Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
General Information
• Cytochalasin B is a cell-permeable fungal toxin / mycotoxin considered to be an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments
Applications
• Cytochalasin B can inhibit platelet aggregation and actin polymerization
• Cytochalasin B is commonly used in studies on cytokinesis due to its ability to act as an inhibitor
• It is used for characterizing some of the polymerization properties of actin
• This compound can also induce DNA fragmentation, inhibit cell division, and inhibit glucose transport, among other molecular processes
• It could be used as a probe for the two hexose-transport systems in rat L6 myoblasts
• Cytochalasin B is commonly used in studies of glucose transporters (GLUT)
• It can be used in in vitro micronucleus assay protocols
Literature References
Brzozowska, K.; Johannes, C.; Obe, G.; Hentschel, R.; Morand, J.; Moss, R.; Wittig, A.; Sauerwein, W.; Liniecki, J.; Szumiel, I.; Wojcik, A. Effect of temperature during irradiation on the level of micronuclei in human peripheral blood lymphocytes exposed to X-rays and neutrons. Int J Radiat Biol. 2009, 85, (10), 891-899.
MacLean-Fletcher, S.; Pollard, T. D. Mechanism of action of cytochalasin B on actin. Cell. 1998, 20, (2), 329-341.
Fenech, M.; Morley, A. A. Measurement of micronuclei in lymphocytes. Mutation Research/Environmental Mutagenesis and Related Subjects. 1985, 147, (1-2), 29-36.