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Proteintech
ZP2 Polyclonal Antibody
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Application
FIGURE: 1 / 2
ZP2 Antibody (21832-1-AP) in IHC (PFA)
Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse ovary tissue using ZP2 antibody (21832-1-AP) at dilution of 1:200 and Multi-rAb CoraLite ® Plus 488-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR002). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).
Product Details
21832-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ZP2 fusion protein Ag16386
Conjugate
Unconjugated
Form
Liquid
Concentration
0.45 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: EIHALWTDFP PSKISRDSEF RMTVKCSYSR NDMLLNINVE SLTPPVASVK LGPFTLILQS YPDNSYQQPY GENEYPLVRF LRQPIYMEVR VLNRDDPNIK LVLDDCWATS TMDPDSFPQW NVVVDGCAYD LDNYQTTFHP VGSSVTHPDH YQRFDMKAFA FVSEAHVLSS LVYFHCSALI CNRLSPDSPL CSVTCPVSSR HRRATGATEA EKMTVSLPGP ILLLSDDSSF RGVGSSDLKA SGSSGEKSRS ETGEEVGSRG AMDTKGHKTA GDVGSKAVAA VAAFAGVVAT LGFIYYLYEK RTVSNH
Target Information
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: zona pellucida 2 glycoprotein; Zona pellucida glycoprotein 2; zona pellucida glycoprotein 2 (sperm receptor); zona pellucida glycoprotein ZP2; Zona pellucida protein A; Zona pellucida sperm-binding protein 2; Zp-2
Gene Aliases: Zp-2; ZP2; ZPA
UniProt ID: (Human) Q05996, (Rat) O54767, (Mouse) P20239
Entrez Gene ID: (Human) 7783, (Rat) 81828, (Mouse) 22787
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