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MM(PEG)24 Methyl-PEG-Maleimide Reagent
MM(PEG)24 Methyl-PEG-Maleimide Reagent
Thermo Scientific™

MM(PEG)24 Methyl-PEG-Maleimide Reagent

Thermo Scientific Pierce MM(PEG)24 is a methyl-terminated, polyethylene glycol compound (24 PEG units) activated with a maleimide group for covalentRead more
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Catalog NumberQuantity
22713100 mg
Catalog number 22713
Price (USD)
441.65
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588.00
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100 mg
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Price (USD)
441.65
Online Exclusive
588.00
Save 146.35 (25%)
Each
Add to cart
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Thermo Scientific Pierce MM(PEG)24 is a methyl-terminated, polyethylene glycol compound (24 PEG units) activated with a maleimide group for covalent pegylation of sulfhydryls on proteins (e.g., cysteines) or assay surfaces.

Features of MM(PEG)24:

• Maleimide-activated for efficient PEGylation of sulfhydryl groups at pH 6.5-7.5; reaction of maleimide group results in formation of stable, irreversible thioether bonds
• Fully characterized PEGylation reagents with defined PEG chain lengths; molecules of discrete molecular weight for consistency of performance in protein-modification applications
• Provided with 24 ethylene glycol units, enabling modification procedures to be optimized for a specific application while retaining all the benefits associated with protein PEGylation
• PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity
• Easy-to-follow instructions increase the likelihood of a successful outcome

PEGylation Applications:
• PEGylate amine surfaces
• Add inert mass to proteins, immunogens, drug compounds and probes
• Improve solubility (decrease aggregation) of proteins or peptides without affecting function
• Protect proteins from proteolysis

Why PEGylate a protein or peptide?
PEG-containing reagents have been used to modify proteins to provide specific advantages. Protein PEGylation can improve the stability of the modified protein, protect it from proteolytic digestion, increase its half life in biological applications, mask it from causing an immunogenic response, decrease its antigenicity or potential toxicity, improve its solubility, diminish the potential for aggregation, and minimize interference for both in vitro and in vivo applications. Polyethylene glycol, also called polyethylene oxide (PEO), has these effects because it is nontoxic, nonimmunogenic, hydrophilic, water soluble and highly flexible.

Advantages of Discrete-length mPEG-NHS Ester Compounds:
These reagents are specially synthesized as homogeneous compounds of discrete chain length and defined molecular weight. As such, they enable precise control and optimization of surface protein modification experiments. By contrast, typical preparations of PEG compounds are heterogeneous mixtures composed of multiple chain lengths and a range of molecular weights.

Related Products
MM(PEG)12 Methyl-PEG-Maleimide Reagent
For Research Use Only. Not for use in diagnostic procedures.
Specifications
DescriptionPierce MM(PEG)24
FormPowder
Label TypePolyethylene Glycol (PEG), Blocking Groups
Quantity100 mg
Reactive MoietyMaleimide
SolubilityWater
Chemical ReactivityThiol
Product TypeMaleimide Reagent
Spacer24 ethylene glycol units
Unit SizeEach
Contents & Storage
Upon receipt store desiccated at 4°C. Product is shipped at ambient temperature.
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Lot #Certificate TypeDateCatalog Number(s)
3213387Certificate of AnalysisJun 03, 202522713
ZI391615Certificate of AnalysisOct 15, 202422713
ZD378147Certificate of AnalysisApr 25, 202422713
YD372659Certificate of AnalysisMay 02, 202322713
YC369999Certificate of AnalysisMar 25, 202322713
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