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Proteintech
PSMD1 Polyclonal Antibody
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Product Details
17709-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PSMD1 fusion protein Ag12009
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: AVSDVNDDVR RAAVESLGFI LFRTPEQCPS VVSLLSESYN PHVRYGAAMA LGICCAGTGN KEAINLLEPM TNDPVNYVRQ GALIASALIM IQQTEITCPK VNQFRQLYSK VINDKHDDVM AKFGAILAQG ILDAGGHNVT ISLQSRTGHT HMPSVVGVLV FTQFWFWFPL SHFLSLAYTP TCVIGLNKDL KMPKVQYKSN CKPSTFAYPA PLEVPKEKEK EKVSTAVLSI TAKAKKKEKE KEKKEEEKME VDEAEKKEEK EKKKEPEPNF QLLDNPARVM PAQLKVLTMP ETCRYQPFKP LSIGGIIILK DTSEDIEELV EPVAAHGPKI EEEEQEPEPP EPFEYIDD
Target Information
Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 26S proteasome non-ATPase regulatory subunit 1; 26S proteasome p112 subunit; 26S proteasome regulatory subunit RPN2; 26S proteasome regulatory subunit S1; 26S proteasome subunit p112; 26S proteasome, subunit p112; MGC133040; MGC133041; proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
Gene Aliases: 2410026J11Rik; P112; PSMD1; Rpn2; S1
UniProt ID: (Human) Q99460, (Mouse) Q3TXS7, (Rat) O88761
Entrez Gene ID: (Human) 5707, (Mouse) 70247, (Rat) 83806
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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