This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
Atropine is a competitive and reversible antagonist of muscarinic acetylcholine receptors on both central and peripheral neurons
Atropine was originally isolated from the belladonna plant Atropa belladonna but is also found in other Solanaceae plants
Atropine is a drug that can be used to slow heart rate, decrease salivary secretions, and treat poisoning caused by cholinergic or muscarinic agents
Applications
It is used to block activation of muscarinic receptors in laboratory mice
It can be used in a laboratory setting to decrease oral and airway secretions in research animals
Atropine has been used to study heart rate and blood pressure variability in swine
Literature references
Driessen, A.K.; McGovern, A.E.; Behrens, R.; Moe, A.A.K.; Farrell, M.J.; Mazzone, S.B. A role for neurokinin 1 receptor expressing neurons in the paratrigeminal nucleus in bradykinin-evoked cough in guinea-pigs. J Physiol. 2020, 598(11), 2257-2275.
Egorov, A.V.; Schumacher, D.; Medert, R., Birnbaumer, L.; Freichel, M.; Draguhn, A. TRPC channels are not required for graded persistent activity in entorhinal cortex neurons. Hippocampus. 2019 Nov;29(11):1038-1048. doi: 10.1002/hipo.23094.
Poletto, R.; Janczak, A.M.; Marchant-Forde, R.M.; Marchant-Forde, J.N.; Matthews, D.L.; Dowell, C.A.; Hogan, D.F.; Freeman, L.J.; Lay, D.C. Jr. Identification of low and high frequency ranges for heart rate variability and blood pressure variability analyses using pharmacological autonomic blockade with atropine and propranolol in swine. Physiol Behav. 2011 May 3;103(2):188-96.