L(+)-Amethopterin hydrate, 99%, Thermo Scientific Chemicals
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L(+)-Amethopterin hydrate, 99%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

L(+)-Amethopterin hydrate, 99%, Thermo Scientific Chemicals

L(+)-Amethopterin hydrate, CAS # 133073-73-1, is an effective inhibitor of dihydrofolate reductase, which may have anti-tumor activity.
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25 mg
500 mg
Packaging:
Glass Bottle
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Catalog number 208100250
Price (USD)/ Each
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Ends: 31-Dec-2024
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Quantity:
25 mg
Packaging:
Glass Bottle
Request bulk or custom format
Price (USD)/ Each
44.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
52.20 
Save 7.55 (14%)
Add to cart
L(+)-Amethopterin hydrate, 99%, Thermo Scientific Chemicals
Catalog number208100250
Price (USD)/ Each
44.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
52.20 
Save 7.55 (14%)
-
Add to cart
Chemical Identifiers
CAS133073-73-1
IUPAC Name(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
Molecular FormulaC20H22N8O5
InChI KeyFBOZXECLQNJBKD-UGPWUYPHNA-N
SMILESCN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
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SpecificationsSpecification SheetSpecification Sheet
Infrared spectrumConforms
Specific optical rotationon anhydrous substance
Appearance (Color)Yellow to orange
HPLC>=98.5 %
Specific optical rotation+19° to +24° (20°C, 589 nm) (c=1, 14 g/l Na2CO3)
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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General description
• L(+)-Amethopterin hydrate, is a potent inhibitor of dihydrofolate reductase
• It has tumoricidal activity
Applications
• L(+)-Amethopterin hydrate is an inhibitor of dihydrofolate reductase
• It can be used in anti-tumor studies
• It is a cell cycle arrest agent, which can inhibit synthesis of DNA, RNA, and proteins
• It can also inhibit production of pro-inflammatory cytokines
RUO – Research Use Only

General References:

  1. Friedman, B.; Cronstein, B. Methotrexate mechanism in treatment of rheumatoid arthritis. Joint Bone Spine. 2019, 86(3), 301-307.
  2. Sasso, S.P.; Gilli, R.M.; Sari, J.C.; Rimet, O.S.; Briand, C.M. Thermodynamic study of dihydrofolate reductase inhibitor selectivity. Biochim Biophys Acta. 1994, 20, 1207(1), 74-9.
  3. Pittman, S.M.; Strickland, D.; Ireland, C.M. Polymerization of tubulin in apoptotic cells is not cell cycle dependent. Exp Cell Res. 1994, 215 (2), 263-72.