Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
General description
• Ouabain octahydrate is a water-soluble, light-sensitive powder that is stable at ambient temperatures
• It is a glycoside comprised of rhamnose and ouabagenin, and is derived from the ripe seeds of Strophanthus gratus and the bark of Acokanthera ouabaio
Applications
• Ouabain octahydrate works by binding the Na+/K+ ATPase pump, thus disrupting its function, and leading to an increase in intracellular Na+.
• The inhibitory action of ouabain octahydrate on the Na+/K+ pump in cardiac cells makes it a pharmaceutical cardioactive agent
• Ouabain octahydrate has also been found to induce cytotoxic effects through a steroidal signal transduction pathway, in laboratory preparations
Literature References
Gao J.; Wymore R.S.; Wang Y.; Gaudette G.R.; Krukenkamp I.B.; Cohen I.S.; Mathias R.T. Isoform-specific stimulation of cardiac Na/K pumps by nanomolar concentrations of glycosides. J Gen Physiol. 2002, 119(4), 297-312.
Hamlyn J. M.; Blaustein M.P.; Bova S.; DuCharme D.W.; Harris D.W.; Mandel F.; Mathews W.R.; Ludens J.H. Identification and characterization of an ouabain-like compound from human plasma. Proc Natl Acad Sci U S A. 1991, 15, 88(14), 6259-63.
Hamlyn J. M.; Laredo J.; Shah J. R.; Lu Z. R.; Hamilton B. P. 11-hydroxylation in the biosynthesis of endogenous ouabain: multiple implications. Ann N Y Acad Sci. 2003, 986, 685-93.
Kulikov, A.; Eva, A.; Kirch, U.; Boldyrev, A.; Scheiner-Bobis G. Ouabain activates signaling pathways associated with cell death in human neuroblastoma Biochim Biophys Acta 2007, 1768(7), 1691-702.