Search Thermo Fisher Scientific
Element Search
Structure Search
Thermo Scientific Chemicals
Scopolamine hydrobromide trihydrate, 99%, Thermo Scientific Chemicals
Scopolamine hydrobromide trihydrate, CAS # 6533-68-2, is the trihydrate form of scopolamine hydrobromide that shows competitive anti-muscarinic activity by blocking the actions of endogenous acetylcholine or exogenous agonists. It also shows anti-spasmodic and anti-emetic activities.
Have Questions?
Change view
Catalog number 161750050
Price (USD)/ Each
183.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
216.00 Save 32.35 (15%)
-
Quantity:
5 g
Packaging:
Glass bottle
Price (USD)/ Each
183.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
216.00 Save 32.35 (15%)
Scopolamine hydrobromide trihydrate, 99%, Thermo Scientific Chemicals
Catalog number161750050
Price (USD)/ Each
183.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
216.00 Save 32.35 (15%)
-
Chemical Identifiers
CAS6533-68-2
IUPAC Namehydrogen (1S,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0²,⁴]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate trihydrate bromide
Molecular FormulaC17H28BrNO7
InChI KeyLACQPOBCQQPVIT-FCFGRTKISA-N
SMILES[H+].O.O.O.[Br-].CN1[C@H]2CC(C[C@H]1[C@@H]1O[C@H]21)OC(=O)[C@H](CO)C1=CC=CC=C1
View more
Specifications
Specification Sheet
Specification SheetTitration with HClO4>=98.5 %
Appearance (Color)Colorless to white
Appearance (Form)Crystalline powder or crystals
Infrared spectrumConforms
Specific optical rotation-24° to -27° (20°C, 589 nm) (c=5, H2O)
View more
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Information
• Scopolamine hydrobromide trihydrate is a salt form of scopolamine, a tropane alkaloid derived from plants of the nightshade family (Solanaceae), mainly Hyoscyamus niger and Atropa belladonna
• Scopolamine hydrobromide trihydrate, demonstrates competitive anti-muscarinic activity blocking the actions of endogenous acetylcholine or exogenous agonists
• It also shows anti-spasmodic and anti-emetic activities
Applications
• It has been described that scopolamine inhibits muscarinic acetylcholine receptors (mAChRs) with some selectivity for M1 mAChRs
• It is structurally similar to acetylcholine and can antagonize acetylcholine activity mediated by muscarinic receptors located on structures innervated by postganglionic cholinergic nerves and on smooth muscles (that respond to acetylcholine but lack cholinergic innervation)
• Scopolamine hydrobromide trihydrate can induce amnesia in laboratory animals and so it is frequently used in animal models of memory deficit
• Scopolamine hydrobromide trihydrate is used to induce cognitive deficits in animal models of Alzheimer’s disease
• Scopolamine, has been employed in several studies to understand, identify, and characterize biological targets for Alzheimer's disease
RUO – Research Use Only
General References:
- Saikia, B.; Barua, c.; Sarma, J. Zanthoxylum alatum ameliorates scopolamine-induced amnesia in rats: Behavioral, biochemical, and molecular evidence. Indian J Pharmacol. 2018, 50, (1), 30–38.
- Devore, S.; Almeida,L.; Linster, C. Distinct Roles of Bulbar Muscarinic and Nicotinic Receptors in Olfactory Discrimination Learning. J Neurosci. 2014, 34, (34), 11244–11260.
- Venkatesan, R.; Subedi, L. Yeo, E.; Kim, S. Lactucopicrin ameliorates oxidative stress mediated by scopolamine-induced neurotoxicity through activation of the NRF2 pathway. Neurochem Int. 2016, 99, 133-146.
- Appenroth, D.; Decker, M.; Tränkle, C.; Mohr, K.; Lehmann, J.; Fleck, C. In vivo investigations on the cholinesterase-inhibiting effects of tricyclic quinazolinimines: Scopolamine-induced cognitive impairments in rats are attenuated at low dosage and reinforced at higher dosage. Pflügers Archiv - European Journal of Physiology. 2008, 455, 895–901.