4[C@H](O)CC5(C)[C@H](CCC5(O)C4CCC3(O)C2)C2=CC(=O)OC2)C(O)C(O)C1O
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Specifications
Specification Sheet
Specification SheetAppearance (Color)White to off-white
Appearance (Form)Crystalline powder
Infrared spectrumConforms
Solubility(1 % in water) Clear colorless
HPLC>=95 %
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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General description
• Ouabain octahydrate is a water-soluble, light-sensitive powder that is stable at ambient temperatures
• It is a glycoside comprised of rhamnose and ouabagenin, and is derived from the ripe seeds of Strophanthus gratus and the bark of Acokanthera ouabaio
Applications
• Ouabain octahydrate works by binding the Na+/K+ ATPase pump, thus disrupting its function, and leading to an increase in intracellular Na+.
• The inhibitory action of ouabain octahydrate on the Na+/K+ pump in cardiac cells makes it a pharmaceutical cardioactive agent
• Ouabain octahydrate has also been found to induce cytotoxic effects through a steroidal signal transduction pathway, in laboratory preparations
RUO – Research Use Only
General References:
- Gao J.; Wymore R.S.; Wang Y.; Gaudette G.R.; Krukenkamp I.B.; Cohen I.S.; Mathias R.T. Isoform-specific stimulation of cardiac Na/K pumps by nanomolar concentrations of glycosides. J Gen Physiol. 2002, 119(4), 297-312.
- Hamlyn J. M.; Blaustein M.P.; Bova S.; DuCharme D.W.; Harris D.W.; Mandel F.; Mathews W.R.; Ludens J.H. Identification and characterization of an ouabain-like compound from human plasma. Proc Natl Acad Sci U S A. 1991, 15, 88(14), 6259-63.
- Hamlyn J. M.; Laredo J.; Shah J. R.; Lu Z. R.; Hamilton B. P. 11-hydroxylation in the biosynthesis of endogenous ouabain: multiple implications. Ann N Y Acad Sci. 2003, 986, 685-93.
- Kulikov, A.; Eva, A.; Kirch, U.; Boldyrev, A.; Scheiner-Bobis G. Ouabain activates signaling pathways associated with cell death in human neuroblastoma Biochim Biophys Acta 2007, 1768(7), 1691-702.