Product References
Recombinant ferritin-based nanoparticles as neoantigen carriers significantly inhibit tumor growth and metastasis.
Journal of nanobiotechnology
Zheng W,Li S,Shi Z,Su K,Ding Y,Zhang L,Tang Q,Han J,Zhao H,Wang F,Zhang H,Hong Z
315-03 was used in Cell Culture to develop a safe and effective neoantigen peptide delivery system (neoantigen-ferritin nanoparticles, neoantigen-FNs) that successfully achieved effective lymph node targeting and induced robust antitumor immune responses.
Sat Sep 14 00:00:00 UTC 2024
Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells.
Cell reports. Medicine
Sprooten J,Vanmeerbeek I,Datsi A,Govaerts J,Naulaerts S,Laureano RS,Borràs DM,Calvet A,Malviya V,Kuballa M,Felsberg J,Sabel MC,Rapp M,Knobbe-Thomsen C,Liu P,Zhao L,Kepp O,Boon L,Tejpar S,Borst J,Kroemer G,Schlenner S,De Vleeschouwer S,Sorg RV,Garg AD
315-03 was used in Cell Culture to propose that a multimodal immunotherapy and vaccination regimen is mandatory to overcome T cell-depleted tumors.
Tue Jan 16 00:00:00 UTC 2024
Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines.
Nature nanotechnology
Han X,Alameh MG,Butowska K,Knox JJ,Lundgreen K,Ghattas M,Gong N,Xue L,Xu Y,Lavertu M,Bates P,Xu J,Nie G,Zhong Y,Weissman D,Mitchell MJ
315-03 was used in In vitro experiments to develop an Lipid nanoparticle component-an adjuvant lipidoid-that can enhance the adjuvanticity of mRNA-LNP vaccines.
Fri Sep 01 00:00:00 UTC 2023
NLRP12-expressing dendritic cells mediate both dissemination of infection and adaptive immune responses in visceral leishmaniasis.
iScience
Valadares DG,Clay OS,Chen Y,Scorza BM,Cassel SL,Sutterwala FS,Wilson ME
315-03 was used in In vitro experiments to hypothesize that Nlrp12-expressing DCs are required for efficient dissemination and immune clearance of L. infantum from the site of initial infection.
Fri Mar 17 00:00:00 UTC 2023
Deletion of Nox4 enhances remyelination following cuprizone-induced demyelination by increasing phagocytic capacity of microglia and macrophages in mice.
Glia
Yamanaka K,Nakamura K,Shibahara T,Takashima M,Takaki H,Hidaka M,Komori M,Yoshikawa Y,Wakisaka Y,Ago T,Kitazono T
315-03 was used in Cell Culture to examine the effect of Nox4 deletion on demyelination-remyelination, the most common pathological change in the brain.
Wed Mar 01 00:00:00 UTC 2023
Myeloid autophagy genes protect mice against fatal TNF- and LPS-induced cytokine storm syndromes.
Autophagy
Wang YT,Sansone A,Smirnov A,Stallings CL,Orvedahl A
315-03 was used in In vitro experiments to identify autophagy gene sets and specific cell types that protect against fatal inflammation due to CSS, highlighting important differences in two commonly used murine models of the disorder.
Sat Apr 01 00:00:00 UTC 2023
BCL2 Inhibition Reveals a Dendritic Cell-Specific Immune Checkpoint That Controls Tumor Immunosurveillance.
Cancer discovery
Zhao L,Liu P,Mao M,Zhang S,Bigenwald C,Dutertre CA,Lehmann CHK,Pan H,Paulhan N,Amon L,Buqué A,Yamazaki T,Galluzzi L,Kloeckner B,Silvin A,Pan Y,Chen H,Tian AL,Ly P,Dudziak D,Zitvogel L,Kepp O,Kroemer G
315-03 was used in Cell Culture to indicate that BCL2 blockade can be used to sensitize solid cancers to PD-1/PD-L1-targeting immunotherapy.
Wed Nov 01 00:00:00 UTC 2023
NS5806 reduces carrageenan-evoked inflammation by suppressing extracellular signal-regulated kinase activation in primary sensory neurons and immune cells.
European journal of pain (London, England)
Yang PY,Tsaur ML
315-03 was used in Cell Culture to show that NS5806 only acts on neurons.
Fri Sep 01 00:00:00 UTC 2023
METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism.
Cell stem cell
Han L,Dong L,Leung K,Zhao Z,Li Y,Gao L,Chen Z,Xue J,Qing Y,Li W,Pokharel SP,Gao M,Chen M,Shen C,Tan B,Small A,Wang K,Zhang Z,Qin X,Yang L,Wunderlich M,Zhang B,Mulloy JC,Marcucci G,Chen CW,Wei M,Su R,Chen J,Deng X
315-03 was used in Cell Culture to show that METTL16 is a highly essential gene for the survival of acute myeloid leukemia (AML) cells via CRISPR-Cas9 screening and experimental validation.
Thu Jan 05 00:00:00 UTC 2023
Robust IL-2-dependent antitumor immunotherapy requires targeting the high-affinity IL-2R on tumor-specific CD8+ T cells.
Journal for immunotherapy of cancer
LaPorte KM,Hernandez R,Santos Savio A,Malek TR
315-03 was used in Cell Culture to test an IL-2 biologic, mouse IL-2/CD25, with selectivity toward the high-affinity IL-2R to support antitumor responses to tumours that vary in their immunogenicity.
Thu Jun 01 00:00:00 UTC 2023
Tumor Cell Nanovaccines Based on Genetically Engineered Antibody-Anchored Membrane.
Advanced materials (Deerfield Beach, Fla.)
Li Y,Zhang H,Wang R,Wang Y,Li R,Zhu M,Zhang X,Zhao Z,Wan Y,Zhuang J,Zhang H,Huang X
315-03 was used in Cell Culture to report agonistic-antibody-boosted tumor cell nanovaccines that are genetically engineered antibody-anchored membrane (AAM) technology, capable of effectively activating costimulatory pathways.
Wed Mar 01 00:00:00 UTC 2023
Modeling human yolk sac hematopoiesis with pluripotent stem cells.
The Journal of experimental medicine
Atkins MH,Scarfò R,McGrath KE,Yang D,Palis J,Ditadi A,Keller GM
Mon Mar 07 00:00:00 UTC 2022
Sustained Exosome-Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and MiRNAs, and Sustained Release Formulation.
Small (Weinheim an der Bergstrasse, Germany)
Kwak G,Cheng J,Kim H,Song S,Lee SJ,Yang Y,Jeong JH,Lee JE,Messersmith PB,Kim SH
Fri Apr 01 00:00:00 UTC 2022
IL-6-elafin genetically modified macrophages as a lung immunotherapeutic strategy against Pseudomonas aeruginosa infections.
Molecular therapy : the journal of the American Society of Gene Therapy
Kheir S,Villeret B,Garcia-Verdugo I,Sallenave JM
Wed Jan 05 00:00:00 UTC 2022
Heme-stress activated NRF2 skews fate trajectories of bone marrow cells from dendritic cells towards red pulp-like macrophages in hemolytic anemia.
Cell death and differentiation
Vallelian F,Buzzi RM,Pfefferlé M,Yalamanoglu A,Dubach IL,Wassmer A,Gentinetta T,Hansen K,Humar R,Schulthess N,Schaer CA,Schaer DJ
Mon Aug 01 00:00:00 UTC 2022
Saponin-based adjuvant-induced dendritic cell cross-presentation is dependent on PERK activation.
Cellular and molecular life sciences : CMLS
Huis In 't Veld LGM,Ho NI,Wassink M,den Brok MH,Adema GJ
315-03 was used in In vitro experiments to show that SBAs specifically induce the PKR-like Endoplasmic Reticulum kinase (PERK) pathway and that SBA-induced DC cross-presentation is dependent on activation of the PERK pathway.
Sat Apr 09 00:00:00 UTC 2022
Saponin-based adjuvant-induced dendritic cell cross-presentation is dependent on PERK activation.
Cellular and molecular life sciences : CMLS
Huis In 't Veld LGM,Ho NI,Wassink M,den Brok MH,Adema GJ
315-03 was used in In vitro experiments to show that SBAs specifically induce the PKR-like Endoplasmic Reticulum kinase (PERK) pathway and that SBA-induced DC cross-presentation is dependent on activation of the PERK pathway.
Sat Apr 09 00:00:00 UTC 2022
Irg1/itaconate metabolic pathway is a crucial determinant of dendritic cells immune-priming function and contributes to resolute allergen-induced airway inflammation.
Mucosal immunology
Jaiswal AK,Yadav J,Makhija S,Mazumder S,Mitra AK,Suryawanshi A,Sandey M,Mishra A
Tue Feb 01 00:00:00 UTC 2022
Taurolithocholic acid but not tauroursodeoxycholic acid rescues phagocytosis activity of bone marrow-derived macrophages under inflammatory stress.
Journal of cellular physiology
Wu S,Romero-Ramírez L,Mey J
Tue Feb 01 00:00:00 UTC 2022
Short palate, lung, and nasal epithelial clone 1 (SPLUNC1) level determines steroid-resistant airway inflammation in aging.
American journal of physiology. Lung cellular and molecular physiology
Jaiswal AK,Yadav J,Makhija S,Sandey M,Suryawanshi A,Mitra AK,Mishra A
Sat Jan 01 00:00:00 UTC 2022
Role of Cholinergic Anti-Inflammatory Pathway in Protecting Sepsis-Induced Acute Lung Injury through Regulation of the Conventional Dendritic Cells.
Mediators of inflammation
Li R,Hu X,Chen H,Zhao Y,Gao X,Yuan Y,Guo H,Huang H,Zou X,Qi H,Liu H,Shang Y
Thu Mar 31 00:00:00 UTC 2022
A Novel In Situ Dendritic Cell Vaccine Triggered by Rose Bengal Enhances Adaptive Antitumour Immunity.
Journal of immunology research
Zhang L,Du J,Song Q,Zhang C,Wu X
315-03 was used in Sample Preparation (FC/FACS) to study the synergistic antitumour effect of combining intralesional Rose Bengal (RB) with immature dendritic cells (DCs) (RB-iDCs) to reveal that the RB-iDC vaccine can synergistically destroy the primary tumour, inhibit distant metastasis, and prevent tumour relapse in a lung cancer mouse model, which provides important preclinical data for the development of a novel combinatorial immunotherapy.
Tue Mar 29 00:00:00 UTC 2022
Upregulation of CD3ζ and L-selectin in antigen-specific cytotoxic T lymphocytes by eliminating myeloid-derived suppressor cells with doxorubicin to improve killing efficacy of neuroblastoma cells in vitro.
Journal of clinical laboratory analysis
Xu W,Li S,Li M,Zhou H,Yang X
Sat Jan 01 00:00:00 UTC 2022
Extracellular nicotinamide phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4.
iScience
Colombo G,Travelli C,Porta C,Genazzani AA
315-03 was used in Sample Preparation (Western Blotting) to demonstrate that eNAMPT promotes inflammation by favoring both the recruitment of myeloid cells and the induction of an inflammatory transcriptional program.
Fri Apr 15 00:00:00 UTC 2022
Positively charged nanocomplex modulates dendritic cell differentiation to enhance Th1 immune response.
Materials today. Bio
Wu YW,Wang WY,Chen YH
315-03 was used in Cell Culture to clarify the effects of surface charge and size on the immune response, smaller chitosan (Cs)-based nanocomplex (CNC) and negatively charged CNC encapsulating ovalbumin are tested on dendritic cell 2.4 cells.
Thu Dec 15 00:00:00 UTC 2022
Aryl hydrocarbon receptor activation ameliorates experimental colitis by modulating the tolerogenic dendritic and regulatory T cell formation.
Cell & bioscience
Cui X,Ye Z,Wang D,Yang Y,Jiao C,Ma J,Tang N,Zhang H
315-03 was used in Cell Culture to investigate whether the activation of AhR can induce tolerogenic DCs (tolDCs) and the differentiation of regulatory T (Treg) cells, as well as ameliorate experimental colitis.
Sat Apr 23 00:00:00 UTC 2022
Neutrophil-dendritic cell interaction plays an important role in live attenuated Leishmania vaccine induced immunity.
PLoS neglected tropical diseases
Bhattacharya P,Ismail N,Saxena A,Gannavaram S,Dey R,Oljuskin T,Akue A,Takeda K,Yu J,Karmakar S,Dagur PK,McCoy JP,Nakhasi HL
315-03 was used in Cell Culture to show that LdCen-/- containing neutrophils phagocytized by DC markedly influence the phenotype and antigen presenting capacity of DCs early on and thus play an immune-regulatory role in shaping vaccine induced host protective response.
Tue Feb 01 00:00:00 UTC 2022
C-type lectin receptor CLEC4A2 promotes tissue adaptation of macrophages and protects against atherosclerosis.
Nature communications
Park I,Goddard ME,Cole JE,Zanin N,Lyytikäinen LP,Lehtimäki T,Andreakos E,Feldmann M,Udalova I,Drozdov I,Monaco C
Tue Jan 11 00:00:00 UTC 2022
Promoting antigen escape from dendritic cell endosomes potentiates anti-tumoral immunity.
Cell reports. Medicine
Bikorimana JP,Salame N,Beaudoin S,Balood M,Crosson T,Abusarah J,Talbot S,Löbenberg R,Plouffe S,Rafei M
315-03 was used in Cell Culture to present a new Accum-based formulation designed to promote endosome-to-cytosol escape, triggering a potent anti-tumoral repsonse by the DCs.
Tue Mar 15 00:00:00 UTC 2022
Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression.
Nature communications
Qi M,Xia Y,Wu Y,Zhang Z,Wang X,Lu L,Dai C,Song Y,Xu K,Ji W,Zhan L
315-03 was used in In vitro experiments to demonstrate that Lin28B promotes lung metastasis of breast cancer by building an immune-suppressive pre-metastatic niche.
Wed Feb 16 00:00:00 UTC 2022
Re-engineered BCG overexpressing cyclic di-AMP augments trained immunity and exhibits improved efficacy against bladder cancer.
Nature communications
Singh AK,Praharaj M,Lombardo KA,Yoshida T,Matoso A,Baras AS,Zhao L,Srikrishna G,Huang J,Prasad P,Powell JD,Kates M,McConkey D,Pardoll DM,Bishai WR,Bivalacqua TJ
315-03 was used in Sample Preparation (FC/FACS) to e-engineer BCG to express high levels of c-di-AMP, a PAMP recognized by stimulator of interferon genes (STING).
Tue Feb 15 00:00:00 UTC 2022
Nanocarriers based on bacterial membrane materials for cancer vaccine delivery.
Nature protocols
Zhao X,Zhao R,Nie G
315-03 was used in Cell Culture to develop two different types of nanocarrier based on bacterial membrane materials, which employ genetically engineered outer-membrane vesicles (OMVs), or hybrid membrane vesicles containing bacterial cytoplasmic membrane, respectively.
Sat Oct 01 00:00:00 UTC 2022
Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function.
Cell reports
Alam MM,Yang D,Li XQ,Liu J,Back TC,Trivett A,Karim B,Barbut D,Zasloff M,Oppenheim JJ
315-03 was used in Cell Culture to show that αS is a critical mediator of inflammatory and immune responses.
Tue Jan 11 00:00:00 UTC 2022
An improved organotypic cell culture system to study tissue-resident macrophages ex vivo.
Cell reports methods
Aktories P,Petry P,Glatz P,Andrieux G,Oschwald A,Botterer H,Gorka O,Erny D,Boerries M,Henneke P,Groß O,Prinz M,Kierdorf K
315-03 was used in Cell Culture to conclude that his organotypic system offers an ideal screening platform for primary macrophages from different organs that can be used for a wide range of assays and readouts.
Mon Aug 22 00:00:00 UTC 2022
Isolation and culture of pure adult mouse microglia and astrocytes for in vitro characterization and analyses.
STAR protocols
Milner MT,Lawrence GM,Holley CL,Bodea LG,Götz J,Burgener SS,Schroder K
315-03 was used in Cell Culture to provide a protocol for the isolation and culturing of glial cells from the murine brain.
Fri Jun 17 00:00:00 UTC 2022
ASB17 Facilitates the Burst of LPS-Induced Inflammation Through Maintaining TRAF6 Stability.
Frontiers in cellular and infection microbiology
Wan P,Yang G,Zhang S,Zhang Y,Jia Y,Che X,Luo Z,Pan P,Li G,Chen X,Zhang Q,Zhang W,Tan Q,Li Y,Wu J
315-03 was used in Cell Culture to investigate the cellular role of ASB17.
Fri Nov 17 00:00:00 UTC 2023
Endothelial cell-specific expression of serine/threonine kinase 11 modulates dendritic cell differentiation.
Nature communications
Zhao Q,Han YM,Song P,Liu Z,Yuan Z,Zou MH
315-03 was used in Cell Culture to investigate dendritic cell progression in the bone marrow.
Thu Feb 03 00:00:00 UTC 2022
Rapid video-based deep learning of cognate versus non-cognate T cell-dendritic cell interactions.
Scientific reports
Anandakumaran PN,Ayers AG,Muranski P,Creusot RJ,Sia SK
Tue Jan 11 00:00:00 UTC 2022
Protocol for in vitro analysis of pro-inflammatory and metabolic functions of cultured primary murine astrocytes.
STAR protocols
Gutiérrez-Vázquez C,Quintana FJ
315-03 was used in In vitro experiments to investigate molecular mechanisms of astrocyte metabolism and pro-inflammatory activities in neonatal brains.
Fri Mar 18 00:00:00 UTC 2022
The ATG8 Family Proteins GABARAP and GABARAPL1 Target Antigen to Dendritic Cells to Prime CD4+ and CD8+ T Cells.
Cells
Fonderflick L,Baudu T,Adotévi O,Guittaut M,Adami P,Delage-Mourroux R
315-03 was used in Sample Preparation (FC/FACS) to show that B16-F10 cells that expressed the OVA-ATG8 fused proteins stimulated OVA-specific CD8+ T cells, but demonstrated no CD4+ T cell response.
Tue Sep 06 00:00:00 UTC 2022
Ena/VASP proteins at the crossroads of actin nucleation pathways in dendritic cell migration.
Frontiers in cell and developmental biology
Visweshwaran SP,Nayab H,Hoffmann L,Gil M,Liu F,Kühne R,Maritzen T
315-03 was used in Cell Culture to show that the two family members Evl and VASP are expressed in murine DCs and that their loss negatively affects DC macropinocytosis, spreading, and migration.
Tue Oct 25 00:00:00 UTC 2022
Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment.
Cell reports
Papadas A,Deb G,Cicala A,Officer A,Hope C,Pagenkopf A,Flietner E,Morrow ZT,Emmerich P,Wiesner J,Arauz G,Bansal V,Esbona K,Capitini CM,Matkowskyj KA,Deming DA,Politi K,Abrams SI,Harismendy O,Asimakopoulos F
315-03 was used in In vitro experiments to conclude that peritumoral stroma mimicking embryonic provisional matrix remodeling regulates cDC1 abundance and activity to elicit T cell-inflamed tumor microenvironments.
Tue Aug 16 00:00:00 UTC 2022
Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment.
Cell reports
Papadas A,Deb G,Cicala A,Officer A,Hope C,Pagenkopf A,Flietner E,Morrow ZT,Emmerich P,Wiesner J,Arauz G,Bansal V,Esbona K,Capitini CM,Matkowskyj KA,Deming DA,Politi K,Abrams SI,Harismendy O,Asimakopoulos F
315-03 was used in In vitro experiments to conclude that peritumoral stroma mimicking embryonic provisional matrix remodeling regulates cDC1 abundance and activity to elicit T cell-inflamed tumor microenvironments.
Tue Aug 16 00:00:00 UTC 2022
Age-related decline in the resistance of mice to bacterial infection and in LPS/TLR4 pathway-dependent neutrophil responses.
Frontiers in immunology
Hornigold K,Chu JY,Chetwynd SA,Machin PA,Crossland L,Pantarelli C,Anderson KE,Hawkins PT,Segonds-Pichon A,Oxley D,Welch HCE
315-03 was used in In vitro experiments to study neutrophil function in old mice which were exposed to lipopolysaccharide (LPS) endotoxins derived from gram-negative bacteria. With age, neutrophil function is impaired in humans. The study investigated LPS signaling via toll-like receptor (TLR) 4 interaction to determine whether neutrophil responses are similarly impaired in mice and whether mice are an appropriate model for the decline in human neutrophil function.
Tue Sep 13 00:00:00 UTC 2022
Gene therapy of Csf2ra deficiency in mouse fetal monocyte precursors restores alveolar macrophage development and function.
JCI insight
Li F,Okreglicka KM,Piattini F,Pohlmeier LM,Schneider C,Kopf M
315-03 was used in In vitro experiments to study how fetal liver monocytes cultured with GM-CSF (CSF2-cFLiMo) rapidly differentiated into a long-lived, homogeneous alveolar macrophage-like population in vitro and rovide a platform for generation of immature alveolar macrophage-like precursors amenable for genetic manipulation, which will be useful to dissect alveolar macrophage development and function and for pulmonary transplantation therapy.
Fri Apr 08 00:00:00 UTC 2022
eccDNAs are apoptotic products with high innate immunostimulatory activity.
Nature
Wang Y,Wang M,Djekidel MN,Chen H,Liu D,Alt FW,Zhang Y
Mon Nov 01 00:00:00 UTC 2021
Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes.
Nature
Sanmarco LM,Wheeler MA,Gutiérrez-Vázquez C,Polonio CM,Linnerbauer M,Pinho-Ribeiro FA,Li Z,Giovannoni F,Batterman KV,Scalisi G,Zandee SEJ,Heck ES,Alsuwailm M,Rosene DL,Becher B,Chiu IM,Prat A,Quintana FJ
315-03 was used in In vitro experiments to show that LAMP1+TRAIL+ astrocytes limit CNS inflammation by inducing T cell apoptosis, and that this astrocyte subset is maintained by meningeal IFNγ+ NK cells that are licensed by the microbiome.
Mon Feb 01 00:00:00 UTC 2021
Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells.
Nature
Casanova-Acebes M,Dalla E,Leader AM,LeBerichel J,Nikolic J,Morales BM,Brown M,Chang C,Troncoso L,Chen ST,Sastre-Perona A,Park MD,Tabachnikova A,Dhainaut M,Hamon P,Maier B,Sawai CM,Agulló-Pascual E,Schober M,Brown BD,Reizis B,Marron T,Kenigsberg E,Moussion C,Benaroch P,Aguirre-Ghiso JA,Merad M
Thu Jul 01 00:00:00 UTC 2021
Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses.
Immunity
Tang Q,Rigby RE,Young GR,Hvidt AK,Davis T,Tan TK,Bridgeman A,Townsend AR,Kassiotis G,Rehwinkel J
Tue Sep 14 00:00:00 UTC 2021
The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake.
Immunity
de Mingo Pulido Á,Hänggi K,Celias DP,Gardner A,Li J,Batista-Bittencourt B,Mohamed E,Trillo-Tinoco J,Osunmakinde O,Peña R,Onimus A,Kaisho T,Kaufmann J,McEachern K,Soliman H,Luca VC,Rodriguez PC,Yu X,Ruffell B
Tue Jun 08 00:00:00 UTC 2021
A novel inactivated whole-cell Pseudomonas aeruginosa vaccine that acts through the cGAS-STING pathway.
Signal transduction and targeted therapy
Ma C,Ma X,Jiang B,Pan H,Liao X,Zhang L,Li W,Luo Y,Shen Z,Cheng X,Lian M,Wang Z
Fri Oct 01 00:00:00 UTC 2021
Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases.
Cellular & molecular immunology
Hou P,Lin Y,Li Z,Lu R,Wang Y,Tian T,Jia P,Zhang X,Cao L,Zhou Z,Li C,Gu J,Guo D
Fri Oct 01 00:00:00 UTC 2021
Calcineurin inhibitors suppress acute graft-versus-host disease via NFAT-independent inhibition of T cell receptor signaling.
The Journal of clinical investigation
Otsuka S,Melis N,Gaida MM,Dutta D,Weigert R,Ashwell JD
315-03 was used in Cell Culture to investigate if effective treatment of acute graft-versus-host disease by cyclosporin A requires nuclear factor of activated T cells-independent inhibition of TCR signaling.
Tue Jun 01 00:00:00 UTC 2021
ER-to-Golgi transport and SEC23-dependent COPII vesicles regulate T cell alloimmunity.
The Journal of clinical investigation
Kim S,Khoriaty R,Li L,McClune M,Kalfa TA,Wu J,Peltier D,Fujiwara H,Sun Y,Oravecz-Wilson K,King RA,Ginsburg D,Reddy P
Tue Jan 19 00:00:00 UTC 2021
A therapeutic cancer vaccine delivers antigens and adjuvants to lymphoid tissues using genetically modified T cells.
The Journal of clinical investigation
Veatch JR,Singhi N,Srivastava S,Szeto JL,Jesernig B,Stull SM,Fitzgibbon M,Sarvothama M,Yechan-Gunja S,James SE,Riddell SR
Mon Aug 16 00:00:00 UTC 2021
Targeted immunotherapy for HER2-low breast cancer with 17p loss.
Science translational medicine
Li Y,Sun Y,Kulke M,Hechler T,Van der Jeught K,Dong T,He B,Miller KD,Radovich M,Schneider BP,Pahl A,Zhang X,Lu X
315-03 was used in Cell Culture to conclude that 17p loss not only drives breast tumorigenesis but also confers therapeutic vulnerabilities that may be used to develop targeted precision immunotherapy.
Wed Feb 10 00:00:00 UTC 2021
Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice.
The Journal of experimental medicine
Veglia F,Hashimoto A,Dweep H,Sanseviero E,De Leo A,Tcyganov E,Kossenkov A,Mulligan C,Nam B,Masters G,Patel J,Bhargava V,Wilkinson P,Smirnov D,Sepulveda MA,Singhal S,Eruslanov EB,Cristescu R,Loboda A,Nefedova Y,Gabrilovich DI
Mon Apr 05 00:00:00 UTC 2021
AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma.
The Journal of experimental medicine
Fukuda K,Okamura K,Riding RL,Fan X,Afshari K,Haddadi NS,McCauley SM,Guney MH,Luban J,Funakoshi T,Yaguchi T,Kawakami Y,Khvorova A,Fitzgerald KA,Harris JE
Mon Sep 06 00:00:00 UTC 2021
DCIR and its ligand asialo-biantennary N-glycan regulate DC function and osteoclastogenesis.
The Journal of experimental medicine
Kaifu T,Yabe R,Maruhashi T,Chung SH,Tateno H,Fujikado N,Hirabayashi J,Iwakura Y
Mon Dec 06 00:00:00 UTC 2021
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
Mon Jul 05 00:00:00 UTC 2021
The histone demethylase Lsd1 regulates multiple repressive gene programs during T cell development.
The Journal of experimental medicine
Stamos DB,Clubb LM,Mitra A,Chopp LB,Nie J,Ding Y,Das A,Venkataganesh H,Lee J,El-Khoury D,Li L,Bhandoola A,Bosselut R,Love PE
Mon Dec 06 00:00:00 UTC 2021
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.
The Journal of experimental medicine
Bittner ZA,Liu X,Mateo Tortola M,Tapia-Abellán A,Shankar S,Andreeva L,Mangan M,Spalinger M,Kalbacher H,Düwell P,Lovotti M,Bosch K,Dickhöfer S,Marcu A,Stevanović S,Herster F,Cardona Gloria Y,Chang TH,Bork F,Greve CL,Löffler MW,Wolz OO,Schilling NA,Kümmerle-Deschner JB,Wagner S,Delor A,Grimbacher B,Hantschel O,Scharl M,Wu H,Latz E,Weber ANR
Mon Nov 01 00:00:00 UTC 2021
Acetylcholine ameliorates colitis by promoting IL-10 secretion of monocytic myeloid-derived suppressor cells through the nAChR/ERK pathway.
Proceedings of the National Academy of Sciences of the United States of America
Zheng W,Song H,Luo Z,Wu H,Chen L,Wang Y,Cui H,Zhang Y,Wang B,Li W,Liu Y,Zhang J,Chu Y,Luo F,Liu J
Tue Mar 16 00:00:00 UTC 2021
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections.
Proceedings of the National Academy of Sciences of the United States of America
Yum S,Li M,Fang Y,Chen ZJ
Tue Apr 06 00:00:00 UTC 2021
Functional genomics and metabolomics advance the ethnobotany of the Samoan traditional medicine "matalafi".
Proceedings of the National Academy of Sciences of the United States of America
Molimau-Samasoni S,Woolner VH,Foliga ST,Robichon K,Patel V,Andreassend SK,Sheridan JP,Te Kawa T,Gresham D,Miller D,Sinclair DJ,La Flamme AC,Melnik AV,Aron A,Dorrestein PC,Atkinson PH,Keyzers RA,Munkacsi AB
Tue Nov 09 00:00:00 UTC 2021
Fever supports CD8+ effector T cell responses by promoting mitochondrial translation.
Proceedings of the National Academy of Sciences of the United States of America
O'Sullivan D,Stanczak MA,Villa M,Uhl FM,Corrado M,Klein Geltink RI,Sanin DE,Apostolova P,Rana N,Edwards-Hicks J,Grzes KM,Kabat AM,Kyle RL,Fabri M,Curtis JD,Buck MD,Patterson AE,Regina A,Field CS,Baixauli F,Puleston DJ,Pearce EJ,Zeiser R,Pearce EL
Tue Jun 22 00:00:00 UTC 2021
Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme.
Proceedings of the National Academy of Sciences of the United States of America
Jentho E,Ruiz-Moreno C,Novakovic B,Kourtzelis I,Megchelenbrink WL,Martins R,Chavakis T,Soares MP,Kalafati L,Guerra J,Roestel F,Bohm P,Godmann M,Grinenko T,Eugster A,Beretta M,Joosten LAB,Netea MG,Bauer M,Stunnenberg HG,Weis S
Tue Oct 19 00:00:00 UTC 2021
Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling.
Proceedings of the National Academy of Sciences of the United States of America
Zhang H,You X,Wang X,Cui L,Wang Z,Xu F,Li M,Yang Z,Liu J,Huang P,Kang Y,Wu J,Xia X
Tue Feb 09 00:00:00 UTC 2021
SLC15A4 mediates M1-prone metabolic shifts in macrophages and guards immune cells from metabolic stress.
Proceedings of the National Academy of Sciences of the United States of America
Kobayashi T,Nguyen-Tien D,Sorimachi Y,Sugiura Y,Suzuki T,Karyu H,Shimabukuro-Demoto S,Uemura T,Okamura T,Taguchi T,Ueki K,Kato N,Goda N,Dohmae N,Takubo K,Suematsu M,Toyama-Sorimachi N
Tue Aug 17 00:00:00 UTC 2021
Opposing functions of β-arrestin 1 and 2 in Parkinson's disease via microglia inflammation and Nprl3.
Cell death and differentiation
Fang Y,Jiang Q,Li S,Zhu H,Xu R,Song N,Ding X,Liu J,Chen M,Song M,Ding J,Lu M,Wu G,Hu G
Tue Jun 01 00:00:00 UTC 2021
The AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity.
Cell death and differentiation
Novoszel P,Drobits B,Holcmann M,Fernandes CS,Tschismarov R,Derdak S,Decker T,Wagner EF,Sibilia M
Sun Aug 01 00:00:00 UTC 2021
A Modular Biomaterial Scaffold-Based Vaccine Elicits Durable Adaptive Immunity to Subunit SARS-CoV-2 Antigens.
Advanced healthcare materials
Langellotto F,Dellacherie MO,Yeager C,Ijaz H,Yu J,Cheng CA,Dimitrakakis N,Seiler BT,Gebre MS,Gilboa T,Johnson R,Storm N,Bardales S,Graveline A,White D,Tringides CM,Cartwright MJ,Doherty EJ,Honko A,Griffiths A,Barouch DH,Walt DR,Mooney DJ
Mon Nov 01 00:00:00 UTC 2021
Granulocyte colony-stimulating factor directly acts on mouse lymphoid-biased but not myeloid-biased hematopoietic stem cells.
Haematologica
Xie M,Zhang S,Dong F,Zhang Q,Wang J,Wang C,Zhu C,Zhang S,Luo B,Wu P,Ema H
315-03 was used in Cell Culture to investigate whether granulocyte colony-stimulating factor directly stimulates hematopoietic stem cells to change their cell cycle state and fate.
Tue Jun 01 00:00:00 UTC 2021
Bifidobacterium dentium-derived y-glutamylcysteine suppresses ER-mediated goblet cell stress and reduces TNBS-driven colonic inflammation.
Gut microbes
Engevik MA,Herrmann B,Ruan W,Engevik AC,Engevik KA,Ihekweazu F,Shi Z,Luck B,Chang-Graham AL,Esparza M,Venable S,Horvath TD,Haidacher SJ,Hoch KM,Haag AM,Schady DA,Hyser JM,Spinler JK,Versalovic J
315-03 was used in Cell Culture to demonstrate positive modulation of the UPR and MUC2 production by B. dentium-secreted compounds.
Thu Nov 18 00:00:00 UTC 2021
IL-33 drives the production of mouse regulatory T cells with enhanced in vivo suppressive activity in skin transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Kawai K,Uchiyama M,Hester J,Issa F
Mon Mar 01 00:00:00 UTC 2021
CXCL12-abundant reticular cells are the major source of IL-6 upon LPS stimulation and thereby regulate hematopoiesis.
Blood advances
Gerosa RC,Boettcher S,Kovtonyuk LV,Hausmann A,Hardt WD,Hidalgo J,Nombela-Arrieta C,Manz MG
Tue Dec 14 00:00:00 UTC 2021
Essential role of M1 macrophages in blocking cytokine storm and pathology associated with murine HSV-1 infection.
PLoS pathogens
Jaggi U,Matundan HH,Yu J,Hirose S,Mueller M,Wormley FL,Ghiasi H
315-03 was used in Sample Preparation (FC/FACS) to study the role and importance of M1 macrophages in HSV-1 infection and eye disease.
Fri Oct 01 00:00:00 UTC 2021
The multi-functional reovirus σ3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury.
PLoS pathogens
Guo Y,Hinchman MM,Lewandrowski M,Cross ST,Sutherland DM,Welsh OL,Dermody TS,Parker JSL
315-03 was used in Sample Preparation (FC/FACS) to indicate that σ3 functions to suppress PKR activation and subsequent SG formation during viral infection and that these functions correlate with virulence in mice.
Thu Jul 01 00:00:00 UTC 2021
Pinaverium Bromide Attenuates Lipopolysaccharide-Induced Excessive Systemic Inflammation via Inhibiting Neutrophil Priming.
Journal of immunology (Baltimore, Md. : 1950)
Chen X,Liu Y,Dolin H,Liu J,Jiang Y,Pan ZK
Thu Apr 15 00:00:00 UTC 2021
Erythropoietin Protects against Diffuse Alveolar Hemorrhage in Mice by Regulating Macrophage Polarization through the EPOR/JAK2/STAT3 Axis.
Journal of immunology (Baltimore, Md. : 1950)
Yang Z,Yan L,Cao H,Gu Y,Zhou P,Shi M,Li G,Jiao X,Li N,Li X,Sun K,Shao F
Thu Apr 15 00:00:00 UTC 2021
Critical Role of Zinc Transporter (ZIP8) in Myeloid Innate Immune Cell Function and the Host Response against Bacterial Pneumonia.
Journal of immunology (Baltimore, Md. : 1950)
Hall SC,Smith DR,Dyavar SR,Wyatt TA,Samuelson DR,Bailey KL,Knoell DL
Wed Sep 01 00:00:00 UTC 2021
Manganese-Doped Silica-Based Nanoparticles Promote the Efficacy of Antigen-Specific Immunotherapy.
Journal of immunology (Baltimore, Md. : 1950)
Chandra J,Teoh SM,Kuo P,Tolley L,Bashaw AA,Tuong ZK,Liu Y,Chen Z,Wells JW,Yu C,Frazer IH,Yu M
Mon Mar 01 00:00:00 UTC 2021
TLR3-Activated Monocyte-Derived Dendritic Cells Trigger Progression from Acute Viral Infection to Chronic Disease in the Lung.
Journal of immunology (Baltimore, Md. : 1950)
Wang X,Wu K,Keeler SP,Mao D,Agapov EV,Zhang Y,Holtzman MJ
Mon Mar 15 00:00:00 UTC 2021
Lymphocyte Activation Gene-3 Regulates Dendritic Cell Metabolic Programing and T Cell Priming Function.
Journal of immunology (Baltimore, Md. : 1950)
Garcia Cruz D,Giri RR,Gamiotea Turro D,Balsbaugh JL,Adler AJ,Rodriguez A
Mon Nov 01 00:00:00 UTC 2021
Dendritic Cell-Specific Role for Pellino2 as a Mediator of TLR9 Signaling Pathway.
Journal of immunology (Baltimore, Md. : 1950)
Oleszycka E,Rodgers AM,Xu L,Moynagh PN
Mon Nov 01 00:00:00 UTC 2021
CDCP1 on Dendritic Cells Contributes to the Development of a Model of Kawasaki Disease.
Journal of immunology (Baltimore, Md. : 1950)
Lun Y,Borjini N,Miura NN,Ohno N,Singer NG,Lin F
Tue Jun 15 00:00:00 UTC 2021
β-Arrestin 2 Regulates Inflammatory Responses against Mycobacterium tuberculosis Infection through ERK1/2 Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Wen Q,Li Y,Han Z,Liu H,Zhang S,Chen Y,He J,Du X,Fu Y,Zhang L,Zhang Z,Huang Y,Zhou X,Zhou C,Hu S,Ma L
Tue Jun 01 00:00:00 UTC 2021
STING Agonist Mitigates Experimental Autoimmune Encephalomyelitis by Stimulating Type I IFN-Dependent and -Independent Immune-Regulatory Pathways.
Journal of immunology (Baltimore, Md. : 1950)
Johnson BM,Uchimura T,Gallovic MD,Thamilarasan M,Chou WC,Gibson SA,Deng M,Tam JW,Batty CJ,Williams J,Matsushima GK,Bachelder EM,Ainslie KM,Markovic-Plese S,Ting JP
Sat May 01 00:00:00 UTC 2021
The Sympathetic Nervous System Modulates Cancer Vaccine Activity through Monocyte-Derived Cells.
Journal of immunology (Baltimore, Md. : 1950)
Hinkle L,Liu Y,Meng C,Chen Z,Mai J,Zhang L,Xu Y,Pan PY,Chen SH,Shen H
Wed Dec 15 00:00:00 UTC 2021
Fibroblastic reticular cell response to dendritic cells requires coordinated activity of podoplanin, CD44 and CD9.
Journal of cell science
de Winde CM,Makris S,Millward LJ,Cantoral-Rebordinos JA,Benjamin AC,Martínez VG,Acton SE
315-03 was used in Cell Culture to show a multi-faceted FRC response to DCs, which requires CD44 and CD9 in addition to podoplanin.
Thu Jul 15 00:00:00 UTC 2021
Exosomes Derived from RM-1 Cells Promote the Recruitment of MDSCs into Tumor Microenvironment by Upregulating CXCR4 via TLR2/NF-κB Pathway.
Journal of oncology
Li N,Wang Y,Xu H,Wang H,Gao Y,Zhang Y
Fri Oct 22 00:00:00 UTC 2021
A Helminth-Derived Chitinase Structurally Similar to Mammalian Chitinase Displays Immunomodulatory Properties in Inflammatory Lung Disease.
Journal of immunology research
Ebner F,Lindner K,Janek K,Niewienda A,Malecki PH,Weiss MS,Sutherland TE,Heuser A,Kühl AA,Zentek J,Hofmann A,Hartmann S
Wed Mar 09 00:00:00 UTC 2022
Infusion of Kupffer Cells Expanded in Vitro Ameliorated Liver Fibrosis in a Murine Model of Liver Injury.
Cell transplantation
Li W,He F
315-03 was used in Cell Culture to investigate the use of granulocyte-macrophage colony stimulating factor to produce Kupffer cells.
Wed Nov 17 00:00:00 UTC 2021
linc-AAM Facilitates Gene Expression Contributing to Macrophage Activation and Adaptive Immune Responses.
Cell reports
Chen X,He Y,Zhu Y,Du J,Sun H
Tue Jan 05 00:00:00 UTC 2021
Dabigatran activates inflammation resolution by promoting fibrinogen-like protein 2 shedding and RvD5n-3 DPA production.
Theranostics
Lei J,Zhou Y,Zhao H,Chen Y,Yan G,Wu L,Xu Y,Zhang J,Zhang X,Wang J,Li D,Li Y
315-03 was used in In vitro experiments to investigate Fgl2, RvD5n-3 DPA in sepsis.
Thu Jul 29 00:00:00 UTC 2021
Antigen presentation between T cells drives Th17 polarization under conditions of limiting antigen.
Cell reports
Boccasavia VL,Bovolenta ER,Villanueva A,Borroto A,Oeste CL,van Santen HM,Prieto C,Alonso-López D,Diaz-Muñoz MD,Batista FD,Alarcón B
Tue Mar 16 00:00:00 UTC 2021
Effect of resolvin D5 on T cell differentiation and osteoclastogenesis analyzed by lipid mediator profiling in the experimental arthritis.
Scientific reports
Yamada H,Saegusa J,Sendo S,Ueda Y,Okano T,Shinohara M,Morinobu A
Fri Aug 27 00:00:00 UTC 2021
Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis.
iScience
Chatterjee S,Yabaji SM,Rukhlenko OS,Bhattacharya B,Waligurski E,Vallavoju N,Ray S,Kholodenko BN,Brown LE,Beeler AB,Ivanov AR,Kobzik L,Porco JA,Kramnik I
Fri Aug 20 00:00:00 UTC 2021
Dicer-independent snRNA/snoRNA-derived nuclear RNA 3 regulates tumor-associated macrophage function by epigenetically repressing inducible nitric oxide synthase transcription.
Cancer communications (London, England)
Shi Y,Shi Q,Shen Q,Zhang Q,Cao X
Mon Feb 01 00:00:00 UTC 2021
The miR-424(322)/503 gene cluster regulates pro- versus anti-inflammatory skin DC subset differentiation by modulating TGF-β signaling.
Cell reports
Zyulina V,Yan KK,Ju B,Schwarzenberger E,Passegger C,Tam-Amersdorfer C,Pan Q,Sconocchia T,Pollack C,Shaner B,Zebisch A,Easton J,Yu J,Silva JM,Strobl H
Tue Apr 27 00:00:00 UTC 2021
Pharmacological inhibitors of anaplastic lymphoma kinase (ALK) induce immunogenic cell death through on-target effects.
Cell death & disease
Petrazzuolo A,Perez-Lanzon M,Martins I,Liu P,Kepp O,Minard-Colin V,Maiuri MC,Kroemer G
Fri Jul 16 00:00:00 UTC 2021
A two-adjuvant multiantigen candidate vaccine induces superior protective immune responses against SARS-CoV-2 challenge.
Cell reports
Jiang W,Shi L,Cai L,Wang X,Li J,Li H,Liang J,Gu Q,Ji G,Li J,Liu L,Sun M
315-03 was used in Cell Culture to suggest that the developed vaccine can elicit a multifaceted immune response and induce robust viral clearance in the URT, which makes it a potential vaccine for preventing disease and infection of SARS-CoV-2.
Tue Dec 14 00:00:00 UTC 2021
Chronic stress physically spares but functionally impairs innate-like invariant T cells.
Cell reports
Rudak PT,Choi J,Parkins KM,Summers KL,Jackson DN,Foster PJ,Skaro AI,Leslie K,McAlister VC,Kuchroo VK,Inoue W,Lantz O,Haeryfar SMM
Tue Apr 13 00:00:00 UTC 2021
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.
Nature communications
Yang Z,Xu G,Wang B,Liu Y,Zhang L,Jing T,Tang M,Xu X,Jiao K,Xiang L,Fu Y,Tang D,Zhang X,Jin W,Zhuang G,Zhao X,Liu Y
315-03 was used in Flow cytometry/Cell sorting to show that the deubiquitinase USP12 is commonly downregulated in the KrasG12D-driven mouse lung tumour and human non-small cell lung cancer owing to the activation of AKT-mTOR signalling.
Wed Aug 11 00:00:00 UTC 2021
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.
Nature communications
Yang Z,Xu G,Wang B,Liu Y,Zhang L,Jing T,Tang M,Xu X,Jiao K,Xiang L,Fu Y,Tang D,Zhang X,Jin W,Zhuang G,Zhao X,Liu Y
315-03 was used in Flow cytometry/Cell sorting to show that the deubiquitinase USP12 is commonly downregulated in the KrasG12D-driven mouse lung tumour and human non-small cell lung cancer owing to the activation of AKT-mTOR signalling.
Wed Aug 11 00:00:00 UTC 2021
Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression.
iScience
AbuEid M,McAllister DM,McOlash L,Harwig MC,Cheng G,Drouillard D,Boyle KA,Hardy M,Zielonka J,Johnson BD,Hill RB,Kalyanaraman B,Dwinell MB
Fri Jun 25 00:00:00 UTC 2021
Characterization and Functional Analysis of Tumor-Derived Microparticles.
Current protocols
Ma J,Tang K,Zhang H,Wei K,Huang B
Tue Jun 01 00:00:00 UTC 2021
Mitochondrial CMPK2 mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways.
iScience
Lai JH,Wu DW,Wu CH,Hung LF,Huang CY,Ka SM,Chen A,Chang ZF,Ho LJ
Fri Jun 25 00:00:00 UTC 2021
Mitochondrial CMPK2 mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways.
iScience
Lai JH,Wu DW,Wu CH,Hung LF,Huang CY,Ka SM,Chen A,Chang ZF,Ho LJ
Fri Jun 25 00:00:00 UTC 2021
Phagocytic 'teeth' and myosin-II 'jaw' power target constriction during phagocytosis.
eLife
Vorselen D,Barger SR,Wang Y,Cai W,Theriot JA,Gauthier NC,Krendel M
315-03 was used in Sample Preparation (FC/FACS) to investigate the mechanisms of actomyosin undergo phagocytosis.
Thu Oct 28 00:00:00 UTC 2021
SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis.
iScience
Sangaletti S,Botti L,Gulino A,Lecis D,Bassani B,Portararo P,Milani M,Cancila V,De Cecco L,Dugo M,Tripodo C,Colombo MP
Fri Jun 25 00:00:00 UTC 2021
Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling.
Nature communications
Wang J,Wang J,Hong W,Zhang L,Song L,Shi Q,Shao Y,Hao G,Fang C,Qiu Y,Yang L,Yang Z,Wang J,Cao J,Yang B,He Q,Weng Q
Wed Oct 27 00:00:00 UTC 2021
P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression.
Nature communications
Yeini E,Ofek P,Pozzi S,Albeck N,Ben-Shushan D,Tiram G,Golan S,Kleiner R,Sheinin R,Israeli Dangoor S,Reich-Zeliger S,Grossman R,Ram Z,Brem H,Hyde TM,Magod P,Friedmann-Morvinski D,Madi A,Satchi-Fainaro R
Fri Mar 26 00:00:00 UTC 2021
Intrinsic activation of β-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to immune evasion in hepatocellular carcinoma.
Scientific reports
Akasu M,Shimada S,Kabashima A,Akiyama Y,Shimokawa M,Akahoshi K,Kudo A,Yamaoka S,Tanabe M,Tanaka S
Tue Aug 24 00:00:00 UTC 2021
Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine.
Communications biology
Klooster JPT,Bol-Schoenmakers M,van Summeren K,van Vliet ALW,de Haan CAM,van Kuppeveld FJM,Verkoeijen S,Pieters R
315-03 was used in Cell Culture to indicate that IL22 contributes to the innate responses against both bacteria and viruses.
Thu May 27 00:00:00 UTC 2021
Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine.
Communications biology
Klooster JPT,Bol-Schoenmakers M,van Summeren K,van Vliet ALW,de Haan CAM,van Kuppeveld FJM,Verkoeijen S,Pieters R
315-03 was used in Cell Culture to indicate that IL22 contributes to the innate responses against both bacteria and viruses.
Thu May 27 00:00:00 UTC 2021
Extracellular vesicles package dsDNA to aggravate Crohn's disease by activating the STING pathway.
Cell death & disease
Zhao F,Zheng T,Gong W,Wu J,Xie H,Li W,Zhang R,Liu P,Liu J,Wu X,Zhao Y,Ren J
Fri Aug 27 00:00:00 UTC 2021
Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis.
Nature communications
Wang X,Hu LP,Qin WT,Yang Q,Chen DY,Li Q,Zhou KX,Huang PQ,Xu CJ,Li J,Yao LL,Wang YH,Tian GA,Yang JY,Yang MW,Liu DJ,Sun YW,Jiang SH,Zhang XL,Zhang ZG
Fri Jan 08 00:00:00 UTC 2021
Biomechanical forces enhance directed migration and activation of bone marrow-derived dendritic cells.
Scientific reports
Kang JH,Lee HJ,Kim OH,Yun YJ,Seo YJ,Lee HJ
Tue Jun 08 00:00:00 UTC 2021
An epidemic Zika virus isolate suppresses antiviral immunity by disrupting antigen presentation pathways.
Nature communications
Pardy RD,Valbon SF,Cordeiro B,Krawczyk CM,Richer MJ
Wed Jun 30 00:00:00 UTC 2021
Subunit vaccine protects against a clinical isolate of Mycobacterium avium in wild type and immunocompromised mouse models.
Scientific reports
Larsen SE,Reese VA,Pecor T,Berube BJ,Cooper SK,Brewer G,Ordway D,Henao-Tamayo M,Podell BK,Baldwin SL,Coler RN
Tue Apr 27 00:00:00 UTC 2021
Exposure to the Gram-Negative Bacteria Pseudomonas aeruginosa Influences the Lung Dendritic Cell Population Signature by Interfering With CD103 Expression.
Frontiers in cellular and infection microbiology
Brassard J,Roy J,Lemay AM,Beaulieu MJ,Bernatchez E,Veillette M,Duchaine C,Blanchet MR
315-03 was used in Sample Preparation (FC/FACS) to verify whether the capacity of cDCs to express CD103 following P. aeruginosa exposure impacts the immune response.
Tue Jul 27 00:00:00 UTC 2021
TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens.
Nature communications
Yabe R,Chung SH,Murayama MA,Kubo S,Shimizu K,Akahori Y,Maruhashi T,Seno A,Kaifu T,Saijo S,Iwakura Y
Mon Jan 04 00:00:00 UTC 2021
Generation of a chemical genetic model for JAK3.
Scientific reports
Remenyi J,Naik RJ,Wang J,Razsolkov M,Verano A,Cai Q,Tan L,Toth R,Raggett S,Baillie C,Traynor R,Hastie CJ,Gray NS,Arthur JSC
Wed May 12 00:00:00 UTC 2021
The RNA-binding protein LUC7L2 mediates MITA/STING intron retention to negatively regulate innate antiviral response.
Cell discovery
Li C,Feng L,Luo WW,Lei CQ,Li M,Shu HB
Tue Jun 22 00:00:00 UTC 2021
The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling.
Cell reports
Li S,Kuang M,Chen L,Li Y,Liu S,Du H,Cao L,You F
Tue Jan 19 00:00:00 UTC 2021
4-methylumbelliferone-mediated polarization of M1 macrophages correlate with decreased hepatocellular carcinoma aggressiveness in mice.
Scientific reports
Rodríguez MM,Onorato A,Cantero MJ,Domínguez L,Bayo J,Fiore E,García M,Atorrasagasti C,Canbay A,Malvicini M,Mazzolini GD
Thu Mar 18 00:00:00 UTC 2021
Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury.
Cell death & disease
Liu Q,Wu J,Zhang X,Li X,Wu X,Zhao Y,Ren J
Sat Jul 03 00:00:00 UTC 2021
The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response.
Nature communications
Liu B,Huang J,Ashraf A,Rahaman O,Lou J,Wang L,Cai P,Wen J,Anwaar S,Liu X,Ni H,Ganguly D,Zhao J,Yang CY
Fri Jul 02 00:00:00 UTC 2021
Impact of Gold Nanoparticles on the Functions of Macrophages and Dendritic Cells.
Cells
Dey AK,Gonon A,Pécheur EI,Pezet M,Villiers C,Marche PN
315-03 was used in Cell Culture to investigate gold nanoparticle effect on the immune system.
Thu Jan 07 00:00:00 UTC 2021
PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy.
Nature communications
Koerner J,Horvath D,Herrmann VL,MacKerracher A,Gander B,Yagita H,Rohayem J,Groettrup M
Tue May 18 00:00:00 UTC 2021
PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy.
Nature communications
Koerner J,Horvath D,Herrmann VL,MacKerracher A,Gander B,Yagita H,Rohayem J,Groettrup M
Tue May 18 00:00:00 UTC 2021
Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization.
Nature communications
Zhang L,Zhang K,Zhang J,Zhu J,Xi Q,Wang H,Zhang Z,Cheng Y,Yang G,Liu H,Guo X,Zhou D,Xue Z,Li Y,Zhang Q,Da Y,Liu L,Yin Z,Yao Z,Zhang R
Wed Jul 14 00:00:00 UTC 2021
Immunomodulation of dendritic cells by Lactobacillus reuteri surface components and metabolites.
Physiological reports
Engevik MA,Ruan W,Esparza M,Fultz R,Shi Z,Engevik KA,Engevik AC,Ihekweazu FD,Visuthranukul C,Venable S,Schady DA,Versalovic J
Fri Jan 01 00:00:00 UTC 2021
Antifungal activity of dendritic cell lysosomal proteins against Cryptococcus neoformans.
Scientific reports
Nelson BN,Beakley SG,Posey S,Conn B,Maritz E,Seshu J,Wozniak KL
Wed Jun 30 00:00:00 UTC 2021
Virus-based vaccine vectors with distinct replication mechanisms differentially infect and activate dendritic cells.
NPJ vaccines
Chiale C,Marchese AM,Furuya Y,Robek MD
Mon Nov 22 00:00:00 UTC 2021
Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells.
Nature communications
Xing J,Zhang A,Du Y,Fang M,Minze LJ,Liu YJ,Li XC,Zhang Z
315-03 was used in In vitro experiments to investigate the role of poly(ADP-ribose) polymerase 9 on type I IFN production in dendritic cells.
Tue May 11 00:00:00 UTC 2021
IL-10-/- Enhances DCs Immunity Against Chlamydia psittaci Infection via OX40L/NLRP3 and IDO/Treg Pathways.
Frontiers in immunology
Li Q,Li X,Quan H,Wang Y,Qu G,Shen Z,He C
315-03 was used in Cell Culture to uncover the involvement of IL-10 and dendritic cells in the regulation of Chlamydia psittaci infection.
Mon Sep 27 00:00:00 UTC 2021
Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation.
FEBS open bio
Cao X,Liu L,Zhang Y,Yang Y
Mon Feb 01 00:00:00 UTC 2021
Circulating mature dendritic cells homing to the thymus promote thymic epithelial cells involution via the Jagged1/Notch3 axis.
Cell death discovery
Wu H,Li X,Zhou C,Yu Q,Ge S,Pan Z,Zhao Y,Xia S,Zhou X,Liu X,Wang H,Shao Q
Mon Aug 30 00:00:00 UTC 2021
FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity.
Nature communications
Mysore V,Cullere X,Mears J,Rosetti F,Okubo K,Liew PX,Zhang F,Madera-Salcedo I,Rosenbauer F,Stone RM,Aster JC,von Andrian UH,Lichtman AH,Raychaudhuri S,Mayadas TN
Mon Aug 09 00:00:00 UTC 2021
FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity.
Nature communications
Mysore V,Cullere X,Mears J,Rosetti F,Okubo K,Liew PX,Zhang F,Madera-Salcedo I,Rosenbauer F,Stone RM,Aster JC,von Andrian UH,Lichtman AH,Raychaudhuri S,Mayadas TN
Mon Aug 09 00:00:00 UTC 2021
Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state.
Nature medicine
Cerezo-Wallis D,Contreras-Alcalde M,Troulé K,Catena X,Mucientes C,Calvo TG,Cañón E,Tejedo C,Pennacchi PC,Hogan S,Kölblinger P,Tejero H,Chen AX,Ibarz N,Graña-Castro O,Martinez L,Muñoz J,Ortiz-Romero P,Rodriguez-Peralto JL,Gómez-López G,Al-Shahrour F,Rabadán R,Levesque MP,Olmeda D,Soengas MS
Tue Dec 01 00:00:00 UTC 2020
MAFG-driven astrocytes promote CNS inflammation.
Nature
Wheeler MA,Clark IC,Tjon EC,Li Z,Zandee SEJ,Couturier CP,Watson BR,Scalisi G,Alkwai S,Rothhammer V,Rotem A,Heyman JA,Thaploo S,Sanmarco LM,Ragoussis J,Weitz DA,Petrecca K,Moffitt JR,Becher B,Antel JP,Prat A,Quintana FJ
315-03 was used in Cell Culture to identify candidate therapeutic targets in multiple sclerosis.
Sat Feb 01 00:00:00 UTC 2020
Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer.
Cell
Katzenelenbogen Y,Sheban F,Yalin A,Yofe I,Svetlichnyy D,Jaitin DA,Bornstein C,Moshe A,Keren-Shaul H,Cohen M,Wang SY,Li B,David E,Salame TM,Weiner A,Amit I
Thu Aug 20 00:00:00 UTC 2020
Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression.
Cell
Devalaraja S,To TKJ,Folkert IW,Natesan R,Alam MZ,Li M,Tada Y,Budagyan K,Dang MT,Zhai L,Lobel GP,Ciotti GE,Eisinger-Mathason TSK,Asangani IA,Weber K,Simon MC,Haldar M
Thu Mar 19 00:00:00 UTC 2020
Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition.
Cell
Priem B,van Leent MMT,Teunissen AJP,Sofias AM,Mourits VP,Willemsen L,Klein ED,Oosterwijk RS,Meerwaldt AE,Munitz J,Prévot G,Vera Verschuur A,Nauta SA,van Leeuwen EM,Fisher EL,de Jong KAM,Zhao Y,Toner YC,Soultanidis G,Calcagno C,Bomans PHH,Friedrich H,Sommerdijk N,Reiner T,Duivenvoorden R,Zupančič E,Di Martino JS,Kluza E,Rashidian M,Ploegh HL,Dijkhuizen RM,Hak S,Pérez-Medina C,Bravo-Cordero JJ,de Winther MPJ,Joosten LAB,van Elsas A,Fayad ZA,Rialdi A,Torre D,Guccione E,Ochando J,Netea MG,Griffioen AW,Mulder WJM
Thu Oct 29 00:00:00 UTC 2020
The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.
Cell
Kitamoto S,Nagao-Kitamoto H,Jiao Y,Gillilland MG,Hayashi A,Imai J,Sugihara K,Miyoshi M,Brazil JC,Kuffa P,Hill BD,Rizvi SM,Wen F,Bishu S,Inohara N,Eaton KA,Nusrat A,Lei YL,Giannobile WV,Kamada N
Thu Jul 23 00:00:00 UTC 2020
Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics.
Immunity
Zenke S,Palm MM,Braun J,Gavrilov A,Meiser P,Böttcher JP,Beyersdorf N,Ehl S,Gerard A,Lämmermann T,Schumacher TN,Beltman JB,Rohr JC
Tue Feb 18 00:00:00 UTC 2020
High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity.
Immunity
Kim S,Bagadia P,Anderson DA,Liu TT,Huang X,Theisen DJ,O'Connor KW,Ohara RA,Iwata A,Murphy TL,Murphy KM
Tue Oct 13 00:00:00 UTC 2020
Visualizing Synaptic Transfer of Tumor Antigens among Dendritic Cells.
Cancer cell
Ruhland MK,Roberts EW,Cai E,Mujal AM,Marchuk K,Beppler C,Nam D,Serwas NK,Binnewies M,Krummel MF
Mon Jun 08 00:00:00 UTC 2020
Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice.
Blood
Zambetti NA,Firestone AJ,Remsberg JR,Huang BJ,Wong JC,Long AM,Predovic M,Suciu RM,Inguva A,Kogan SC,Haigis KM,Cravatt BF,Shannon K
Thu May 14 00:00:00 UTC 2020
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Cell stem cell
Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J
315-03 was used in In vitro experiments to reveal crucial functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.
Thu Jul 02 00:00:00 UTC 2020
Spatial distribution of IL4 controls iNKT cell-DC crosstalk in tumors.
Cellular & molecular immunology
Wang L,Liu Z,Wang L,Wu Q,Li X,Xie D,Zhang H,Zhang Y,Gu L,Xue Y,Yue T,Liu G,Ji W,Wei H,Xu T,Bai L
Fri May 01 00:00:00 UTC 2020
U3-1402 sensitizes HER3-expressing tumors to PD-1 blockade by immune activation.
The Journal of clinical investigation
Haratani K,Yonesaka K,Takamura S,Maenishi O,Kato R,Takegawa N,Kawakami H,Tanaka K,Hayashi H,Takeda M,Maeda N,Kagari T,Hirotani K,Tsurutani J,Nishio K,Doi K,Miyazawa M,Nakagawa K
Thu Jan 02 00:00:00 UTC 2020
Hard Nanomaterials in Time of Viral Pandemics.
ACS nano
Reina G,Peng S,Jacquemin L,Andrade AF,Bianco A
Tue Aug 25 00:00:00 UTC 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Mon Mar 02 00:00:00 UTC 2020
USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2.
The Journal of experimental medicine
Cai Z,Zhang MX,Tang Z,Zhang Q,Ye J,Xiong TC,Zhang ZD,Zhong B
Mon May 04 00:00:00 UTC 2020
The GM-CSF-IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses.
The Journal of experimental medicine
Arnold IC,Artola-Boran M,Gurtner A,Bertram K,Bauer M,Frangez Z,Becher B,Kopf M,Yousefi S,Simon HU,Tzankov A,Müller A
Mon Dec 07 00:00:00 UTC 2020
The GM-CSF-IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses.
The Journal of experimental medicine
Arnold IC,Artola-Boran M,Gurtner A,Bertram K,Bauer M,Frangez Z,Becher B,Kopf M,Yousefi S,Simon HU,Tzankov A,Müller A
Mon Dec 07 00:00:00 UTC 2020
TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis.
The Journal of experimental medicine
Yan D,Wang J,Sun H,Zamani A,Zhang H,Chen W,Tang A,Ruan Q,Yang X,Chen YH,Wan X
Mon Feb 03 00:00:00 UTC 2020
Erythrocyte-driven immunization via biomimicry of their natural antigen-presenting function.
Proceedings of the National Academy of Sciences of the United States of America
Ukidve A,Zhao Z,Fehnel A,Krishnan V,Pan DC,Gao Y,Mandal A,Muzykantov V,Mitragotri S
Tue Jul 28 00:00:00 UTC 2020
TLR4 abrogates the Th1 immune response through IRF1 and IFN-β to prevent immunopathology during L. infantum infection.
PLoS pathogens
Sacramento LA,Benevides L,Maruyama SR,Tavares L,Fukutani KF,Francozo M,Sparwasser T,Cunha FQ,Almeida RP,da Silva JS,Carregaro V
315-03 was used in Cell Culture to investigate the role of TLR4 during L. infantum infection.
Sun Mar 01 00:00:00 UTC 2020
Effect of mesenchymal stem cell-derived exosomes on the induction of mouse tolerogenic dendritic cells.
Journal of cellular physiology
Shahir M,Mahmoud Hashemi S,Asadirad A,Varahram M,Kazempour-Dizaji M,Folkerts G,Garssen J,Adcock I,Mortaz E
Thu Oct 01 00:00:00 UTC 2020
LncRNA Dnmt3aos regulates Dnmt3a expression leading to aberrant DNA methylation in macrophage polarization.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Li X,Zhang Y,Pei W,Zhang M,Yang H,Zhong M,Kong X,Xu Y,Zhu X,Chen T,Ye J,Lv K
Wed Apr 01 00:00:00 UTC 2020
Depletion of miR-21 in dendritic cells aggravates renal ischemia-reperfusion injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Jia P,Pan T,Xu S,Fang Y,Song N,Guo M,Liang Y,Xu X,Ding X
Tue Sep 01 00:00:00 UTC 2020
Deletion of Ppard in CD11c+ cells attenuates atherosclerosis in ApoE knockout mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Tian D,Hong H,Shang W,Ho CC,Dong J,Tian XY
Sat Feb 01 00:00:00 UTC 2020
A secreted pore-forming protein modulates cellular endolysosomes to augment antigen presentation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Deng CJ,Liu L,Liu LZ,Wang QQ,Guo XL,Lee WH,Li SA,Zhang Y
Thu Oct 01 00:00:00 UTC 2020
IgA Triggers Cell Death of Neutrophils When Primed by Inflammatory Mediators.
Journal of immunology (Baltimore, Md. : 1950)
Wehrli M,Schneider C,Cortinas-Elizondo F,Verschoor D,Frias Boligan K,Adams OJ,Hlushchuk R,Engelmann C,Daudel F,Villiger PM,Seibold F,Yawalkar N,Vonarburg C,Miescher S,Lötscher M,Kaufmann T,Münz C,Mueller C,Djonov V,Simon HU,von Gunten S
Sun Nov 15 00:00:00 UTC 2020
Suppression of Mll1-Complex by Stat3/Cebpβ-Induced miR-21a/21b/181b Maintains the Accumulation, Homeostasis, and Immunosuppressive Function of Polymorphonuclear Myeloid-Derived Suppressor Cells.
Journal of immunology (Baltimore, Md. : 1950)
Zhang Z,Huang X,Wang E,Huang Y,Yang R
Mon Jun 15 00:00:00 UTC 2020
The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Greenberg ZJ,Monlish DA,Bartnett RL,Yang Y,Shen G,Li W,Bednarski JJ,Schuettpelz LG
Wed Jan 01 00:00:00 UTC 2020
Naringenin Enhances the Antitumor Effect of Therapeutic Vaccines by Promoting Antigen Cross-Presentation.
Journal of immunology (Baltimore, Md. : 1950)
Wang L,Zeng W,Wang L,Wang Z,Yin X,Qin Y,Zhang F,Zhang C,Liang W
Sat Feb 01 00:00:00 UTC 2020
CCL17 in Inflammation and Pain.
Journal of immunology (Baltimore, Md. : 1950)
Lee KM,Jarnicki A,Achuthan A,Fleetwood AJ,Anderson GP,Ellson C,Feeney M,Modis LK,Smith JE,Hamilton JA,Cook A
Wed Jul 01 00:00:00 UTC 2020
Exploiting Pre-Existing CD4+ T Cell Help from Bacille Calmette-Guérin Vaccination to Improve Antiviral Antibody Responses.
Journal of immunology (Baltimore, Md. : 1950)
Ng TW,Wirchnianski AS,Wec AZ,Fels JM,Johndrow CT,Saunders KO,Liao HX,Chan J,Jacobs WR,Chandran K,Porcelli SA
Wed Jul 15 00:00:00 UTC 2020
Myeloid Cell-Intrinsic IRF5 Promotes T Cell Responses through Multiple Distinct Checkpoints In Vivo, and IRF5 Immune-Mediated Disease Risk Variants Modulate These Myeloid Cell Functions.
Journal of immunology (Baltimore, Md. : 1950)
Yan J,Hedl M,Abraham C
Sat Aug 15 00:00:00 UTC 2020
Tolerogenic Dendritic Cells Generated by BAFF Silencing Ameliorate Collagen-Induced Arthritis by Modulating the Th17/Regulatory T Cell Balance.
Journal of immunology (Baltimore, Md. : 1950)
Zhao Y,Sun X,Yang X,Zhang B,Li S,Han P,Zhang B,Wang X,Li S,Chang Y,Wei W
Sat Feb 01 00:00:00 UTC 2020
IRF4 Expression Is Required for the Immunoregulatory Activity of Conventional Type 2 Dendritic Cells in Settings of Chronic Bacterial Infection and Cancer.
Journal of immunology (Baltimore, Md. : 1950)
Zhang X,Artola-Boran M,Fallegger A,Arnold IC,Weber A,Reuter S,Taube C,Müller A
Thu Oct 01 00:00:00 UTC 2020
OTUD1 Negatively Regulates Type I IFN Induction by Disrupting Noncanonical Ubiquitination of IRF3.
Journal of immunology (Baltimore, Md. : 1950)
Zhang Z,Wang D,Wang P,Zhao Y,You F
Wed Apr 01 00:00:00 UTC 2020
Small GTPase ARF6 Is a Coincidence-Detection Code for RPH3A Polarization in Neutrophil Polarization.
Journal of immunology (Baltimore, Md. : 1950)
Ren C,Yuan Q,Jian X,Randazzo PA,Tang W,Wu D
Sat Feb 15 00:00:00 UTC 2020
IFNs Drive Development of Novel IL-15-Responsive Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Gordon SM,Nishiguchi MA,Chase JM,Mani S,Mainigi MA,Behrens EM
Sat Aug 15 00:00:00 UTC 2020
P2Y6 Deficiency Enhances Dendritic Cell-Mediated Th1/Th17 Differentiation and Aggravates Experimental Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Li Z,He C,Zhang J,Zhang H,Wei H,Wu S,Jiang W
Wed Jul 15 00:00:00 UTC 2020
Interleukin-38 alleviates cardiac remodelling after myocardial infarction.
Journal of cellular and molecular medicine
Wei Y,Lan Y,Zhong Y,Yu K,Xu W,Zhu R,Sun H,Ding Y,Wang Y,Zeng Q
Wed Jan 01 00:00:00 UTC 2020
TSLP Produced by Aspergillus fumigatus-Stimulated DCs Promotes a Th17 Response Through the JAK/STAT Signaling Pathway in Fungal Keratitis.
Investigative ophthalmology & visual science
Han F,Guo H,Wang L,Zhang Y,Sun L,Dai C,Wu X
315-03 was used in Cell Culture to investigate the role of thymic stromal lymphopoietin secreted by Aspergillus fumigatus-stimulated dendritic cells during the T helper 17 immune response.
Tue Dec 01 00:00:00 UTC 2020
RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA.
Nature communications
Zhang ZD,Xiong TC,Yao SQ,Wei MC,Chen M,Lin D,Zhong B
Mon Nov 02 00:00:00 UTC 2020
GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis.
Nature communications
Regan-Komito D,Swann JW,Demetriou P,Cohen ES,Horwood NJ,Sansom SN,Griseri T
Thu Jan 09 00:00:00 UTC 2020
TLR9-IL-2 axis exacerbates allergic asthma by preventing IL-17A hyperproduction.
Scientific reports
Murakami Y,Ishii T,Nunokawa H,Kurata K,Narita T,Yamashita N
Thu Oct 22 00:00:00 UTC 2020
TonEBP in dendritic cells mediates pro-inflammatory maturation and Th1/Th17 responses.
Cell death & disease
Ye BJ,Lee HH,Yoo EJ,Lee CY,Lee JH,Kang HJ,Jeong GW,Park H,Lee-Kwon W,Choi SY,Kwon HM
Thu Jun 04 00:00:00 UTC 2020
Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate.
Science advances
Pessoa Rodrigues C,Herman JS,Herquel B,Valsecchi CIK,Stehle T,Grün D,Akhtar A
315-03 was used in In vitro experiments to study the mechanism by which histone H4 lysine 16 acetyltransferase MOF regulates erythropoiesis.
Fri May 01 00:00:00 UTC 2020
Donor myeloid derived suppressor cells (MDSCs) prolong allogeneic cardiac graft survival through programming of recipient myeloid cells in vivo.
Scientific reports
Cai S,Choi JY,Borges TJ,Zhang H,Miao J,Ichimura T,Li X,Xu S,Chu P,Eskandari SK,Allos H,Alhaddad JB,Muhsin SA,Yatim K,Riella LV,Sage PT,Chandraker AK,Azzi JR
Fri Aug 28 00:00:00 UTC 2020
Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics.
Science immunology
Alshetaiwi H,Pervolarakis N,McIntyre LL,Ma D,Nguyen Q,Rath JA,Nee K,Hernandez G,Evans K,Torosian L,Silva A,Walsh C,Kessenbrock K
315-03 was used in Sample Preparation (FC/FACS) to establish the MDSC-specific gene signature and identify CD84 as a surface marker for improved detection and enrichment of MDSCs in breast cancers.
Fri Feb 21 00:00:00 UTC 2020
Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice.
Nature communications
Zuo B,Qi H,Lu Z,Chen L,Sun B,Yang R,Zhang Y,Liu Z,Gao X,You A,Wu L,Jing R,Zhou Q,Yin H
Tue Apr 14 00:00:00 UTC 2020
Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML.
Nature communications
Basilico S,Wang X,Kennedy A,Tzelepis K,Giotopoulos G,Kinston SJ,Quiros PM,Wong K,Adams DJ,Carnevalli LS,Huntly BJP,Vassiliou GS,Calero-Nieto FJ,Göttgens B
Mon Mar 16 00:00:00 UTC 2020
Mucosal Vaccination for Influenza Protection Enhanced by Catalytic Immune-Adjuvant.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Qin T,Ma S,Miao X,Tang Y,Huangfu D,Wang J,Jiang J,Xu N,Yin Y,Chen S,Liu X,Yin Y,Peng D,Gao L
Tue Sep 01 00:00:00 UTC 2020
CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b-CD103+ DCs.
Cell reports
Jin J,Jung IH,Moon SH,Jeon S,Jeong SJ,Sonn SK,Seo S,Lee MN,Song EJ,Kweon HY,Kim S,Kim TK,Kim J,Cho HR,Choi JH,Kwon B,Oh GT
315-03 was used in In vitro experiments to define a mechanism of paracrine immunoregulation operating between adjacent DC subsets in the intestine.
Tue Mar 24 00:00:00 UTC 2020
Mouse CD163 deficiency strongly enhances experimental collagen-induced arthritis.
Scientific reports
Svendsen P,Etzerodt A,Deleuran BW,Moestrup SK
Fri Jul 24 00:00:00 UTC 2020
Synthetic mycobacterial molecular patterns partially complete Freund's adjuvant.
Scientific reports
Dubé JY,McIntosh F,Zarruk JG,David S,Nigou J,Behr MA
Fri Apr 03 00:00:00 UTC 2020
MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia.
Nature communications
Itskovich SS,Gurunathan A,Clark J,Burwinkel M,Wunderlich M,Berger MR,Kulkarni A,Chetal K,Venkatasubramanian M,Salomonis N,Kumar AR,Lee LH
Tue May 12 00:00:00 UTC 2020
Type II Natural Killer T Cells Contribute to Protection Against Systemic Methicillin-Resistant Staphylococcus aureus Infection.
Frontiers in immunology
Genardi S,Visvabharathy L,Cao L,Morgun E,Cui Y,Qi C,Chen YH,Gapin L,Berdyshev E,Wang CR
315-03 was used in Cell Culture to study the role of unconventional T cells in Staphylococcus aureus (SA) infection.
Tue Jun 22 00:00:00 UTC 2021
A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling.
Cell reports
Donado CA,Cao AB,Simmons DP,Croker BA,Brennan PJ,Brenner MB
315-03 was used in Cell Culture to describe an alternative, two-cell model for IL-1β release where invariant natural killer T (iNKT) cells use the death receptor pathway to instruct antigen-presenting cells to secrete IL-1β.
Tue Apr 07 00:00:00 UTC 2020
The Innate Immune Response to Infection Induces Erythropoietin-Dependent Replenishment of the Dendritic Cell Compartment.
Frontiers in immunology
Einwächter H,Heiseke A,Schlitzer A,Gasteiger G,Adler H,Voehringer D,Manz MG,Ruzsics Z,Dölken L,Koszinowski UH,Sparwasser T,Reindl W,Jordan S
315-03 was used in Cell Culture to investigate the molecular and cellular mechanisms of inflammation-induced dendritic cell generation.
Mon Apr 19 00:00:00 UTC 2021
Heparin inhibits proinflammatory and promotes anti-inflammatory macrophage polarization under hyperglycemic stress.
The Journal of biological chemistry
Abbadi A,Loftis J,Wang A,Yu M,Wang Y,Shakya S,Li X,Maytin E,Hascall V
Fri Apr 10 00:00:00 UTC 2020
The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.
Proceedings of the National Academy of Sciences of the United States of America
Scholz F,Grau M,Menzel L,Graband A,Zapukhlyak M,Leutz A,Janz M,Lenz G,Rehm A,Höpken UE
Tue Oct 20 00:00:00 UTC 2020
BCAP Regulates Dendritic Cell Maturation Through the Dual-Regulation of NF-κB and PI3K/AKT Signaling During Infection.
Frontiers in immunology
Miao Y,Jiang M,Qi L,Yang D,Xiao W,Fang F
315-03 was used in Sample Preparation (Western Blotting) to investigate the role of BCAP and its interaction on dendritic cells.
Thu Mar 25 00:00:00 UTC 2021
Distinct Populations of Immune-Suppressive Macrophages Differentiate from Monocytic Myeloid-Derived Suppressor Cells in Cancer.
Cell reports
Kwak T,Wang F,Deng H,Condamine T,Kumar V,Perego M,Kossenkov A,Montaner LJ,Xu X,Xu W,Zheng C,Schuchter LM,Amaravadi RK,Mitchell TC,Karakousis GC,Mulligan C,Nam B,Masters G,Hockstein N,Bennett J,Nefedova Y,Gabrilovich DI
315-03 was used in In vitro experiments to reveal the pathway of the development of immune-suppressive macrophages and suggests an approach to their selective targeting.
Tue Dec 29 00:00:00 UTC 2020
Manipulation of the tumor microenvironment by cytokine gene transfection enhances dendritic cell-based immunotherapy.
FASEB bioAdvances
Wijesekera DPH,Yuba E,De Silva NH,Watanabe SI,Tsukamoto M,Ichida C,Izawa T,Itoh K,Kanegi R,Hatoya S,Yamate J,Inaba T,Sugiura K
Wed Jan 01 00:00:00 UTC 2020
Choice of Nanovaccine Delivery Mode Has Profound Impacts on the Intralymph Node Spatiotemporal Distribution and Immunotherapy Efficacy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Wang J,Wang S,Ye T,Li F,Gao X,Wang Y,Ye P,Qing S,Wang C,Yue H,Wu J,Wei W,Ma G
Thu Oct 01 00:00:00 UTC 2020
Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response.
Nature communications
Yu X,Dai Y,Zhao Y,Qi S,Liu L,Lu L,Luo Q,Zhang Z
Fri Feb 28 00:00:00 UTC 2020
Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors.
Cell
Ponzetta A,Carriero R,Carnevale S,Barbagallo M,Molgora M,Perucchini C,Magrini E,Gianni F,Kunderfranco P,Polentarutti N,Pasqualini F,Di Marco S,Supino D,Peano C,Cananzi F,Colombo P,Pilotti S,Alomar SY,Bonavita E,Galdiero MR,Garlanda C,Mantovani A,Jaillon S
315-03 was used in In vitro experiments to conclude that neutrophils driving UTCαβ polarization and type 1 immunity are essential for resistance against murine sarcomas and selected human tumors.
Thu Jul 11 00:00:00 UTC 2019
Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR.
Cell
Mogilenko DA,Haas JT,L'homme L,Fleury S,Quemener S,Levavasseur M,Becquart C,Wartelle J,Bogomolova A,Pineau L,Molendi-Coste O,Lancel S,Dehondt H,Gheeraert C,Melchior A,Dewas C,Nikitin A,Pic S,Rabhi N,Annicotte JS,Oyadomari S,Velasco-Hernandez T,Cammenga J,Foretz M,Viollet B,Vukovic M,Villacreces A,Kranc K,Carmeliet P,Marot G,Boulter A,Tavernier S,Berod L,Longhi MP,Paget C,Janssens S,Staumont-Sallé D,Aksoy E,Staels B,Dombrowicz D
Thu May 16 00:00:00 UTC 2019
Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade.
Cell research
Jacquelot N,Yamazaki T,Roberti MP,Duong CPM,Andrews MC,Verlingue L,Ferrere G,Becharef S,Vétizou M,Daillère R,Messaoudene M,Enot DP,Stoll G,Ugel S,Marigo I,Foong Ngiow S,Marabelle A,Prevost-Blondel A,Gaudreau PO,Gopalakrishnan V,Eggermont AM,Opolon P,Klein C,Madonna G,Ascierto PA,Sucker A,Schadendorf D,Smyth MJ,Soria JC,Kroemer G,Bronte V,Wargo J,Zitvogel L
Tue Oct 01 00:00:00 UTC 2019
Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.
Immunity
Castro-Dopico T,Dennison TW,Ferdinand JR,Mathews RJ,Fleming A,Clift D,Stewart BJ,Jing C,Strongili K,Labzin LI,Monk EJM,Saeb-Parsy K,Bryant CE,Clare S,Parkes M,Clatworthy MR
Tue Apr 16 00:00:00 UTC 2019
IL-10-Dependent Crosstalk between Murine Marginal Zone B Cells, Macrophages, and CD8α+ Dendritic Cells Promotes Listeria monocytogenes Infection.
Immunity
Liu D,Yin X,Olyha SJ,Nascimento MSL,Chen P,White T,Gowthaman U,Zhang T,Gertie JA,Zhang B,Xu L,Yurieva M,Devine L,Williams A,Eisenbarth SC
Tue Jul 16 00:00:00 UTC 2019
A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils.
Immunity
Janela B,Patel AA,Lau MC,Goh CC,Msallam R,Kong WT,Fehlings M,Hubert S,Lum J,Simoni Y,Malleret B,Zolezzi F,Chen J,Poidinger M,Satpathy AT,Briseno C,Wohn C,Malissen B,Murphy KM,Maini AA,Vanhoutte L,Guilliams M,Vial E,Hennequin L,Newell E,Ng LG,Musette P,Yona S,Hacini-Rachinel F,Ginhoux F
Tue Apr 16 00:00:00 UTC 2019
The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons.
Immunity
Daniels BP,Kofman SB,Smith JR,Norris GT,Snyder AG,Kolb JP,Gao X,Locasale JW,Martinez J,Gale M,Loo YM,Oberst A
Tue Jan 15 00:00:00 UTC 2019
Intratumor Adoptive Transfer of IL-12 mRNA Transiently Engineered Antitumor CD8+ T Cells.
Cancer cell
Etxeberria I,Bolaños E,Quetglas JI,Gros A,Villanueva A,Palomero J,Sánchez-Paulete AR,Piulats JM,Matias-Guiu X,Olivera I,Ochoa MC,Labiano S,Garasa S,Rodriguez I,Vidal A,Mancheño U,Hervás-Stubbs S,Azpilikueta A,Otano I,Aznar MA,Sanmamed MF,Inogés S,Berraondo P,Teijeira Á,Melero I
Mon Dec 09 00:00:00 UTC 2019
Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells.
Cancer cell
Du H,Hirabayashi K,Ahn S,Kren NP,Montgomery SA,Wang X,Tiruthani K,Mirlekar B,Michaud D,Greene K,Herrera SG,Xu Y,Sun C,Chen Y,Ma X,Ferrone CR,Pylayeva-Gupta Y,Yeh JJ,Liu R,Savoldo B,Ferrone S,Dotti G
Mon Feb 11 00:00:00 UTC 2019
CD40 Ligand-Modified Chimeric Antigen Receptor T Cells Enhance Antitumor Function by Eliciting an Endogenous Antitumor Response.
Cancer cell
Kuhn NF,Purdon TJ,van Leeuwen DG,Lopez AV,Curran KJ,Daniyan AF,Brentjens RJ
Mon Mar 18 00:00:00 UTC 2019
TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.
Cell stem cell
Yamashita M,Passegué E
315-03 was used in Cell Culture to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.
Thu Sep 05 00:00:00 UTC 2019
Dectin-2-induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis.
The Journal of clinical investigation
Miyabe C,Miyabe Y,Bricio-Moreno L,Lian J,Rahimi RA,Miura NN,Ohno N,Iwakura Y,Kawakami T,Luster AD
Thu Jun 06 00:00:00 UTC 2019
cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.
The Journal of clinical investigation
Wang Z,Chen J,Hu J,Zhang H,Xu F,He W,Wang X,Li M,Lu W,Zeng G,Zhou P,Huang P,Chen S,Li W,Xia LP,Xia X
Tue Aug 13 00:00:00 UTC 2019
Systemic silencing of PHD2 causes reversible immune regulatory dysfunction.
The Journal of clinical investigation
Yamamoto A,Hester J,Macklin PS,Kawai K,Uchiyama M,Biggs D,Bishop T,Bull K,Cheng X,Cawthorne E,Coleman ML,Crockford TL,Davies B,Dow LE,Goldin R,Kranc K,Kudo H,Lawson H,McAuliffe J,Milward K,Scudamore CL,Soilleux E,Issa F,Ratcliffe PJ,Pugh CW
Tue Jun 04 00:00:00 UTC 2019
Thioesterase PPT1 balances viral resistance and efficient T cell crosspriming in dendritic cells.
The Journal of experimental medicine
Ou P,Wen L,Liu X,Huang J,Huang X,Su C,Wang L,Ni H,Reizis B,Yang CY
Mon Sep 02 00:00:00 UTC 2019
Oncogenic kinase inhibition limits Batf3-dependent dendritic cell development and antitumor immunity.
The Journal of experimental medicine
Medina BD,Liu M,Vitiello GA,Seifert AM,Zeng S,Bowler T,Zhang JQ,Cavnar MJ,Loo JK,Param NJ,Maltbaek JH,Rossi F,Balachandran V,DeMatteo RP
Mon Jun 03 00:00:00 UTC 2019
CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes.
The Journal of experimental medicine
Rapp M,Wintergerst MWM,Kunz WG,Vetter VK,Knott MML,Lisowski D,Haubner S,Moder S,Thaler R,Eiber S,Meyer B,Röhrle N,Piseddu I,Grassmann S,Layritz P,Kühnemuth B,Stutte S,Bourquin C,von Andrian UH,Endres S,Anz D
Mon May 06 00:00:00 UTC 2019
Self-reactive CD4+ IL-3+ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis.
The Journal of experimental medicine
Anzai A,Mindur JE,Halle L,Sano S,Choi JL,He S,McAlpine CS,Chan CT,Kahles F,Valet C,Fenn AM,Nairz M,Rattik S,Iwamoto Y,Fairweather D,Walsh K,Libby P,Nahrendorf M,Swirski FK
Mon Feb 04 00:00:00 UTC 2019
Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs.
The Journal of experimental medicine
Mastio J,Condamine T,Dominguez G,Kossenkov AV,Donthireddy L,Veglia F,Lin C,Wang F,Fu S,Zhou J,Viatour P,Lavilla-Alonso S,Polo AT,Tcyganov EN,Mulligan C,Nam B,Bennett J,Masters G,Guarino M,Kumar A,Nefedova Y,Vonderheide RH,Languino LR,Abrams SI,Gabrilovich DI
Mon Sep 02 00:00:00 UTC 2019
Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR.
The Journal of experimental medicine
Deng M,Guo H,Tam JW,Johnson BM,Brickey WJ,New JS,Lenox A,Shi H,Golenbock DT,Koller BH,McKinnon KP,Beutler B,Ting JP
Mon Dec 02 00:00:00 UTC 2019
Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3.
The Journal of experimental medicine
von Gamm M,Schaub A,Jones AN,Wolf C,Behrens G,Lichti J,Essig K,Macht A,Pircher J,Ehrlich A,Davari K,Chauhan D,Busch B,Wurst W,Feederle R,Feuchtinger A,Tschöp MH,Friedel CC,Hauck SM,Sattler M,Geerlof A,Hornung V,Heissmeyer V,Schulz C,Heikenwalder M,Glasmacher E
Mon Jul 01 00:00:00 UTC 2019
Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages.
EMBO molecular medicine
Wu H,Han Y,Rodriguez Sillke Y,Deng H,Siddiqui S,Treese C,Schmidt F,Friedrich M,Keye J,Wan J,Qin Y,Kühl AA,Qin Z,Siegmund B,Glauben R
Thu Nov 07 00:00:00 UTC 2019
Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages.
EMBO molecular medicine
Wu H,Han Y,Rodriguez Sillke Y,Deng H,Siddiqui S,Treese C,Schmidt F,Friedrich M,Keye J,Wan J,Qin Y,Kühl AA,Qin Z,Siegmund B,Glauben R
Thu Nov 07 00:00:00 UTC 2019
Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn's disease, produces an inflammatory polysaccharide.
Proceedings of the National Academy of Sciences of the United States of America
Henke MT,Kenny DJ,Cassilly CD,Vlamakis H,Xavier RJ,Clardy J
Tue Jun 25 00:00:00 UTC 2019
Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen.
Proceedings of the National Academy of Sciences of the United States of America
Fujita K,Chakarov S,Kobayashi T,Sakamoto K,Voisin B,Duan K,Nakagawa T,Horiuchi K,Amagai M,Ginhoux F,Nagao K
Tue Jul 16 00:00:00 UTC 2019
Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America
Wang KW,Zhan X,McAlpine W,Zhang Z,Choi JH,Shi H,Misawa T,Yue T,Zhang D,Wang Y,Ludwig S,Russell J,Tang M,Li X,Murray AR,Moresco EMY,Turer EE,Beutler B
Tue Jun 04 00:00:00 UTC 2019
Six1 regulates leukemia stem cell maintenance in acute myeloid leukemia.
Cancer science
Chu Y,Chen Y,Li M,Shi D,Wang B,Lian Y,Cheng X,Wang X,Xu M,Cheng T,Shi J,Yuan W
Mon Jul 01 00:00:00 UTC 2019
LACC1 Regulates TNF and IL-17 in Mouse Models of Arthritis and Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Skon-Hegg C,Zhang J,Wu X,Sagolla M,Ota N,Wuster A,Tom J,Doran E,Ramamoorthi N,Caplazi P,Monroe J,Lee WP,Behrens TW
Tue Jan 01 00:00:00 UTC 2019
Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1.
Journal of immunology (Baltimore, Md. : 1950)
Khor B,Conway KL,Omar AS,Biton M,Haber AL,Rogel N,Baxt LA,Begun J,Kuballa P,Gagnon JD,Lassen KG,Regev A,Xavier RJ
315-03 was used in Cell Culture to show that ATG16L1 and ATG16L2 contribute very distinctly to autophagy and cellular ontogeny in myeloid, lymphoid, and epithelial lineages.
Tue Oct 01 00:00:00 UTC 2019
Dlg1 Maintains Dendritic Cell Function by Securing Voltage-Gated K+ Channel Integrity.
Journal of immunology (Baltimore, Md. : 1950)
Dong X,Wei L,Guo X,Yang Z,Wu C,Li P,Lu L,Qi H,Shi Y,Hu X,Wu L,Chen L,Liu W
315-03 was used in Cell Culture to investigate the knoeckout of Dlg1 on Ab responses in mice.
Sat Jun 01 00:00:00 UTC 2019
Macrophages Are a Potent Source of Streptococcus-Induced IFN-β.
Journal of immunology (Baltimore, Md. : 1950)
Feuerstein R,Gres V,Elias Perdigó N,Baasch S,Freudenhammer M,Elling R,Henneke P
Sun Dec 15 00:00:00 UTC 2019
Macrophage HIF-2α regulates tumor-suppressive Spint1 in the tumor microenvironment.
Molecular carcinogenesis
Susen RM,Bauer R,Olesch C,Fuhrmann DC,Fink AF,Dehne N,Jain A,Ebersberger I,Schmid T,Brüne B
Fri Nov 01 00:00:00 UTC 2019
FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation.
Nature communications
Yan J,Zhao Q,Gabrusiewicz K,Kong LY,Xia X,Wang J,Ott M,Xu J,Davis RE,Huo L,Rao G,Sun SC,Watowich SS,Heimberger AB,Li S
Fri Jan 25 00:00:00 UTC 2019
The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis.
Cell reports
Hou X,Chen G,Bracamonte-Baran W,Choi HS,Diny NL,Sung J,Hughes D,Won T,Wood MK,Talor MV,Hackam DJ,Klingel K,Davogustto G,Taegtmeyer H,Coppens I,Barin JG,Čiháková D
315-03 was used in Cell Culture to propose that MHCII+Ly6Clo MDMs are associated with the reduction of cardiac fibrosis and prevention of the myocarditis sequalae.
Tue Jul 02 00:00:00 UTC 2019
cGAS/STING/TBK1/IRF3 Signaling Pathway Activates BMDCs Maturation Following Mycobacterium bovis Infection.
International journal of molecular sciences
Li Q,Liu C,Yue R,El-Ashram S,Wang J,He X,Zhao D,Zhou X,Xu L
315-03 was used in Cell Culture to find that M. bovis promoted phenotypic maturation and functional activation of BMDCs via the cGAS signaling pathway, with the type I IFN and its receptor (IFNAR) contributing.
Tue Feb 19 00:00:00 UTC 2019
Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype.
Nature communications
Frank AC,Ebersberger S,Fink AF,Lampe S,Weigert A,Schmid T,Ebersberger I,Syed SN,Brüne B
Fri Mar 08 00:00:00 UTC 2019
Signal Integration of IFN-I and IFN-II With TLR4 Involves Sequential Recruitment of STAT1-Complexes and NFκB to Enhance Pro-inflammatory Transcription.
Frontiers in immunology
Piaszyk-Borychowska A,Széles L,Csermely A,Chiang HC,Wesoły J,Lee CK,Nagy L,Bluyssen HAR
315-03 was used in In vitro experiments to perform a comprehensive genome-wide analysis of mouse vascular smooth muscle cells, macrophages, and dendritic cells in response to IFNα, IFNγ, and/or LPS.
Wed Oct 28 00:00:00 UTC 2020
Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.
Cell reports
Bailey JD,Diotallevi M,Nicol T,McNeill E,Shaw A,Chuaiphichai S,Hale A,Starr A,Nandi M,Stylianou E,McShane H,Davis S,Fischer R,Kessler BM,McCullagh J,Channon KM,Crabtree MJ
315-03 was used in Cell Culture to investigate nitrogen oxide in mitochondrial respiration for macrophage activation.
Tue Jul 02 00:00:00 UTC 2019
Additive effects of inhibiting both mTOR and glutamine metabolism on the arthritis in SKG mice.
Scientific reports
Ueda Y,Saegusa J,Okano T,Sendo S,Yamada H,Nishimura K,Morinobu A
Tue Apr 23 00:00:00 UTC 2019
Lipoarabinomannan from Mycobacterium indicus pranii shows immunostimulatory activity and induces autophagy in macrophages.
PloS one
Singh B,Saqib M,Chakraborty A,Bhaskar S
315-03 was used in Cell Culture to study the component/s of mycobacterium indicus pranii (MIP) responsible for autophagy induction.
Fri Mar 20 00:00:00 UTC 2020
Dendritic cell-associated B7-H3 suppresses the production of autoantibodies and renal inflammation in a mouse model of systemic lupus erythematosus.
Cell death & disease
Zheng X,Xiao ZX,Hu L,Fang X,Luo L,Chen L
Tue May 21 00:00:00 UTC 2019
Crizotinib-induced immunogenic cell death in non-small cell lung cancer.
Nature communications
Liu P,Zhao L,Pol J,Levesque S,Petrazzuolo A,Pfirschke C,Engblom C,Rickelt S,Yamazaki T,Iribarren K,Senovilla L,Bezu L,Vacchelli E,Sica V,Melis A,Martin T,Xia L,Yang H,Li Q,Chen J,Durand S,Aprahamian F,Lefevre D,Broutin S,Paci A,Bongers A,Minard-Colin V,Tartour E,Zitvogel L,Apetoh L,Ma Y,Pittet MJ,Kepp O,Kroemer G
Tue Apr 02 00:00:00 UTC 2019
Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma.
Nature communications
Czystowska-Kuzmicz M,Sosnowska A,Nowis D,Ramji K,Szajnik M,Chlebowska-Tuz J,Wolinska E,Gaj P,Grazul M,Pilch Z,Zerrouqi A,Graczyk-Jarzynka A,Soroczynska K,Cierniak S,Koktysz R,Elishaev E,Gruca S,Stefanowicz A,Blaszczyk R,Borek B,Gzik A,Whiteside T,Golab J
Fri Jul 05 00:00:00 UTC 2019
Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response.
Nature communications
Pokharel SM,Shil NK,Gc JB,Colburn ZT,Tsai SY,Segovia JA,Chang TH,Bandyopadhyay S,Natesan S,Jones JCR,Bose S
Mon Apr 01 00:00:00 UTC 2019
DOCK8 is expressed in microglia, and it regulates microglial activity during neurodegeneration in murine disease models.
The Journal of biological chemistry
Namekata K,Guo X,Kimura A,Arai N,Harada C,Harada T
Fri Sep 06 00:00:00 UTC 2019
AI-powered transmitted light microscopy for functional analysis of live cells.
Scientific reports
Kim D,Min Y,Oh JM,Cho YK
Thu Dec 05 00:00:00 UTC 2019
RGMB enhances the suppressive activity of the monomeric secreted form of CTLA-4.
Scientific reports
Sekiya T,Takaki S
Mon May 06 00:00:00 UTC 2019
Rhinovirus-induced IFNβ expression is NFκB-dependent and regulated by the macrophage microenvironment.
Scientific reports
Menzel M,Kosinski J,Uller L,Akbarshahi H
Mon Sep 16 00:00:00 UTC 2019
P2X7 Receptor Stimulation Is Not Required for Oxalate Crystal-Induced Kidney Injury.
Scientific reports
Luz HL,Reichel M,Unwin RJ,Mutig K,Najenson AC,Tonner LM,Eckardt KU,Tam FWK,Knauf F
Fri Dec 27 00:00:00 UTC 2019
Macroautophagy in Dendritic Cells Controls the Homeostasis and Stability of Regulatory T Cells.
Cell reports
Niven J,Madelon N,Page N,Caruso A,Harlé G,Lemeille S,Seemayer CA,Hugues S,Gannagé M
315-03 was used in Sample Preparation (FC/FACS) to study how Tregs are expanded and have phenotypic alterations and impaired suppressive functions in mice with autophagy-deficient dendritic cells (DCs).
Tue Jul 02 00:00:00 UTC 2019
Treating ischemia via recruitment of antigen-specific T cells.
Science advances
Kwee BJ,Seo BR,Najibi AJ,Li AW,Shih TY,White D,Mooney DJ
315-03 was used in Cell Culture to support the premise that antigen depots may provide a treatment for ischemic diseases in patients previously vaccinated with aluminum-containing adjuvants.
Mon Jul 01 00:00:00 UTC 2019
Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation.
Nature communications
Zhou J,Huang S,Wang Z,Huang J,Xu L,Tang X,Wan YY,Li QJ,Symonds ALJ,Long H,Zhu B
Mon Jun 03 00:00:00 UTC 2019
Oligomeric self-association contributes to E2A-PBX1-mediated oncogenesis.
Scientific reports
Lin CH,Wang Z,Duque-Afonso J,Wong SH,Demeter J,Loktev AV,Somervaille TCP,Jackson PK,Cleary ML
Wed Mar 20 00:00:00 UTC 2019
Population snapshots predict early haematopoietic and erythroid hierarchies.
Nature
Tusi BK,Wolock SL,Weinreb C,Hwang Y,Hidalgo D,Zilionis R,Waisman A,Huh JR,Klein AM,Socolovsky M
315-03 was used in Cell Culture to illustrate the utility of coupling population snapshots with predictive fate models, to gain in vivo insights of early hempatopoetic and erythroid lineage sorting.
Thu Mar 01 00:00:00 UTC 2018
Population snapshots predict early haematopoietic and erythroid hierarchies.
Nature
Tusi BK,Wolock SL,Weinreb C,Hwang Y,Hidalgo D,Zilionis R,Waisman A,Huh JR,Klein AM,Socolovsky M
315-03 was used in Cell Culture to illustrate the utility of coupling population snapshots with predictive fate models, to gain in vivo insights of early hempatopoetic and erythroid lineage sorting.
Thu Mar 01 00:00:00 UTC 2018
Clonal analysis of lineage fate in native haematopoiesis.
Nature
Rodriguez-Fraticelli AE,Wolock SL,Weinreb CS,Panero R,Patel SH,Jankovic M,Sun J,Calogero RA,Klein AM,Camargo FD
Thu Jan 11 00:00:00 UTC 2018
Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting.
Cell
Cohen M,Giladi A,Gorki AD,Solodkin DG,Zada M,Hladik A,Miklosi A,Salame TM,Halpern KB,David E,Itzkovitz S,Harkany T,Knapp S,Amit I
Thu Nov 01 00:00:00 UTC 2018
The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery.
Cell
Xia Y,Xie Y,Yu Z,Xiao H,Jiang G,Zhou X,Yang Y,Li X,Zhao M,Li L,Zheng M,Han S,Zong Z,Meng X,Deng H,Ye H,Fa Y,Wu H,Oldfield E,Hu X,Liu W,Shi Y,Zhang Y
Thu Nov 01 00:00:00 UTC 2018
Metabolic Induction of Trained Immunity through the Mevalonate Pathway.
Cell
Bekkering S,Arts RJW,Novakovic B,Kourtzelis I,van der Heijden CDCC,Li Y,Popa CD,Ter Horst R,van Tuijl J,Netea-Maier RT,van de Veerdonk FL,Chavakis T,Joosten LAB,van der Meer JWM,Stunnenberg H,Riksen NP,Netea MG
Thu Jan 11 00:00:00 UTC 2018
EVIR: chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens.
Nature methods
Squadrito ML,Cianciaruso C,Hansen SK,De Palma M
Thu Mar 01 00:00:00 UTC 2018
Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy.
Immunity
Li J,Byrne KT,Yan F,Yamazoe T,Chen Z,Baslan T,Richman LP,Lin JH,Sun YH,Rech AJ,Balli D,Hay CA,Sela Y,Merrell AJ,Liudahl SM,Gordon N,Norgard RJ,Yuan S,Yu S,Chao T,Ye S,Eisinger-Mathason TSK,Faryabi RB,Tobias JW,Lowe SW,Coussens LM,Wherry EJ,Vonderheide RH,Stanger BZ
Tue Jul 17 00:00:00 UTC 2018
The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity.
Immunity
Uchimura T,Oyama Y,Deng M,Guo H,Wilson JE,Rampanelli E,Cook KD,Misumi I,Tan X,Chen L,Johnson B,Tam J,Chou WC,Brickey WJ,Petrucelli A,Whitmire JK,Ting JPY
Tue Dec 18 00:00:00 UTC 2018
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.
Immunity
Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z
Tue Apr 17 00:00:00 UTC 2018
Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance.
Immunity
Braza MS,van Leent MMT,Lameijer M,Sanchez-Gaytan BL,Arts RJW,Pérez-Medina C,Conde P,Garcia MR,Gonzalez-Perez M,Brahmachary M,Fay F,Kluza E,Kossatz S,Dress RJ,Salem F,Rialdi A,Reiner T,Boros P,Strijkers GJ,Calcagno CC,Ginhoux F,Marazzi I,Lutgens E,Nicolaes GAF,Weber C,Swirski FK,Nahrendorf M,Fisher EA,Duivenvoorden R,Fayad ZA,Netea MG,Mulder WJM,Ochando J
Tue Nov 20 00:00:00 UTC 2018
ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia.
Cancer cell
Maes T,Mascaró C,Tirapu I,Estiarte A,Ciceri F,Lunardi S,Guibourt N,Perdones A,Lufino MMP,Somervaille TCP,Wiseman DH,Duy C,Melnick A,Willekens C,Ortega A,Martinell M,Valls N,Kurz G,Fyfe M,Castro-Palomino JC,Buesa C
Mon Mar 12 00:00:00 UTC 2018
Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy.
Cancer cell
Medler TR,Murugan D,Horton W,Kumar S,Cotechini T,Forsyth AM,Leyshock P,Leitenberger JJ,Kulesz-Martin M,Margolin AA,Werb Z,Coussens LM
Mon Oct 08 00:00:00 UTC 2018
Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity.
Cancer cell
Kunimoto H,Meydan C,Nazir A,Whitfield J,Shank K,Rapaport F,Maher R,Pronier E,Meyer SC,Garrett-Bakelman FE,Tallman M,Melnick A,Levine RL,Shih AH
Mon Jan 08 00:00:00 UTC 2018
A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice.
Blood
Dahlin JS,Hamey FK,Pijuan-Sala B,Shepherd M,Lau WWY,Nestorowa S,Weinreb C,Wolock S,Hannah R,Diamanti E,Kent DG,Göttgens B,Wilson NK
Thu May 24 00:00:00 UTC 2018
Ring1A and Ring1B inhibit expression of Glis2 to maintain murine MOZ-TIF2 AML stem cells.
Blood
Shima H,Takamatsu-Ichihara E,Shino M,Yamagata K,Katsumoto T,Aikawa Y,Fujita S,Koseki H,Kitabayashi I
Thu Apr 19 00:00:00 UTC 2018
Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.
The Journal of clinical investigation
Zhao B,Mei Y,Cao L,Zhang J,Sumagin R,Yang J,Gao J,Schipma MJ,Wang Y,Thorsheim C,Zhao L,Stalker T,Stein B,Wen QJ,Crispino JD,Abrams CS,Ji P
Tue Jan 02 00:00:00 UTC 2018
Cancer vaccine formulation dictates synergy with CTLA-4 and PD-L1 checkpoint blockade therapy.
The Journal of clinical investigation
Hailemichael Y,Woods A,Fu T,He Q,Nielsen MC,Hasan F,Roszik J,Xiao Z,Vianden C,Khong H,Singh M,Sharma M,Faak F,Moore D,Dai Z,Anthony SM,Schluns KS,Sharma P,Engelhard VH,Overwijk WW
Mon Apr 02 00:00:00 UTC 2018
Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy.
The Journal of clinical investigation
Zhang P,He F,Bai J,Yamamoto S,Chen S,Zhang L,Sheng M,Zhang L,Guo Y,Man N,Yang H,Wang S,Cheng T,Nimer SD,Zhou Y,Xu M,Wang QF,Yang FC
Mon Dec 03 00:00:00 UTC 2018
Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease.
The Journal of clinical investigation
Tsantikos E,Lau M,Castelino CM,Maxwell MJ,Passey SL,Hansen MJ,McGregor NE,Sims NA,Steinfort DP,Irving LB,Anderson GP,Hibbs ML
Fri Jun 01 00:00:00 UTC 2018
Dinaciclib induces immunogenic cell death and enhances anti-PD1-mediated tumor suppression.
The Journal of clinical investigation
Hossain DMS,Javaid S,Cai M,Zhang C,Sawant A,Hinton M,Sathe M,Grein J,Blumenschein W,Pinheiro EM,Chackerian A
Thu Feb 01 00:00:00 UTC 2018
RAF/MEK/extracellular signal-related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions.
The Journal of experimental medicine
Hogstad B,Berres ML,Chakraborty R,Tang J,Bigenwald C,Serasinghe M,Lim KPH,Lin H,Man TK,Remark R,Baxter S,Kana V,Jordan S,Karoulia Z,Kwan WH,Leboeuf M,Brandt E,Salmon H,McClain K,Poulikakos P,Chipuk J,Mulder WJM,Allen CE,Merad M
Tue Jan 02 00:00:00 UTC 2018
CRL4DCAF2 negatively regulates IL-23 production in dendritic cells and limits the development of psoriasis.
The Journal of experimental medicine
Huang T,Gao Z,Zhang Y,Fan K,Wang F,Li Y,Zhong J,Fan HY,Cao Q,Zhou J,Xiao Y,Hu H,Jin J
Mon Aug 06 00:00:00 UTC 2018
Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis.
The Journal of experimental medicine
Jensen CT,Åhsberg J,Sommarin MNE,Strid T,Somasundaram R,Okuyama K,Ungerbäck J,Kupari J,Airaksinen MS,Lang S,Bryder D,Soneji S,Karlsson G,Sigvardsson M
Mon Jul 02 00:00:00 UTC 2018
A20-binding inhibitor of NF-κB (ABIN) 2 negatively regulates allergic airway inflammation.
The Journal of experimental medicine
Ventura S,Cano F,Kannan Y,Breyer F,Pattison MJ,Wilson MS,Ley SC
Mon Nov 05 00:00:00 UTC 2018
Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation.
The Journal of experimental medicine
Arnold IC,Artola-Borán M,Tallón de Lara P,Kyburz A,Taube C,Ottemann K,van den Broek M,Yousefi S,Simon HU,Müller A
Mon Aug 06 00:00:00 UTC 2018
Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection.
The Journal of experimental medicine
Huynh JP,Lin CC,Kimmey JM,Jarjour NN,Schwarzkopf EA,Bradstreet TR,Shchukina I,Shpynov O,Weaver CT,Taneja R,Artyomov MN,Edelson BT,Stallings CL
Mon Jul 02 00:00:00 UTC 2018
The WD40 domain of ATG16L1 is required for its non-canonical role in lipidation of LC3 at single membranes.
The EMBO journal
Fletcher K,Ulferts R,Jacquin E,Veith T,Gammoh N,Arasteh JM,Mayer U,Carding SR,Wileman T,Beale R,Florey O
315-03 was used in Cell Culture to demonstrate activation of non-canonical autophagy dependent on the WD40 CTD during influenza A virus infection.
Thu Feb 15 00:00:00 UTC 2018
Bryostatin-1 alleviates experimental multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America
Kornberg MD,Smith MD,Shirazi HA,Calabresi PA,Snyder SH,Kim PM
Tue Feb 27 00:00:00 UTC 2018
The Activin A-Peroxisome Proliferator-Activated Receptor Gamma Axis Contributes to the Transcriptome of GM-CSF-Conditioned Human Macrophages.
Frontiers in immunology
Nieto C,Bragado R,Municio C,Sierra-Filardi E,Alonso B,Escribese MM,Domínguez-Andrés J,Ardavín C,Castrillo A,Vega MA,Puig-Kröger A,Corbí AL
315-03 was used in Cell Culture to investigate GM-CSF dependence on PPARγ.
Thu Feb 14 00:00:00 UTC 2019
An Immunosuppressive Tick Salivary Gland Protein DsCystatin Interferes With Toll-Like Receptor Signaling by Downregulating TRAF6.
Frontiers in immunology
Sun T,Wang F,Pan W,Wu Q,Wang J,Dai J
315-03 was used in Cell Culture to characterise the immunosuppressive function of DsCystatin from Dermacentor silvarum of China.
Fri Aug 09 00:00:00 UTC 2019
Cleavage of TL1A Differentially Regulates Its Effects on Innate and Adaptive Immune Cells.
Journal of immunology (Baltimore, Md. : 1950)
Ferdinand JR,Richard AC,Meylan F,Al-Shamkhani A,Siegel RM
Thu Feb 15 00:00:00 UTC 2018
GM-CSF Culture Revisited: Preparation of Bulk Populations of Highly Pure Dendritic Cells from Mouse Bone Marrow.
Journal of immunology (Baltimore, Md. : 1950)
Jin D,Sprent J
Thu Nov 15 00:00:00 UTC 2018
The Essential Role of Double-Stranded RNA-Dependent Antiviral Signaling in the Degradation of Nonself Single-Stranded RNA in Nonimmune Cells.
Journal of immunology (Baltimore, Md. : 1950)
Kimura S,Matsumiya T,Shiba Y,Nakanishi M,Hayakari R,Kawaguchi S,Yoshida H,Imaizumi T
Wed Aug 01 00:00:00 UTC 2018
IL-36α from Skin-Resident Cells Plays an Important Role in the Pathogenesis of Imiquimod-Induced Psoriasiform Dermatitis by Forming a Local Autoamplification Loop.
Journal of immunology (Baltimore, Md. : 1950)
Hashiguchi Y,Yabe R,Chung SH,Murayama MA,Yoshida K,Matsuo K,Kubo S,Saijo S,Nakamura Y,Matsue H,Iwakura Y
Sun Jul 01 00:00:00 UTC 2018
The p38-MK2/3 Module Is Critical for IL-33-Induced Signaling and Cytokine Production in Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Göpfert C,Andreas N,Weber F,Häfner N,Yakovleva T,Gaestel M,Kamradt T,Drube S
Thu Feb 01 00:00:00 UTC 2018
Cutting Edge: Quantitative Determination of CD40L Threshold for IL-12 and IL-23 Production from Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Abdi K,Laky K,Padhan K,Petrovas C,Skinner J,Kabat J,Dorward DW,Brzostowski J,Long EO,Trinchieri G,Varma R
Thu Nov 15 00:00:00 UTC 2018
miR-340 Alleviates Psoriasis in Mice through Direct Targeting of IL-17A.
Journal of immunology (Baltimore, Md. : 1950)
Bian J,Liu R,Fan T,Liao L,Wang S,Geng W,Wang T,Shi W,Ruan Q
Sat Sep 01 00:00:00 UTC 2018
The Effects of Dendritic Cell Hypersensitivity on Persistent Viral Infection.
Journal of immunology (Baltimore, Md. : 1950)
Tsau JS,Huang X,Lai CY,Hedrick SM
Thu Feb 15 00:00:00 UTC 2018
Filamin A Is Required for Optimal T Cell Integrin-Mediated Force Transmission, Flow Adhesion, and T Cell Trafficking.
Journal of immunology (Baltimore, Md. : 1950)
Savinko T,Guenther C,Uotila LM,Llort Asens M,Yao S,Tojkander S,Fagerholm SC
Tue May 01 00:00:00 UTC 2018
Mitochondrial Deacetylase SIRT3 Plays an Important Role in Donor T Cell Responses after Experimental Allogeneic Hematopoietic Transplantation.
Journal of immunology (Baltimore, Md. : 1950)
Toubai T,Tamaki H,Peltier DC,Rossi C,Oravecz-Wilson K,Liu C,Zajac C,Wu J,Sun Y,Fujiwara H,Henig I,Kim S,Lombard DB,Reddy P
Sat Dec 01 00:00:00 UTC 2018
Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
O'Donnell JA,Lehman J,Roderick JE,Martinez-Marin D,Zelic M,Doran C,Hermance N,Lyle S,Pasparakis M,Fitzgerald KA,Marshak-Rothstein A,Kelliher MA
Mon Jan 15 00:00:00 UTC 2018
The Transcription Factors PU.1 and IRF4 Determine Dendritic Cell-Specific Expression of RALDH2.
Journal of immunology (Baltimore, Md. : 1950)
Yashiro T,Yamaguchi M,Watanuki Y,Kasakura K,Nishiyama C
Sat Dec 15 00:00:00 UTC 2018
Route of Antigen Presentation Can Determine the Selection of Foxp3-Dependent or Foxp3-Independent Dominant Immune Tolerance.
Journal of immunology (Baltimore, Md. : 1950)
Agua-Doce A,Caridade M,Oliveira VG,Bergman L,Lafaille MC,Lafaille JJ,Demengeot J,Graca L
Mon Jan 01 00:00:00 UTC 2018
Oncolytic Reovirus Inhibits Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in a TLR3-Dependent Manner.
Journal of immunology (Baltimore, Md. : 1950)
Katayama Y,Tachibana M,Kurisu N,Oya Y,Terasawa Y,Goda H,Kobiyama K,Ishii KJ,Akira S,Mizuguchi H,Sakurai F
Sun Apr 15 00:00:00 UTC 2018
Lnc-chop Promotes Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor and Inflammatory Environments.
Journal of immunology (Baltimore, Md. : 1950)
Gao Y,Wang T,Li Y,Zhang Y,Yang R
Sun Apr 15 00:00:00 UTC 2018
CSF-1 in Inflammatory and Arthritic Pain Development.
Journal of immunology (Baltimore, Md. : 1950)
Saleh R,Lee MC,Khiew SH,Louis C,Fleetwood AJ,Achuthan A,Förster I,Cook AD,Hamilton JA
Mon Oct 01 00:00:00 UTC 2018
Therapeutic Application of an Extract of Helicobacter pylori Ameliorates the Development of Allergic Airway Disease.
Journal of immunology (Baltimore, Md. : 1950)
van Wijck Y,de Kleijn S,John-Schuster G,Mertens TCJ,Hiemstra PS,Müller A,Smits HH,Taube C
Thu Mar 01 00:00:00 UTC 2018
Blocking Matrix Metalloproteinase-9 Abrogates Collagen-Induced Arthritis via Inhibiting Dendritic Cell Migration.
Journal of immunology (Baltimore, Md. : 1950)
He J,Li X,Zhuang J,Han J,Luo G,Yang F,Sun Y,Liao P,Han Y,He Y,Shi H,Sun E
Sat Dec 15 00:00:00 UTC 2018
Golgi Phosphoprotein 2 Is a Novel Regulator of IL-12 Production and Macrophage Polarization.
Journal of immunology (Baltimore, Md. : 1950)
Zhang W,Kim H,Lv J,Zhao N,Ma X
Thu Feb 15 00:00:00 UTC 2018
Melanoma exosomes promote mixed M1 and M2 macrophage polarization.
Cytokine
Bardi GT,Smith MA,Hood JL
315-03 was used in Sample Preparation to provide the first evidence that melanoma exosomes can induce a mixed M1 and M2 pro-tumor macrophage activation phenotype.
Tue May 01 00:00:00 UTC 2018
Silencing of suppressor of cytokine signaling 1 enhances the immunological effect of mucin 1-calreticulin-primed 4T1 cell-treated dendritic cells in breast cancer treatment.
Oncology letters
Qin S,Gao Z,Liu Y,Liu C,Wang J,Zou LL
315-03 was used in Cell Culture to investigate the effects of silencing suppressor of cytokine signalling 1 in dendritic cells on antigen presentation.
Thu Feb 01 00:00:00 UTC 2018
Rab32-related antimicrobial pathway is involved in the progression of dextran sodium sulfate-induced colitis.
FEBS open bio
Xie X,Ni Q,Zhou D,Wan Y
Mon Oct 01 00:00:00 UTC 2018
Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells.
Nature communications
Lopes N,Charaix J,Cédile O,Sergé A,Irla M
Wed Mar 28 00:00:00 UTC 2018
The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation.
Nature communications
Nechama M,Kwon J,Wei S,Kyi AT,Welner RS,Ben-Dov IZ,Arredouani MS,Asara JM,Chen CH,Tsai CY,Nelson KF,Kobayashi KS,Israel E,Zhou XZ,Nicholson LK,Lu KP
Mon Apr 23 00:00:00 UTC 2018
Chitin promotes antigen-specific Th2 cell-mediated murine asthma through induction of IL-33-mediated IL-1β production by DCs.
Scientific reports
Arae K,Morita H,Unno H,Motomura K,Toyama S,Okada N,Ohno T,Tamari M,Orimo K,Mishima Y,Suto H,Okumura K,Sudo K,Miyazawa H,Taguchi H,Saito H,Matsumoto K,Nakae S
Mon Aug 06 00:00:00 UTC 2018
Granulocyte-macrophage colony-stimulating factor receptor expression in clinical pain disorder tissues and role in neuronal sensitization.
Pain reports
Donatien P,Anand U,Yiangou Y,Sinisi M,Fox M,MacQuillan A,Quick T,Korchev YE,Anand P
315-03 was used in In vitro experiments to investigate granulocyte-macrophage colony-stimulating factor receptor in cancer and pain.
Wed Mar 30 00:00:00 UTC 2022
POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity.
Nature communications
Zhang L,Liu Y,Wang B,Xu G,Yang Z,Tang M,Ma A,Jing T,Xu X,Zhang X,Liu Y
Fri Oct 12 00:00:00 UTC 2018
An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction.
Nature communications
Xia H,Luo H,Shan C,Muruato AE,Nunes BTD,Medeiros DBA,Zou J,Xie X,Giraldo MI,Vasconcelos PFC,Weaver SC,Wang T,Rajsbaum R,Shi PY
Mon Jan 29 00:00:00 UTC 2018
Modulation of double-stranded RNA pattern recognition receptor signaling in ovarian cancer cells promotes inflammatory queues.
Oncotarget
Muccioli M,Nandigam H,Loftus T,Singh M,Venkatesh A,Wright J,Pate M,McCall K,Benencia F
315-03 was used in In vitro experiments to investigate the potential of mouse and human ovarian cancer cells to produce inflammatory factors in response to pathogen recognition receptor signalling.
Fri Nov 30 00:00:00 UTC 2018
Regulatory T cell-derived extracellular vesicles modify dendritic cell function.
Scientific reports
Tung SL,Boardman DA,Sen M,Letizia M,Peng Q,Cianci N,Dioni L,Carlin LM,Lechler R,Bollati V,Lombardi G,Smyth LA
Tue Apr 17 00:00:00 UTC 2018
Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis.
Nature communications
Ryzhakov G,West NR,Franchini F,Clare S,Ilott NE,Sansom SN,Bullers SJ,Pearson C,Costain A,Vaughan-Jackson A,Goettel JA,Ermann J,Horwitz BH,Buti L,Lu X,Mukhopadhyay S,Snapper SB,Powrie F
Tue Sep 18 00:00:00 UTC 2018
Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration.
Nature communications
Guak H,Al Habyan S,Ma EH,Aldossary H,Al-Masri M,Won SY,Ying T,Fixman ED,Jones RG,McCaffrey LM,Krawczyk CM
Mon Jun 25 00:00:00 UTC 2018
A 21.6 kDa tegumental protein of Clonorchis sinensis induces a Th1/Th2 mixed immune response in mice.
Immunity, inflammation and disease
Chung E,Kim YJ,Lee MR,Cho SH,Ju JW
Sat Dec 01 00:00:00 UTC 2018
Lamin A/C augments Th1 differentiation and response against vaccinia virus and Leishmania major.
Cell death & disease
Toribio-Fernández R,Zorita V,Rocha-Perugini V,Iborra S,Martínez Del Hoyo G,Chevre R,Dorado B,Sancho D,Sanchez-Madrid F,Andrés V,Gonzalez-Granado JM
Mon Jan 08 00:00:00 UTC 2018
Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells in Murine Bone Marrow.
Stem cell reports
Karatepe K,Zhu H,Zhang X,Guo R,Kambara H,Loison F,Liu P,Yu H,Ren Q,Luo X,Manis J,Cheng T,Ma F,Xu Y,Luo HR
Tue Nov 13 00:00:00 UTC 2018
Chemokine (C-X-C motif) ligand 1 and CXCL2 produced by tumor promote the generation of monocytic myeloid-derived suppressor cells.
Cancer science
Shi H,Han X,Sun Y,Shang C,Wei M,Ba X,Zeng X
315-03 was used in Cell Culture to show a novel role of CXCL1 and CXCL2 in promoting mo-MDSC generation by favoring the differentiation of bone marrow cells in tumor-bearing conditions, which suggests that inhibition of CXCL1 and CXCL2 could decrease mo-MDSC generation and improve host immunosurveillance.
Sat Dec 01 00:00:00 UTC 2018
Granulocyte-macrophage colony-stimulating factor improves mouse peripheral nerve regeneration following sciatic nerve crush.
The European journal of neuroscience
Bombeiro AL,Pereira BTN,de Oliveira ALR
315-03 was used in In vivo experiments to suggest that GM-CSF may have beneficial effects on early axonal regeneration.
Sat Sep 01 00:00:00 UTC 2018
The effect of PU.1 knockdown on gene expression and function of mast cells.
Scientific reports
Oda Y,Kasakura K,Fujigaki I,Kageyama A,Okumura K,Ogawa H,Yashiro T,Nishiyama C
Wed Jan 31 00:00:00 UTC 2018
Metabolic labeling of HIV-1 envelope glycoprotein gp120 to elucidate the effect of gp120 glycosylation on antigen uptake.
The Journal of biological chemistry
Sun L,Ishihara M,Middleton DR,Tiemeyer M,Avci FY
Fri Sep 28 00:00:00 UTC 2018
UBXN3B positively regulates STING-mediated antiviral immune responses.
Nature communications
Yang L,Wang L,Ketkar H,Ma J,Yang G,Cui S,Geng T,Mordue DG,Fujimoto T,Cheng G,You F,Lin R,Fikrig E,Wang P
Wed Jun 13 00:00:00 UTC 2018
Cell wall mannan of Candida krusei mediates dendritic cell apoptosis and orchestrates Th17 polarization via TLR-2/MyD88-dependent pathway.
Scientific reports
Nguyen TNY,Padungros P,Wongsrisupphakul P,Sa-Ard-Iam N,Mahanonda R,Matangkasombut O,Choo MK,Ritprajak P
Tue Nov 20 00:00:00 UTC 2018
Microbial metabolite sensor GPR43 controls severity of experimental GVHD.
Nature communications
Fujiwara H,Docampo MD,Riwes M,Peltier D,Toubai T,Henig I,Wu SJ,Kim S,Taylor A,Brabbs S,Liu C,Zajac C,Oravecz-Wilson K,Sun Y,Núñez G,Levine JE,van den Brink MRM,Ferrara JLM,Reddy P
Mon Sep 10 00:00:00 UTC 2018
Quillaja brasiliensis saponin-based nanoparticulate adjuvants are capable of triggering early immune responses.
Scientific reports
Cibulski SP,Rivera-Patron M,Mourglia-Ettlin G,Casaravilla C,Yendo ACA,Fett-Neto AG,Chabalgoity JA,Moreno M,Roehe PM,Silveira F
Tue Sep 11 00:00:00 UTC 2018
Resolvin E1 attenuates murine psoriatic dermatitis.
Scientific reports
Sawada Y,Honda T,Nakamizo S,Otsuka A,Ogawa N,Kobayashi Y,Nakamura M,Kabashima K
Wed Aug 08 00:00:00 UTC 2018
IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity.
Nature
Molgora M,Bonavita E,Ponzetta A,Riva F,Barbagallo M,Jaillon S,Popović B,Bernardini G,Magrini E,Gianni F,Zelenay S,Jonjić S,Santoni A,Garlanda C,Mantovani A
Thu Nov 02 00:00:00 UTC 2017
KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.
Cell
Burgess MR,Hwang E,Mroue R,Bielski CM,Wandler AM,Huang BJ,Firestone AJ,Young A,Lacap JA,Crocker L,Asthana S,Davis EM,Xu J,Akagi K,Le Beau MM,Li Q,Haley B,Stokoe D,Sampath D,Taylor BS,Evangelista M,Shannon K
Thu Feb 23 00:00:00 UTC 2017
Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes.
Immunity
Yáñez A,Coetzee SG,Olsson A,Muench DE,Berman BP,Hazelett DJ,Salomonis N,Grimes HL,Goodridge HS
Tue Nov 21 00:00:00 UTC 2017
Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling.
Immunity
Xu MM,Pu Y,Han D,Shi Y,Cao X,Liang H,Chen X,Li XD,Deng L,Chen ZJ,Weichselbaum RR,Fu YX
Tue Aug 15 00:00:00 UTC 2017
Inflammatory Ly6Chigh Monocytes Protect against Candidiasis through IL-15-Driven NK Cell/Neutrophil Activation.
Immunity
Domínguez-Andrés J,Feo-Lucas L,Minguito de la Escalera M,González L,López-Bravo M,Ardavín C
Tue Jun 20 00:00:00 UTC 2017
SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells.
Immunity
Stephen TL,Payne KK,Chaurio RA,Allegrezza MJ,Zhu H,Perez-Sanz J,Perales-Puchalt A,Nguyen JM,Vara-Ailor AE,Eruslanov EB,Borowsky ME,Zhang R,Laufer TM,Conejo-Garcia JR
Tue Jan 17 00:00:00 UTC 2017
Migrating Myeloid Cells Sense Temporal Dynamics of Chemoattractant Concentrations.
Immunity
Petrie Aronin CE,Zhao YM,Yoon JS,Morgan NY,Prüstel T,Germain RN,Meier-Schellersheim M
Tue Nov 21 00:00:00 UTC 2017
Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity.
Cell metabolism
Westerterp M,Gautier EL,Ganda A,Molusky MM,Wang W,Fotakis P,Wang N,Randolph GJ,D'Agati VD,Yvan-Charvet L,Tall AR
315-03 was used in In vitro experiments to identify an essential role of DC cholesterol efflux pathways in maintaining immune tolerance.
Tue Jun 06 00:00:00 UTC 2017
Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses.
Cell metabolism
Thwe PM,Pelgrom LR,Cooper R,Beauchamp S,Reisz JA,D'Alessandro A,Everts B,Amiel E
315-03 was used in In vitro experiments to study the contributions of intracellular glucose stores to glucose sourcing for the support of dendritic cell activation.
Tue Sep 05 00:00:00 UTC 2017
BCAP inhibits proliferation and differentiation of myeloid progenitors in the steady state and during demand situations.
Blood
Duggan JM,Buechler MB,Olson RM,Hohl TM,Hamerman JA
Thu Mar 16 00:00:00 UTC 2017
The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation.
Blood
Mizukawa B,O'Brien E,Moreira DC,Wunderlich M,Hochstetler CL,Duan X,Liu W,Orr E,Grimes HL,Mulloy JC,Zheng Y
Thu Sep 14 00:00:00 UTC 2017
Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies.
The Journal of experimental medicine
Tanaka T,Nakajima-Takagi Y,Aoyama K,Tara S,Oshima M,Saraya A,Koide S,Si S,Manabe I,Sanada M,Nakayama M,Masuko M,Sone H,Koseki H,Iwama A
Mon Oct 02 00:00:00 UTC 2017
Bim suppresses the development of SLE by limiting myeloid inflammatory responses.
The Journal of experimental medicine
Tsai F,Homan PJ,Agrawal H,Misharin AV,Abdala-Valencia H,Haines GK,Dominguez S,Bloomfield CL,Saber R,Chang A,Mohan C,Hutcheson J,Davidson A,Budinger GRS,Bouillet P,Dorfleutner A,Stehlik C,Winter DR,Cuda CM,Perlman H
Mon Dec 04 00:00:00 UTC 2017
In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein.
The Journal of experimental medicine
Deeg CM,Hassan E,Mutz P,Rheinemann L,Götz V,Magar L,Schilling M,Kallfass C,Nürnberger C,Soubies S,Kochs G,Haller O,Schwemmle M,Staeheli P
Mon May 01 00:00:00 UTC 2017
BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection.
The Journal of experimental medicine
Kitada S,Kayama H,Okuzaki D,Koga R,Kobayashi M,Arima Y,Kumanogoh A,Murakami M,Ikawa M,Takeda K
Mon May 01 00:00:00 UTC 2017
Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis.
The Journal of experimental medicine
Karmaus PWF,Herrada AA,Guy C,Neale G,Dhungana Y,Long L,Vogel P,Avila J,Clish CB,Chi H
Mon Sep 04 00:00:00 UTC 2017
A noncanonical function of cGAMP in inflammasome priming and activation.
The Journal of experimental medicine
Swanson KV,Junkins RD,Kurkjian CJ,Holley-Guthrie E,Pendse AA,El Morabiti R,Petrucelli A,Barber GN,Benedict CA,Ting JP
Mon Dec 04 00:00:00 UTC 2017
Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine.
Autophagy
Chen X,Clark J,Wunderlich M,Fan C,Davis A,Chen S,Guan JL,Mulloy JC,Kumar A,Zheng Y
315-03 was used in Cell Culture to uncover anti-leukemic effects of choloroquine being independent of autophagy which can be enhanced via vesicular exocytotis inhibition, and autophagy being an insignificant target of MA9-AML therapy.
Thu May 04 00:00:00 UTC 2017
Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages.
Proceedings of the National Academy of Sciences of the United States of America
Kanemaru H,Yamane F,Fukushima K,Matsuki T,Kawasaki T,Ebina I,Kuniyoshi K,Tanaka H,Maruyama K,Maeda K,Satoh T,Akira S
Tue Aug 29 00:00:00 UTC 2017
Natural Killer T-cell Immunotherapy in Combination with Chemotherapy-Induced Immunogenic Cell Death Targets Metastatic Breast Cancer.
Cancer immunology research
Gebremeskel S,Lobert L,Tanner K,Walker B,Oliphant T,Clarke LE,Dellaire G,Johnston B
315-03 was used in In vitro experiments to investigate natural killer T cells in cancer control.
Fri Dec 01 00:00:00 UTC 2017
The Novel Toll-Like Receptor 2 Agonist SUP3 Enhances Antigen Presentation and T Cell Activation by Dendritic Cells.
Frontiers in immunology
Guo X,Wu N,Shang Y,Liu X,Wu T,Zhou Y,Liu X,Huang J,Liao X,Wu L
315-03 was used in Sample Preparation (FC/FACS) to show that SUP3 could serve as a novel promising immune adjuvant in vaccine development and immune modulations.
Wed Nov 20 00:00:00 UTC 2019
Suppression of murine tumour growth through CD8+ cytotoxic T lymphocytes via activated DEC-205+ dendritic cells by sequential administration of α-galactosylceramide in vivo.
Immunology
Kogo H,Shimizu M,Negishi Y,Uchida E,Takahashi H
Sat Jul 01 00:00:00 UTC 2017
A Schistosoma japonicum Infection Promotes the Expansion of Myeloid-Derived Suppressor Cells by Activating the JAK/STAT3 Pathway.
Journal of immunology (Baltimore, Md. : 1950)
Yang Q,Qiu H,Xie H,Qi Y,Cha H,Qu J,Wang M,Feng Y,Ye X,Mu J,Huang J
Thu Jun 15 00:00:00 UTC 2017
Monitoring C5aR2 Expression Using a Floxed tdTomato-C5aR2 Knock-In Mouse.
Journal of immunology (Baltimore, Md. : 1950)
Karsten CM,Wiese AV,Mey F,Figge J,Woodruff TM,Reuter T,Scurtu O,Kordowski A,Almeida LN,Briukhovetska D,Quell KM,Sun J,Ender F,Schmudde I,Vollbrandt T,Laumonnier Y,Köhl J
Wed Nov 01 00:00:00 UTC 2017
An Anti-Inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis.
Journal of immunology (Baltimore, Md. : 1950)
Clay GM,Valadares DG,Graff JW,Ulland TK,Davis RE,Scorza BM,Zhanbolat BS,Chen Y,Sutterwala FS,Wilson ME
Sun Oct 15 00:00:00 UTC 2017
Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Deng W,Yang J,Lin X,Shin J,Gao J,Zhong XP
Sun Jan 01 00:00:00 UTC 2017
A Chlamydia-Specific TCR-Transgenic Mouse Demonstrates Th1 Polyfunctionality with Enhanced Effector Function.
Journal of immunology (Baltimore, Md. : 1950)
Poston TB,Qu Y,Girardi J,O'Connell CM,Frazer LC,Russell AN,Wall M,Nagarajan UM,Darville T
Sun Oct 15 00:00:00 UTC 2017
Filamin A Regulates Neutrophil Adhesion, Production of Reactive Oxygen Species, and Neutrophil Extracellular Trap Release.
Journal of immunology (Baltimore, Md. : 1950)
Uotila LM,Guenther C,Savinko T,Lehti TA,Fagerholm SC
Wed Nov 15 00:00:00 UTC 2017
Mer Receptor Tyrosine Kinase Signaling Prevents Self-Ligand Sensing and Aberrant Selection in Germinal Centers.
Journal of immunology (Baltimore, Md. : 1950)
Schell SL,Soni C,Fasnacht MJ,Domeier PP,Cooper TK,Rahman ZSM
Fri Dec 15 00:00:00 UTC 2017
PALLD Regulates Phagocytosis by Enabling Timely Actin Polymerization and Depolymerization.
Journal of immunology (Baltimore, Md. : 1950)
Sun HM,Chen XL,Chen XJ,Liu J,Ma L,Wu HY,Huang QH,Xi XD,Yin T,Zhu J,Chen Z,Chen SJ
Fri Sep 01 00:00:00 UTC 2017
Surface LAMP-2 Is an Endocytic Receptor That Diverts Antigen Internalized by Human Dendritic Cells into Highly Immunogenic Exosomes.
Journal of immunology (Baltimore, Md. : 1950)
Leone DA,Peschel A,Brown M,Schachner H,Ball MJ,Gyuraszova M,Salzer-Muhar U,Fukuda M,Vizzardelli C,Bohle B,Rees AJ,Kain R
Sat Jul 15 00:00:00 UTC 2017
Oxidized Low-Density Lipoprotein Loading of Macrophages Downregulates TLR-Induced Proinflammatory Responses in a Gene-Specific and Temporal Manner through Transcriptional Control.
Journal of immunology (Baltimore, Md. : 1950)
Jongstra-Bilen J,Zhang CX,Wisnicki T,Li MK,White-Alfred S,Ilaalagan R,Ferri DM,Deonarain A,Wan MH,Hyduk SJ,Cummins CL,Cybulsky MI
Fri Sep 15 00:00:00 UTC 2017
NFAT1 Regulates Systemic Autoimmunity through the Modulation of a Dendritic Cell Property.
Journal of immunology (Baltimore, Md. : 1950)
Chae CS,Kim GC,Park ES,Lee CG,Verma R,Cho HL,Jun CD,Yoo YJ,Im SH
Wed Nov 01 00:00:00 UTC 2017
HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress.
Journal of immunology (Baltimore, Md. : 1950)
Ge M,Luo Z,Qiao Z,Zhou Y,Cheng X,Geng Q,Cai Y,Wan P,Xiong Y,Liu F,Wu K,Liu Y,Wu J
Wed Nov 01 00:00:00 UTC 2017
Monitoring C3aR Expression Using a Floxed tdTomato-C3aR Reporter Knock-in Mouse.
Journal of immunology (Baltimore, Md. : 1950)
Quell KM,Karsten CM,Kordowski A,Almeida LN,Briukhovetska D,Wiese AV,Sun J,Ender F,Antoniou K,Schröder T,Schmudde I,Berger JL,König P,Vollbrandt T,Laumonnier Y,Köhl J
Sat Jul 15 00:00:00 UTC 2017
Immunogenic Dendritic Cell Generation from Pluripotent Stem Cells by Ectopic Expression of Runx3.
Journal of immunology (Baltimore, Md. : 1950)
Takacs E,Boto P,Simo E,Csuth TI,Toth BM,Raveh-Amit H,Pap A,Kovács EG,Kobolak J,Benkö S,Dinnyes A,Szatmari I
Sun Jan 01 00:00:00 UTC 2017
TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF-TBK1 Interaction.
Journal of immunology (Baltimore, Md. : 1950)
Ye W,Hu MM,Lei CQ,Zhou Q,Lin H,Sun MS,Shu HB
Fri Sep 01 00:00:00 UTC 2017
The Ets2 Repressor Factor (Erf) Is Required for Effective Primitive and Definitive Hematopoiesis.
Molecular and cellular biology
Peraki I,Palis J,Mavrothalassitis G
315-03 was used in In vitro experiments to study how Erf is required in all three waves of embryonic hematopoiesis to show that Erf is required for both primitive and erythromyeloid progenitor waves of hematopoietic stem cell (HSC)-independent hematopoiesis as well as for the normal function of HSCs.
Sun Oct 01 00:00:00 UTC 2017
The protection role of Atg16l1 in CD11c+dendritic cells in murine colitis.
Immunobiology
Zhang H,Zheng L,Chen J,Fukata M,Ichikawa R,Shih DQ,Zhang X
315-03 was used in Sample Preparation (WB) to investigate Atg16l1 mutation in mouse models of inflammatory bowel syndrome.
Sat Jul 01 00:00:00 UTC 2017
Yolk sac erythromyeloid progenitors expressing gain of function PTPN11 have functional features of JMML but are not sufficient to cause disease in mice.
Developmental dynamics : an official publication of the American Association of Anatomists
Tarnawsky SP,Yoshimoto M,Deng L,Chan RJ,Yoder MC
315-03 was used in Sample Preparation (FC/FACS) to investigate the effects of juvenile myelomonocytic leukemia-initiating PTPN11 mutations on pediatric myeloproliferative neoplasm.
Fri Dec 01 00:00:00 UTC 2017
Fibroblast growth factors (FGFs) prime the limb specific Shh enhancer for chromatin changes that balance histone acetylation mediated by E26 transformation-specific (ETS) factors.
eLife
Peluso S,Douglas A,Hill A,De Angelis C,Moore BL,Grimes G,Petrovich G,Essafi A,Hill RE
Tue Sep 26 00:00:00 UTC 2017
Activation of invariant natural killer T cells stimulated with microbial α-mannosyl glycolipids.
Scientific reports
Shimamura M,Yamamura M,Nabeshima T,Kitano N,van den Elzen P,Yesilkaya H,Andrew P,Illarionov P
Tue Aug 29 00:00:00 UTC 2017
CCR5 Directs the Mobilization of CD11b+Gr1+Ly6Clow Polymorphonuclear Myeloid Cells from the Bone Marrow to the Blood to Support Tumor Development.
Cell reports
Hawila E,Razon H,Wildbaum G,Blattner C,Sapir Y,Shaked Y,Umansky V,Karin N
315-03 was used in Cell Culture to show that, beyond chemoattraction, the interaction between CCR5 and its ligands promotes the proliferation of CCR5+ PMN-MDSCs at the BM and, later, potentiates their immune-suppressive activities at the tumor site in part by inducing arginase-1.
Tue Nov 21 00:00:00 UTC 2017
DOCK8 Protein Regulates Macrophage Migration through Cdc42 Protein Activation and LRAP35a Protein Interaction.
The Journal of biological chemistry
Shiraishi A,Uruno T,Sanematsu F,Ushijima M,Sakata D,Hara T,Fukui Y
Fri Feb 10 00:00:00 UTC 2017
A Critical Analysis of the Role of SNARE Protein SEC22B in Antigen Cross-Presentation.
Cell reports
Wu SJ,Niknafs YS,Kim SH,Oravecz-Wilson K,Zajac C,Toubai T,Sun Y,Prasad J,Peltier D,Fujiwara H,Hedig I,Mathewson ND,Khoriaty R,Ginsburg D,Reddy P
315-03 was used in Cell Culture to demonstrate that contrary to the accepted model, SEC22B is not necessary for cross-presentation, cautioning against extrapolating phenotypes from knockdown studies alone.
Tue Jun 27 00:00:00 UTC 2017
Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.
Scientific reports
Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H
Mon Feb 06 00:00:00 UTC 2017
RNA sequencing analysis of activated macrophages treated with the anti-HIV ABX464 in intestinal inflammation.
Scientific data
Manchon L,Chebli K,Papon L,Paul C,Garcel A,Campos N,Scherrer D,Ehrlich H,Hahne M,Tazi J
Tue Oct 17 00:00:00 UTC 2017
Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice.
Molecular therapy. Methods & clinical development
Lee S,Kivimäe S,Szoka FC
315-03 was used in In vitro experiments to generate Hoxb8-dependent myeloid progenitors (HDPs) by transducing lineage-negative bone marrow cells with a constitutively expressed Hoxb8 flanked by loxP. HDPs proliferate indefinitely and differentiate into MΦ when Hoxb8 is removed by a tamoxifen-inducible Cre.
Fri Dec 15 00:00:00 UTC 2017
E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses.
Nature communications
Song Y,Lai L,Chong Z,He J,Zhang Y,Xue Y,Xie Y,Chen S,Dong P,Chen L,Chen Z,Dai F,Wan X,Xiao P,Cao X,Liu Y,Wang Q
315-03 was used in Cell Culture to identify FBXW7 as an important interacting partner for RIG-I.
Mon Mar 13 00:00:00 UTC 2017
TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells.
Nature communications
Saitoh SI,Abe F,Kanno A,Tanimura N,Mori Saitoh Y,Fukui R,Shibata T,Sato K,Ichinohe T,Hayashi M,Kubota K,Kozuka-Hata H,Oyama M,Kikko Y,Katada T,Kontani K,Miyake K
Fri Nov 17 00:00:00 UTC 2017
Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells.
Nature communications
Lee PP,Lobato-Márquez D,Pramanik N,Sirianni A,Daza-Cajigal V,Rivers E,Cavazza A,Bouma G,Moulding D,Hultenby K,Westerberg LS,Hollinshead M,Lau YL,Burns SO,Mostowy S,Bajaj-Elliott M,Thrasher AJ
Fri Nov 17 00:00:00 UTC 2017
A unique tolerizing dendritic cell phenotype induced by the synthetic triterpenoid CDDO-DFPA (RTA-408) is protective against EAE.
Scientific reports
Wei HJ,Pareek TK,Liu Q,Letterio JJ
Tue Aug 29 00:00:00 UTC 2017
Development of a Curative Therapeutic Vaccine (TheraVac) for the Treatment of Large Established Tumors.
Scientific reports
Nie Y,Yang D,Trivett A,Han Z,Xin H,Chen X,Oppenheim JJ
Fri Oct 27 00:00:00 UTC 2017
Non-thermal atmospheric plasma ameliorates imiquimod-induced psoriasis-like skin inflammation in mice through inhibition of immune responses and up-regulation of PD-L1 expression.
Scientific reports
Lee YS,Lee MH,Kim HJ,Won HR,Kim CH
Tue Nov 14 00:00:00 UTC 2017
Immunotherapy with subcutaneous immunogenic autologous tumor lysate increases murine glioblastoma survival.
Scientific reports
Belmans J,Van Woensel M,Creyns B,Dejaegher J,Bullens DM,Van Gool SW
Tue Oct 24 00:00:00 UTC 2017
Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses.
Nature communications
Cruz-Adalia A,Ramirez-Santiago G,Osuna-Pérez J,Torres-Torresano M,Zorita V,Martínez-Riaño A,Boccasavia V,Borroto A,Martínez Del Hoyo G,González-Granado JM,Alarcón B,Sánchez-Madrid F,Veiga E
Fri Nov 17 00:00:00 UTC 2017
p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis.
Nature communications
Okuma A,Hanyu A,Watanabe S,Hara E
Tue Dec 12 00:00:00 UTC 2017
Tumour cell conditioned medium reveals greater M2 skewing of macrophages in the absence of properdin.
Immunity, inflammation and disease
Al-Rayahi IA,Browning MJ,Stover C
Wed Mar 01 00:00:00 UTC 2017
Oleate but not stearate induces the regulatory phenotype of myeloid suppressor cells.
Scientific reports
Wu H,Weidinger C,Schmidt F,Keye J,Friedrich M,Yerinde C,Willimsky G,Qin Z,Siegmund B,Glauben R
Tue Aug 08 00:00:00 UTC 2017
Inhibiting DPP4 in a mouse model of HHT1 results in a shift towards regenerative macrophages and reduces fibrosis after myocardial infarction.
PloS one
Dingenouts CKE,Bakker W,Lodder K,Wiesmeijer KC,Moerkamp AT,Maring JA,Arthur HM,Smits AM,Goumans MJ
315-03 was used in In vitro experiments to demonstrate that systemic dipeptidyl peptidase-4 inhibition restores the impaired mononuclear cells homing in Eng+/- animals post-myocardial infarction, and enhances cardiac repair.
Fri Jan 12 00:00:00 UTC 2018
Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability.
Nature communications
Gao Z,Li Y,Wang F,Huang T,Fan K,Zhang Y,Zhong J,Cao Q,Chao T,Jia J,Yang S,Zhang L,Xiao Y,Zhou JY,Feng XH,Jin J
Mon Nov 27 00:00:00 UTC 2017
Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia.
Nature communications
Krishnasamy K,Limbourg A,Kapanadze T,Gamrekelashvili J,Beger C,Häger C,Lozanovski VJ,Falk CS,Napp LC,Bauersachs J,Mack M,Haller H,Weber C,Adams RH,Limbourg FP
Mon Oct 16 00:00:00 UTC 2017
Toxoplasma gondii tachyzoite-extract acts as a potent immunomodulator against allergic sensitization and airway inflammation.
Scientific reports
Drinić M,Wagner A,Sarate P,Zwicker C,Korb E,Loupal G,Peschke R,Joachim A,Wiedermann U,Schabussova I
Thu Nov 09 00:00:00 UTC 2017
STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells.
Nature communications
Nunes-Hasler P,Maschalidi S,Lippens C,Castelbou C,Bouvet S,Guido D,Bermont F,Bassoy EY,Page N,Merkler D,Hugues S,Martinvalet D,Manoury B,Demaurex N
Fri Nov 24 00:00:00 UTC 2017
Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines.
EBioMedicine
Hayashi M,Aoshi T,Haseda Y,Kobiyama K,Wijaya E,Nakatsu N,Igarashi Y,Standley DM,Yamada H,Honda-Okubo Y,Hara H,Saito T,Takai T,Coban C,Petrovsky N,Ishii KJ
315-03 was used in Cell Culture to study the immunological characteristics and mechanism of action of delta inulin-derived microparticle Advax.
Wed Feb 01 00:00:00 UTC 2017
A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse.
The Journal of biological chemistry
Bloch N,Gläsker S,Sitaram P,Hofmann H,Shepard CN,Schultz ML,Kim B,Landau NR
Fri Jan 20 00:00:00 UTC 2017
Metabolic maintenance of cell asymmetry following division in activated T lymphocytes.
Nature
Verbist KC,Guy CS,Milasta S,Liedmann S,Kamiński MM,Wang R,Green DR
315-03 was used in Cell Culture to investigate the mechanisms that sustain differential cell fates in daughter T cells after activation by an antigen-presenting cell.
Thu Apr 21 00:00:00 UTC 2016
Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens.
Cell
Dixit A,Parnas O,Li B,Chen J,Fulco CP,Jerby-Arnon L,Marjanovic ND,Dionne D,Burks T,Raychowdhury R,Adamson B,Norman TM,Lander ES,Weissman JS,Friedman N,Regev A
Thu Dec 15 00:00:00 UTC 2016
Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq.
Cell
Jaitin DA,Weiner A,Yofe I,Lara-Astiaso D,Keren-Shaul H,David E,Salame TM,Tanay A,van Oudenaarden A,Amit I
Thu Dec 15 00:00:00 UTC 2016
The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response.
Cell research
Yang Y,Wang SY,Huang ZF,Zou HM,Yan BR,Luo WW,Wang YY
Tue Mar 01 00:00:00 UTC 2016
Scaffolding protein Gab1 regulates myeloid dendritic cell migration in allergic asthma.
Cell research
Zhang Y,Xu Y,Liu S,Guo X,Cen D,Xu J,Li H,Li K,Zeng C,Lu L,Zhou Y,Shen H,Cheng H,Zhang X,Ke Y
Tue Nov 01 00:00:00 UTC 2016
The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells.
Immunity
Menezes S,Melandri D,Anselmi G,Perchet T,Loschko J,Dubrot J,Patel R,Gautier EL,Hugues S,Longhi MP,Henry JY,Quezada SA,Lauvau G,Lennon-Duménil AM,Gutiérrez-Martínez E,Bessis A,Gomez-Perdiguero E,Jacome-Galarza CE,Garner H,Geissmann F,Golub R,Nussenzweig MC,Guermonprez P
Tue Dec 20 00:00:00 UTC 2016
S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.
Nature immunology
Wang F,Alain T,Szretter KJ,Stephenson K,Pol JG,Atherton MJ,Hoang HD,Fonseca BD,Zakaria C,Chen L,Rangwala Z,Hesch A,Chan ESY,Tuinman C,Suthar MS,Jiang Z,Ashkar AA,Thomas G,Kozma SC,Gale M,Fitzgerald KA,Diamond MS,Mossman K,Sonenberg N,Wan Y,Lichty BD
Sun May 01 00:00:00 UTC 2016
Mouse host unlicensed NK cells promote donor allogeneic bone marrow engraftment.
Blood
Alvarez M,Sun K,Murphy WJ
Thu Mar 03 00:00:00 UTC 2016
High-dose dexamethasone corrects impaired myeloid-derived suppressor cell function via Ets1 in immune thrombocytopenia.
Blood
Hou Y,Feng Q,Xu M,Li GS,Liu XN,Sheng Z,Zhou H,Ma J,Wei Y,Sun YX,Yu YY,Qiu JH,Shao LL,Liu XG,Hou M,Peng J
Thu Mar 24 00:00:00 UTC 2016
GATA2 regulates dendritic cell differentiation.
Blood
Onodera K,Fujiwara T,Onishi Y,Itoh-Nakadai A,Okitsu Y,Fukuhara N,Ishizawa K,Shimizu R,Yamamoto M,Harigae H
Thu Jul 28 00:00:00 UTC 2016
Control of GVHD by regulatory T cells depends on TNF produced by T cells and TNFR2 expressed by regulatory T cells.
Blood
Leclerc M,Naserian S,Pilon C,Thiolat A,Martin GH,Pouchy C,Dominique C,Belkacemi Y,Charlotte F,Maury S,Salomon BL,Cohen JL
Thu Sep 22 00:00:00 UTC 2016
EGFR regulates macrophage activation and function in bacterial infection.
The Journal of clinical investigation
Hardbower DM,Singh K,Asim M,Verriere TG,Olivares-Villagómez D,Barry DP,Allaman MM,Washington MK,Peek RM,Piazuelo MB,Wilson KT
Thu Sep 01 00:00:00 UTC 2016
Donor dendritic cell-derived exosomes promote allograft-targeting immune response.
The Journal of clinical investigation
Liu Q,Rojas-Canales DM,Divito SJ,Shufesky WJ,Stolz DB,Erdos G,Sullivan ML,Gibson GA,Watkins SC,Larregina AT,Morelli AE
Mon Aug 01 00:00:00 UTC 2016
Uropathogenic Escherichia coli strain CFT073 disrupts NLRP3 inflammasome activation.
The Journal of clinical investigation
Waldhuber A,Puthia M,Wieser A,Cirl C,Dürr S,Neumann-Pfeifer S,Albrecht S,Römmler F,Müller T,Zheng Y,Schubert S,Groß O,Svanborg C,Miethke T
Fri Jul 01 00:00:00 UTC 2016
Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation.
The Journal of clinical investigation
Achuthan A,Cook AD,Lee MC,Saleh R,Khiew HW,Chang MW,Louis C,Fleetwood AJ,Lacey DC,Christensen AD,Frye AT,Lam PY,Kusano H,Nomura K,Steiner N,Förster I,Nutt SL,Olshansky M,Turner SJ,Hamilton JA
Thu Sep 01 00:00:00 UTC 2016
IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity.
The Journal of experimental medicine
Domeier PP,Chodisetti SB,Soni C,Schell SL,Elias MJ,Wong EB,Cooper TK,Kitamura D,Rahman ZS
Mon May 02 00:00:00 UTC 2016
Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites.
The Journal of experimental medicine
Wan X,Thomas JW,Unanue ER
Mon May 30 00:00:00 UTC 2016
Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a.
The Journal of experimental medicine
Cheung KL,Jarrett R,Subramaniam S,Salimi M,Gutowska-Owsiak D,Chen YL,Hardman C,Xue L,Cerundolo V,Ogg G
Mon Oct 17 00:00:00 UTC 2016
PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.
The Journal of experimental medicine
Kong D,Shen Y,Liu G,Zuo S,Ji Y,Lu A,Nakamura M,Lazarus M,Stratakis CA,Breyer RM,Yu Y
Mon Sep 19 00:00:00 UTC 2016
RAB43 facilitates cross-presentation of cell-associated antigens by CD8α+ dendritic cells.
The Journal of experimental medicine
Kretzer NM,Theisen DJ,Tussiwand R,Briseño CG,Grajales-Reyes GE,Wu X,Durai V,Albring J,Bagadia P,Murphy TL,Murphy KM
Mon Dec 12 00:00:00 UTC 2016
Interferon-γ facilitates hepatic antiviral T cell retention for the maintenance of liver-induced systemic tolerance.
The Journal of experimental medicine
Zeng Z,Li L,Chen Y,Wei H,Sun R,Tian Z
Mon May 30 00:00:00 UTC 2016
TLR9-mediated inflammation drives a Ccr2-independent peripheral monocytosis through enhanced extramedullary monocytopoiesis.
Proceedings of the National Academy of Sciences of the United States of America
Weaver LK,Chu N,Behrens EM
Tue Sep 27 00:00:00 UTC 2016
Scavenging nucleic acid debris to combat autoimmunity and infectious disease.
Proceedings of the National Academy of Sciences of the United States of America
Holl EK,Shumansky KL,Borst LB,Burnette AD,Sample CJ,Ramsburg EA,Sullenger BA
Tue Aug 30 00:00:00 UTC 2016
Non-invasive Imaging of Sendai Virus Infection in Pharmacologically Immunocompromised Mice: NK and T Cells, but not Neutrophils, Promote Viral Clearance after Therapy with Cyclophosphamide and Dexamethasone.
PLoS pathogens
Mostafa HH,Vogel P,Srinivasan A,Russell CJ
315-03 was used in In vivo experiments to demonstrate the use of bioluminescence to study respiratory viral progression and the role of natural killer and T-cells in Sendai virus clearance after treatment with dexamethasone and cyclophosphamide.
Thu Sep 01 00:00:00 UTC 2016
Rel B-modified dendritic cells possess tolerogenic phenotype and functions on lupus splenic lymphocytes in vitro.
Immunology
Wu H,Lo Y,Chan A,Law KS,Mok MY
Thu Sep 01 00:00:00 UTC 2016
IL-27 Induced by Select Candida spp. via TLR7/NOD2 Signaling and IFN-β Production Inhibits Fungal Clearance.
Journal of immunology (Baltimore, Md. : 1950)
Patin EC,Jones AV,Thompson A,Clement M,Liao CT,Griffiths JS,Wallace LE,Bryant CE,Lang R,Rosenstiel P,Humphreys IR,Taylor PR,Jones GW,Orr SJ
Fri Jul 01 00:00:00 UTC 2016
LSm14A Plays a Critical Role in Antiviral Immune Responses by Regulating MITA Level in a Cell-Specific Manner.
Journal of immunology (Baltimore, Md. : 1950)
Liu TT,Yang Q,Li M,Zhong B,Ran Y,Liu LL,Yang Y,Wang YY,Shu HB
Wed Jun 15 00:00:00 UTC 2016
Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Primiano MJ,Lefker BA,Bowman MR,Bree AG,Hubeau C,Bonin PD,Mangan M,Dower K,Monks BG,Cushing L,Wang S,Guzova J,Jiao A,Lin LL,Latz E,Hepworth D,Hall JP
Thu Sep 15 00:00:00 UTC 2016
Integrated Nanovaccine with MicroRNA-148a Inhibition Reprograms Tumor-Associated Dendritic Cells by Modulating miR-148a/DNMT1/SOCS1 Axis.
Journal of immunology (Baltimore, Md. : 1950)
Liu L,Yi H,Wang C,He H,Li P,Pan H,Sheng N,Ji M,Cai L,Ma Y
Mon Aug 15 00:00:00 UTC 2016
Zinc Induces Dendritic Cell Tolerogenic Phenotype and Skews Regulatory T Cell-Th17 Balance.
Journal of immunology (Baltimore, Md. : 1950)
George MM,Subramanian Vignesh K,Landero Figueroa JA,Caruso JA,Deepe GS
Thu Sep 01 00:00:00 UTC 2016
Calcitonin Gene-Related Peptide-Exposed Endothelial Cells Bias Antigen Presentation to CD4+ T Cells toward a Th17 Response.
Journal of immunology (Baltimore, Md. : 1950)
Ding W,Stohl LL,Xu L,Zhou XK,Manni M,Wagner JA,Granstein RD
Tue Mar 01 00:00:00 UTC 2016
c-Src Suppresses Dendritic Cell Antitumor Activity via T Cell Ig and Mucin Protein-3 Receptor.
Journal of immunology (Baltimore, Md. : 1950)
Gujar R,Maurya N,Yadav V,Gupta M,Arora S,Khatri N,Sen P
Thu Sep 01 00:00:00 UTC 2016
Tolerogenic Phenotype of IFN-γ-Induced IDO+ Dendritic Cells Is Maintained via an Autocrine IDO-Kynurenine/AhR-IDO Loop.
Journal of immunology (Baltimore, Md. : 1950)
Li Q,Harden JL,Anderson CD,Egilmez NK
Mon Aug 01 00:00:00 UTC 2016
Semaphorin 7A Promotes Chemokine-Driven Dendritic Cell Migration.
Journal of immunology (Baltimore, Md. : 1950)
van Rijn A,Paulis L,te Riet J,Vasaturo A,Reinieren-Beeren I,van der Schaaf A,Kuipers AJ,Schulte LP,Jongbloets BC,Pasterkamp RJ,Figdor CG,van Spriel AB,Buschow SI
Fri Jan 01 00:00:00 UTC 2016
Suboptimal Antigen Presentation Contributes to Virulence of Mycobacterium tuberculosis In Vivo.
Journal of immunology (Baltimore, Md. : 1950)
Grace PS,Ernst JD
Fri Jan 01 00:00:00 UTC 2016
Phosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity.
Journal of immunology (Baltimore, Md. : 1950)
Lee MJ,Yoshimoto E,Saijo S,Iwakura Y,Lin X,Katz HR,Kanaoka Y,Barrett NA
Fri Jul 01 00:00:00 UTC 2016
Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration.
Journal of immunology (Baltimore, Md. : 1950)
Lo TH,Silveira PA,Fromm PD,Verma ND,Vu PA,Kupresanin F,Adam R,Kato M,Cogger VC,Clark GJ,Hart DN
Mon Aug 01 00:00:00 UTC 2016
Broad Infiltration of Macrophages Leads to a Proinflammatory State in Streptozotocin-Induced Hyperglycemic Mice.
Journal of immunology (Baltimore, Md. : 1950)
Niu S,Bian Z,Tremblay A,Luo Y,Kidder K,Mansour A,Zen K,Liu Y
Sat Oct 15 00:00:00 UTC 2016
Piperlongumine Suppresses Dendritic Cell Maturation by Reducing Production of Reactive Oxygen Species and Has Therapeutic Potential for Rheumatoid Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Xiao Y,Shi M,Qiu Q,Huang M,Zeng S,Zou Y,Zhan Z,Liang L,Yang X,Xu H
Wed Jun 15 00:00:00 UTC 2016
Siglec-E Negatively Regulates the Activation of TLR4 by Controlling Its Endocytosis.
Journal of immunology (Baltimore, Md. : 1950)
Wu Y,Ren D,Chen GY
Sat Oct 15 00:00:00 UTC 2016
Cooperative Activity of GABP with PU.1 or C/EBPε Regulates Lamin B Receptor Gene Expression, Implicating Their Roles in Granulocyte Nuclear Maturation.
Journal of immunology (Baltimore, Md. : 1950)
Malu K,Garhwal R,Pelletier MG,Gotur D,Halene S,Zwerger M,Yang ZF,Rosmarin AG,Gaines P
Mon Aug 01 00:00:00 UTC 2016
Inverse Correlation between IL-10 and HIF-1α in Macrophages Infected with Histoplasma capsulatum.
Journal of immunology (Baltimore, Md. : 1950)
Fecher RA,Horwath MC,Friedrich D,Rupp J,Deepe GS
Fri Jul 15 00:00:00 UTC 2016
Low-Intensity Focused Ultrasound Induces Reversal of Tumor-Induced T Cell Tolerance and Prevents Immune Escape.
Journal of immunology (Baltimore, Md. : 1950)
Bandyopadhyay S,Quinn TJ,Scandiuzzi L,Basu I,Partanen A,Tomé WA,Macian F,Guha C
Mon Feb 15 00:00:00 UTC 2016
Streptococci Engage TLR13 on Myeloid Cells in a Site-Specific Fashion.
Journal of immunology (Baltimore, Md. : 1950)
Kolter J,Feuerstein R,Spoeri E,Gharun K,Elling R,Trieu-Cuot P,Goldmann T,Waskow C,Chen ZJ,Kirschning CJ,Deshmukh SD,Henneke P
Tue Mar 15 00:00:00 UTC 2016
NADPH Oxidase-Derived Superoxide Provides a Third Signal for CD4 T Cell Effector Responses.
Journal of immunology (Baltimore, Md. : 1950)
Padgett LE,Tse HM
Thu Sep 01 00:00:00 UTC 2016
Dendritic Cell KLF2 Expression Regulates T Cell Activation and Proatherogenic Immune Responses.
Journal of immunology (Baltimore, Md. : 1950)
Alberts-Grill N,Engelbertsen D,Bu D,Foks A,Grabie N,Herter JM,Kuperwaser F,Chen T,Destefano G,Jarolim P,Lichtman AH
Thu Dec 15 00:00:00 UTC 2016
Alveolar Epithelial Cell-Derived Prostaglandin E2 Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Speth JM,Bourdonnay E,Penke LR,Mancuso P,Moore BB,Weinberg JB,Peters-Golden M
Wed Jun 15 00:00:00 UTC 2016
Repulsive guidance molecule a blockade exerts the immunoregulatory function in DCs stimulated with ABP and LPS.
Human vaccines & immunotherapeutics
Xu X,Gao Y,Zhai Z,Zhang S,Shan F,Feng J
315-03 was used in Sample Preparation (FC/FACS) to show that dendritic cells treated with RGMa-neutralising antibodies present with tolerogenic and immunoregulatory characteristics.
Tue Aug 02 00:00:00 UTC 2016
Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE/NFκB Pathway Suppression.
Journal of diabetes research
Zhou Z,Tang Y,Jin X,Chen C,Lu Y,Liu L,Shen C
315-03 was used in Cell Culture to investigate the use of metformin to treat AGEs-induced inflammatory response in macrophages.
Tue Jun 06 00:00:00 UTC 2017
CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis.
Biology open
Salao K,Jiang L,Li H,Tsai VW,Husaini Y,Curmi PM,Brown LJ,Brown DA,Breit SN
315-03 was used in In vitro experiments to suggest that CLIC1 regulates DC phagosomal pH to ensure optimal processing of antigen for presentation to antigen-specific T-cells.
Sun May 15 00:00:00 UTC 2016
Toll-Like Receptor 9 Activation Rescues Impaired Antibody Response in Needle-free Intradermal DNA Vaccination.
Scientific reports
Arunachalam PS,Mishra R,Badarinath K,Selvam D,Payeli SK,Stout RR,Ranga U
Fri Sep 23 00:00:00 UTC 2016
Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells.
Nature communications
Baptista MA,Keszei M,Oliveira M,Sunahara KK,Andersson J,Dahlberg CI,Worth AJ,Liedén A,Kuo IC,Wallin RP,Snapper SB,Eidsmo L,Scheynius A,Karlsson MC,Bouma G,Burns SO,Forsell MN,Thrasher AJ,Nylén S,Westerberg LS
Mon Jul 18 00:00:00 UTC 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
Tue Aug 09 00:00:00 UTC 2016
The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions.
The Journal of biological chemistry
Dyer DP,Salanga CL,Johns SC,Valdambrini E,Fuster MM,Milner CM,Day AJ,Handel TM
Fri Jun 10 00:00:00 UTC 2016
Mint3/Apba3 depletion ameliorates severe murine influenza pneumonia and macrophage cytokine production in response to the influenza virus.
Scientific reports
Uematsu T,Fujita T,Nakaoka HJ,Hara T,Kobayashi N,Murakami Y,Seiki M,Sakamoto T
Thu Nov 24 00:00:00 UTC 2016
RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity.
Blood cancer journal
Chin DW,Sakurai M,Nah GS,Du L,Jacob B,Yokomizo T,Matsumura T,Suda T,Huang G,Fu XY,Ito Y,Nakajima H,Osato M
Fri Jan 08 00:00:00 UTC 2016
Impact of CD200-Fc on dendritic cells in lupus-prone NZB/WF1 mice.
Scientific reports
Yin Y,Zhao L,Zhang F,Zhang X
Mon Aug 22 00:00:00 UTC 2016
Prevention of allograft rejection in heart transplantation through concurrent gene silencing of TLR and Kinase signaling pathways.
Scientific reports
Wang H,Zhang X,Zheng X,Lan Z,Shi J,Jiang J,Zwiep T,Li Q,Quan D,Zhang ZX,Min W
Fri Sep 23 00:00:00 UTC 2016
Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.
Nature communications
Göbel K,Pankratz S,Asaridou CM,Herrmann AM,Bittner S,Merker M,Ruck T,Glumm S,Langhauser F,Kraft P,Krug TF,Breuer J,Herold M,Gross CC,Beckmann D,Korb-Pap A,Schuhmann MK,Kuerten S,Mitroulis I,Ruppert C,Nolte MW,Panousis C,Klotz L,Kehrel B,Korn T,Langer HF,Pap T,Nieswandt B,Wiendl H,Chavakis T,Kleinschnitz C,Meuth SG
Wed May 18 00:00:00 UTC 2016
Complement component 3 deficiency prolongs MHC-II disparate skin allograft survival by increasing the CD4(+) CD25(+) regulatory T cells population.
Scientific reports
Zheng QY,Liang SJ,Li GQ,Lv YB,Li Y,Tang M,Zhang K,Xu GL,Zhang KQ
Mon Sep 19 00:00:00 UTC 2016
Immunomodulatory and Antitumor Effects of a Novel TLR7 Agonist Combined with Lapatinib.
Scientific reports
Gao N,Zhong J,Wang X,Jin Z,Li W,Liu Y,Diao Y,Wang Z,Jiang W,Jin G
Wed Dec 21 00:00:00 UTC 2016
Beta 1-integrin ligation and TLR ligation enhance GM-CSF-induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties.
Scientific reports
Yokota-Nakatsuma A,Ohoka Y,Takeuchi H,Song SY,Iwata M
Tue Nov 29 00:00:00 UTC 2016
Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells.
Nature communications
Zhao Y,Chu X,Chen J,Wang Y,Gao S,Jiang Y,Zhu X,Tan G,Zhao W,Yi H,Xu H,Ma X,Lu Y,Yi Q,Wang S
Fri Aug 05 00:00:00 UTC 2016
Loss of XIAP facilitates switch to TNFα-induced necroptosis in mouse neutrophils.
Cell death & disease
Wicki S,Gurzeler U,Wei-Lynn Wong W,Jost PJ,Bachmann D,Kaufmann T
Thu Oct 13 00:00:00 UTC 2016
Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation.
Nature communications
den Brok MH,Büll C,Wassink M,de Graaf AM,Wagenaars JA,Minderman M,Thakur M,Amigorena S,Rijke EO,Schrier CC,Adema GJ
Mon Nov 07 00:00:00 UTC 2016
Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation.
Scientific reports
McGuire VA,Ruiz-Zorrilla Diez T,Emmerich CH,Strickson S,Ritorto MS,Sutavani RV,Weiβ A,Houslay KF,Knebel A,Meakin PJ,Phair IR,Ashford ML,Trost M,Arthur JS
Mon Aug 08 00:00:00 UTC 2016
Combining Exosomes Derived from Immature DCs with Donor Antigen-Specific Treg Cells Induces Tolerance in a Rat Liver Allograft Model.
Scientific reports
Ma B,Yang JY,Song WJ,Ding R,Zhang ZC,Ji HC,Zhang X,Wang JL,Yang XS,Tao KS,Dou KF,Li X
Mon Sep 19 00:00:00 UTC 2016
The helminth product, ES-62 modulates dendritic cell responses by inducing the selective autophagolysosomal degradation of TLR-transducers, as exemplified by PKCδ.
Scientific reports
Eason RJ,Bell KS,Marshall FA,Rodgers DT,Pineda MA,Steiger CN,Al-Riyami L,Harnett W,Harnett MM
Mon Nov 21 00:00:00 UTC 2016
M2-polarized macrophages contribute to neovasculogenesis, leading to relapse of oral cancer following radiation.
Scientific reports
Okubo M,Kioi M,Nakashima H,Sugiura K,Mitsudo K,Aoki I,Taniguchi H,Tohnai I
Wed Jun 08 00:00:00 UTC 2016
The anti-apoptotic Bcl-2 family protein A1/Bfl-1 regulates neutrophil survival and homeostasis and is controlled via PI3K and JAK/STAT signaling.
Cell death & disease
Vier J,Groth M,Sochalska M,Kirschnek S
Thu Feb 18 00:00:00 UTC 2016
Glucocorticoid Induces Hepatic Steatosis by Inhibiting Activating Transcription Factor 3 (ATF3)/S100A9 Protein Signaling in Granulocytic Myeloid-derived Suppressor Cells.
The Journal of biological chemistry
Liu YF,Wei JY,Shi MH,Jiang H,Zhou J
Fri Oct 07 00:00:00 UTC 2016
Manipulation of Interleukin-1β and Interleukin-18 Production by Yersinia pestis Effectors YopJ and YopM and Redundant Impact on Virulence.
The Journal of biological chemistry
Ratner D,Orning MP,Starheim KK,Marty-Roix R,Proulx MK,Goguen JD,Lien E
Fri May 06 00:00:00 UTC 2016
miR-24, miR-30b and miR-142-3p interfere with antigen processing and presentation by primary macrophages and dendritic cells.
Scientific reports
Naqvi AR,Fordham JB,Ganesh B,Nares S
Fri Sep 09 00:00:00 UTC 2016
In Vitro Neuroprotective and Anti-Inflammatory Activities of Natural and Semi-Synthetic Spirosteroid Analogues.
Molecules (Basel, Switzerland)
García-Pupo L,Zaldo-Castro A,Exarchou V,Tacoronte-Morales JE,Pieters L,Vanden Berghe W,Nuñez-Figueredo Y,Delgado-Hernández R
315-03 was used in Cell Culture to provide further insights into the role of specific modifications of the A and B rings of sapogenins for their neuroprotective potential.
Fri Jul 29 00:00:00 UTC 2016
Critical Role of Transcription Factor PU.1 in the Function of the OX40L/TNFSF4 Promoter in Dendritic Cells.
Scientific reports
Yashiro T,Hara M,Ogawa H,Okumura K,Nishiyama C
Thu Oct 06 00:00:00 UTC 2016
Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice.
Scientific reports
Watari K,Shibata T,Nabeshima H,Shinoda A,Fukunaga Y,Kawahara A,Karasuyama K,Fukushi J,Iwamoto Y,Kuwano M,Ono M
Mon Jan 18 00:00:00 UTC 2016
Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer.
The Journal of biological chemistry
Miki Y,Kidoguchi Y,Sato M,Taketomi Y,Taya C,Muramatsu K,Gelb MH,Yamamoto K,Murakami M
Fri Jul 22 00:00:00 UTC 2016
Combinational Immunotherapy with Allo-DRibble Vaccines and Anti-OX40 Co-Stimulation Leads to Generation of Cross-Reactive Effector T Cells and Tumor Regression.
Scientific reports
Yu G,Li Y,Cui Z,Morris NP,Weinberg AD,Fox BA,Urba WJ,Wang L,Hu HM
Tue Nov 22 00:00:00 UTC 2016
Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells.
The Journal of biological chemistry
Wittmann A,Lamprinaki D,Bowles KM,Katzenellenbogen E,Knirel YA,Whitfield C,Nishimura T,Matsumoto N,Yamamoto K,Iwakura Y,Saijo S,Kawasaki N
Fri Aug 19 00:00:00 UTC 2016
Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages.
Nature communications
Canton J,Schlam D,Breuer C,Gütschow M,Glogauer M,Grinstein S
Wed Apr 06 00:00:00 UTC 2016
Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 (Ape1/Ref-1) Modulates Antigen Presenting Cell-mediated T Helper Cell Type 1 Responses.
The Journal of biological chemistry
Akhter N,Takeda Y,Nara H,Araki A,Ishii N,Asao N,Asao H
Fri Nov 04 00:00:00 UTC 2016
Bacillus amyloliquefaciens SQR9 induces dendritic cell maturation and enhances the immune response against inactivated avian influenza virus.
Scientific reports
Huang L,Qin T,Yin Y,Gao X,Lin J,Yang Q,Yu Q
Fri Feb 19 00:00:00 UTC 2016
AML1/ETO accelerates cell migration and impairs cell-to-cell adhesion and homing of hematopoietic stem/progenitor cells.
Scientific reports
Saia M,Termanini A,Rizzi N,Mazza M,Barbieri E,Valli D,Ciana P,Gruszka AM,Alcalay M
Fri Oct 07 00:00:00 UTC 2016
Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche.
Nature communications
Hu X,Garcia M,Weng L,Jung X,Murakami JL,Kumar B,Warden CD,Todorov I,Chen CC
Mon Oct 10 00:00:00 UTC 2016
Mice Deficient in Angiopoietin-like Protein 2 (Angptl2) Gene Show Increased Susceptibility to Bacterial Infection Due to Attenuated Macrophage Activity.
The Journal of biological chemistry
Yugami M,Odagiri H,Endo M,Tsutsuki H,Fujii S,Kadomatsu T,Masuda T,Miyata K,Terada K,Tanoue H,Ito H,Morinaga J,Horiguchi H,Sugizaki T,Akaike T,Gotoh T,Takai T,Sawa T,Mizuta H,Oike Y
Fri Sep 02 00:00:00 UTC 2016
A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In Vivo Infection.
Cell reports
Tzeng TC,Schattgen S,Monks B,Wang D,Cerny A,Latz E,Fitzgerald K,Golenbock DT
315-03 was used in Cell Culture to develop transgenic mice that express the fluorescent adaptor protein, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and characterized the formation of assembled inflammasome complexes (specks") in primary cells and tissues."
Tue Jul 12 00:00:00 UTC 2016
Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity.
Nature
Carmi Y,Spitzer MH,Linde IL,Burt BM,Prestwood TR,Perlman N,Davidson MG,Kenkel JA,Segal E,Pusapati GV,Bhattacharya N,Engleman EG
Thu May 07 00:00:00 UTC 2015
Efficient intracellular delivery of native proteins.
Cell
D'Astolfo DS,Pagliero RJ,Pras A,Karthaus WR,Clevers H,Prasad V,Lebbink RJ,Rehmann H,Geijsen N
Thu Apr 23 00:00:00 UTC 2015
GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c(+)MHCII(+) Macrophages and Dendritic Cells.
Immunity
Helft J,Böttcher J,Chakravarty P,Zelenay S,Huotari J,Schraml BU,Goubau D,Reis e Sousa C
Tue Jun 16 00:00:00 UTC 2015
MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia.
Blood
Roychoudhury J,Clark JP,Gracia-Maldonado G,Unnisa Z,Wunderlich M,Link KA,Dasgupta N,Aronow B,Huang G,Mulloy JC,Kumar AR
Thu Apr 16 00:00:00 UTC 2015
In vitro-generated MDSCs prevent murine GVHD by inducing type 2 T cells without disabling antitumor cytotoxicity.
Blood
Messmann JJ,Reisser T,Leithäuser F,Lutz MB,Debatin KM,Strauss G
Thu Aug 27 00:00:00 UTC 2015
IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production.
Blood
Yáñez A,Ng MY,Hassanzadeh-Kiabi N,Goodridge HS
Thu Feb 26 00:00:00 UTC 2015
Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses.
The Journal of experimental medicine
Sawada Y,Honda T,Hanakawa S,Nakamizo S,Murata T,Ueharaguchi-Tanada Y,Ono S,Amano W,Nakajima S,Egawa G,Tanizaki H,Otsuka A,Kitoh A,Dainichi T,Ogawa N,Kobayashi Y,Yokomizo T,Arita M,Nakamura M,Miyachi Y,Kabashima K
Mon Oct 19 00:00:00 UTC 2015
Insulin-InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages.
The Journal of experimental medicine
Xia P,Wang S,Du Y,Huang G,Satoh T,Akira S,Fan Z
Mon Dec 14 00:00:00 UTC 2015
Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation.
Proceedings of the National Academy of Sciences of the United States of America
Wang W,Gao Q,Yang M,Zhang X,Yu L,Lawas M,Li X,Bryant-Genevier M,Southall NT,Marugan J,Ferrer M,Xu H
Tue Mar 17 00:00:00 UTC 2015
Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration.
Proceedings of the National Academy of Sciences of the United States of America
Krishnaswamy JK,Singh A,Gowthaman U,Wu R,Gorrepati P,Sales Nascimento M,Gallman A,Liu D,Rhebergen AM,Calabro S,Xu L,Ranney P,Srivastava A,Ranson M,Gorham JD,McCaw Z,Kleeberger SR,Heinz LX,Müller AC,Bennett KL,Superti-Furga G,Henao-Mejia J,Sutterwala FS,Williams A,Flavell RA,Eisenbarth SC
Tue Mar 10 00:00:00 UTC 2015
Controlled analysis of nanoparticle charge on mucosal and systemic antibody responses following pulmonary immunization.
Proceedings of the National Academy of Sciences of the United States of America
Fromen CA,Robbins GR,Shen TW,Kai MP,Ting JP,DeSimone JM
Tue Jan 13 00:00:00 UTC 2015
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases.
Proceedings of the National Academy of Sciences of the United States of America
Gao D,Li T,Li XD,Chen X,Li QZ,Wight-Carter M,Chen ZJ
Tue Oct 20 00:00:00 UTC 2015
IL-1R signaling enables bystander cells to overcome bacterial blockade of host protein synthesis.
Proceedings of the National Academy of Sciences of the United States of America
Copenhaver AM,Casson CN,Nguyen HT,Duda MM,Shin S
Tue Jun 16 00:00:00 UTC 2015
CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer.
Proceedings of the National Academy of Sciences of the United States of America
Cheah MT,Chen JY,Sahoo D,Contreras-Trujillo H,Volkmer AK,Scheeren FA,Volkmer JP,Weissman IL
Tue Apr 14 00:00:00 UTC 2015
Injectable, Pore-Forming Hydrogels for In Vivo Enrichment of Immature Dendritic Cells.
Advanced healthcare materials
Verbeke CS,Mooney DJ
315-03 was used in Conjugation assays to investigate dendritic cell modulation by biomaterial-based vaccines.
Wed Dec 09 00:00:00 UTC 2015
Dendritic cell CD83 homotypic interactions regulate inflammation and promote mucosal homeostasis.
Mucosal immunology
Bates JM,Flanagan K,Mo L,Ota N,Ding J,Ho S,Liu S,Roose-Girma M,Warming S,Diehl L
Sun Mar 01 00:00:00 UTC 2015
Mannose 6 phosphorylation of lysosomal enzymes controls B cell functions.
The Journal of cell biology
Otomo T,Schweizer M,Kollmann K,Schumacher V,Muschol N,Tolosa E,Mittrücker HW,Braulke T
Mon Jan 19 00:00:00 UTC 2015
TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN.
European journal of immunology
Temizoz B,Kuroda E,Ohata K,Jounai N,Ozasa K,Kobiyama K,Aoshi T,Ishii KJ
Wed Apr 01 00:00:00 UTC 2015
Batf3-dependent CD103+ dendritic cells are major producers of IL-12 that drive local Th1 immunity against Leishmania major infection in mice.
European journal of immunology
Martínez-López M,Iborra S,Conde-Garrosa R,Sancho D
Thu Jan 01 00:00:00 UTC 2015
MN1-Fli1 oncofusion transforms murine hematopoietic progenitor cells into acute megakaryoblastic leukemia cells.
Oncogenesis
Wenge DV,Felipe-Fumero E,Angenendt L,Schliemann C,Schmidt E,Schmidt LH,Thiede C,Ehninger G,Berdel WE,Arteaga MF,Mikesch JH
Mon Dec 21 00:00:00 UTC 2015
Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation.
Stem cells (Dayton, Ohio)
Zeng Y,Broxmeyer HE,Staser K,Chitteti BR,Park SJ,Hahn S,Cooper S,Sun Z,Jiang L,Yang X,Yuan J,Kosoff R,Sandusky G,Srour EF,Chernoff J,Clapp DW
Fri May 01 00:00:00 UTC 2015
A novel regulatory macrophage induced by a helminth molecule instructs IL-10 in CD4+ T cells and protects against mucosal inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Ziegler T,Rausch S,Steinfelder S,Klotz C,Hepworth MR,Kühl AA,Burda PC,Lucius R,Hartmann S
Sun Feb 15 00:00:00 UTC 2015
Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Vaeth M,Zee I,Concepcion AR,Maus M,Shaw P,Portal-Celhay C,Zahra A,Kozhaya L,Weidinger C,Philips J,Unutmaz D,Feske S
Sat Aug 01 00:00:00 UTC 2015
TSLP expression: analysis with a ZsGreen TSLP reporter mouse.
Journal of immunology (Baltimore, Md. : 1950)
Dewas C,Chen X,Honda T,Junttila I,Linton J,Udey MC,Porcella SF,Sturdevant DE,Feigenbaum L,Koo L,Williams J,Paul WE
Sun Feb 01 00:00:00 UTC 2015
miR-155 Upregulation in Dendritic Cells Is Sufficient To Break Tolerance In Vivo by Negatively Regulating SHIP1.
Journal of immunology (Baltimore, Md. : 1950)
Lind EF,Millar DG,Dissanayake D,Savage JC,Grimshaw NK,Kerr WG,Ohashi PS
Sun Nov 15 00:00:00 UTC 2015
Interaction of Macrophage Antigen 1 and CD40 Ligand Leads to IL-12 Production and Resistance in CD40-Deficient Mice Infected with Leishmania major.
Journal of immunology (Baltimore, Md. : 1950)
Okwor I,Jia P,Uzonna JE
Thu Oct 01 00:00:00 UTC 2015
IL-4-Producing Dendritic Cells Induced during Schistosoma japonica Infection Promote Th2 Cells via IL-4-Dependent Pathway.
Journal of immunology (Baltimore, Md. : 1950)
Ma YL,Huang FJ,Cong L,Gong WC,Bai HM,Li J,Chen CX,Zhou NY,Jiang XL,Yin L,Chen XP
Thu Oct 15 00:00:00 UTC 2015
Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma.
Journal of immunology (Baltimore, Md. : 1950)
Dey M,Chang AL,Miska J,Wainwright DA,Ahmed AU,Balyasnikova IV,Pytel P,Han Y,Tobias A,Zhang L,Qiao J,Lesniak MS
Wed Jul 01 00:00:00 UTC 2015
Engulfment of activated apoptotic cells abolishes TGF-β-mediated immunoregulation via the induction of IL-6.
Journal of immunology (Baltimore, Md. : 1950)
Notley CA,Brown MA,McGovern JL,Jordan CK,Ehrenstein MR
Sun Feb 15 00:00:00 UTC 2015
Regulatory Rebound in IL-12-Treated Tumors Is Driven by Uncommitted Peripheral Regulatory T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Li Q,Virtuoso LP,Anderson CD,Egilmez NK
Sat Aug 01 00:00:00 UTC 2015
TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils.
Journal of immunology (Baltimore, Md. : 1950)
Radjabova V,Mastroeni P,Skjødt K,Zaccone P,de Bono B,Goodall JC,Chilvers ER,Juss JK,Jones DC,Trowsdale J,Barrow AD
Thu Oct 01 00:00:00 UTC 2015
FOXO3-NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function.
Journal of immunology (Baltimore, Md. : 1950)
Thompson MG,Larson M,Vidrine A,Barrios K,Navarro F,Meyers K,Simms P,Prajapati K,Chitsike L,Hellman LM,Baker BM,Watkins SK
Tue Dec 15 00:00:00 UTC 2015
Genetic vaccines to potentiate the effective CD103+ dendritic cell-mediated cross-priming of antitumor immunity.
Journal of immunology (Baltimore, Md. : 1950)
Zhang Y,Chen G,Liu Z,Tian S,Zhang J,Carey CD,Murphy KM,Storkus WJ,Falo LD,You Z
Mon Jun 15 00:00:00 UTC 2015
FTY720 Abrogates Collagen-Induced Arthritis by Hindering Dendritic Cell Migration to Local Lymph Nodes.
Journal of immunology (Baltimore, Md. : 1950)
Han Y,Li X,Zhou Q,Jie H,Lao X,Han J,He J,Liu X,Gu D,He Y,Sun E
Sun Nov 01 00:00:00 UTC 2015
Optimal T Cell Activation and B Cell Antibody Responses In Vivo Require the Interaction between Leukocyte Function-Associated Antigen-1 and Kindlin-3.
Journal of immunology (Baltimore, Md. : 1950)
Morrison VL,Uotila LM,Llort Asens M,Savinko T,Fagerholm SC
Wed Jul 01 00:00:00 UTC 2015
A Lymphotoxin/Type I IFN Axis Programs CD8+ T Cells To Infiltrate a Self-Tissue and Propagate Immunopathology.
Journal of immunology (Baltimore, Md. : 1950)
Ng D,Maître B,Cummings D,Lin A,Ward LA,Rahbar R,Mossman KL,Ohashi PS,Gommerman JL
Sun Nov 15 00:00:00 UTC 2015
Beta-catenin signaling drives differentiation and proinflammatory function of IRF8-dependent dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Cohen SB,Smith NL,McDougal C,Pepper M,Shah S,Yap GS,Acha-Orbea H,Jiang A,Clausen BE,Rudd BD,Denkers EY
Thu Jan 01 00:00:00 UTC 2015
Haploinsufficiency for Stard7 is associated with enhanced allergic responses in lung and skin.
Journal of immunology (Baltimore, Md. : 1950)
Yang L,Lewkowich I,Apsley K,Fritz JM,Wills-Karp M,Weaver TE
Mon Jun 15 00:00:00 UTC 2015
Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.
Journal of immunology (Baltimore, Md. : 1950)
Suryawanshi A,Manoharan I,Hong Y,Swafford D,Majumdar T,Taketo MM,Manicassamy B,Koni PA,Thangaraju M,Sun Z,Mellor AL,Munn DH,Manicassamy S
Wed Apr 01 00:00:00 UTC 2015
IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Shimizu K,Nakajima A,Sudo K,Liu Y,Mizoroki A,Ikarashi T,Horai R,Kakuta S,Watanabe T,Iwakura Y
Wed Apr 01 00:00:00 UTC 2015
Internalized Cryptococcus neoformans Activates the Canonical Caspase-1 and the Noncanonical Caspase-8 Inflammasomes.
Journal of immunology (Baltimore, Md. : 1950)
Chen M,Xing Y,Lu A,Fang W,Sun B,Chen C,Liao W,Meng G
Sun Nov 15 00:00:00 UTC 2015
Extracorporeal photopheresis promotes IL-1β production.
Journal of immunology (Baltimore, Md. : 1950)
Yakut E,Jakobs C,Peric A,Michel G,Baal N,Bein G,Brüne B,Hornung V,Hackstein H
Sun Mar 15 00:00:00 UTC 2015
FOXO1 regulates dendritic cell activity through ICAM-1 and CCR7.
Journal of immunology (Baltimore, Md. : 1950)
Dong G,Wang Y,Xiao W,Pacios Pujado S,Xu F,Tian C,Xiao E,Choi Y,Graves DT
Wed Apr 15 00:00:00 UTC 2015
Monitoring and cell-specific deletion of C5aR1 using a novel floxed GFP-C5aR1 reporter knock-in mouse.
Journal of immunology (Baltimore, Md. : 1950)
Karsten CM,Laumonnier Y,Eurich B,Ender F,Bröker K,Roy S,Czabanska A,Vollbrandt T,Figge J,Köhl J
Sun Feb 15 00:00:00 UTC 2015
Expression of Cationic Amino Acid Transporter 2 Is Required for Myeloid-Derived Suppressor Cell-Mediated Control of T Cell Immunity.
Journal of immunology (Baltimore, Md. : 1950)
Cimen Bozkus C,Elzey BD,Crist SA,Ellies LG,Ratliff TL
Tue Dec 01 00:00:00 UTC 2015
β-arrestin1 is critical for the full activation of NLRP3 and NLRC4 inflammasomes.
Journal of immunology (Baltimore, Md. : 1950)
Mao K,Chen S,Wang Y,Zeng Y,Ma Y,Hu Y,Zhang H,Sun S,Wu X,Meng G,Pei G,Sun B
Sun Feb 15 00:00:00 UTC 2015
Deficiency of CD40 Reveals an Important Role for LIGHT in Anti-Leishmania Immunity.
Journal of immunology (Baltimore, Md. : 1950)
Okwor I,Xu G,Tang H,Liang Y,Fu YX,Uzonna JE
Wed Jul 01 00:00:00 UTC 2015
A ceramide analogue stimulates dendritic cells to promote T cell responses upon virus infections.
Journal of immunology (Baltimore, Md. : 1950)
Pritzl CJ,Seo YJ,Xia C,Vijayan M,Stokes ZD,Hahm B
Fri May 01 00:00:00 UTC 2015
Effector T Cell Egress via Afferent Lymph Modulates Local Tissue Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Gómez D,Diehl MC,Crosby EJ,Weinkopff T,Debes GF
Thu Oct 15 00:00:00 UTC 2015
The In Vivo Granulopoietic Response to Dexamethasone Injection Is Abolished in Perforin-Deficient Mutant Mice and Corrected by Lymphocyte Transfer from Nonsensitized Wild-Type Donors.
Mediators of inflammation
Xavier-Elsas P,da Silva CL,Vieira BM,Masid-de-Brito D,Queto T,de Luca B,Vieira TS,Gaspar-Elsas MI
315-03 was used in Cell Culture to demonstrate that the perforin-dependent, granulopoietic response to dexamethasone can be restored by transfer of innate lymphocyte subpopulations.
Fri Feb 12 00:00:00 UTC 2016
Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling.
The Journal of biological chemistry
Antonopoulos C,Russo HM,El Sanadi C,Martin BN,Li X,Kaiser WJ,Mocarski ES,Dubyak GR
Fri Aug 14 00:00:00 UTC 2015
TLR-3 stimulation improves anti-tumor immunity elicited by dendritic cell exosome-based vaccines in a murine model of melanoma.
Scientific reports
Damo M,Wilson DS,Simeoni E,Hubbell JA
Thu Dec 03 00:00:00 UTC 2015
Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity.
Scientific reports
Uematsu T,Iizasa E,Kobayashi N,Yoshida H,Hara H
Wed Dec 02 00:00:00 UTC 2015
Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury.
Nature communications
Ito M,Shichita T,Okada M,Komine R,Noguchi Y,Yoshimura A,Morita R
Wed Jun 10 00:00:00 UTC 2015
TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus.
Nature communications
Matsuda T,Murao N,Katano Y,Juliandi B,Kohyama J,Akira S,Kawai T,Nakashima K
Mon Mar 09 00:00:00 UTC 2015
Higher Sensitivity of Foxp3+ Treg Compared to Foxp3- Conventional T Cells to TCR-Independent Signals for CD69 Induction.
PloS one
Bremser A,Brack M,Izcue A
315-03 was used in Sample Prep (FC/FACS) to investigate the effects of TCR signals on T cells through studying the expression of T cell activation marker CD69.
Tue May 24 00:00:00 UTC 2016
Can dendritic cells improve whole cancer cell vaccines based on immunogenically killed cancer cells?
Oncoimmunology
Cicchelero L,Denies S,Devriendt B,de Rooster H,Sanders NN
315-03 was used in In vitro experiments to study whether dendritic cells can improve whole cancer cell vaccines.
Tue Dec 01 00:00:00 UTC 2015
Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts.
Stem cell reports
Neri T,Muggeo S,Paulis M,Caldana ME,Crisafulli L,Strina D,Focarelli ML,Faggioli F,Recordati C,Scaramuzza S,Scanziani E,Mantero S,Buracchi C,Sobacchi C,Lombardo A,Naldini L,Vezzoni P,Villa A,Ficara F
Tue Oct 13 00:00:00 UTC 2015
Fancb deficiency impairs hematopoietic stem cell function.
Scientific reports
Du W,Amarachintha S,Erden O,Wilson A,Meetei AR,Andreassen PR,Namekawa SH,Pang Q
Fri Dec 11 00:00:00 UTC 2015
CD8(+)NKT-like cells regulate the immune response by killing antigen-bearing DCs.
Scientific reports
Wang C,Liu X,Li Z,Chai Y,Jiang Y,Wang Q,Ji Y,Zhu Z,Wan Y,Yuan Z,Chang Z,Zhang M
Tue Sep 15 00:00:00 UTC 2015
IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells.
Nature communications
Wan CK,Li P,Spolski R,Oh J,Andraski AB,Du N,Yu ZX,Dillon CP,Green DR,Leonard WJ
Thu Aug 13 00:00:00 UTC 2015
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.
Nature communications
Alvarez S,Díaz M,Flach J,Rodriguez-Acebes S,López-Contreras AJ,Martínez D,Cañamero M,Fernández-Capetillo O,Isern J,Passegué E,Méndez J
Mon Oct 12 00:00:00 UTC 2015
A TLR9 agonist enhances the anti-tumor immunity of peptide and lipopeptide vaccines via different mechanisms.
Scientific reports
Song YC,Liu SJ
Tue Jul 28 00:00:00 UTC 2015
Apoptotic cell clearance of Leishmania major-infected neutrophils by dendritic cells inhibits CD8⁺ T-cell priming in vitro by Mer tyrosine kinase-dependent signaling.
Cell death & disease
Ribeiro-Gomes FL,Romano A,Lee S,Roffê E,Peters NC,Debrabant A,Sacks D
Thu Dec 10 00:00:00 UTC 2015
Deficiency of β Common Receptor Moderately Attenuates the Progression of Myeloproliferative Neoplasm in NrasG12D/+ Mice.
The Journal of biological chemistry
Zhang J,Ranheim EA,Du J,Liu Y,Wang J,Kong G,Zhang J
Fri Jul 31 00:00:00 UTC 2015
A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells.
Nature communications
Cook PC,Owen H,Deaton AM,Borger JG,Brown SL,Clouaire T,Jones GR,Jones LH,Lundie RJ,Marley AK,Morrison VL,Phythian-Adams AT,Wachter E,Webb LM,Sutherland TE,Thomas GD,Grainger JR,Selfridge J,McKenzie AN,Allen JE,Fagerholm SC,Maizels RM,Ivens AC,Bird A,MacDonald AS
Fri Apr 24 00:00:00 UTC 2015
A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3.
Nature
Murthy A,Li Y,Peng I,Reichelt M,Katakam AK,Noubade R,Roose-Girma M,DeVoss J,Diehl L,Graham RR,van Lookeren Campagne M
Thu Feb 27 00:00:00 UTC 2014
Endosomes are specialized platforms for bacterial sensing and NOD2 signalling.
Nature
Nakamura N,Lill JR,Phung Q,Jiang Z,Bakalarski C,de Mazière A,Klumperman J,Schlatter M,Delamarre L,Mellman I
Thu May 08 00:00:00 UTC 2014
L-Myc expression by dendritic cells is required for optimal T-cell priming.
Nature
KC W,Satpathy AT,Rapaport AS,Briseño CG,Wu X,Albring JC,Russler-Germain EV,Kretzer NM,Durai V,Persaud SP,Edelson BT,Loschko J,Cella M,Allen PM,Nussenzweig MC,Colonna M,Sleckman BP,Murphy TL,Murphy KM
Thu Mar 13 00:00:00 UTC 2014
CRISPR-Cas9 knockin mice for genome editing and cancer modeling.
Cell
Platt RJ,Chen S,Zhou Y,Yim MJ,Swiech L,Kempton HR,Dahlman JE,Parnas O,Eisenhaure TM,Jovanovic M,Graham DB,Jhunjhunwala S,Heidenreich M,Xavier RJ,Langer R,Anderson DG,Hacohen N,Regev A,Feng G,Sharp PA,Zhang F
Thu Oct 09 00:00:00 UTC 2014
Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages.
Cell
Haldar M,Kohyama M,So AY,Kc W,Wu X,Briseño CG,Satpathy AT,Kretzer NM,Arase H,Rajasekaran NS,Wang L,Egawa T,Igarashi K,Baltimore D,Murphy TL,Murphy KM
Thu Mar 13 00:00:00 UTC 2014
Autoimmune disorders associated with gain of function of the intracellular sensor MDA5.
Immunity
Funabiki M,Kato H,Miyachi Y,Toki H,Motegi H,Inoue M,Minowa O,Yoshida A,Deguchi K,Sato H,Ito S,Shiroishi T,Takeyasu K,Noda T,Fujita T
Thu Feb 20 00:00:00 UTC 2014
Epigenetic control of dendritic cell development and fate determination of common myeloid progenitor by Mysm1.
Blood
Won H,Nandakumar V,Yates P,Sanchez S,Jones L,Huang XF,Chen SY
Thu Oct 23 00:00:00 UTC 2014
Skin exposure promotes a Th2-dependent sensitization to peanut allergens.
The Journal of clinical investigation
Tordesillas L,Goswami R,Benedé S,Grishina G,Dunkin D,Järvinen KM,Maleki SJ,Sampson HA,Berin MC
Sat Nov 01 00:00:00 UTC 2014
Circulating T follicular regulatory and helper cells have memory-like properties.
The Journal of clinical investigation
Sage PT,Alvarez D,Godec J,von Andrian UH,Sharpe AH
Mon Dec 01 00:00:00 UTC 2014
Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons.
The Journal of experimental medicine
Pietras EM,Lakshminarasimhan R,Techner JM,Fong S,Flach J,Binnewies M,Passegué E
Mon Feb 10 00:00:00 UTC 2014
Initiation of MLL-rearranged AML is dependent on C/EBPα.
The Journal of experimental medicine
Ohlsson E,Hasemann MS,Willer A,Lauridsen FK,Rapin N,Jendholm J,Porse BT
Mon Jan 13 00:00:00 UTC 2014
Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension.
The Journal of experimental medicine
Sawada H,Saito T,Nickel NP,Alastalo TP,Glotzbach JP,Chan R,Haghighat L,Fuchs G,Januszyk M,Cao A,Lai YJ,Perez Vde J,Kim YM,Wang L,Chen PI,Spiekerkoetter E,Mitani Y,Gurtner GC,Sarnow P,Rabinovitch M
Mon Feb 10 00:00:00 UTC 2014
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
The Journal of experimental medicine
Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z
Mon Sep 22 00:00:00 UTC 2014
Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response.
The Journal of experimental medicine
Wang D,Zheng M,Qiu Y,Guo C,Ji J,Lei L,Zhang X,Liang J,Lou J,Huang W,Dong B,Wu S,Wang J,Ke Y,Cao X,Zhou YT,Lu L
Mon Dec 15 00:00:00 UTC 2014
High c-Kit expression identifies hematopoietic stem cells with impaired self-renewal and megakaryocytic bias.
The Journal of experimental medicine
Shin JY,Hu W,Naramura M,Park CY
Mon Feb 10 00:00:00 UTC 2014
CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity.
The Journal of experimental medicine
Jia XM,Tang B,Zhu LL,Liu YH,Zhao XQ,Gorjestani S,Hsu YM,Yang L,Guan JH,Xu GT,Lin X
Mon Oct 20 00:00:00 UTC 2014
Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America
Brenner D,Brüstle A,Lin GH,Lang PA,Duncan GS,Knobbe-Thomsen CB,St Paul M,Reardon C,Tusche MW,Snow B,Hamilton SR,Pfefferle A,Gilani SO,Ohashi PS,Lang KS,Mak TW
Tue Jan 21 00:00:00 UTC 2014
C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens.
Proceedings of the National Academy of Sciences of the United States of America
Baudino L,Sardini A,Ruseva MM,Fossati-Jimack L,Cook HT,Scott D,Simpson E,Botto M
Tue Jan 28 00:00:00 UTC 2014
Local immunostimulation leading to rejection of accepted male skin grafts by female mice as a model for cancer immunotherapy.
Proceedings of the National Academy of Sciences of the United States of America
Bourdeaux C,Lurquin C,Jacquemart I,Lethé B,Brasseur F,van Baren N,Baurain JF,Dyson J,Van Snick J,Uyttenhove C,Boon T
Tue Mar 04 00:00:00 UTC 2014
Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity.
Proceedings of the National Academy of Sciences of the United States of America
Kuniyoshi K,Takeuchi O,Pandey S,Satoh T,Iwasaki H,Akira S,Kawai T
Tue Apr 15 00:00:00 UTC 2014
FcγRIIb inhibits immune complex-induced VEGF-A production and intranodal lymphangiogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Clatworthy MR,Harford SK,Mathews RJ,Smith KG
Tue Dec 16 00:00:00 UTC 2014
Essential role for autophagy during invariant NKT cell development.
Proceedings of the National Academy of Sciences of the United States of America
Salio M,Puleston DJ,Mathan TS,Shepherd D,Stranks AJ,Adamopoulou E,Veerapen N,Besra GS,Hollander GA,Simon AK,Cerundolo V
Tue Dec 30 00:00:00 UTC 2014
Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction.
Proceedings of the National Academy of Sciences of the United States of America
Brennan PJ,Tatituri RV,Heiss C,Watts GF,Hsu FF,Veerapen N,Cox LR,Azadi P,Besra GS,Brenner MB
Tue Sep 16 00:00:00 UTC 2014
K-RasV14I recapitulates Noonan syndrome in mice.
Proceedings of the National Academy of Sciences of the United States of America
Hernández-Porras I,Fabbiano S,Schuhmacher AJ,Aicher A,Cañamero M,Cámara JA,Cussó L,Desco M,Heeschen C,Mulero F,Bustelo XR,Guerra C,Barbacid M
Tue Nov 18 00:00:00 UTC 2014
ABCG1-mediated generation of extracellular cholesterol microdomains.
Journal of lipid research
Freeman SR,Jin X,Anzinger JJ,Xu Q,Purushothaman S,Fessler MB,Addadi L,Kruth HS
Wed Jan 01 00:00:00 UTC 2014
1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice.
Journal of immunology (Baltimore, Md. : 1950)
Ferreira GB,Gysemans CA,Demengeot J,da Cunha JP,Vanherwegen AS,Overbergh L,Van Belle TL,Pauwels F,Verstuyf A,Korf H,Mathieu C
Thu May 01 00:00:00 UTC 2014
Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN-γ-producing T cells.
Journal of immunology (Baltimore, Md. : 1950)
Mori T,Iwasaki Y,Seki Y,Iseki M,Katayama H,Yamamoto K,Takatsu K,Takaki S
Fri Aug 15 00:00:00 UTC 2014
Cell depletion in mice that express diphtheria toxin receptor under the control of SiglecH encompasses more than plasmacytoid dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Swiecki M,Wang Y,Riboldi E,Kim AH,Dzutsev A,Gilfillan S,Vermi W,Ruedl C,Trinchieri G,Colonna M
Thu May 01 00:00:00 UTC 2014
Distinct roles of the anaphylatoxins C3a and C5a in dendritic cell-mediated allergic asthma.
Journal of immunology (Baltimore, Md. : 1950)
Engelke C,Wiese AV,Schmudde I,Ender F,Ströver HA,Vollbrandt T,König P,Laumonnier Y,Köhl J
Mon Dec 01 00:00:00 UTC 2014
Lymphatic specific disruption in the fine structure of heparan sulfate inhibits dendritic cell traffic and functional T cell responses in the lymph node.
Journal of immunology (Baltimore, Md. : 1950)
Yin X,Johns SC,Kim D,Mikulski Z,Salanga CL,Handel TM,Macal M,Zúñiga EI,Fuster MM
Sat Mar 01 00:00:00 UTC 2014
TLR-induced cytokines promote effective proinflammatory natural Th17 cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Massot B,Michel ML,Diem S,Ohnmacht C,Latour S,Dy M,Eberl G,Leite-de-Moraes MC
Sun Jun 15 00:00:00 UTC 2014
Inflammation conditions mature dendritic cells to retain the capacity to present new antigens but with altered cytokine secretion function.
Journal of immunology (Baltimore, Md. : 1950)
Vega-Ramos J,Roquilly A,Zhan Y,Young LJ,Mintern JD,Villadangos JA
Wed Oct 15 00:00:00 UTC 2014
Chemokines as novel and versatile reagents for flow cytometry and cell sorting.
Journal of immunology (Baltimore, Md. : 1950)
Le Brocq ML,Fraser AR,Cotton G,Woznica K,McCulloch CV,Hewitt KD,McKimmie CS,Nibbs RJB,Campbell JDM,Graham GJ
Sun Jun 15 00:00:00 UTC 2014
Linkage between dendritic and T cell commitments in human circulating hematopoietic progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Kyoizumi S,Kubo Y,Kajimura J,Yoshida K,Hayashi T,Nakachi K,Young LF,Moore MA,van den Brink MR,Kusunoki Y
Sun Jun 15 00:00:00 UTC 2014
Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signaling.
Journal of immunology (Baltimore, Md. : 1950)
Balmer ML,Schürch CM,Saito Y,Geuking MB,Li H,Cuenca M,Kovtonyuk LV,McCoy KD,Hapfelmeier S,Ochsenbein AF,Manz MG,Slack E,Macpherson AJ
Sat Nov 15 00:00:00 UTC 2014
Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases.
Journal of immunology (Baltimore, Md. : 1950)
Xie JH,Yamniuk AP,Borowski V,Kuhn R,Susulic V,Rex-Rabe S,Yang X,Zhou X,Zhang Y,Gillooly K,Brosius R,Ravishankar R,Waggie K,Mink K,Price L,Rehfuss R,Tamura J,An Y,Cheng L,Abramczyk B,Ignatovich O,Drew P,Grant S,Bryson JW,Suchard S,Salter-Cid L,Nadler S,Suri A
Thu May 01 00:00:00 UTC 2014
CCL2 shapes macrophage polarization by GM-CSF and M-CSF: identification of CCL2/CCR2-dependent gene expression profile.
Journal of immunology (Baltimore, Md. : 1950)
Sierra-Filardi E,Nieto C,Domínguez-Soto A,Barroso R,Sánchez-Mateos P,Puig-Kroger A,López-Bravo M,Joven J,Ardavín C,Rodríguez-Fernández JL,Sánchez-Torres C,Mellado M,Corbí AL
Tue Apr 15 00:00:00 UTC 2014
Eosinophil-derived IL-10 supports chronic nematode infection.
Journal of immunology (Baltimore, Md. : 1950)
Huang L,Gebreselassie NG,Gagliardo LF,Ruyechan MC,Lee NA,Lee JJ,Appleton JA
Wed Oct 15 00:00:00 UTC 2014
Independent of plasmacytoid dendritic cell (pDC) infection, pDC triggered by virus-infected cells mount enhanced type I IFN responses of different composition as opposed to pDC stimulated with free virus.
Journal of immunology (Baltimore, Md. : 1950)
Frenz T,Graalmann L,Detje CN,Döring M,Grabski E,Scheu S,Kalinke U
Mon Sep 01 00:00:00 UTC 2014
MicroRNA-155 and MicroRNA-21 promote the expansion of functional myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Li L,Zhang J,Diao W,Wang D,Wei Y,Zhang CY,Zen K
Sat Feb 01 00:00:00 UTC 2014
GM-CSF-licensed CD11b+ lung dendritic cells orchestrate Th2 immunity to Blomia tropicalis.
Journal of immunology (Baltimore, Md. : 1950)
Zhou Q,Ho AW,Schlitzer A,Tang Y,Wong KH,Wong FH,Chua YL,Angeli V,Mortellaro A,Ginhoux F,Kemeny DM
Tue Jul 15 00:00:00 UTC 2014
IL-5 triggers a cooperative cytokine network that promotes eosinophil precursor maturation.
Journal of immunology (Baltimore, Md. : 1950)
Fulkerson PC,Schollaert KL,Bouffi C,Rothenberg ME
Wed Oct 15 00:00:00 UTC 2014
B cell-intrinsic MyD88 signaling is essential for IgE responses in lungs exposed to pollen allergens.
Journal of immunology (Baltimore, Md. : 1950)
Matsushita K,Yoshimoto T
Mon Dec 15 00:00:00 UTC 2014
Cutting edge: FYCO1 recruitment to dectin-1 phagosomes is accelerated by light chain 3 protein and regulates phagosome maturation and reactive oxygen production.
Journal of immunology (Baltimore, Md. : 1950)
Ma J,Becker C,Reyes C,Underhill DM
Sat Feb 15 00:00:00 UTC 2014
Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Cuda CM,Misharin AV,Gierut AK,Saber R,Haines GK,Hutcheson J,Hedrick SM,Mohan C,Budinger GS,Stehlik C,Perlman H
Sun Jun 15 00:00:00 UTC 2014
Antigen-dependent versus -independent activation of invariant NKT cells during infection.
Journal of immunology (Baltimore, Md. : 1950)
Holzapfel KL,Tyznik AJ,Kronenberg M,Hogquist KA
Sun Jun 15 00:00:00 UTC 2014
The role of spartin and its novel ubiquitin binding region in DALIS occurrence.
Molecular biology of the cell
Karlsson AB,Washington J,Dimitrova V,Hooper C,Shekhtman A,Bakowska JC
315-03 was used in In vitro experiments to study the role of multifunctional protein spartin in dendritic aggresome-like induced structures.
Tue Apr 01 00:00:00 UTC 2014
The formylpeptide receptor 2 (Fpr2) and its endogenous ligand cathelin-related antimicrobial peptide (CRAMP) promote dendritic cell maturation.
The Journal of biological chemistry
Chen K,Xiang Y,Huang J,Gong W,Yoshimura T,Jiang Q,Tessarollo L,Le Y,Wang JM
Fri Jun 20 00:00:00 UTC 2014
Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages.
Nature communications
Ling GS,Bennett J,Woollard KJ,Szajna M,Fossati-Jimack L,Taylor PR,Scott D,Franzoso G,Cook HT,Botto M
Tue Nov 24 00:00:00 UTC 2015
Thrombin cleavage of osteopontin disrupts a pro-chemotactic sequence for dendritic cells, which is compensated by the release of its pro-chemotactic C-terminal fragment.
The Journal of biological chemistry
Shao Z,Morser J,Leung LLK
Fri Sep 26 00:00:00 UTC 2014
Tumor progression locus 2-dependent oxidative burst drives phosphorylation of extracellular signal-regulated kinase during TLR3 and 9 signaling.
The Journal of biological chemistry
Kuriakose T,Rada B,Watford WT
Fri Dec 26 00:00:00 UTC 2014
High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.
Scientific reports
Nair SK,Tomaras GD,Sales AP,Boczkowski D,Chan C,Plonk K,Cai Y,Dannull J,Kepler TB,Pruitt SK,Weinhold KJ
Wed Apr 23 00:00:00 UTC 2014
FOXO3A directs a protective autophagy program in haematopoietic stem cells.
Nature
Warr MR,Binnewies M,Flach J,Reynaud D,Garg T,Malhotra R,Debnath J,Passegué E
Thu Feb 21 00:00:00 UTC 2013
T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response.
Immunity
Carrera Silva EA,Chan PY,Joannas L,Errasti AE,Gagliani N,Bosurgi L,Jabbour M,Perry A,Smith-Chakmakova F,Mucida D,Cheroutre H,Burstyn-Cohen T,Leighton JA,Lemke G,Ghosh S,Rothlin CV
Thu Jul 25 00:00:00 UTC 2013
miR-142-3p prevents macrophage differentiation during cancer-induced myelopoiesis.
Immunity
Sonda N,Simonato F,Peranzoni E,Calì B,Bortoluzzi S,Bisognin A,Wang E,Marincola FM,Naldini L,Gentner B,Trautwein C,Sackett SD,Zanovello P,Molon B,Bronte V
Thu Jun 27 00:00:00 UTC 2013
The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells.
Immunity
Wan CK,Oh J,Li P,West EE,Wong EA,Andraski AB,Spolski R,Yu ZX,He J,Kelsall BL,Leonard WJ
Thu Mar 21 00:00:00 UTC 2013
Tumor necrosis factor-α blocks differentiation and enhances suppressive activity of immature myeloid cells during chronic inflammation.
Immunity
Sade-Feldman M,Kanterman J,Ish-Shalom E,Elnekave M,Horwitz E,Baniyash M
Thu Mar 21 00:00:00 UTC 2013
Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.
Immunity
Koblansky AA,Jankovic D,Oh H,Hieny S,Sungnak W,Mathur R,Hayden MS,Akira S,Sher A,Ghosh S
Thu Jan 24 00:00:00 UTC 2013
The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia.
Cancer cell
Arteaga MF,Mikesch JH,Qiu J,Christensen J,Helin K,Kogan SC,Dong S,So CW
Mon Mar 18 00:00:00 UTC 2013
A CALM-derived nuclear export signal is essential for CALM-AF10-mediated leukemogenesis.
Blood
Conway AE,Scotland PB,Lavau CP,Wechsler DS
Thu Jun 06 00:00:00 UTC 2013
The β2 integrin-kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo.
Blood
Morrison VL,MacPherson M,Savinko T,Lek HS,Prescott A,Fagerholm SC
Thu Aug 22 00:00:00 UTC 2013
Disease-associated missense mutations in the EVH1 domain disrupt intrinsic WASp function causing dysregulated actin dynamics and impaired dendritic cell migration.
Blood
Worth AJ,Metelo J,Bouma G,Moulding D,Fritzsche M,Vernay B,Charras G,Cory GO,Thrasher AJ,Burns SO
Thu Jan 03 00:00:00 UTC 2013
CD8α+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3.
Blood
Seillet C,Jackson JT,Markey KA,Brady HJ,Hill GR,Macdonald KP,Nutt SL,Belz GT
Thu Feb 28 00:00:00 UTC 2013
Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo.
Blood
Shieh A,Ward AF,Donlan KL,Harding-Theobald ER,Xu J,Mullighan CG,Zhang C,Chen SC,Su X,Downing JR,Bollag GE,Shannon KM
Thu Jun 13 00:00:00 UTC 2013
Neutrophil differentiation into a unique hybrid population exhibiting dual phenotype and functionality of neutrophils and dendritic cells.
Blood
Matsushima H,Geng S,Lu R,Okamoto T,Yao Y,Mayuzumi N,Kotol PF,Chojnacki BJ,Miyazaki T,Gallo RL,Takashima A
Thu Mar 07 00:00:00 UTC 2013
Neddylation plays an important role in the regulation of murine and human dendritic cell function.
Blood
Mathewson N,Toubai T,Kapeles S,Sun Y,Oravecz-Wilson K,Tamaki H,Wang Y,Hou G,Sun Y,Reddy P
Thu Sep 19 00:00:00 UTC 2013
The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity in mice through the lytic synapse formation.
Blood
Sakai Y,Tanaka Y,Yanagihara T,Watanabe M,Duan X,Terasawa M,Nishikimi A,Sanematsu F,Fukui Y
Thu Jul 18 00:00:00 UTC 2013
Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences.
Blood
Martinez FO,Helming L,Milde R,Varin A,Melgert BN,Draijer C,Thomas B,Fabbri M,Crawshaw A,Ho LP,Ten Hacken NH,Cobos Jiménez V,Kootstra NA,Hamann J,Greaves DR,Locati M,Mantovani A,Gordon S
Thu Feb 28 00:00:00 UTC 2013
Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk.
The Journal of clinical investigation
Staser K,Park SJ,Rhodes SD,Zeng Y,He YZ,Shew MA,Gehlhausen JR,Cerabona D,Menon K,Chen S,Sun Z,Yuan J,Ingram DA,Nalepa G,Yang FC,Clapp DW
Tue Jan 01 00:00:00 UTC 2013
Cognate antigen directs CD8+ T cell migration to vascularized transplants.
The Journal of clinical investigation
Walch JM,Zeng Q,Li Q,Oberbarnscheidt MH,Hoffman RA,Williams AL,Rothstein DM,Shlomchik WD,Kim JV,Camirand G,Lakkis FG
Sat Jun 01 00:00:00 UTC 2013
Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica.
The Journal of clinical investigation
Zhang H,Verkman AS
Wed May 01 00:00:00 UTC 2013
Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice.
The Journal of clinical investigation
Chang T,Krisman K,Theobald EH,Xu J,Akutagawa J,Lauchle JO,Kogan S,Braun BS,Shannon K
Tue Jan 01 00:00:00 UTC 2013
Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis.
The Journal of clinical investigation
Waight JD,Netherby C,Hensen ML,Miller A,Hu Q,Liu S,Bogner PN,Farren MR,Lee KP,Liu K,Abrams SI
Tue Oct 01 00:00:00 UTC 2013
Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators.
The Journal of experimental medicine
Miki Y,Yamamoto K,Taketomi Y,Sato H,Shimo K,Kobayashi T,Ishikawa Y,Ishii T,Nakanishi H,Ikeda K,Taguchi R,Kabashima K,Arita M,Arai H,Lambeau G,Bollinger JM,Hara S,Gelb MH,Murakami M
Mon Jun 03 00:00:00 UTC 2013
N-ras couples antigen receptor signaling to Eomesodermin and to functional CD8+ T cell memory but not to effector differentiation.
The Journal of experimental medicine
Iborra S,Ramos M,Arana DM,Lázaro S,Aguilar F,Santos E,López D,Fernández-Malavé E,Del Val M
Mon Jul 01 00:00:00 UTC 2013
Sortase-mediated modification of αDEC205 affords optimization of antigen presentation and immunization against a set of viral epitopes.
Proceedings of the National Academy of Sciences of the United States of America
Swee LK,Guimaraes CP,Sehrawat S,Spooner E,Barrasa MI,Ploegh HL
Tue Jan 22 00:00:00 UTC 2013
Immunoglobulins drive terminal maturation of splenic dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America
Zietara N,Łyszkiewicz M,Puchałka J,Pei G,Gutierrez MG,Lienenklaus S,Hobeika E,Reth M,Martins dos Santos VA,Krueger A,Weiss S
Tue Feb 05 00:00:00 UTC 2013
Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Lamagna C,Scapini P,van Ziffle JA,DeFranco AL,Lowell CA
Tue Aug 27 00:00:00 UTC 2013
B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells.
Proceedings of the National Academy of Sciences of the United States of America
Kobayashi Y,Iwata A,Suzuki K,Suto A,Kawashima S,Saito Y,Owada T,Kobayashi M,Watanabe N,Nakajima H
Tue Mar 26 00:00:00 UTC 2013
CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Arndt K,Grinenko T,Mende N,Reichert D,Portz M,Ripich T,Carmeliet P,Corbeil D,Waskow C
Tue Apr 02 00:00:00 UTC 2013
A T-cell response to a liver-stage Plasmodium antigen is not boosted by repeated sporozoite immunizations.
Proceedings of the National Academy of Sciences of the United States of America
Murphy SC,Kas A,Stone BC,Bevan MJ
Tue Apr 09 00:00:00 UTC 2013
Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus.
Proceedings of the National Academy of Sciences of the United States of America
Lee H,Komano J,Saitoh Y,Yamaoka S,Kozaki T,Misawa T,Takahama M,Satoh T,Takeuchi O,Yamamoto N,Matsuura Y,Saitoh T,Akira S
Tue Jul 23 00:00:00 UTC 2013
Mesenchymal stem cells are mobilized from the bone marrow during inflammation.
Frontiers in immunology
Koning JJ,Kooij G,de Vries HE,Nolte MA,Mebius RE
Wed Mar 06 00:00:00 UTC 2013
IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling.
PLoS pathogens
Lazear HM,Lancaster A,Wilkins C,Suthar MS,Huang A,Vick SC,Clepper L,Thackray L,Brassil MM,Virgin HW,Nikolich-Zugich J,Moses AV,Gale M,Früh K,Diamond MS
Tue Jan 01 00:00:00 UTC 2013
Prostaglandin E2 increases hematopoietic stem cell survival and accelerates hematopoietic recovery after radiation injury.
Stem cells (Dayton, Ohio)
Porter RL,Georger MA,Bromberg O,McGrath KE,Frisch BJ,Becker MW,Calvi LM
Fri Feb 01 00:00:00 UTC 2013
Parasite-derived arginase influences secondary anti-Leishmania immunity by regulating programmed cell death-1-mediated CD4+ T cell exhaustion.
Journal of immunology (Baltimore, Md. : 1950)
Mou Z,Muleme HM,Liu D,Jia P,Okwor IB,Kuriakose SM,Beverley SM,Uzonna JE
Mon Apr 01 00:00:00 UTC 2013
Mesenchymal stem cells tune the development of monocyte-derived dendritic cells toward a myeloid-derived suppressive phenotype through growth-regulated oncogene chemokines.
Journal of immunology (Baltimore, Md. : 1950)
Chen HW,Chen HY,Wang LT,Wang FH,Fang LW,Lai HY,Chen HH,Lu J,Hung MS,Cheng Y,Chen MY,Liu SJ,Chong P,Lee OK,Hsu SC
Wed May 15 00:00:00 UTC 2013
Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Fukasaka M,Ori D,Kawagoe T,Uematsu S,Maruyama K,Okazaki T,Kozaki T,Imamura T,Tartey S,Mino T,Satoh T,Akira S,Takeuchi O
Sat Jun 01 00:00:00 UTC 2013
Scavenger receptor A modulates the immune response to pulmonary Cryptococcus neoformans infection.
Journal of immunology (Baltimore, Md. : 1950)
Qiu Y,Dayrit JK,Davis MJ,Carolan JF,Osterholzer JJ,Curtis JL,Olszewski MA
Mon Jul 01 00:00:00 UTC 2013
Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA.
Journal of immunology (Baltimore, Md. : 1950)
Pan H,O'Brien TF,Wright G,Yang J,Shin J,Wright KL,Zhong XP
Mon Jul 15 00:00:00 UTC 2013
Galectin-3 facilitates neutrophil recruitment as an innate immune response to a parasitic protozoa cutaneous infection.
Journal of immunology (Baltimore, Md. : 1950)
Bhaumik P,St-Pierre G,Milot V,St-Pierre C,Sato S
Tue Jan 15 00:00:00 UTC 2013
Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1.
Journal of immunology (Baltimore, Md. : 1950)
Yamazaki C,Sugiyama M,Ohta T,Hemmi H,Hamada E,Sasaki I,Fukuda Y,Yano T,Nobuoka M,Hirashima T,Iizuka A,Sato K,Tanaka T,Hoshino K,Kaisho T
Sat Jun 15 00:00:00 UTC 2013
Altered immunity and dendritic cell activity in the periphery of mice after long-term engraftment with bone marrow from ultraviolet-irradiated mice.
Journal of immunology (Baltimore, Md. : 1950)
Ng RL,Scott NM,Strickland DH,Gorman S,Grimbaldeston MA,Norval M,Waithman J,Hart PH
Sat Jun 01 00:00:00 UTC 2013
The key role of IL-6-arginase cascade for inducing dendritic cell-dependent CD4(+) T cell dysfunction in tumor-bearing mice.
Journal of immunology (Baltimore, Md. : 1950)
Narita Y,Kitamura H,Wakita D,Sumida K,Masuko K,Terada S,Nakano K,Nishimura T
Tue Jan 15 00:00:00 UTC 2013
Cathepsin K is involved in development of psoriasis-like skin lesions through TLR-dependent Th17 activation.
Journal of immunology (Baltimore, Md. : 1950)
Hirai T,Kanda T,Sato K,Takaishi M,Nakajima K,Yamamoto M,Kamijima R,Digiovanni J,Sano S
Wed May 01 00:00:00 UTC 2013
Enhanced endoplasmic reticulum entry of tumor antigen is crucial for cross-presentation induced by dendritic cell-targeted vaccination.
Journal of immunology (Baltimore, Md. : 1950)
Wang H,Yu X,Guo C,Zuo D,Fisher PB,Subjeck JR,Wang XY
Sun Dec 15 00:00:00 UTC 2013
SWAP-70 restricts spontaneous maturation of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Ocaña-Morgner C,Götz A,Wahren C,Jessberger R
Sat Jun 01 00:00:00 UTC 2013
Cutting edge: IL-6-dependent autoimmune disease: dendritic cells as a sufficient, but transient, source.
Journal of immunology (Baltimore, Md. : 1950)
Leech MD,Barr TA,Turner DG,Brown S,O'Connor RA,Gray D,Mellanby RJ,Anderton SM
Fri Feb 01 00:00:00 UTC 2013
Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus.
Journal of immunology (Baltimore, Md. : 1950)
Bossaller L,Rathinam VA,Bonegio R,Chiang PI,Busto P,Wespiser AR,Caffrey DR,Li QZ,Mohan C,Fitzgerald KA,Latz E,Marshak-Rothstein A
Sun Sep 01 00:00:00 UTC 2013
Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Ohta S,Imamura M,Xing W,Boyce JA,Balestrieri B
Sat Jun 15 00:00:00 UTC 2013
Proapoptotic chemotherapeutic drugs induce noncanonical processing and release of IL-1β via caspase-8 in dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Antonopoulos C,El Sanadi C,Kaiser WJ,Mocarski ES,Dubyak GR
Fri Nov 01 00:00:00 UTC 2013
Leishmania-infected MHC class IIhigh dendritic cells polarize CD4+ T cells toward a nonprotective T-bet+ IFN-γ+ IL-10+ phenotype.
Journal of immunology (Baltimore, Md. : 1950)
Resende M,Moreira D,Augusto J,Cunha J,Neves B,Cruz MT,Estaquier J,Cordeiro-da-Silva A,Silvestre R
Mon Jul 01 00:00:00 UTC 2013
Adiponectin deficiency suppresses lymphoma growth in mice by modulating NK cells, CD8 T cells, and myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Han S,Jeong AL,Lee S,Park JS,Kim KD,Choi I,Yoon SR,Lee MS,Lim JS,Han SH,Yoon DY,Yang Y
Wed May 01 00:00:00 UTC 2013
Glioma stem cell-targeted dendritic cells as a tumor vaccine against malignant glioma.
Yonsei medical journal
Ji B,Chen Q,Liu B,Wu L,Tian D,Guo Z,Yi W
Tue Jan 01 00:00:00 UTC 2013
UCP2 deficiency helps to restrict the pathogenesis of experimental cutaneous and visceral leishmaniosis in mice.
PLoS neglected tropical diseases
Carrión J,Abengozar MA,Fernández-Reyes M,Sánchez-Martín C,Rial E,Domínguez-Bernal G,González-Barroso MM
Mon Jul 29 00:00:00 UTC 2013
Major histocompatibility complex (MHC) class II-peptide complexes arrive at the plasma membrane in cholesterol-rich microclusters.
The Journal of biological chemistry
Bosch B,Heipertz EL,Drake JR,Roche PA
Fri May 10 00:00:00 UTC 2013
Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner.
The Journal of biological chemistry
Åhsberg J,Ungerbäck J,Strid T,Welinder E,Stjernberg J,Larsson M,Qian H,Sigvardsson M
Fri Nov 15 00:00:00 UTC 2013
Toll-like receptor 4 engagement drives differentiation of human and murine dendritic cells from a pro- into an anti-inflammatory mode.
PloS one
Luger R,Valookaran S,Knapp N,Vizzardelli C,Dohnal AM,Felzmann T
Fri Sep 06 00:00:00 UTC 2013
Spleen tyrosine kinase (Syk)-dependent calcium signals mediate efficient CpG-induced exocytosis of tumor necrosis factor α (TNFα) in innate immune cells.
The Journal of biological chemistry
Rao S,Liu X,Freedman BD,Behrens EM
Fri May 03 00:00:00 UTC 2013
Orientia tsutsugamushi subverts dendritic cell functions by escaping from autophagy and impairing their migration.
PLoS neglected tropical diseases
Choi JH,Cheong TC,Ha NY,Ko Y,Cho CH,Jeon JH,So I,Kim IK,Choi MS,Kim IS,Cho NH
Wed Jun 19 00:00:00 UTC 2013
Live single cell functional phenotyping in droplet nano-liter reactors.
Scientific reports
Konry T,Golberg A,Yarmush M
Mon Nov 11 00:00:00 UTC 2013
Dysregulated hematopoietic stem and progenitor cell activity promotes interleukin-23-driven chronic intestinal inflammation.
Immunity
Griseri T,McKenzie BS,Schiering C,Powrie F
Fri Dec 14 00:00:00 UTC 2012
Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression.
Blood
Adhikary S,Kocieda VP,Yen JH,Tuma RF,Ganea D
Thu Nov 01 00:00:00 UTC 2012
Regulatory dendritic cells program B cells to differentiate into CD19hiFcγIIbhi regulatory B cells through IFN-β and CD40L.
Blood
Qian L,Qian C,Chen Y,Bai Y,Bao Y,Lu L,Cao X
Thu Jul 19 00:00:00 UTC 2012
The tumor suppressor p15Ink4b regulates the differentiation and maturation of conventional dendritic cells.
Blood
Fares J,Koller R,Humeniuk R,Wolff L,Bies J
Thu May 24 00:00:00 UTC 2012
Negative effects of GM-CSF signaling in a murine model of t(8;21)-induced leukemia.
Blood
Matsuura S,Yan M,Lo MC,Ahn EY,Weng S,Dangoor D,Matin M,Higashi T,Feng GS,Zhang DE
Thu Mar 29 00:00:00 UTC 2012
Ribosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts.
Blood
Horos R,Ijspeert H,Pospisilova D,Sendtner R,Andrieu-Soler C,Taskesen E,Nieradka A,Cmejla R,Sendtner M,Touw IP,von Lindern M
Thu Jan 05 00:00:00 UTC 2012
IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors.
Blood
Becker AM,Michael DG,Satpathy AT,Sciammas R,Singh H,Bhattacharya D
Thu Mar 01 00:00:00 UTC 2012
Conjugation of lymphoma idiotype to CD40 antibody enhances lymphoma vaccine immunogenicity and antitumor effects in mice.
Blood
Carlring J,Szabo MJ,Dickinson R,De Leenheer E,Heath AW
Thu Mar 01 00:00:00 UTC 2012
Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice.
Blood
Schepers K,Hsiao EC,Garg T,Scott MJ,Passegué E
Thu Oct 25 00:00:00 UTC 2012
Mouse NK cell-mediated rejection of bone marrow allografts exhibits patterns consistent with Ly49 subset licensing.
Blood
Sun K,Alvarez M,Ames E,Barao I,Chen M,Longo DL,Redelman D,Murphy WJ
Thu Feb 09 00:00:00 UTC 2012
FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation.
Blood
Itkin T,Ludin A,Gradus B,Gur-Cohen S,Kalinkovich A,Schajnovitz A,Ovadya Y,Kollet O,Canaani J,Shezen E,Coffin DJ,Enikolopov GN,Berg T,Piacibello W,Hornstein E,Lapidot T
Thu Aug 30 00:00:00 UTC 2012
Critical role of P1-Runx1 in mouse basophil development.
Blood
Mukai K,BenBarak MJ,Tachibana M,Nishida K,Karasuyama H,Taniuchi I,Galli SJ
Thu Jul 05 00:00:00 UTC 2012
Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function.
Blood
Schuettpelz LG,Gopalan PK,Giuste FO,Romine MP,van Os R,Link DC
Thu Oct 11 00:00:00 UTC 2012
TNF signaling drives myeloid-derived suppressor cell accumulation.
The Journal of clinical investigation
Zhao X,Rong L,Zhao X,Li X,Liu X,Deng J,Wu H,Xu X,Erben U,Wu P,Syrbe U,Sieper J,Qin Z
Thu Nov 01 00:00:00 UTC 2012
Viral acute lower respiratory infections impair CD8+ T cells through PD-1.
The Journal of clinical investigation
Erickson JJ,Gilchuk P,Hastings AK,Tollefson SJ,Johnson M,Downing MB,Boyd KL,Johnson JE,Kim AS,Joyce S,Williams JV
Wed Aug 01 00:00:00 UTC 2012
The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells.
The Journal of clinical investigation
Brüstle A,Brenner D,Knobbe CB,Lang PA,Virtanen C,Hershenfield BM,Reardon C,Lacher SM,Ruland J,Ohashi PS,Mak TW
Sat Dec 01 00:00:00 UTC 2012
Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.
The Journal of experimental medicine
Satpathy AT,KC W,Albring JC,Edelson BT,Kretzer NM,Bhattacharya D,Murphy TL,Murphy KM
Mon Jun 04 00:00:00 UTC 2012
High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.
The Journal of experimental medicine
Yang D,Postnikov YV,Li Y,Tewary P,de la Rosa G,Wei F,Klinman D,Gioannini T,Weiss JP,Furusawa T,Bustin M,Oppenheim JJ
Mon Jan 16 00:00:00 UTC 2012
B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1.
The Journal of experimental medicine
Karnowski A,Chevrier S,Belz GT,Mount A,Emslie D,D'Costa K,Tarlinton DM,Kallies A,Corcoran LM
Mon Oct 22 00:00:00 UTC 2012
Injectable preformed scaffolds with shape-memory properties.
Proceedings of the National Academy of Sciences of the United States of America
Bencherif SA,Sands RW,Bhatta D,Arany P,Verbeke CS,Edwards DA,Mooney DJ
Tue Nov 27 00:00:00 UTC 2012
Injectable preformed scaffolds with shape-memory properties.
Proceedings of the National Academy of Sciences of the United States of America
Bencherif SA,Sands RW,Bhatta D,Arany P,Verbeke CS,Edwards DA,Mooney DJ
Tue Nov 27 00:00:00 UTC 2012
Regulation of memory CD4 T-cell pool size and function by natural killer T cells in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Iwamura C,Shinoda K,Endo Y,Watanabe Y,Tumes DJ,Motohashi S,Kawahara K,Kinjo Y,Nakayama T
Tue Oct 16 00:00:00 UTC 2012
Alpha-1-antitrypsin monotherapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation.
Proceedings of the National Academy of Sciences of the United States of America
Tawara I,Sun Y,Lewis EC,Toubai T,Evers R,Nieves E,Azam T,Dinarello CA,Reddy P
Tue Jan 10 00:00:00 UTC 2012
Mouse model recapitulating human Fcγ receptor structural and functional diversity.
Proceedings of the National Academy of Sciences of the United States of America
Smith P,DiLillo DJ,Bournazos S,Li F,Ravetch JV
Tue Apr 17 00:00:00 UTC 2012
Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naive CD4+ and CD8+ T cells.
Proceedings of the National Academy of Sciences of the United States of America
Mandl JN,Liou R,Klauschen F,Vrisekoop N,Monteiro JP,Yates AJ,Huang AY,Germain RN
Tue Oct 30 00:00:00 UTC 2012
DENV inhibits type I IFN production in infected cells by cleaving human STING.
PLoS pathogens
Aguirre S,Maestre AM,Pagni S,Patel JR,Savage T,Gutman D,Maringer K,Bernal-Rubio D,Shabman RS,Simon V,Rodriguez-Madoz JR,Mulder LC,Barber GN,Fernandez-Sesma A
Thu Apr 04 00:00:00 UTC 2013
GABAergic signaling is linked to a hypermigratory phenotype in dendritic cells infected by Toxoplasma gondii.
PLoS pathogens
Fuks JM,Arrighi RB,Weidner JM,Kumar Mendu S,Jin Z,Wallin RP,Rethi B,Birnir B,Barragan A
Thu May 23 00:00:00 UTC 2013
The receptor Slamf1 on the surface of myeloid lineage cells controls susceptibility to infection by Trypanosoma cruzi.
PLoS pathogens
Calderón J,Maganto-Garcia E,Punzón C,Carrión J,Terhorst C,Fresno M
Tue Jan 29 00:00:00 UTC 2013
Effective adoptive transfer of haploidentical tumor-specific T cells in B16-melanoma bearing mice.
Chinese medical journal
Cui NP,Xie SJ,Han JS,Ma ZF,Chen BP,Cai JH
Thu Mar 01 00:00:00 UTC 2012
Effects of interferon-α-transduced tumor cell vaccines and blockade of programmed cell death-1 on the growth of established tumors.
Cancer gene therapy
Omori R,Eguchi J,Hiroishi K,Ishii S,Hiraide A,Sakaki M,Doi H,Kajiwara A,Ito T,Kogo M,Imawari M
Sat Sep 01 00:00:00 UTC 2012
Autoreactive preplasma cells break tolerance in the absence of regulation by dendritic cells and macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Gilbert MR,Wagner NJ,Jones SZ,Wisz AB,Roques JR,Krum KN,Lee SR,Nickeleit V,Hulbert C,Thomas JW,Gauld SB,Vilen BJ
Sun Jul 15 00:00:00 UTC 2012
Lpa2 is a negative regulator of both dendritic cell activation and murine models of allergic lung inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Emo J,Meednu N,Chapman TJ,Rezaee F,Balys M,Randall T,Rangasamy T,Georas SN
Sun Apr 15 00:00:00 UTC 2012
Neuropeptide signaling activates dendritic cell-mediated type 1 immune responses through neurokinin-2 receptor.
Journal of immunology (Baltimore, Md. : 1950)
Kitamura H,Kobayashi M,Wakita D,Nishimura T
Tue May 01 00:00:00 UTC 2012
CD47(high) expression on CD4 effectors identifies functional long-lived memory T cell progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Van VQ,Raymond M,Baba N,Rubio M,Wakahara K,Susin SA,Sarfati M
Tue May 01 00:00:00 UTC 2012
Smad3-deficient CD11b(+)Gr1(+) myeloid-derived suppressor cells prevent allograft rejection via the nitric oxide pathway.
Journal of immunology (Baltimore, Md. : 1950)
Wu T,Sun C,Chen Z,Zhen Y,Peng J,Qi Z,Yang X,Zhao Y
Thu Nov 15 00:00:00 UTC 2012
Selective blockade of herpesvirus entry mediator-B and T lymphocyte attenuator pathway ameliorates acute graft-versus-host reaction.
Journal of immunology (Baltimore, Md. : 1950)
del Rio ML,Jones ND,Buhler L,Norris P,Shintani Y,Ware CF,Rodriguez-Barbosa JI
Tue May 15 00:00:00 UTC 2012
Regulation of the inflammatory response: enhancing neutrophil infiltration under chronic inflammatory conditions.
Journal of immunology (Baltimore, Md. : 1950)
Bian Z,Guo Y,Ha B,Zen K,Liu Y
Sun Jan 15 00:00:00 UTC 2012
Dendritic cell-specific disruption of TGF-β receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Ramalingam R,Larmonier CB,Thurston RD,Midura-Kiela MT,Zheng SG,Ghishan FK,Kiela PR
Mon Oct 15 00:00:00 UTC 2012
Lamin B receptor regulates the growth and maturation of myeloid progenitors via its sterol reductase domain: implications for cholesterol biosynthesis in regulating myelopoiesis.
Journal of immunology (Baltimore, Md. : 1950)
Subramanian G,Chaudhury P,Malu K,Fowler S,Manmode R,Gotur D,Zwerger M,Ryan D,Roberti R,Gaines P
Sun Jan 01 00:00:00 UTC 2012
Splenic stroma-educated regulatory dendritic cells induce apoptosis of activated CD4 T cells via Fas ligand-enhanced IFN-γ and nitric oxide.
Journal of immunology (Baltimore, Md. : 1950)
Xu X,Yi H,Guo Z,Qian C,Xia S,Yao Y,Cao X
Wed Feb 01 00:00:00 UTC 2012
Selective dependence of H2-M3-restricted CD8 responses on IL-15.
Journal of immunology (Baltimore, Md. : 1950)
Müller JR,Waldmann TA,Dubois S
Thu Mar 15 00:00:00 UTC 2012
Stimulation of dopamine receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity.
Journal of immunology (Baltimore, Md. : 1950)
Prado C,Contreras F,González H,Díaz P,Elgueta D,Barrientos M,Herrada AA,Lladser Á,Bernales S,Pacheco R
Sun Apr 01 00:00:00 UTC 2012
Regulation of B cell linker protein transcription by PU.1 and Spi-B in murine B cell acute lymphoblastic leukemia.
Journal of immunology (Baltimore, Md. : 1950)
Xu LS,Sokalski KM,Hotke K,Christie DA,Zarnett O,Piskorz J,Thillainadesan G,Torchia J,DeKoter RP
Mon Oct 01 00:00:00 UTC 2012
Activation of the NLRP3 inflammasome by group B streptococci.
Journal of immunology (Baltimore, Md. : 1950)
Costa A,Gupta R,Signorino G,Malara A,Cardile F,Biondo C,Midiri A,Galbo R,Trieu-Cuot P,Papasergi S,Teti G,Henneke P,Mancuso G,Golenbock DT,Beninati C
Wed Feb 15 00:00:00 UTC 2012
SAP is required for the development of innate phenotype in H2-M3--restricted Cd8(+) T cells.
Journal of immunology (Baltimore, Md. : 1950)
Bediako Y,Bian Y,Zhang H,Cho H,Stein PL,Wang CR
Thu Nov 15 00:00:00 UTC 2012
Identification of TLT2 as an engulfment receptor for apoptotic cells.
Journal of immunology (Baltimore, Md. : 1950)
de Freitas A,Banerjee S,Xie N,Cui H,Davis KI,Friggeri A,Fu M,Abraham E,Liu G
Fri Jun 15 00:00:00 UTC 2012
Kv1.3 deletion biases T cells toward an immunoregulatory phenotype and renders mice resistant to autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Gocke AR,Lebson LA,Grishkan IV,Hu L,Nguyen HM,Whartenby KA,Chandy KG,Calabresi PA
Fri Jun 15 00:00:00 UTC 2012
Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Dervovic DD,Ciofani M,Kianizad K,Zúñiga-Pflücker JC
Mon Oct 01 00:00:00 UTC 2012
The role of Gr1+ cells after anti-CD20 treatment in type 1 diabetes in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950)
Hu C,Du W,Zhang X,Wong FS,Wen L
Sun Jan 01 00:00:00 UTC 2012
Lipopolysaccharide-activated dendritic cells: "exhausted" or alert and waiting?
Journal of immunology (Baltimore, Md. : 1950)
Abdi K,Singh NJ,Matzinger P
Fri Jun 15 00:00:00 UTC 2012
Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells.
Journal of immunology (Baltimore, Md. : 1950)
Sage PT,Varghese LM,Martinelli R,Sciuto TE,Kamei M,Dvorak AM,Springer TA,Sharpe AH,Carman CV
Sun Apr 15 00:00:00 UTC 2012
Failure to induce IFN-β production during Staphylococcus aureus infection contributes to pathogenicity.
Journal of immunology (Baltimore, Md. : 1950)
Kaplan A,Ma J,Kyme P,Wolf AJ,Becker CA,Tseng CW,Liu GY,Underhill DM
Thu Nov 01 00:00:00 UTC 2012
Defining GM-CSF- and macrophage-CSF-dependent macrophage responses by in vitro models.
Journal of immunology (Baltimore, Md. : 1950)
Lacey DC,Achuthan A,Fleetwood AJ,Dinh H,Roiniotis J,Scholz GM,Chang MW,Beckman SK,Cook AD,Hamilton JA
Fri Jun 01 00:00:00 UTC 2012
Exposure to nicotine adversely affects the dendritic cell system and compromises host response to vaccination.
Journal of immunology (Baltimore, Md. : 1950)
Nouri-Shirazi M,Guinet E
Thu Mar 01 00:00:00 UTC 2012
Protective role for TLR4 signaling in atherosclerosis progression as revealed by infection with a common oral pathogen.
Journal of immunology (Baltimore, Md. : 1950)
Hayashi C,Papadopoulos G,Gudino CV,Weinberg EO,Barth KR,Madrigal AG,Chen Y,Ning H,LaValley M,Gibson FC,Hamilton JA,Genco CA
Mon Oct 01 00:00:00 UTC 2012
Intestinal epithelial cell-derived semaphorin 7A negatively regulates development of colitis via αvβ1 integrin.
Journal of immunology (Baltimore, Md. : 1950)
Kang S,Okuno T,Takegahara N,Takamatsu H,Nojima S,Kimura T,Yoshida Y,Ito D,Ohmae S,You DJ,Toyofuku T,Jang MH,Kumanogoh A
Wed Feb 01 00:00:00 UTC 2012
Usp18 promotes conventional CD11b+ dendritic cell development.
Journal of immunology (Baltimore, Md. : 1950)
Cong XL,Lo MC,Reuter BA,Yan M,Fan JB,Zhang DE
Tue May 15 00:00:00 UTC 2012
B7-DC-Ig enhances vaccine effect by a novel mechanism dependent on PD-1 expression level on T cell subsets.
Journal of immunology (Baltimore, Md. : 1950)
Mkrtichyan M,Najjar YG,Raulfs EC,Liu L,Langerman S,Guittard G,Ozbun L,Khleif SN
Sat Sep 01 00:00:00 UTC 2012
Augmented IL-15Rα expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice.
Journal of immunology (Baltimore, Md. : 1950)
Zhang M,Ju W,Yao Z,Yu P,Wei BR,Simpson RM,Waitz R,Fassò M,Allison JP,Waldmann TA
Fri Jun 15 00:00:00 UTC 2012
Concurrent bacterial stimulation alters the function of helminth-activated dendritic cells, resulting in IL-17 induction.
Journal of immunology (Baltimore, Md. : 1950)
Perona-Wright G,Lundie RJ,Jenkins SJ,Webb LM,Grencis RK,MacDonald AS
Thu Mar 01 00:00:00 UTC 2012
Deciphering the pathways of death of Histoplasma capsulatum-infected macrophages: implications for the immunopathogenesis of early infection.
Journal of immunology (Baltimore, Md. : 1950)
Deepe GS,Buesing WR
Sun Jan 01 00:00:00 UTC 2012
Sphingosine analogue AAL-R increases TLR7-mediated dendritic cell responses via p38 and type I IFN signaling pathways.
Journal of immunology (Baltimore, Md. : 1950)
Seo YJ,Pritzl CJ,Vijayan M,Blake CR,McClain ME,Hahm B
Tue May 15 00:00:00 UTC 2012
15 kDa granulysin causes differentiation of monocytes to dendritic cells but lacks cytotoxic activity.
Journal of immunology (Baltimore, Md. : 1950)
Clayberger C,Finn MW,Wang T,Saini R,Wilson C,Barr VA,Sabatino M,Castiello L,Stroncek D,Krensky AM
Fri Jun 15 00:00:00 UTC 2012
Maturation of morphology, phenotype and functions of murine bone marrow-derived dendritic cells (DCs) induced by polysaccharide Kureha (PSK).
Human vaccines & immunotherapeutics
Tan Y,Meng Y,Wang Z,Shan F,Wang Q,Zhang N
315-03 was used in Cell Culture to indicate that PSK could markedly promote maturation of DCs and this adjuvant-like activity may have potential therapeutic value in vaccine preparation.
Sat Dec 01 00:00:00 UTC 2012
Plasma membrane proteomes of differentially matured dendritic cells identified by LC-MS/MS combined with iTRAQ labelling.
Journal of proteomics
Ferret-Bernard S,Castro-Borges W,Dowle AA,Sanin DE,Cook PC,Turner JD,MacDonald AS,Thomas JR,Mountford AP
Wed Jan 04 00:00:00 UTC 2012
Mitigating an undesirable immune response of inherent susceptibility to cutaneous leishmaniosis in a mouse model: the role of the pathoantigenic HISA70 DNA vaccine.
Veterinary research
Domínguez-Bernal G,Horcajo P,Orden JA,De La Fuente R,Herrero-Gil A,Ordóñez-Gutiérrez L,Carrión J
Thu Aug 09 00:00:00 UTC 2012
NADPH oxidase is internalized by clathrin-coated pits and localizes to a Rab27A/B GTPase-regulated secretory compartment in activated macrophages.
The Journal of biological chemistry
Ejlerskov P,Christensen DP,Beyaie D,Burritt JB,Paclet MH,Gorlach A,van Deurs B,Vilhardt F
Fri Feb 10 00:00:00 UTC 2012
Mycobacterium tuberculosis infection of dendritic cells leads to partially caspase-1/11-independent IL-1β and IL-18 secretion but not to pyroptosis.
PloS one
Abdalla H,Srinivasan L,Shah S,Mayer-Barber KD,Sher A,Sutterwala FS,Briken V
Fri Apr 19 00:00:00 UTC 2013
Adjuvant properties of thermal component of hyperthermia enhanced transdermal immunization: effect on dendritic cells.
PloS one
Joshi N,Duhan V,Lingwal N,Bhaskar S,Upadhyay P
Fri Jun 29 00:00:00 UTC 2012
Bcl-2 family member Bcl-G is not a proapoptotic protein.
Cell death & disease
Giam M,Okamoto T,Mintern JD,Strasser A,Bouillet P
Thu Oct 11 00:00:00 UTC 2012
Amiloride enhances antigen specific CTL by faciliting HBV DNA vaccine entry into cells.
PloS one
Geng S,Zhong Y,Wang S,Liu H,Zou Q,Xie X,Li C,Yu Q,He Z,Wang B
Mon Aug 13 00:00:00 UTC 2012
Leishmania mexicana induces limited recruitment and activation of monocytes and monocyte-derived dendritic cells early during infection.
PLoS neglected tropical diseases
Petritus PM,Manzoni-de-Almeida D,Gimblet C,Gonzalez Lombana C,Scott P
Fri Mar 01 00:00:00 UTC 2013
Neisseria gonorrhoeae suppresses dendritic cell-induced, antigen-dependent CD4 T cell proliferation.
PloS one
Zhu W,Ventevogel MS,Knilans KJ,Anderson JE,Oldach LM,McKinnon KP,Hobbs MM,Sempowski GD,Duncan JA
Wed Nov 28 00:00:00 UTC 2012
Type II-activated murine macrophages produce IL-4.
PloS one
La Flamme AC,Kharkrang M,Stone S,Mirmoeini S,Chuluundorj D,Kyle R
Wed May 01 00:00:00 UTC 2013
Recombinant heat shock protein 70 in combination with radiotherapy as a source of tumor antigens to improve dendritic cell immunotherapy.
Frontiers in oncology
Wang YS,Liu SJ,Huang SC,Chang CC,Huang YC,Fong WL,Chi MS,Chi KH
Thu Nov 01 00:00:00 UTC 2012
Tolerance induction by exosomes from immature dendritic cells and rapamycin in a mouse cardiac allograft model.
PloS one
Li X,Li JJ,Yang JY,Wang DS,Zhao W,Song WJ,Li WM,Wang JF,Han W,Zhang ZC,Yu Y,Cao DY,Dou KF
Thu Feb 07 00:00:00 UTC 2013
Mechanisms of dendritic cell lysosomal killing of Cryptococcus.
Scientific reports
Hole CR,Bui H,Wormley FL,Wozniak KL
Mon Jun 10 00:00:00 UTC 2013
Functional identification of dendritic cells in the teleost model, rainbow trout (Oncorhynchus mykiss).
PloS one
Bassity E,Clark TG
Mon Aug 20 00:00:00 UTC 2012
Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice.
The Journal of biological chemistry
Xiao C,Wang RH,Lahusen TJ,Park O,Bertola A,Maruyama T,Reynolds D,Chen Q,Xu X,Young HA,Chen WJ,Gao B,Deng CX
Fri Dec 07 00:00:00 UTC 2012
Inhibition of dendritic cell migration by transforming growth factor-β1 increases tumor-draining lymph node metastasis.
Journal of experimental & clinical cancer research : CR
Imai K,Minamiya Y,Koyota S,Ito M,Saito H,Sato Y,Motoyama S,Sugiyama T,Ogawa J
Tue Jan 10 00:00:00 UTC 2012
Topographical and biological evidence revealed FTY720-mediated anergy-polarization of mouse bone marrow-derived dendritic cells in vitro.
PloS one
Zeng X,Wang T,Zhu C,Xing X,Ye Y,Lai X,Song B,Zeng Y
Mon Oct 22 00:00:00 UTC 2012
Mind bomb-1 in dendritic cells is specifically required for Notch-mediated T helper type 2 differentiation.
PloS one
Jeong HW,Kim JH,Kim JY,Ha SJ,Kong YY
Tue Sep 04 00:00:00 UTC 2012
The Role of Vitamin D and Vitamin D Receptor in Immunity to Leishmania major Infection.
Journal of parasitology research
Whitcomb JP,Deagostino M,Ballentine M,Fu J,Tenniswood M,Welsh J,Cantorna M,McDowell MA
Thu Nov 10 00:00:00 UTC 2011
Transcutaneous immunization system using a hydrotropic formulation induces a potent antigen-specific antibody response.
PloS one
Takatani-Nakase T,Tokuyama E,Komai M,Takahashi K
Fri Apr 05 00:00:00 UTC 2013
Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens.
The Journal of biological chemistry
Ma J,Becker C,Lowell CA,Underhill DM
Fri Oct 05 00:00:00 UTC 2012
Simian immunodeficiency virus-Vpx for improving integrase defective lentiviral vector-based vaccines.
Retrovirology
Negri DR,Rossi A,Blasi M,Michelini Z,Leone P,Chiantore MV,Baroncelli S,Perretta G,Cimarelli A,Klotman ME,Cara A
Wed Aug 22 00:00:00 UTC 2012
Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Rα in human monocytes and dendritic cells.
The Journal of biological chemistry
Müller JR,Waldmann TA,Kruhlak MJ,Dubois S
Fri Nov 23 00:00:00 UTC 2012
Gene silencing of IL-12 in dendritic cells inhibits autoimmune arthritis.
Journal of translational medicine
Li R,Zheng X,Popov I,Zhang X,Wang H,Suzuki M,Necochea-Campion RD,French PW,Chen D,Siu L,Koos D,Inman RD,Min WP
Tue Jan 31 00:00:00 UTC 2012
Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and intracellular signaling in dendritic cells.
The Journal of biological chemistry
Yeang HXA,Hamdam JM,Al-Huseini LMA,Sethu S,Djouhri L,Walsh J,Kitteringham N,Park BK,Goldring CE,Sathish JG
Fri Mar 23 00:00:00 UTC 2012
Prostaglandin E2-induced IL-23p19 subunit is regulated by cAMP-responsive element-binding protein and C/AATT enhancer-binding protein β in bone marrow-derived dendritic cells.
The Journal of biological chemistry
Kocieda VP,Adhikary S,Emig F,Yen JH,Toscano MG,Ganea D
Fri Oct 26 00:00:00 UTC 2012
Dendritic cell based PSMA immunotherapy for prostate cancer using a CD40-targeted adenovirus vector.
PloS one
Williams BJ,Bhatia S,Adams LK,Boling S,Carroll JL,Li XL,Rogers DL,Korokhov N,Kovesdi I,Pereboev AV,Curiel DT,Mathis JM
Tue May 07 00:00:00 UTC 2013
Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.
PloS one
Yamaguchi T,Hamanaka S,Kamiya A,Okabe M,Kawarai M,Wakiyama Y,Umino A,Hayama T,Sato H,Lee YS,Kato-Itoh M,Masaki H,Kobayashi T,Yamazaki S,Nakauchi H
Wed Jan 16 00:00:00 UTC 2013
Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.
PloS one
Yamaguchi T,Hamanaka S,Kamiya A,Okabe M,Kawarai M,Wakiyama Y,Umino A,Hayama T,Sato H,Lee YS,Kato-Itoh M,Masaki H,Kobayashi T,Yamazaki S,Nakauchi H
Wed Jan 16 00:00:00 UTC 2013
Burn injury triggered dysfunction in dendritic cell response to TLR9 activation and resulted in skewed T cell functions.
PloS one
Shen H,de Almeida PE,Kang KH,Yao P,Chan CW
Thu May 16 00:00:00 UTC 2013
Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway.
Nature
Anthony RM,Kobayashi T,Wermeling F,Ravetch JV
Sun Jun 19 00:00:00 UTC 2011
Systematic discovery of TLR signaling components delineates viral-sensing circuits.
Cell
Chevrier N,Mertins P,Artyomov MN,Shalek AK,Iannacone M,Ciaccio MF,Gat-Viks I,Tonti E,DeGrace MM,Clauser KR,Garber M,Eisenhaure TM,Yosef N,Robinson J,Sutton A,Andersen MS,Root DE,von Andrian U,Jones RB,Park H,Carr SA,Regev A,Amit I,Hacohen N
Fri Nov 11 00:00:00 UTC 2011
Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.
Immunity
Saitoh T,Satoh T,Yamamoto N,Uematsu S,Takeuchi O,Kawai T,Akira S
Fri Mar 25 00:00:00 UTC 2011
Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking.
Immunity
Fukui R,Saitoh S,Kanno A,Onji M,Shibata T,Ito A,Onji M,Matsumoto M,Akira S,Yoshida N,Miyake K
Fri Jul 22 00:00:00 UTC 2011
Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms.
Immunity
Kuroda E,Ishii KJ,Uematsu S,Ohata K,Coban C,Akira S,Aritake K,Urade Y,Morimoto Y
Fri Apr 22 00:00:00 UTC 2011
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.
Cancer cell
Mali RS,Ramdas B,Ma P,Shi J,Munugalavadla V,Sims E,Wei L,Vemula S,Nabinger SC,Goodwin CB,Chan RJ,Traina F,Visconte V,Tiu RV,Lewis TA,Stern AM,Wen Q,Crispino JD,Boswell HS,Kapur R
Tue Sep 13 00:00:00 UTC 2011
B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen.
Nature immunology
Puga I,Cols M,Barra CM,He B,Cassis L,Gentile M,Comerma L,Chorny A,Shan M,Xu W,Magri G,Knowles DM,Tam W,Chiu A,Bussel JB,Serrano S,Lorente JA,Bellosillo B,Lloreta J,Juanpere N,Alameda F,Baró T,de Heredia CD,Torán N,Català A,Torrebadell M,Fortuny C,Cusí V,Carreras C,Diaz GA,Blander JM,Farber CM,Silvestri G,Cunningham-Rundles C,Calvillo M,Dufour C,Notarangelo LD,Lougaris V,Plebani A,Casanova JL,Ganal SC,Diefenbach A,Aróstegui JI,Juan M,Yagüe J,Mahlaoui N,Donadieu J,Chen K,Cerutti A
Sun Dec 25 00:00:00 UTC 2011
In vitro generation of HSC-like cells from murine ESCs/iPSCs by enforced expression of LIM-homeobox transcription factor Lhx2.
Blood
Kitajima K,Minehata K,Sakimura K,Nakano T,Hara T
Thu Apr 07 00:00:00 UTC 2011
H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunity.
Blood
Iborra S,Soto M,Stark-Aroeira L,Castellano E,Alarcón B,Alonso C,Santos E,Fernández-Malavé E
Thu May 12 00:00:00 UTC 2011
Emergency granulopoiesis promotes neutrophil-dendritic cell encounters that prevent mouse lung allograft acceptance.
Blood
Kreisel D,Sugimoto S,Zhu J,Nava R,Li W,Okazaki M,Yamamoto S,Ibrahim M,Huang HJ,Toth KA,Ritter JH,Krupnick AS,Miller MJ,Gelman AE
Thu Dec 01 00:00:00 UTC 2011
In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors.
Blood
Richie Ehrlich LI,Serwold T,Weissman IL
Thu Mar 03 00:00:00 UTC 2011
Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells.
Blood
Chan G,Cheung LS,Yang W,Milyavsky M,Sanders AD,Gu S,Hong WX,Liu AX,Wang X,Barbara M,Sharma T,Gavin J,Kutok JL,Iscove NN,Shannon KM,Dick JE,Neel BG,Braun BS
Thu Apr 21 00:00:00 UTC 2011
Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15Rα.
Blood
Sato N,Sabzevari H,Fu S,Ju W,Petrus MN,Bamford RN,Waldmann TA,Tagaya Y
Thu Apr 14 00:00:00 UTC 2011
Ikaros-Notch axis in host hematopoietic cells regulates experimental graft-versus-host disease.
Blood
Toubai T,Sun Y,Tawara I,Friedman A,Liu C,Evers R,Nieves E,Malter C,Chockley P,Maillard I,Winandy S,Reddy P
Thu Jul 07 00:00:00 UTC 2011
Regulatory dendritic cells program generation of interleukin-4-producing alternative memory CD4 T cells with suppressive activity.
Blood
Xu X,Guo Z,Jiang X,Yao Y,Gao Q,Ding Y,Cao X
Thu Jan 27 00:00:00 UTC 2011
Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis.
The Journal of clinical investigation
Kreisel D,Sugimoto S,Tietjens J,Zhu J,Yamamoto S,Krupnick AS,Carmody RJ,Gelman AE
Sat Jan 01 00:00:00 UTC 2011
CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice.
The Journal of clinical investigation
Weber C,Meiler S,Döring Y,Koch M,Drechsler M,Megens RT,Rowinska Z,Bidzhekov K,Fecher C,Ribechini E,van Zandvoort MA,Binder CJ,Jelinek I,Hristov M,Boon L,Jung S,Korn T,Lutz MB,Förster I,Zenke M,Hieronymus T,Junt T,Zernecke A
Fri Jul 01 00:00:00 UTC 2011
Absence of Stat1 in donor CD4⁺ T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice.
The Journal of clinical investigation
Ma H,Lu C,Ziegler J,Liu A,Sepulveda A,Okada H,Lentzsch S,Mapara MY
Fri Jul 01 00:00:00 UTC 2011
Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia.
The Journal of experimental medicine
Heltemes-Harris LM,Willette MJ,Ramsey LB,Qiu YH,Neeley ES,Zhang N,Thomas DA,Koeuth T,Baechler EC,Kornblau SM,Farrar MA
Mon Jun 06 00:00:00 UTC 2011
Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes.
The Journal of experimental medicine
Barrett NA,Rahman OM,Fernandez JM,Parsons MW,Xing W,Austen KF,Kanaoka Y
Mon Mar 14 00:00:00 UTC 2011
Invariant NKT cells are required for airway inflammation induced by environmental antigens.
The Journal of experimental medicine
Wingender G,Rogers P,Batzer G,Lee MS,Bai D,Pei B,Khurana A,Kronenberg M,Horner AA
Mon Jun 06 00:00:00 UTC 2011
Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration.
The Journal of experimental medicine
Kurachi M,Kurachi J,Suenaga F,Tsukui T,Abe J,Ueha S,Tomura M,Sugihara K,Takamura S,Kakimi K,Matsushima K
Mon Aug 01 00:00:00 UTC 2011
ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18.
The Journal of experimental medicine
Yamamoto M,Ma JS,Mueller C,Kamiyama N,Saiga H,Kubo E,Kimura T,Okamoto T,Okuyama M,Kayama H,Nagamune K,Takashima S,Matsuura Y,Soldati-Favre D,Takeda K
Mon Jul 04 00:00:00 UTC 2011
Natural killer (NK)-dendritic cell interactions generate MHC class II-dressed NK cells that regulate CD4+ T cells.
Proceedings of the National Academy of Sciences of the United States of America
Nakayama M,Takeda K,Kawano M,Takai T,Ishii N,Ogasawara K
Tue Nov 08 00:00:00 UTC 2011
Specific microtubule-depolymerizing agents augment efficacy of dendritic cell-based cancer vaccines.
Journal of biomedical science
Wen CC,Chen HM,Chen SS,Huang LT,Chang WT,Wei WC,Chou LC,Arulselvan P,Wu JB,Kuo SC,Yang NS
Mon Jun 20 00:00:00 UTC 2011
Topical application of marine briarane-type diterpenes effectively inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and dermatitis in murine skin.
Journal of biomedical science
Wei WC,Lin SY,Chen YJ,Wen CC,Huang CY,Palanisamy A,Yang NS,Sheu JH
Wed Dec 21 00:00:00 UTC 2011
Interleukin-1β produced in response to islet autoantigen presentation differentiates T-helper 17 cells at the expense of regulatory T-cells: Implications for the timing of tolerizing immunotherapy.
Diabetes
Bertin-Maghit S,Pang D,O'Sullivan B,Best S,Duggan E,Paul S,Thomas H,Kay TW,Harrison LC,Steptoe R,Thomas R
Sat Jan 01 00:00:00 UTC 2011
Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila.
PLoS pathogens
Fontana MF,Banga S,Barry KC,Shen X,Tan Y,Luo ZQ,Vance RE
Tue Feb 01 00:00:00 UTC 2011
Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection.
PLoS pathogens
Brien JD,Daffis S,Lazear HM,Cho H,Suthar MS,Gale M,Diamond MS
Thu Sep 01 00:00:00 UTC 2011
Murid herpesvirus-4 exploits dendritic cells to infect B cells.
PLoS pathogens
Gaspar M,May JS,Sukla S,Frederico B,Gill MB,Smith CM,Belz GT,Stevenson PG
Tue Nov 01 00:00:00 UTC 2011
Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control.
PLoS pathogens
Butcher BA,Fox BA,Rommereim LM,Kim SG,Maurer KJ,Yarovinsky F,Herbert DR,Bzik DJ,Denkers EY
Thu Sep 01 00:00:00 UTC 2011
Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice.
Arthritis research & therapy
Misaki K,Morinobu A,Saegusa J,Kasagi S,Fujita M,Miyamoto Y,Matsuki F,Kumagai S
Wed May 18 00:00:00 UTC 2011
Inhibition of microRNA let-7i depresses maturation and functional state of dendritic cells in response to lipopolysaccharide stimulation via targeting suppressor of cytokine signaling 1.
Journal of immunology (Baltimore, Md. : 1950)
Zhang M,Liu F,Jia H,Zhang Q,Yin L,Liu W,Li H,Yu B,Wu J
Mon Aug 15 00:00:00 UTC 2011
Murine syngeneic graft-versus-host disease is responsive to broad-spectrum antibiotic therapy.
Journal of immunology (Baltimore, Md. : 1950)
Brandon JA,Jennings CD,Kaplan AM,Bryson JS
Tue Mar 15 00:00:00 UTC 2011
Nucleosides from Phlebotomus papatasi salivary gland ameliorate murine collagen-induced arthritis by impairing dendritic cell functions.
Journal of immunology (Baltimore, Md. : 1950)
Carregaro V,Sá-Nunes A,Cunha TM,Grespan R,Oliveira CJ,Lima-Junior DS,Costa DL,Verri WA,Milanezi CM,Pham VM,Brand DD,Valenzuela JG,Silva JS,Ribeiro JM,Cunha FQ
Sat Oct 15 00:00:00 UTC 2011
The phosphatase SRC homology region 2 domain-containing phosphatase-1 is an intrinsic central regulator of dendritic cell function.
Journal of immunology (Baltimore, Md. : 1950)
Ramachandran IR,Song W,Lapteva N,Seethammagari M,Slawin KM,Spencer DM,Levitt JM
Fri Apr 01 00:00:00 UTC 2011
Human metapneumovirus glycoprotein G inhibits TLR4-dependent signaling in monocyte-derived dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Kolli D,Bao X,Liu T,Hong C,Wang T,Garofalo RP,Casola A
Fri Jul 01 00:00:00 UTC 2011
Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors.
Journal of immunology (Baltimore, Md. : 1950)
Iwata-Kajihara T,Sumimoto H,Kawamura N,Ueda R,Takahashi T,Mizuguchi H,Miyagishi M,Takeda K,Kawakami Y
Fri Jul 01 00:00:00 UTC 2011
Yersinia pestis YopE contains a dominant CD8 T cell epitope that confers protection in a mouse model of pneumonic plague.
Journal of immunology (Baltimore, Md. : 1950)
Lin JS,Szaba FM,Kummer LW,Chromy BA,Smiley ST
Fri Jul 15 00:00:00 UTC 2011
The acquisition of antigen cross-presentation function by newly formed dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Sathe P,Pooley J,Vremec D,Mintern J,Jin JO,Wu L,Kwak JY,Villadangos JA,Shortman K
Sun May 01 00:00:00 UTC 2011
Genetic segregation of inflammatory lung disease and autoimmune disease severity in SHIP-1-/- mice.
Journal of immunology (Baltimore, Md. : 1950)
Maxwell MJ,Duan M,Armes JE,Anderson GP,Tarlinton DM,Hibbs ML
Wed Jun 15 00:00:00 UTC 2011
Induction of endoplasmic reticulum-endosome fusion for antigen cross-presentation induced by poly (γ-glutamic acid) nanoparticles.
Journal of immunology (Baltimore, Md. : 1950)
Mukai Y,Yoshinaga T,Yoshikawa M,Matsuo K,Yoshikawa T,Matsuo K,Niki K,Yoshioka Y,Okada N,Nakagawa S
Thu Dec 15 00:00:00 UTC 2011
Intracellular HMGB1 negatively regulates efferocytosis.
Journal of immunology (Baltimore, Md. : 1950)
Banerjee S,de Freitas A,Friggeri A,Zmijewski JW,Liu G,Abraham E
Tue Nov 01 00:00:00 UTC 2011
CD204 suppresses large heat shock protein-facilitated priming of tumor antigen gp100-specific T cells and chaperone vaccine activity against mouse melanoma.
Journal of immunology (Baltimore, Md. : 1950)
Qian J,Yi H,Guo C,Yu X,Zuo D,Chen X,Kane JM,Repasky EA,Subjeck JR,Wang XY
Thu Sep 15 00:00:00 UTC 2011
Chronic chemoimmunotherapy achieves cure of spontaneous murine mammary tumors via persistent blockade of posttherapy counter-regulation.
Journal of immunology (Baltimore, Md. : 1950)
Rowswell-Turner RB,Harden JL,Nair RE,Gu T,Kilinc MO,Egilmez NK
Sat Oct 15 00:00:00 UTC 2011
Suppressive effect of bacterial polysaccharides on BAFF system is responsible for their poor immunogenicity.
Journal of immunology (Baltimore, Md. : 1950)
Kanswal S,Katsenelson N,Allman W,Uslu K,Blake MS,Akkoyunlu M
Tue Feb 15 00:00:00 UTC 2011
Local delivery of GM-CSF protects mice from lethal pneumococcal pneumonia.
Journal of immunology (Baltimore, Md. : 1950)
Steinwede K,Tempelhof O,Bolte K,Maus R,Bohling J,Ueberberg B,Länger F,Christman JW,Paton JC,Ask K,Maharaj S,Kolb M,Gauldie J,Welte T,Maus UA
Tue Nov 15 00:00:00 UTC 2011
Antimicrobial peptides inhibit polyinosinic-polycytidylic acid-induced immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Hasan M,Ruksznis C,Wang Y,Leifer CA
Thu Dec 01 00:00:00 UTC 2011
Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
LaCasse CJ,Janikashvili N,Larmonier CB,Alizadeh D,Hanke N,Kartchner J,Situ E,Centuori S,Har-Noy M,Bonnotte B,Katsanis E,Larmonier N
Thu Dec 15 00:00:00 UTC 2011
Successful colon cancer eradication after chemoimmunotherapy is associated with profound phenotypic change of intratumoral myeloid cells.
Journal of immunology (Baltimore, Md. : 1950)
Medina-Echeverz J,Fioravanti J,Zabala M,Ardaiz N,Prieto J,Berraondo P
Sat Jan 15 00:00:00 UTC 2011
Recruitment of dendritic cells is responsible for intestinal epithelial damage in the pathogenesis of necrotizing enterocolitis by Cronobacter sakazakii.
Journal of immunology (Baltimore, Md. : 1950)
Emami CN,Mittal R,Wang L,Ford HR,Prasadarao NV
Wed Jun 15 00:00:00 UTC 2011
P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses.
Journal of immunology (Baltimore, Md. : 1950)
Lawson CD,Donald S,Anderson KE,Patton DT,Welch HC
Tue Feb 01 00:00:00 UTC 2011
Convergence of the mammalian target of rapamycin complex 1- and glycogen synthase kinase 3-β-signaling pathways regulates the innate inflammatory response.
Journal of immunology (Baltimore, Md. : 1950)
Wang H,Brown J,Gu Z,Garcia CA,Liang R,Alard P,Beurel E,Jope RS,Greenway T,Martin M
Sun May 01 00:00:00 UTC 2011
Cutting Edge: Distinct waves of BCL6 expression during T follicular helper cell development.
Journal of immunology (Baltimore, Md. : 1950)
Baumjohann D,Okada T,Ansel KM
Thu Sep 01 00:00:00 UTC 2011
Attenuated atherosclerotic lesions in apoE-Fcγ-chain-deficient hyperlipidemic mouse model is associated with inhibition of Th17 cells and promotion of regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Ng HP,Burris RL,Nagarajan S
Thu Dec 01 00:00:00 UTC 2011
The role of glycogen synthase kinase 3 in regulating IFN-β-mediated IL-10 production.
Journal of immunology (Baltimore, Md. : 1950)
Wang H,Brown J,Garcia CA,Tang Y,Benakanakere MR,Greenway T,Alard P,Kinane DF,Martin M
Sat Jan 15 00:00:00 UTC 2011
Inhibition of tumor-induced myeloid-derived suppressor cell function by a nanoparticulated adjuvant.
Journal of immunology (Baltimore, Md. : 1950)
Fernández A,Mesa C,Marigo I,Dolcetti L,Clavell M,Oliver L,Fernández LE,Bronte V
Sat Jan 01 00:00:00 UTC 2011
Elf3 regulates allergic airway inflammation by controlling dendritic cell-driven T cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Kushwah R,Oliver JR,Wu J,Chang Z,Hu J
Tue Nov 01 00:00:00 UTC 2011
Cardiolipin binds to CD1d and stimulates CD1d-restricted γδ T cells in the normal murine repertoire.
Journal of immunology (Baltimore, Md. : 1950)
Dieudé M,Striegl H,Tyznik AJ,Wang J,Behar SM,Piccirillo CA,Levine JS,Zajonc DM,Rauch J
Fri Apr 15 00:00:00 UTC 2011
Sensitivity and resistance to regulation by IL-4 during Th17 maturation.
Journal of immunology (Baltimore, Md. : 1950)
Cooney LA,Towery K,Endres J,Fox DA
Tue Nov 01 00:00:00 UTC 2011
The A2B adenosine receptor promotes Th17 differentiation via stimulation of dendritic cell IL-6.
Journal of immunology (Baltimore, Md. : 1950)
Wilson JM,Kurtz CC,Black SG,Ross WG,Alam MS,Linden J,Ernst PB
Wed Jun 15 00:00:00 UTC 2011
Dendritic cells distinguish individual chemokine signals through CCR7 and CXCR4.
Journal of immunology (Baltimore, Md. : 1950)
Ricart BG,John B,Lee D,Hunter CA,Hammer DA
Sat Jan 01 00:00:00 UTC 2011
Nonconventional CD8+ T cell responses to Listeria infection in mice lacking MHC class Ia and H2-M3.
Journal of immunology (Baltimore, Md. : 1950)
Cho H,Choi HJ,Xu H,Felio K,Wang CR
Sat Jan 01 00:00:00 UTC 2011
NLRC5 deficiency does not influence cytokine induction by virus and bacteria infections.
Journal of immunology (Baltimore, Md. : 1950)
Kumar H,Pandey S,Zou J,Kumagai Y,Takahashi K,Akira S,Kawai T
Sat Jan 15 00:00:00 UTC 2011
CpG promotes cross-presentation of dead cell-associated antigens by pre-CD8α+ dendritic cells [corrected].
Journal of immunology (Baltimore, Md. : 1950)
de Brito C,Tomkowiak M,Ghittoni R,Caux C,Leverrier Y,Marvel J
Tue Feb 01 00:00:00 UTC 2011
TLT2 potentiates neutrophil antibacterial activity and chemotaxis in response to G protein-coupled receptor-mediated signaling.
Journal of immunology (Baltimore, Md. : 1950)
Halpert MM,Thomas KA,King RG,Justement LB
Thu Sep 01 00:00:00 UTC 2011
Acid-sensing ion channels contribute to the effect of acidosis on the function of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Tong J,Wu WN,Kong X,Wu PF,Tian L,Du W,Fang M,Zheng F,Chen JG,Tan Z,Gong F
Tue Mar 15 00:00:00 UTC 2011
Thymic stromal lymphopoietin is produced by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Kashyap M,Rochman Y,Spolski R,Samsel L,Leonard WJ
Mon Aug 01 00:00:00 UTC 2011
Protease-activated receptor 2 activation of myeloid dendritic cells regulates allergic airway inflammation.
Respiratory research
Lewkowich IP,Day SB,Ledford JR,Zhou P,Dienger K,Wills-Karp M,Page K
Wed Sep 21 00:00:00 UTC 2011
Subcellular antigen location influences T-cell activation during acute infection with Toxoplasma gondii.
PloS one
Gregg B,Dzierszinski F,Tait E,Jordan KA,Hunter CA,Roos DS
Tue Dec 06 00:00:00 UTC 2011
Species difference of CD137 ligand signaling in human and murine monocytes.
PloS one
Tang Q,Jiang D,Shao Z,Martínez Gómez JM,Schwarz H
Fri Jan 14 00:00:00 UTC 2011
Prostaglandin E2 induces matrix metalloproteinase 9 expression in dendritic cells through two independent signaling pathways leading to activator protein 1 (AP-1) activation.
The Journal of biological chemistry
Yen JH,Kocieda VP,Jing H,Ganea D
Fri Nov 11 00:00:00 UTC 2011
Salmonella enterica serovar Typhimurium lacking hfq gene confers protective immunity against murine typhoid.
PloS one
Allam US,Krishna MG,Lahiri A,Joy O,Chakravortty D
Wed Feb 09 00:00:00 UTC 2011
Mice with different susceptibility to Japanese encephalitis virus infection show selective neutralizing antibody response and myeloid cell infectivity.
PloS one
Wang K,Deubel V
Mon Jan 30 00:00:00 UTC 2012
DC-STAMP knock-down deregulates cytokine production and T-cell stimulatory capacity of LPS-matured dendritic cells.
BMC immunology
Sanecka A,Ansems M,Prosser AC,Danielski K,Warner K,den Brok MH,Jansen BJ,Eleveld-Trancikova D,Adema GJ
Thu Oct 06 00:00:00 UTC 2011
Combination immunotherapy and active-specific tumor cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer.
Journal of translational medicine
van den Engel NK,Rüttinger D,Rusan M,Kammerer R,Zimmermann W,Hatz RA,Winter H
Mon Aug 22 00:00:00 UTC 2011
Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production.
PloS one
McGehee AM,Strijbis K,Guillen E,Eng T,Kirak O,Ploegh HL
Wed Apr 20 00:00:00 UTC 2011
Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tract.
mBio
Parker D,Martin FJ,Soong G,Harfenist BS,Aguilar JL,Ratner AJ,Fitzgerald KA,Schindler C,Prince A
Thu Oct 27 00:00:00 UTC 2011
NOD dendritic cells stimulated with Lactobacilli preferentially produce IL-10 versus IL-12 and decrease diabetes incidence.
Clinical & developmental immunology
Manirarora JN,Parnell SA,Hu YH,Kosiewicz MM,Alard P
Thu Oct 27 00:00:00 UTC 2011
Selective serotonin reuptake inhibitors attenuate the antigen presentation from dendritic cells to effector T lymphocytes.
FEMS immunology and medical microbiology
Branco-de-Almeida LS,Kajiya M,Cardoso CR,Silva MJ,Ohta K,Rosalen PL,Franco GC,Han X,Taubman MA,Kawai T
Mon Aug 01 00:00:00 UTC 2011
In vivo migration of dendritic cells labeled with synthetic superparamagnetic iron oxide.
International journal of nanomedicine
Mou Y,Hou Y,Chen B,Hua Z,Zhang Y,Xie H,Xia G,Wang Z,Huang X,Han W,Ni Y,Hu Q
Tue Mar 27 00:00:00 UTC 2012
Differential requirement for cathepsin D for processing of the full length and C-terminal fragment of the malaria antigen MSP1.
PloS one
Tulone C,Sponaas AM,Raiber EA,Tabor AB,Langhorne J,Chain BM
Fri Feb 24 00:00:00 UTC 2012
Rational design of pathogen-mimicking amphiphilic materials as nanoadjuvants.
Scientific reports
Ulery BD,Petersen LK,Phanse Y,Kong CS,Broderick SR,Kumar D,Ramer-Tait AE,Carrillo-Conde B,Rajan K,Wannemuehler MJ,Bellaire BH,Metzger DW,Narasimhan B
Tue Sep 10 00:00:00 UTC 2013
Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development.
PloS one
Yamamoto M,Kato T,Hotta C,Nishiyama A,Kurotaki D,Yoshinari M,Takami M,Ichino M,Nakazawa M,Matsuyama T,Kamijo R,Kitagawa S,Ozato K,Tamura T
Thu Feb 02 00:00:00 UTC 2012
Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization.
PloS one
Edelson BT,Bradstreet TR,KC W,Hildner K,Herzog JW,Sim J,Russell JH,Murphy TL,Unanue ER,Murphy KM
Thu Mar 15 00:00:00 UTC 2012
Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity.
PloS one
Otsuka A,Kubo M,Honda T,Egawa G,Nakajima S,Tanizaki H,Kim B,Matsuoka S,Watanabe T,Nakae S,Miyachi Y,Kabashima K
Thu Jan 26 00:00:00 UTC 2012
The interaction between different types of activated RAW 264.7 cells and macrophage inflammatory protein-1 alpha.
Radiation oncology (London, England)
He Z,Zhang H,Yang C,Zhou Y,Zhou Y,Han G,Xia L,Ouyang W,Zhou F,Zhou Y,Xie C
Fri Jul 22 00:00:00 UTC 2011
TGF-β suppresses β-catenin-dependent tolerogenic activation program in dendritic cells.
PloS one
Vander Lugt B,Beck ZT,Fuhlbrigge RC,Hacohen N,Campbell JJ,Boes M
Mon Oct 17 00:00:00 UTC 2011
In vivo microRNA-155 expression influences antigen-specific T cell-mediated immune responses generated by DNA vaccination.
Cell & bioscience
Mao CP,He L,Tsai YC,Peng S,Kang TH,Pang X,Monie A,Hung CF,Wu TC
Tue Jan 18 00:00:00 UTC 2011
Gelsolin-independent podosome formation in dendritic cells.
PloS one
Hammarfjord O,Falet H,Gurniak C,Hartwig JH,Wallin RP
Tue Nov 15 00:00:00 UTC 2011
MIF synergizes with Trypanosoma cruzi antigens to promote efficient dendritic cell maturation and IL-12 production via p38 MAPK.
International journal of biological sciences
Terrazas CA,Huitron E,Vazquez A,Juarez I,Camacho GM,Calleja EA,Rodriguez-Sosa M
Tue May 29 00:00:00 UTC 2012
Gamma-ray irradiation impairs dendritic cell migration to CCL19 by down-regulation of CCR7 and induction of cell apoptosis.
International journal of biological sciences
Liu C,Lin J,Zhao L,Yang Y,Gao F,Li B,Cui J,Cai J
Mon Feb 14 00:00:00 UTC 2011
Analysis of two major intracellular phospholipases A(2) (PLA(2)) in mast cells reveals crucial contribution of cytosolic PLA(2)α, not Ca(2+)-independent PLA(2)β, to lipid mobilization in proximal mast cells and distal fibroblasts.
The Journal of biological chemistry
Ueno N,Taketomi Y,Yamamoto K,Hirabayashi T,Kamei D,Kita Y,Shimizu T,Shinzawa K,Tsujimoto Y,Ikeda K,Taguchi R,Murakami M
Fri Oct 28 00:00:00 UTC 2011
Ubiquitin-mediated regulation of CD86 protein expression by the ubiquitin ligase membrane-associated RING-CH-1 (MARCH1).
The Journal of biological chemistry
Corcoran K,Jabbour M,Bhagwandin C,Deymier MJ,Theisen DL,Lybarger L
Fri Oct 28 00:00:00 UTC 2011
Generation and labeling of murine bone marrow-derived dendritic cells with Qdot nanocrystals for tracking studies.
Journal of visualized experiments : JoVE
Muccioli M,Pate M,Omosebi O,Benencia F
Thu Jun 02 00:00:00 UTC 2011
Up-regulation of Th17 cells may underlie inhibition of Treg development caused by immunization with activated syngeneic T cells.
PloS one
Wang L,Lin J,Zhou Z,Huo R,Shen B,Sun Y,Li N
Fri May 18 00:00:00 UTC 2012
The interplay between surfaces and soluble factors define the immunologic and angiogenic properties of myeloid dendritic cells.
BMC immunology
Sprague L,Muccioli M,Pate M,Meles E,McGinty J,Nandigam H,Venkatesh AK,Gu MY,Mansfield K,Rutowski A,Omosebi O,Courreges MC,Benencia F
315-03 was used in Cell Culture to study the effects of different surfaces and soluble factors on the biology of dendritic cells.
Mon Jun 06 00:00:00 UTC 2011
The interplay between surfaces and soluble factors define the immunologic and angiogenic properties of myeloid dendritic cells.
BMC immunology
Sprague L,Muccioli M,Pate M,Meles E,McGinty J,Nandigam H,Venkatesh AK,Gu MY,Mansfield K,Rutowski A,Omosebi O,Courreges MC,Benencia F
315-03 was used in Cell Culture to study the effects of different surfaces and soluble factors on the biology of dendritic cells.
Mon Jun 06 00:00:00 UTC 2011
Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model.
PloS one
Yang C,Kim SH,Bianco NR,Robbins PD
Tue Dec 27 00:00:00 UTC 2011
Excision of an unstable pathogenicity island in Salmonella enterica serovar Enteritidis is induced during infection of phagocytic cells.
PloS one
Quiroz TS,Nieto PA,Tobar HE,Salazar-Echegarai FJ,Lizana RJ,Quezada CP,Santiviago CA,Araya DV,Riedel CA,Kalergis AM,Bueno SM
Tue Feb 28 00:00:00 UTC 2012
Different toll-like receptor stimuli have a profound impact on cytokines required to break tolerance and induce autoimmunity.
PloS one
Lin AC,Dissanayake D,Dhanji S,Elford AR,Ohashi PS
Fri Feb 03 00:00:00 UTC 2012
Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant.
PloS one
Coler RN,Bertholet S,Moutaftsi M,Guderian JA,Windish HP,Baldwin SL,Laughlin EM,Duthie MS,Fox CB,Carter D,Friede M,Vedvick TS,Reed SG
Wed Jan 26 00:00:00 UTC 2011
DNA vaccines delivered by human papillomavirus pseudovirions as a promising approach for generating antigen-specific CD8+ T cell immunity.
Cell & bioscience
Peng S,Ma B,Chen SH,Hung CF,Wu T
Thu Jul 28 00:00:00 UTC 2011
Dendritic cells transfected with scFv from Mab 7.B12 mimicking original antigen gp43 induces protection against experimental Paracoccidioidomycosis.
PloS one
Ferreira KS,Maranhão AQ,Garcia MC,Brígido MM,Santos SS,Lopes JD,Almeida SR
Fri Jan 07 00:00:00 UTC 2011
Comprehensive methylome map of lineage commitment from haematopoietic progenitors.
Nature
Ji H,Ehrlich LI,Seita J,Murakami P,Doi A,Lindau P,Lee H,Aryee MJ,Irizarry RA,Kim K,Rossi DJ,Inlay MA,Serwold T,Karsunky H,Ho L,Daley GQ,Weissman IL,Feinberg AP
Thu Sep 16 00:00:00 UTC 2010
Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas.
Cell
Cheong C,Matos I,Choi JH,Dandamudi DB,Shrestha E,Longhi MP,Jeffrey KL,Anthony RM,Kluger C,Nchinda G,Koh H,Rodriguez A,Idoyaga J,Pack M,Velinzon K,Park CG,Steinman RM
Fri Oct 29 00:00:00 UTC 2010
The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner.
Immunity
Carotta S,Dakic A,D'Amico A,Pang SH,Greig KT,Nutt SL,Wu L
Fri May 28 00:00:00 UTC 2010
STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells.
Immunity
Szanto A,Balint BL,Nagy ZS,Barta E,Dezso B,Pap A,Szeles L,Poliska S,Oros M,Evans RM,Barak Y,Schwabe J,Nagy L
Wed Nov 24 00:00:00 UTC 2010
β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells.
Cancer cell
Yeung J,Esposito MT,Gandillet A,Zeisig BB,Griessinger E,Bonnet D,So CW
Tue Dec 14 00:00:00 UTC 2010
Immunization with host-type CD8{alpha}+ dendritic cells reduces experimental acute GVHD in an IL-10-dependent manner.
Blood
Toubai T,Malter C,Tawara I,Liu C,Nieves E,Lowler KP,Sun Y,Reddy P
Thu Jan 21 00:00:00 UTC 2010
Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding.
Blood
Keeshan K,Bailis W,Dedhia PH,Vega ME,Shestova O,Xu L,Toscano K,Uljon SN,Blacklow SC,Pear WS
Thu Dec 02 00:00:00 UTC 2010
Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding.
Blood
Keeshan K,Bailis W,Dedhia PH,Vega ME,Shestova O,Xu L,Toscano K,Uljon SN,Blacklow SC,Pear WS
Thu Dec 02 00:00:00 UTC 2010
Hematopoietic progenitor cell regulation by CD4+CD25+ T cells.
Blood
Urbieta M,Barao I,Jones M,Jurecic R,Panoskaltsis-Mortari A,Blazar BR,Murphy WJ,Levy RB
Thu Jun 10 00:00:00 UTC 2010
Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}.
Blood
Qiu JJ,Lu X,Zeisig BB,Ma Z,Cai X,Chen S,Gronemeyer H,Tweardy DJ,So CW,Dong S
Thu Jan 21 00:00:00 UTC 2010
Repression of Id2 expression by Gfi-1 is required for B-cell and myeloid development.
Blood
Li H,Ji M,Klarmann KD,Keller JR
Thu Aug 19 00:00:00 UTC 2010
Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia.
Blood
Dedhia PH,Keeshan K,Uljon S,Xu L,Vega ME,Shestova O,Zaks-Zilberman M,Romany C,Blacklow SC,Pear WS
Thu Aug 26 00:00:00 UTC 2010
Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase.
Blood
Chessa TA,Anderson KE,Hu Y,Xu Q,Rausch O,Stephens LR,Hawkins PT
Thu Dec 23 00:00:00 UTC 2010
Indirect inhibition of in vivo and in vitro T-cell responses by intravenous immunoglobulins due to impaired antigen presentation.
Blood
Aubin E,Lemieux R,Bazin R
Thu Mar 04 00:00:00 UTC 2010
Rho-mDia1 pathway is required for adhesion, migration, and T-cell stimulation in dendritic cells.
Blood
Tanizaki H,Egawa G,Inaba K,Honda T,Nakajima S,Moniaga CS,Otsuka A,Ishizaki T,Tomura M,Watanabe T,Miyachi Y,Narumiya S,Okada T,Kabashima K
Thu Dec 23 00:00:00 UTC 2010
Downstream targets of HOXB4 in a cell line model of primitive hematopoietic progenitor cells.
Blood
Lee HM,Zhang H,Schulz V,Tuck DP,Forget BG
Thu Aug 05 00:00:00 UTC 2010
Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development.
Blood
Böiers C,Buza-Vidas N,Jensen CT,Pronk CJ,Kharazi S,Wittmann L,Sitnicka E,Hultquist A,Jacobsen SE
Thu Jun 17 00:00:00 UTC 2010
Lineage-instructive function of C/EBPα in multipotent hematopoietic cells and early thymic progenitors.
Blood
Wölfler A,Danen-van Oorschot AA,Haanstra JR,Valkhof M,Bodner C,Vroegindeweij E,van Strien P,Novak A,Cupedo T,Touw IP
Thu Nov 18 00:00:00 UTC 2010
Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation.
Blood
Starck J,Weiss-Gayet M,Gonnet C,Guyot B,Vicat JM,Morlé F
Thu Dec 02 00:00:00 UTC 2010
Toll-like receptor 2/6 stimulation promotes angiogenesis via GM-CSF as a potential strategy for immune defense and tissue regeneration.
Blood
Grote K,Schuett H,Salguero G,Grothusen C,Jagielska J,Drexler H,Mühlradt PF,Schieffer B
Thu Mar 25 00:00:00 UTC 2010
Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia.
Blood
Pulliam-Leath AC,Ciccone SL,Nalepa G,Li X,Si Y,Miravalle L,Smith D,Yuan J,Li J,Anur P,Orazi A,Vance GH,Yang FC,Hanenberg H,Bagby GC,Clapp DW
Thu Oct 21 00:00:00 UTC 2010
Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation.
Blood
Divito SJ,Wang Z,Shufesky WJ,Liu Q,Tkacheva OA,Montecalvo A,Erdos G,Larregina AT,Morelli AE
Thu Oct 14 00:00:00 UTC 2010
Eosinophil differentiation in the bone marrow is inhibited by T cell-derived IFN-gamma.
Blood
de Bruin AM,Buitenhuis M,van der Sluijs KF,van Gisbergen KP,Boon L,Nolte MA
Thu Oct 07 00:00:00 UTC 2010
Leukemogenic transformation by HOXA cluster genes.
Blood
Bach C,Buhl S,Mueller D,García-Cuéllar MP,Maethner E,Slany RK
Thu Apr 08 00:00:00 UTC 2010
Induction of antitumor immunity against mouse carcinoma by baculovirus-infected dendritic cells.
Cellular & molecular immunology
Suzuki T,Oo Chang M,Kitajima M,Takaku H
Mon Nov 01 00:00:00 UTC 2010
TGF-beta1 gene-modified, immature dendritic cells delay the development of inflammatory bowel disease by inducing CD4(+)Foxp3(+) regulatory T cells.
Cellular & molecular immunology
Cai Z,Zhang W,Li M,Yue Y,Yang F,Yu L,Cao X,Wang J
Fri Jan 01 00:00:00 UTC 2010
The TLR7 agonists imiquimod and gardiquimod improve DC-based immunotherapy for melanoma in mice.
Cellular & molecular immunology
Ma F,Zhang J,Zhang J,Zhang C
Wed Sep 01 00:00:00 UTC 2010
Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice.
The Journal of clinical investigation
Zhu Q,Egelston C,Gagnon S,Sui Y,Belyakov IM,Klinman DM,Berzofsky JA
Mon Feb 01 00:00:00 UTC 2010
CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice.
The Journal of clinical investigation
Si Y,Tsou CL,Croft K,Charo IF
Thu Apr 01 00:00:00 UTC 2010
Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rbeta1 isoform that enhances DC migration.
The Journal of experimental medicine
Robinson RT,Khader SA,Martino CA,Fountain JJ,Teixeira-Coelho M,Pearl JE,Smiley ST,Winslow GM,Woodland DL,Walter MJ,Conejo-Garcia JR,Gubler U,Cooper AM
Mon Mar 15 00:00:00 UTC 2010
CD14 is a coreceptor of Toll-like receptors 7 and 9.
The Journal of experimental medicine
Baumann CL,Aspalter IM,Sharif O,Pichlmair A,Blüml S,Grebien F,Bruckner M,Pasierbek P,Aumayr K,Planyavsky M,Bennett KL,Colinge J,Knapp S,Superti-Furga G
Mon Nov 22 00:00:00 UTC 2010
Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.
The Journal of experimental medicine
Scapini P,Hu Y,Chu CL,Migone TS,Defranco AL,Cassatella MA,Lowell CA
Mon Aug 02 00:00:00 UTC 2010
Induction of type I interferon by adenovirus-encoded small RNAs.
Proceedings of the National Academy of Sciences of the United States of America
Yamaguchi T,Kawabata K,Kouyama E,Ishii KJ,Katayama K,Suzuki T,Kurachi S,Sakurai F,Akira S,Mizuguchi H
Tue Oct 05 00:00:00 UTC 2010
Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism.
Proceedings of the National Academy of Sciences of the United States of America
Nguyen NT,Kimura A,Nakahama T,Chinen I,Masuda K,Nohara K,Fujii-Kuriyama Y,Kishimoto T
Tue Nov 16 00:00:00 UTC 2010
Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Naramura M,Nandwani N,Gu H,Band V,Band H
Tue Sep 14 00:00:00 UTC 2010
LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses.
Proceedings of the National Academy of Sciences of the United States of America
Satoh T,Kato H,Kumagai Y,Yoneyama M,Sato S,Matsushita K,Tsujimura T,Fujita T,Akira S,Takeuchi O
Tue Jan 26 00:00:00 UTC 2010
Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Mortensen M,Ferguson DJ,Edelmann M,Kessler B,Morten KJ,Komatsu M,Simon AK
Tue Jan 12 00:00:00 UTC 2010
Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses.
Proceedings of the National Academy of Sciences of the United States of America
Ritter M,Gross O,Kays S,Ruland J,Nimmerjahn F,Saijo S,Tschopp J,Layland LE,Prazeres da Costa C
Tue Nov 23 00:00:00 UTC 2010
IPS-1 is essential for the control of West Nile virus infection and immunity.
PLoS pathogens
Suthar MS,Ma DY,Thomas S,Lund JM,Zhang N,Daffis S,Rudensky AY,Bevan MJ,Clark EA,Kaja MK,Diamond MS,Gale M
Fri Feb 05 00:00:00 UTC 2010
Rabies virus infection induces type I interferon production in an IPS-1 dependent manner while dendritic cell activation relies on IFNAR signaling.
PLoS pathogens
Faul EJ,Wanjalla CN,Suthar MS,Gale M,Wirblich C,Schnell MJ
Thu Jul 22 00:00:00 UTC 2010
Role of PKR and Type I IFNs in viral control during primary and secondary infection.
PLoS pathogens
Nakayama Y,Plisch EH,Sullivan J,Thomas C,Czuprynski CJ,Williams BR,Suresh M
Thu Jun 24 00:00:00 UTC 2010
RNAi-mediated CD40-CD154 interruption promotes tolerance in autoimmune arthritis.
Arthritis research & therapy
Zheng X,Suzuki M,Zhang X,Ichim TE,Zhu F,Ling H,Shunnar A,Wang MH,Garcia B,Inman RD,Min WP
Fri Aug 13 00:00:00 UTC 2010
Drug antigenicity, immunogenicity, and costimulatory signaling: evidence for formation of a functional antigen through immune cell metabolism.
Journal of immunology (Baltimore, Md. : 1950)
Elsheikh A,Lavergne SN,Castrejon JL,Farrell J,Wang H,Sathish J,Pichler WJ,Park BK,Naisbitt DJ
Wed Dec 01 00:00:00 UTC 2010
Unexpected role for the immunoproteasome subunit LMP2 in antiviral humoral and innate immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Hensley SE,Zanker D,Dolan BP,David A,Hickman HD,Embry AC,Skon CN,Grebe KM,Griffin TA,Chen W,Bennink JR,Yewdell JW
Thu Apr 15 00:00:00 UTC 2010
Neutrophil functions and autoimmune arthritis in the absence of p190RhoGAP: generation and analysis of a novel null mutation in mice.
Journal of immunology (Baltimore, Md. : 1950)
Németh T,Futosi K,Hably C,Brouns MR,Jakob SM,Kovács M,Kertész Z,Walzog B,Settleman J,Mócsai A
Wed Sep 01 00:00:00 UTC 2010
Inhibition of Th2 adaptive immune responses and pulmonary inflammation by leukocyte Ig-like receptor B4 on dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Breslow RG,Rao JJ,Xing W,Hong DI,Barrett NA,Katz HR
Fri Jan 15 00:00:00 UTC 2010
The protein tyrosine phosphatase SHP-1 modulates the suppressive activity of regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Iype T,Sankarshanan M,Mauldin IS,Mullins DW,Lorenz U
Mon Nov 15 00:00:00 UTC 2010
IL-33 exacerbates eosinophil-mediated airway inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Stolarski B,Kurowska-Stolarska M,Kewin P,Xu D,Liew FY
Wed Sep 15 00:00:00 UTC 2010
Hypochlorous acid: a natural adjuvant that facilitates antigen processing, cross-priming, and the induction of adaptive immunity.
Journal of immunology (Baltimore, Md. : 1950)
Prokopowicz ZM,Arce F,Biedroń R,Chiang CL,Ciszek M,Katz DR,Nowakowska M,Zapotoczny S,Marcinkiewicz J,Chain BM
Fri Jan 15 00:00:00 UTC 2010
Immune dysregulation by the rheumatoid arthritis shared epitope.
Journal of immunology (Baltimore, Md. : 1950)
De Almeida DE,Ling S,Pi X,Hartmann-Scruggs AM,Pumpens P,Holoshitz J
Sun Aug 01 00:00:00 UTC 2010
Definition of key variables for the induction of optimal NY-ESO-1-specific T cells in HLA transgene mice.
Journal of immunology (Baltimore, Md. : 1950)
Johannsen A,Genolet R,Legler DF,Luther SA,Luescher IF
Wed Sep 15 00:00:00 UTC 2010
The interactions of multiple cytokines control NK cell maturation.
Journal of immunology (Baltimore, Md. : 1950)
Brady J,Carotta S,Thong RP,Chan CJ,Hayakawa Y,Smyth MJ,Nutt SL
Wed Dec 01 00:00:00 UTC 2010
Antigen aggregation decides the fate of the allergic immune response.
Journal of immunology (Baltimore, Md. : 1950)
Zaborsky N,Brunner M,Wallner M,Himly M,Karl T,Schwarzenbacher R,Ferreira F,Achatz G
Fri Jan 15 00:00:00 UTC 2010
Group V secretory phospholipase A2 reveals its role in house dust mite-induced allergic pulmonary inflammation by regulation of dendritic cell function.
Journal of immunology (Baltimore, Md. : 1950)
Giannattasio G,Fujioka D,Xing W,Katz HR,Boyce JA,Balestrieri B
Fri Oct 01 00:00:00 UTC 2010
Intralesional delivery of dendritic cells engineered to express T-bet promotes protective type 1 immunity and the normalization of the tumor microenvironment.
Journal of immunology (Baltimore, Md. : 1950)
Qu Y,Chen L,Pardee AD,Taylor JL,Wesa AK,Storkus WJ
Wed Sep 01 00:00:00 UTC 2010
TLR4-mediated podosome loss discriminates gram-negative from gram-positive bacteria in their capacity to induce dendritic cell migration and maturation.
Journal of immunology (Baltimore, Md. : 1950)
van Helden SF,van den Dries K,Oud MM,Raymakers RA,Netea MG,van Leeuwen FN,Figdor CG
Mon Feb 01 00:00:00 UTC 2010
Reactive oxygen species level defines two functionally distinctive stages of inflammatory dendritic cell development from mouse bone marrow.
Journal of immunology (Baltimore, Md. : 1950)
Sheng KC,Pietersz GA,Tang CK,Ramsland PA,Apostolopoulos V
Mon Mar 15 00:00:00 UTC 2010
Phosphatidylinositol 3-kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain.
Journal of immunology (Baltimore, Md. : 1950)
Medina EA,Morris IR,Berton MT
Wed Dec 15 00:00:00 UTC 2010
Mechanisms for glycolipid antigen-driven cytokine polarization by Valpha14i NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
Sullivan BA,Nagarajan NA,Wingender G,Wang J,Scott I,Tsuji M,Franck RW,Porcelli SA,Zajonc DM,Kronenberg M
Fri Jan 01 00:00:00 UTC 2010
Treatment of autoimmune arthritis using RNA interference-modulated dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Zheng X,Suzuki M,Ichim TE,Zhang X,Sun H,Zhu F,Shunnar A,Garcia B,Inman RD,Min W
Tue Jun 01 00:00:00 UTC 2010
Aldosterone promotes autoimmune damage by enhancing Th17-mediated immunity.
Journal of immunology (Baltimore, Md. : 1950)
Herrada AA,Contreras FJ,Marini NP,Amador CA,González PA,Cortés CM,Riedel CA,Carvajal CA,Figueroa F,Michea LF,Fardella CE,Kalergis AM
Fri Jan 01 00:00:00 UTC 2010
Ultraviolet irradiation of mice reduces the competency of bone marrow-derived CD11c+ cells via an indomethacin-inhibitable pathway.
Journal of immunology (Baltimore, Md. : 1950)
Ng RL,Bisley JL,Gorman S,Norval M,Hart PH
Wed Dec 15 00:00:00 UTC 2010
The protein tyrosine kinase Tec regulates a CD44highCD62L- Th17 subset.
Journal of immunology (Baltimore, Md. : 1950)
Boucheron N,Sharif O,Schebesta A,Croxford A,Raberger J,Schmidt U,Vigl B,Bauer J,Bankoti R,Lassmann H,Epstein MM,Knapp S,Waisman A,Ellmeier W
Mon Nov 01 00:00:00 UTC 2010
Interference with dendritic cell populations limits early antigen presentation in chronic γ-herpesvirus-68 infection.
Journal of immunology (Baltimore, Md. : 1950)
Mount AM,Masson F,Kupresanin F,Smith CM,May JS,van Rooijen N,Stevenson PG,Belz GT
Wed Sep 15 00:00:00 UTC 2010
Prostaglandin I2-IP signaling promotes Th1 differentiation in a mouse model of contact hypersensitivity.
Journal of immunology (Baltimore, Md. : 1950)
Nakajima S,Honda T,Sakata D,Egawa G,Tanizaki H,Otsuka A,Moniaga CS,Watanabe T,Miyachi Y,Narumiya S,Kabashima K
Sat May 15 00:00:00 UTC 2010
MicroRNA-148/152 impair innate response and antigen presentation of TLR-triggered dendritic cells by targeting CaMKIIα.
Journal of immunology (Baltimore, Md. : 1950)
Liu X,Zhan Z,Xu L,Ma F,Li D,Guo Z,Li N,Cao X
Wed Dec 15 00:00:00 UTC 2010
TLR-activated dendritic cells enhance the response of aged naive CD4 T cells via an IL-6-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Jones SC,Brahmakshatriya V,Huston G,Dibble J,Swain SL
Wed Dec 01 00:00:00 UTC 2010
Antigen-containing liposomes engrafted with flagellin-related peptides are effective vaccines that can induce potent antitumor immunity and immunotherapeutic effect.
Journal of immunology (Baltimore, Md. : 1950)
Faham A,Altin JG
Sun Aug 01 00:00:00 UTC 2010
A critical role for C5L2 in the pathogenesis of experimental allergic asthma.
Journal of immunology (Baltimore, Md. : 1950)
Zhang X,Schmudde I,Laumonnier Y,Pandey MK,Clark JR,König P,Gerard NP,Gerard C,Wills-Karp M,Köhl J
Wed Dec 01 00:00:00 UTC 2010
Dendritic cells induce regulatory T cell proliferation through antigen-dependent and -independent interactions.
Journal of immunology (Baltimore, Md. : 1950)
Zou T,Caton AJ,Koretzky GA,Kambayashi T
Wed Sep 01 00:00:00 UTC 2010
Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice.
Journal of immunology (Baltimore, Md. : 1950)
Watford WT,Wang CC,Tsatsanis C,Mielke LA,Eliopoulos AG,Daskalakis C,Charles N,Odom S,Rivera J,O'Shea J,Tsichlis PN
Fri Jan 01 00:00:00 UTC 2010
TGF-beta1 accelerates dendritic cell differentiation from common dendritic cell progenitors and directs subset specification toward conventional dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Felker P,Seré K,Lin Q,Becker C,Hristov M,Hieronymus T,Zenke M
Mon Nov 01 00:00:00 UTC 2010
IFN-beta inhibits dendritic cell migration through STAT-1-mediated transcriptional suppression of CCR7 and matrix metalloproteinase 9.
Journal of immunology (Baltimore, Md. : 1950)
Yen JH,Kong W,Ganea D
Thu Apr 01 00:00:00 UTC 2010
Ischemic injury enhances dendritic cell immunogenicity via TLR4 and NF-kappa B activation.
Journal of immunology (Baltimore, Md. : 1950)
Jurewicz M,Takakura A,Augello A,Movahedi Naini S,Ichimura T,Zandi-Nejad K,Abdi R
Mon Mar 15 00:00:00 UTC 2010
GATA2 and Sp1 positively regulate the c-kit promoter in mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Maeda K,Nishiyama C,Ogawa H,Okumura K
Fri Oct 01 00:00:00 UTC 2010
Induction of TGF-beta 1, not regulatory T cells, impairs antiviral immunity in the lung following bone marrow transplant.
Journal of immunology (Baltimore, Md. : 1950)
Coomes SM,Wilke CA,Moore TA,Moore BB
Sat May 01 00:00:00 UTC 2010
Heat shock protein 90 mediates efficient antigen cross presentation through the scavenger receptor expressed by endothelial cells-I.
Journal of immunology (Baltimore, Md. : 1950)
Murshid A,Gong J,Calderwood SK
Wed Sep 01 00:00:00 UTC 2010
TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2.
Journal of immunology (Baltimore, Md. : 1950)
Gais P,Tiedje C,Altmayr F,Gaestel M,Weighardt H,Holzmann B
Sat May 15 00:00:00 UTC 2010
Double-stranded RNA exacerbates pulmonary allergic reaction through TLR3: implication of airway epithelium and dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Torres D,Dieudonné A,Ryffel B,Vilain E,Si-Tahar M,Pichavant M,Lassalle P,Trottein F,Gosset P
Thu Jul 01 00:00:00 UTC 2010
Transcription factor E2F1 suppresses dendritic cell maturation.
Journal of immunology (Baltimore, Md. : 1950)
Fang F,Wang Y,Li R,Zhao Y,Guo Y,Jiang M,Sun J,Ma Y,Ren Z,Tian Z,Wei F,Yang D,Xiao W
Tue Jun 01 00:00:00 UTC 2010
IRAK-M removal counteracts dendritic cell vaccine deficits in migration and longevity.
Journal of immunology (Baltimore, Md. : 1950)
Turnis ME,Song XT,Bear A,Foster AE,Gottschalk S,Brenner MK,Chen SY,Rooney CM
Fri Oct 01 00:00:00 UTC 2010
MEKK3 overexpression contributes to the hyperresponsiveness of IL-12-overproducing cells and CD4+ T conventional cells in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950)
Zhang J,Zhu N,Wang Q,Wang J,Ma Y,Qiao C,Li Y,Li X,Su B,Shen B
Wed Sep 15 00:00:00 UTC 2010
Enhanced dendritic cell antigen uptake via alpha2 adrenoceptor-mediated PI3K activation following brief exposure to noradrenaline.
Journal of immunology (Baltimore, Md. : 1950)
Yanagawa Y,Matsumoto M,Togashi H
Mon Nov 15 00:00:00 UTC 2010
Effects of F/G-actin ratio and actin turn-over rate on NADPH oxidase activity in microglia.
BMC immunology
Rasmussen I,Pedersen LH,Byg L,Suzuki K,Sumimoto H,Vilhardt F
Wed Sep 08 00:00:00 UTC 2010
Loss of Jak2 selectively suppresses DC-mediated innate immune response and protects mice from lethal dose of LPS-induced septic shock.
PloS one
Zhong J,Yang P,Muta K,Dong R,Marrero M,Gong F,Wang CY
Tue Mar 09 00:00:00 UTC 2010
An NF-kappaB-dependent role for JunB in the induction of proinflammatory cytokines in LPS-activated bone marrow-derived dendritic cells.
PloS one
Gomard T,Michaud HA,Tempé D,Thiolon K,Pelegrin M,Piechaczyk M
Mon Mar 08 00:00:00 UTC 2010
Identification of a novel marker for dendritic cell maturation, mouse transmembrane protein 123.
The Journal of biological chemistry
Takekoshi T,Tada Y,Watanabe T,Sugaya M,Hoashi T,Komine M,Kawashima T,Shimizu T,Hau CS,Asahina A,Yokomizo T,Sato S,Tamaki K
Fri Oct 08 00:00:00 UTC 2010
In vivo trafficking and immunostimulatory potential of an intranasally-administered primary dendritic cell-based vaccine.
BMC immunology
Vilekar P,Awasthi V,Lagisetty P,King C,Shankar N,Awasthi S
Fri Dec 10 00:00:00 UTC 2010
TLR 9 activation in dendritic cells enhances salmonella killing and antigen presentation via involvement of the reactive oxygen species.
PloS one
Lahiri A,Lahiri A,Das P,Vani J,Shaila MS,Chakravortty D
Fri Oct 29 00:00:00 UTC 2010
The non-pathogenic mycobacteria M. smegmatis and M. fortuitum induce rapid host cell apoptosis via a caspase-3 and TNF dependent pathway.
BMC microbiology
Bohsali A,Abdalla H,Velmurugan K,Briken V
Fri Sep 10 00:00:00 UTC 2010
The neuropeptide calcitonin gene-related peptide causes repression of tumor necrosis factor-alpha transcription and suppression of ATF-2 promoter recruitment in Toll-like receptor-stimulated dendritic cells.
The Journal of biological chemistry
Altmayr F,Jusek G,Holzmann B
Fri Feb 05 00:00:00 UTC 2010
Docosahexaenoic acid prevents dendritic cell maturation and in vitro and in vivo expression of the IL-12 cytokine family.
Lipids in health and disease
Kong W,Yen JH,Vassiliou E,Adhikary S,Toscano MG,Ganea D
Mon Feb 01 00:00:00 UTC 2010
Linear and branched glyco-lipopeptide vaccines follow distinct cross-presentation pathways and generate different magnitudes of antitumor immunity.
PloS one
Renaudet O,Dasgupta G,Bettahi I,Shi A,Nesburn AB,Dumy P,BenMohamed L
Mon Jun 21 00:00:00 UTC 2010
Fed-batch fermentation of GM-CSF-producing glycoengineered Pichia pastoris under controlled specific growth rate.
Microbial cell factories
Jacobs PP,Inan M,Festjens N,Haustraete J,Van Hecke A,Contreras R,Meagher MM,Callewaert N
Tue Nov 23 00:00:00 UTC 2010
The peptide sequence of diacyl lipopeptides determines dendritic cell TLR2-mediated NK activation.
PloS one
Azuma M,Sawahata R,Akao Y,Ebihara T,Yamazaki S,Matsumoto M,Hashimoto M,Fukase K,Fujimoto Y,Seya T
Thu Sep 02 00:00:00 UTC 2010
cis-Urocanic acid attenuates acute dextran sodium sulphate-induced intestinal inflammation.
PloS one
Albert E,Walker J,Thiesen A,Churchill T,Madsen K
Wed Oct 27 00:00:00 UTC 2010
Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells.
Nature
Viale A,De Franco F,Orleth A,Cambiaghi V,Giuliani V,Bossi D,Ronchini C,Ronzoni S,Muradore I,Monestiroli S,Gobbi A,Alcalay M,Minucci S,Pelicci PG
Thu Jan 01 00:00:00 UTC 2009
MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells.
Cell
Sarrazin S,Mossadegh-Keller N,Fukao T,Aziz A,Mourcin F,Vanhille L,Kelly Modis L,Kastner P,Chan S,Duprez E,Otto C,Sieweke MH
Thu Jul 23 00:00:00 UTC 2009
A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses.
Immunity
Meng G,Zhang F,Fuss I,Kitani A,Strober W
Fri Jun 19 00:00:00 UTC 2009
Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis.
Immunity
Lin Y,Ritchea S,Logar A,Slight S,Messmer M,Rangel-Moreno J,Guglani L,Alcorn JF,Strawbridge H,Park SM,Onishi R,Nyugen N,Walter MJ,Pociask D,Randall TD,Gaffen SL,Iwakura Y,Kolls JK,Khader SA
Fri Nov 20 00:00:00 UTC 2009
Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells.
Cancer cell
Kudo-Saito C,Shirako H,Takeuchi T,Kawakami Y
Tue Mar 03 00:00:00 UTC 2009
Autoimmune pancreatitis results from loss of TGFbeta signalling in S100A4-positive dendritic cells.
Gut
Boomershine CS,Chamberlain A,Kendall P,Afshar-Sharif AR,Huang H,Washington MK,Lawson WE,Thomas JW,Blackwell TS,Bhowmick NA
Tue Sep 01 00:00:00 UTC 2009
Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Krüppel-like factors KLF4 and KLF2.
Nature immunology
Yamada T,Park CS,Mamonkin M,Lacorazza HD
Mon Jun 01 00:00:00 UTC 2009
Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells.
Nature immunology
Dejean AS,Beisner DR,Ch'en IL,Kerdiles YM,Babour A,Arden KC,Castrillon DH,DePinho RA,Hedrick SM
Fri May 01 00:00:00 UTC 2009
Balance between Id and E proteins regulates myeloid-versus-lymphoid lineage decisions.
Blood
Cochrane SW,Zhao Y,Welner RS,Sun XH
Thu Jan 29 00:00:00 UTC 2009
Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg-/- mice in vivo.
Blood
Li Y,Chen S,Yuan J,Yang Y,Li J,Ma J,Wu X,Freund M,Pollok K,Hanenberg H,Goebel WS,Yang FC
Thu Mar 05 00:00:00 UTC 2009
Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease.
Blood
King IL,Dickendesher TL,Segal BM
Thu Apr 02 00:00:00 UTC 2009
Interferon beta induces mature dendritic cell apoptosis through caspase-11/caspase-3 activation.
Blood
Yen JH,Ganea D
Thu Aug 13 00:00:00 UTC 2009
A novel in vivo siRNA delivery system specifically targeting dendritic cells and silencing CD40 genes for immunomodulation.
Blood
Zheng X,Vladau C,Zhang X,Suzuki M,Ichim TE,Zhang ZX,Li M,Carrier E,Garcia B,Jevnikar AM,Min WP
Thu Mar 19 00:00:00 UTC 2009
Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function.
Blood
Steimer DA,Boyd K,Takeuchi O,Fisher JK,Zambetti GP,Opferman JT
Thu Mar 19 00:00:00 UTC 2009
Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis.
Blood
Chan G,Kalaitzidis D,Usenko T,Kutok JL,Yang W,Mohi MG,Neel BG
Thu Apr 30 00:00:00 UTC 2009
The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis.
Blood
Kimura A,Rieger MA,Simone JM,Chen W,Wickre MC,Zhu BM,Hoppe PS,O'Shea JJ,Schroeder T,Hennighausen L
Thu Nov 19 00:00:00 UTC 2009
Lymphoid-tissue-specific homing of bone-marrow-derived dendritic cells.
Blood
Creusot RJ,Yaghoubi SS,Chang P,Chia J,Contag CH,Gambhir SS,Fathman CG
Thu Jun 25 00:00:00 UTC 2009
CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice.
The Journal of experimental medicine
Felio K,Nguyen H,Dascher CC,Choi HJ,Li S,Zimmer MI,Colmone A,Moody DB,Brenner MB,Wang CR
Mon Oct 26 00:00:00 UTC 2009
TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis.
The Journal of experimental medicine
Taylor BC,Zaph C,Troy AE,Du Y,Guild KJ,Comeau MR,Artis D
Mon Mar 16 00:00:00 UTC 2009
CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation.
The Journal of experimental medicine
Auffray C,Fogg DK,Narni-Mancinelli E,Senechal B,Trouillet C,Saederup N,Leemput J,Bigot K,Campisi L,Abitbol M,Molina T,Charo I,Hume DA,Cumano A,Lauvau G,Geissmann F
Mon Mar 16 00:00:00 UTC 2009
Niche recycling through division-independent egress of hematopoietic stem cells.
The Journal of experimental medicine
Bhattacharya D,Czechowicz A,Ooi AG,Rossi DJ,Bryder D,Weissman IL
Mon Nov 23 00:00:00 UTC 2009
Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation.
The Journal of experimental medicine
Werninghaus K,Babiak A,Gross O,Hölscher C,Dietrich H,Agger EM,Mages J,Mocsai A,Schoenen H,Finger K,Nimmerjahn F,Brown GD,Kirschning C,Heit A,Andersen P,Wagner H,Ruland J,Lang R
Fri Jan 16 00:00:00 UTC 2009
Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis.
The Journal of experimental medicine
Jakus Z,Simon E,Frommhold D,Sperandio M,Mócsai A
Mon Mar 16 00:00:00 UTC 2009
A role for CD47 in the development of experimental colitis mediated by SIRPalpha+CD103- dendritic cells.
The Journal of experimental medicine
Fortin G,Raymond M,Van VQ,Rubio M,Gautier P,Sarfati M,Franchimont D
Mon Aug 31 00:00:00 UTC 2009
Recombinant vesicular stomatitis virus transduction of dendritic cells enhances their ability to prime innate and adaptive antitumor immunity.
Molecular therapy : the journal of the American Society of Gene Therapy
Boudreau JE,Bridle BW,Stephenson KB,Jenkins KM,Brunellière J,Bramson JL,Lichty BD,Wan Y
Sat Aug 01 00:00:00 UTC 2009
Changes in H5N1 influenza virus hemagglutinin receptor binding domain affect systemic spread.
Proceedings of the National Academy of Sciences of the United States of America
Yen HL,Aldridge JR,Boon AC,Ilyushina NA,Salomon R,Hulse-Post DJ,Marjuki H,Franks J,Boltz DA,Bush D,Lipatov AS,Webby RJ,Rehg JE,Webster RG
Tue Jan 06 00:00:00 UTC 2009
Different cross-presentation pathways in steady-state and inflammatory dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America
Segura E,Albiston AL,Wicks IP,Chai SY,Villadangos JA
Tue Dec 01 00:00:00 UTC 2009
A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection.
Proceedings of the National Academy of Sciences of the United States of America
Marsolais D,Hahm B,Walsh KB,Edelmann KH,McGavern D,Hatta Y,Kawaoka Y,Rosen H,Oldstone MB
Tue Feb 03 00:00:00 UTC 2009
A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome.
Proceedings of the National Academy of Sciences of the United States of America
Ranatunga D,Hedrich CM,Wang F,McVicar DW,Nowak N,Joshi T,Feigenbaum L,Grant LR,Stäger S,Bream JH
Tue Oct 06 00:00:00 UTC 2009
Toll-like receptor 2 dependent immunogenicity of glycoconjugate vaccines containing chemically derived zwitterionic polysaccharides.
Proceedings of the National Academy of Sciences of the United States of America
Gallorini S,Berti F,Mancuso G,Cozzi R,Tortoli M,Volpini G,Telford JL,Beninati C,Maione D,Wack A
Tue Oct 13 00:00:00 UTC 2009
Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response.
Proceedings of the National Academy of Sciences of the United States of America
Oyoshi MK,Elkhal A,Kumar L,Scott JE,Koduru S,He R,Leung DY,Howell MD,Oettgen HC,Murphy GF,Geha RS
Tue Sep 01 00:00:00 UTC 2009
Acetalated dextran is a chemically and biologically tunable material for particulate immunotherapy.
Proceedings of the National Academy of Sciences of the United States of America
Broaders KE,Cohen JA,Beaudette TT,Bachelder EM,Fréchet JM
Tue Apr 07 00:00:00 UTC 2009
Negative regulation of MyD88-dependent signaling by IL-10 in dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America
Chang J,Kunkel SL,Chang CH
Tue Oct 27 00:00:00 UTC 2009
Misguided transcriptional elongation causes mixed lineage leukemia.
PLoS biology
Mueller D,García-Cuéllar MP,Bach C,Buhl S,Maethner E,Slany RK
Sun Nov 01 00:00:00 UTC 2009
Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7.
PLoS pathogens
Daffis S,Suthar MS,Szretter KJ,Gale M,Diamond MS
Thu Oct 01 00:00:00 UTC 2009
GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling.
Journal of leukocyte biology
Fleetwood AJ,Dinh H,Cook AD,Hertzog PJ,Hamilton JA
Sat Aug 01 00:00:00 UTC 2009
The adhesion molecule esam1 is a novel hematopoietic stem cell marker.
Stem cells (Dayton, Ohio)
Ooi AG,Karsunky H,Majeti R,Butz S,Vestweber D,Ishida T,Quertermous T,Weissman IL,Forsberg EC
Sun Mar 01 00:00:00 UTC 2009
A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency.
Journal of immunology (Baltimore, Md. : 1950)
Verhagen AM,Wallace ME,Goradia A,Jones SA,Croom HA,Metcalf D,Collinge JE,Maxwell MJ,Hibbs ML,Alexander WS,Hilton DJ,Kile BT,Starr R
Sun Feb 15 00:00:00 UTC 2009
Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Kambayashi T,Allenspach EJ,Chang JT,Zou T,Shoag JE,Reiner SL,Caton AJ,Koretzky GA
Wed Apr 15 00:00:00 UTC 2009
Skin and peripheral lymph node invariant NKT cells are mainly retinoic acid receptor-related orphan receptor (gamma)t+ and respond preferentially under inflammatory conditions.
Journal of immunology (Baltimore, Md. : 1950)
Doisne JM,Becourt C,Amniai L,Duarte N,Le Luduec JB,Eberl G,Benlagha K
Sat Aug 01 00:00:00 UTC 2009
Vav1 regulates the migration and adhesion of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Spurrell DR,Luckashenak NA,Minney DC,Chaplin A,Penninger JM,Liwski RS,Clements JL,West KA
Wed Jul 01 00:00:00 UTC 2009
Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production.
Journal of immunology (Baltimore, Md. : 1950)
Mielke LA,Elkins KL,Wei L,Starr R,Tsichlis PN,O'Shea JJ,Watford WT
Tue Dec 15 00:00:00 UTC 2009
Dendritic cells use endocytic pathway for cross-priming class Ib MHC-restricted CD8alphaalpha+TCRalphabeta+ T cells with regulatory properties.
Journal of immunology (Baltimore, Md. : 1950)
Smith TR,Tang X,Maricic I,Garcia Z,Fanchiang S,Kumar V
Mon Jun 01 00:00:00 UTC 2009
NF-kappa B p50 regulates C/EBP alpha expression and inflammatory cytokine-induced neutrophil production.
Journal of immunology (Baltimore, Md. : 1950)
Wang D,Paz-Priel I,Friedman AD
Fri May 01 00:00:00 UTC 2009
Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950)
Hamilton-Williams EE,Martinez X,Clark J,Howlett S,Hunter KM,Rainbow DB,Wen L,Shlomchik MJ,Katz JD,Beilhack GF,Wicker LS,Sherman LA
Sat Aug 01 00:00:00 UTC 2009
Mapping of a microbial protein domain involved in binding and activation of the TLR2/TLR1 heterodimer.
Journal of immunology (Baltimore, Md. : 1950)
Liang S,Hosur KB,Lu S,Nawar HF,Weber BR,Tapping RI,Connell TD,Hajishengallis G
Sun Mar 01 00:00:00 UTC 2009
Modified adenine (9-benzyl-2-butoxy-8-hydroxyadenine) redirects Th2-mediated murine lung inflammation by triggering TLR7.
Journal of immunology (Baltimore, Md. : 1950)
Vultaggio A,Nencini F,Fitch PM,Filì L,Maggi L,Fanti P,deVries A,Beccastrini E,Palandri F,Manuelli C,Bani D,Giudizi MG,Guarna A,Annunziato F,Romagnani S,Maggi E,Howie SE,Parronchi P
Thu Jan 15 00:00:00 UTC 2009
Involvement of the NLRP3 inflammasome in innate and humoral adaptive immune responses to fungal beta-glucan.
Journal of immunology (Baltimore, Md. : 1950)
Kumar H,Kumagai Y,Tsuchida T,Koenig PA,Satoh T,Guo Z,Jang MH,Saitoh T,Akira S,Kawai T
Tue Dec 15 00:00:00 UTC 2009
Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Barrett NA,Maekawa A,Rahman OM,Austen KF,Kanaoka Y
Thu Jan 15 00:00:00 UTC 2009
Differential use of CARD9 by dectin-1 in macrophages and dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Goodridge HS,Shimada T,Wolf AJ,Hsu YM,Becker CA,Lin X,Underhill DM
Thu Jan 15 00:00:00 UTC 2009
The A2B adenosine receptor impairs the maturation and immunogenicity of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Wilson JM,Ross WG,Agbai ON,Frazier R,Figler RA,Rieger J,Linden J,Ernst PB
Wed Apr 15 00:00:00 UTC 2009
The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling.
Journal of immunology (Baltimore, Md. : 1950)
Crabé S,Guay-Giroux A,Tormo AJ,Duluc D,Lissilaa R,Guilhot F,Mavoungou-Bigouagou U,Lefouili F,Cognet I,Ferlin W,Elson G,Jeannin P,Gauchat JF
Tue Dec 15 00:00:00 UTC 2009
Furin-processed antigens targeted to the secretory route elicit functional TAP1-/-CD8+ T lymphocytes in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Medina F,Ramos M,Iborra S,de León P,Rodríguez-Castro M,Del Val M
Thu Oct 01 00:00:00 UTC 2009
Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid.
Journal of immunology (Baltimore, Md. : 1950)
Griffith JW,Sun T,McIntosh MT,Bucala R
Thu Oct 15 00:00:00 UTC 2009
IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia.
Journal of immunology (Baltimore, Md. : 1950)
Ueda Y,Cain DW,Kuraoka M,Kondo M,Kelsoe G
Fri May 15 00:00:00 UTC 2009
Characterization of an immediate splenic precursor of CD8+ dendritic cells capable of inducing antiviral T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Bedoui S,Prato S,Mintern J,Gebhardt T,Zhan Y,Lew AM,Heath WR,Villadangos JA,Segura E
Wed Apr 01 00:00:00 UTC 2009
Accumulation of CD11b+ lung dendritic cells in response to fungal infection results from the CCR2-mediated recruitment and differentiation of Ly-6Chigh monocytes.
Journal of immunology (Baltimore, Md. : 1950)
Osterholzer JJ,Chen GH,Olszewski MA,Curtis JL,Huffnagle GB,Toews GB
Tue Dec 15 00:00:00 UTC 2009
Hypoxia prolongs monocyte/macrophage survival and enhanced glycolysis is associated with their maturation under aerobic conditions.
Journal of immunology (Baltimore, Md. : 1950)
Roiniotis J,Dinh H,Masendycz P,Turner A,Elsegood CL,Scholz GM,Hamilton JA
Mon Jun 15 00:00:00 UTC 2009
Common gamma-chain-dependent signals confer selective survival of eosinophils in the murine small intestine.
Journal of immunology (Baltimore, Md. : 1950)
Carlens J,Wahl B,Ballmaier M,Bulfone-Paus S,Förster R,Pabst O
Sun Nov 01 00:00:00 UTC 2009
Chemotherapeutic agents in noncytotoxic concentrations increase antigen presentation by dendritic cells via an IL-12-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Shurin GV,Tourkova IL,Kaneno R,Shurin MR
Wed Jul 01 00:00:00 UTC 2009
A signaling polypeptide derived from an innate immune adaptor molecule can be harnessed as a new class of vaccine adjuvant.
Journal of immunology (Baltimore, Md. : 1950)
Kobiyama K,Takeshita F,Ishii KJ,Koyama S,Aoshi T,Akira S,Sakaue-Sawano A,Miyawaki A,Yamanaka Y,Hirano H,Suzuki K,Okuda K
Sun Feb 01 00:00:00 UTC 2009
4-1BB functions as a survival factor in dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Choi BK,Kim YH,Kwon PM,Lee SC,Kang SW,Kim MS,Lee MJ,Kwon BS
Wed Apr 01 00:00:00 UTC 2009
Sustained and NK/CD4+ T cell-dependent efficient prevention of lung metastasis induced by dendritic cells harboring recombinant Sendai virus.
Journal of immunology (Baltimore, Md. : 1950)
Komaru A,Ueda Y,Furuya A,Tanaka S,Yoshida K,Kato T,Kinoh H,Harada Y,Suzuki H,Inoue M,Hasegawa M,Ichikawa T,Yonemitsu Y
Thu Oct 01 00:00:00 UTC 2009
A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Perona-Wright G,Jenkins SJ,O'Connor RA,Zienkiewicz D,McSorley HJ,Maizels RM,Anderton SM,MacDonald AS
Sun Mar 01 00:00:00 UTC 2009
Discrete domains of MARCH1 mediate its localization, functional interactions, and posttranscriptional control of expression.
Journal of immunology (Baltimore, Md. : 1950)
Jabbour M,Campbell EM,Fares H,Lybarger L
Sun Nov 15 00:00:00 UTC 2009
Protective response to Leishmania major in BALB/c mice requires antigen processing in the absence of DM.
Journal of immunology (Baltimore, Md. : 1950)
Kamala T,Nanda NK
Wed Apr 15 00:00:00 UTC 2009
C3 promotes expansion of CD8+ and CD4+ T cells in a Listeria monocytogenes infection.
Journal of immunology (Baltimore, Md. : 1950)
Nakayama Y,Kim SI,Kim EH,Lambris JD,Sandor M,Suresh M
Tue Sep 01 00:00:00 UTC 2009
CCR7 ligands are required for development of experimental autoimmune encephalomyelitis through generating IL-23-dependent Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Kuwabara T,Ishikawa F,Yasuda T,Aritomi K,Nakano H,Tanaka Y,Okada Y,Lipp M,Kakiuchi T
Sat Aug 15 00:00:00 UTC 2009
Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
Jones TG,Hallgren J,Humbles A,Burwell T,Finkelman FD,Alcaide P,Austen KF,Gurish MF
Thu Oct 15 00:00:00 UTC 2009
Complete elimination of established neuroblastoma by synergistic action of gamma-irradiation and DCs treated with rSeV expressing interferon-beta gene.
Gene therapy
Tatsuta K,Tanaka S,Tajiri T,Shibata S,Komaru A,Ueda Y,Inoue M,Hasegawa M,Suita S,Sueishi K,Taguchi T,Yonemitsu Y
Sun Feb 01 00:00:00 UTC 2009
Dendritic cells transduced with lentiviral-mediated RelB-specific ShRNAs inhibit the development of experimental autoimmune myasthenia gravis.
Molecular immunology
Zhang Y,Yang H,Xiao B,Wu M,Zhou W,Li J,Li G,Christadoss P
Sun Feb 01 00:00:00 UTC 2009
Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia.
Infection and immunity
Kamda JD,Singer SM
Sun Feb 01 00:00:00 UTC 2009
The Toxoplasma gondii-shuttling function of dendritic cells is linked to the parasite genotype.
Infection and immunity
Lambert H,Vutova PP,Adams WC,Loré K,Barragan A
Wed Apr 01 00:00:00 UTC 2009
Cytokine-based log-scale expansion of functional murine dendritic cells.
PloS one
Harada Y,Ueda Y,Kinoh H,Komaru A,Fuji-Ogawa T,Furuya A,Iida A,Hasegawa M,Ichikawa T,Yonemitsu Y
Tue Aug 18 00:00:00 UTC 2009
Dendritic cell-mediated-immunization with xenogenic PrP and adenoviral vectors breaks tolerance and prolongs mice survival against experimental scrapie.
PloS one
Rosset MB,Sacquin A,Lecollinet S,Chaigneau T,Adam M,Crespeau F,Eloit M
Thu May 14 00:00:00 UTC 2009
Fluorescent imaging of antigen released by a skin-invading helminth reveals differential uptake and activation profiles by antigen presenting cells.
PLoS neglected tropical diseases
Paveley RA,Aynsley SA,Cook PC,Turner JD,Mountford AP
Tue Oct 13 00:00:00 UTC 2009
In situ-targeting of dendritic cells with donor-derived apoptotic cells restrains indirect allorecognition and ameliorates allograft vasculopathy.
PloS one
Wang Z,Shufesky WJ,Montecalvo A,Divito SJ,Larregina AT,Morelli AE
Thu May 28 00:00:00 UTC 2009
Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5.
The Journal of biological chemistry
Wang Z,Kumamoto Y,Wang P,Gan X,Lehmann D,Smrcka AV,Cohn L,Iwasaki A,Li L,Wu D
Fri Oct 16 00:00:00 UTC 2009
CD28 co-stimulation down regulates Th17 development.
PloS one
Bouguermouh S,Fortin G,Baba N,Rubio M,Sarfati M
Thu May 28 00:00:00 UTC 2009
Effect of cigarette smoke extract on dendritic cells and their impact on T-cell proliferation.
PloS one
Mortaz E,Kraneveld AD,Smit JJ,Kool M,Lambrecht BN,Kunkel SL,Lukacs NW,Nijkamp FP,Folkerts G
Wed Jul 01 00:00:00 UTC 2009
Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia.
The Journal of biological chemistry
Zhang W,Chan RJ,Chen H,Yang Z,He Y,Zhang X,Luo Y,Yin F,Moh A,Miller LC,Payne RM,Zhang ZY,Fu XY,Shou W
Fri Aug 14 00:00:00 UTC 2009
FIP1L1-PDGFRalpha imposes eosinophil lineage commitment on hematopoietic stem/progenitor cells.
The Journal of biological chemistry
Fukushima K,Matsumura I,Ezoe S,Tokunaga M,Yasumi M,Satoh Y,Shibayama H,Tanaka H,Iwama A,Kanakura Y
Fri Mar 20 00:00:00 UTC 2009
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.
Nature
Saitoh T,Fujita N,Jang MH,Uematsu S,Yang BG,Satoh T,Omori H,Noda T,Yamamoto N,Komatsu M,Tanaka K,Kawai T,Tsujimura T,Takeuchi O,Yoshimori T,Akira S
Thu Nov 13 00:00:00 UTC 2008
Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses.
Immunity
Hall JA,Bouladoux N,Sun CM,Wohlfert EA,Blank RB,Zhu Q,Grigg ME,Berzofsky JA,Belkaid Y
Fri Oct 17 00:00:00 UTC 2008
The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases.
Immunity
Meylan F,Davidson TS,Kahle E,Kinder M,Acharya K,Jankovic D,Bundoc V,Hodges M,Shevach EM,Keane-Myers A,Wang EC,Siegel RM
Fri Jul 18 00:00:00 UTC 2008
Modulation of the antitumor immune response by complement.
Nature immunology
Markiewski MM,DeAngelis RA,Benencia F,Ricklin-Lichtsteiner SK,Koutoulaki A,Gerard C,Coukos G,Lambris JD
315-03 was used in Cell Culture to investigate C5a in the tumour microenvironment affects on tumour growth and CD8+ T cells.
Sat Nov 01 00:00:00 UTC 2008
Defective Notch activation in microenvironment leads to myeloproliferative disease.
Blood
Kim YW,Koo BK,Jeong HW,Yoon MJ,Song R,Shin J,Jeong DC,Kim SH,Kong YY
Mon Dec 01 00:00:00 UTC 2008
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.
The Journal of clinical investigation
De Santo C,Salio M,Masri SH,Lee LY,Dong T,Speak AO,Porubsky S,Booth S,Veerapen N,Besra GS,Gröne HJ,Platt FM,Zambon M,Cerundolo V
Mon Dec 01 00:00:00 UTC 2008
Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines.
Proceedings of the National Academy of Sciences of the United States of America
Zhu Q,Egelston C,Vivekanandhan A,Uematsu S,Akira S,Klinman DM,Belyakov IM,Berzofsky JA
Tue Oct 21 00:00:00 UTC 2008
Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9.
Journal of immunology (Baltimore, Md. : 1950)
Hara H,Ishihara C,Takeuchi A,Xue L,Morris SW,Penninger JM,Yoshida H,Saito T
Tue Jul 15 00:00:00 UTC 2008
CX3CR1+ c-kit+ bone marrow cells give rise to CD103+ and CD103- dendritic cells with distinct functional properties.
Journal of immunology (Baltimore, Md. : 1950)
del Rio ML,Rodriguez-Barbosa JI,Bölter J,Ballmaier M,Dittrich-Breiholz O,Kracht M,Jung S,Förster R
Sat Nov 01 00:00:00 UTC 2008
Ion channels modulating mouse dendritic cell functions.
Journal of immunology (Baltimore, Md. : 1950)
Matzner N,Zemtsova IM,Nguyen TX,Duszenko M,Shumilina E,Lang F
Sat Nov 15 00:00:00 UTC 2008
TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Radhakrishnan S,Arneson LN,Upshaw JL,Howe CL,Felts SJ,Colonna M,Leibson PJ,Rodriguez M,Pease LR
Mon Dec 01 00:00:00 UTC 2008
Uncoupling of induced protein processing from maturation in dendritic cells exposed to a highly antigenic preparation from a helminth parasite.
Journal of immunology (Baltimore, Md. : 1950)
Marshall FA,Pearce EJ
Mon Dec 01 00:00:00 UTC 2008
Imatinib mesylate inhibits CD4+ CD25+ regulatory T cell activity and enhances active immunotherapy against BCR-ABL- tumors.
Journal of immunology (Baltimore, Md. : 1950)
Larmonier N,Janikashvili N,LaCasse CJ,Larmonier CB,Cantrell J,Situ E,Lundeen T,Bonnotte B,Katsanis E
Sat Nov 15 00:00:00 UTC 2008
Misoprostol impairs female reproductive tract innate immunity against Clostridium sordellii.
Journal of immunology (Baltimore, Md. : 1950)
Aronoff DM,Hao Y,Chung J,Coleman N,Lewis C,Peres CM,Serezani CH,Chen GH,Flamand N,Brock TG,Peters-Golden M
Sun Jun 15 00:00:00 UTC 2008
Expansion of Foxp3+ regulatory T cells in mice infected with the filarial parasite Brugia malayi.
Journal of immunology (Baltimore, Md. : 1950)
McSorley HJ,Harcus YM,Murray J,Taylor MD,Maizels RM
Sat Nov 01 00:00:00 UTC 2008
Intrarectal vaccination with recombinant vaccinia virus expressing carcinoembronic antigen induces mucosal and systemic immunity and prevents progression of colorectal cancer.
Journal of immunology (Baltimore, Md. : 1950)
Kim-Schulze S,Kim HS,Wainstein A,Kim DW,Yang WC,Moroziewicz D,Mong PY,Bereta M,Taback B,Wang Q,Kaufman HL
Mon Dec 01 00:00:00 UTC 2008
Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions.
Journal of immunology (Baltimore, Md. : 1950)
Nagahara K,Arikawa T,Oomizu S,Kontani K,Nobumoto A,Tateno H,Watanabe K,Niki T,Katoh S,Miyake M,Nagahata S,Hirabayashi J,Kuchroo VK,Yamauchi A,Hirashima M
Mon Dec 01 00:00:00 UTC 2008
Bone marrow-derived IFN-producing killer dendritic cells account for the tumoricidal activity of unpulsed dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Himoudi N,Nabarro S,Buddle J,Eddaoudi A,Thrasher AJ,Anderson J
Sat Nov 01 00:00:00 UTC 2008
IFN consensus sequence binding protein (Icsbp) is critical for eosinophil development.
Journal of immunology (Baltimore, Md. : 1950)
Milanovic M,Terszowski G,Struck D,Liesenfeld O,Carstanjen D
Wed Oct 01 00:00:00 UTC 2008
Herpes virus oncolytic therapy reverses tumor immune dysfunction and facilitates tumor antigen presentation.
Cancer biology & therapy
Benencia F,Courrèges MC,Fraser NW,Coukos G
315-03 was used in Cell Culture to show how oncolytic HSV-1716 generates vaccination effects and that that oncolytic therapy with HSV-1716 facilitates antitumor immune responses.
Fri Aug 01 00:00:00 UTC 2008
Culture of myeloid dendritic cells from bone marrow precursors.
Journal of visualized experiments : JoVE
Boudreau J,Koshy S,Cummings D,Wan Y
315-03 was used in Cell Culture to demonstrate flow cytometric comparisons of expression of two co-stimulatory molecules, CD86 and CD40, and the cytokine, IL-12, following overnight stimulation with CpG or mock treatment.
Fri Jul 25 00:00:00 UTC 2008
Allergen uptake, activation, and IL-23 production by pulmonary myeloid DCs drives airway hyperresponsiveness in asthma-susceptible mice.
PloS one
Lewkowich IP,Lajoie S,Clark JR,Herman NS,Sproles AA,Wills-Karp M
Fri Mar 20 00:00:00 UTC 2009
Flow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells.
PloS one
Kalaitzidis D,Neel BG
Tue Feb 10 00:00:00 UTC 2009
Cerebrospinal fluid dendritic cells infiltrate the brain parenchyma and target the cervical lymph nodes under neuroinflammatory conditions.
PloS one
Hatterer E,Touret M,Belin MF,Honnorat J,Nataf S
Thu Oct 02 00:00:00 UTC 2008
Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway.
Journal of neuroinflammation
Pais TF,Figueiredo C,Peixoto R,Braz MH,Chatterjee S
Thu Oct 09 00:00:00 UTC 2008
Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells.
Blood
Vremec D,O'Keeffe M,Hochrein H,Fuchsberger M,Caminschi I,Lahoud M,Shortman K
Thu Feb 01 00:00:00 UTC 2007
Immunomodulatory effects of aqueous birch pollen extracts and phytoprostanes on primary immune responses in vivo.
The Journal of allergy and clinical immunology
Gutermuth J,Bewersdorff M,Traidl-Hoffmann C,Ring J,Mueller MJ,Behrendt H,Jakob T
Wed Aug 01 00:00:00 UTC 2007
Gr-1high polymorphonuclear leukocytes and NK cells act via IL-15 to clear intracellular Haemophilus influenzae in experimental murine peritonitis and pneumonia.
Journal of immunology (Baltimore, Md. : 1950)
Miyazaki S,Ishikawa F,Shimizu K,Ubagai T,Edelstein PH,Yamaguchi K
Mon Oct 15 00:00:00 UTC 2007
Chemoattraction of macrophages, T lymphocytes, and mast cells is evolutionarily conserved within the human alpha-defensin family.
Journal of immunology (Baltimore, Md. : 1950)
Grigat J,Soruri A,Forssmann U,Riggert J,Zwirner J
Sat Sep 15 00:00:00 UTC 2007
IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Kreymborg K,Etzensperger R,Dumoutier L,Haak S,Rebollo A,Buch T,Heppner FL,Renauld JC,Becher B
Sat Dec 15 00:00:00 UTC 2007
A regulatory effect of the balance between TNF-alpha and IL-6 in the granulomatous and inflammatory response to Rhodococcus aurantiacus infection in mice.
Journal of immunology (Baltimore, Md. : 1950)
Kohanawa M
Sat Jul 01 00:00:00 UTC 2006
Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow.
The Journal of experimental medicine
Ueda Y,Kondo M,Kelsoe G
Mon Jun 06 00:00:00 UTC 2005
Chemokine receptor-mediated delivery directs self-tumor antigen efficiently into the class II processing pathway in vitro and induces protective immunity in vivo.
Blood
Biragyn A,Ruffini PA,Coscia M,Harvey LK,Neelapu SS,Baskar S,Wang JM,Kwak LW
Fri Oct 01 00:00:00 UTC 2004
Induction of potent antitumor immunity by in situ targeting of intratumoral DCs.
The Journal of clinical investigation
Furumoto K,Soares L,Engleman EG,Merad M
Mon Mar 01 00:00:00 UTC 2004
Stem cell factor can stimulate the formation of eosinophils by two types of murine eosinophil progenitor cells.
Stem cells (Dayton, Ohio)
Metcalf D,Mifsud S,Di Rago L
Wed Mar 12 00:00:00 UTC 2003
Noncovalent association with stress protein facilitates cross-priming of CD8+ T cells to tumor cell antigens by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Kammerer R,Stober D,Riedl P,Oehninger C,Schirmbeck R,Reimann J
315-03 was used in In vitro experiments to investigate protein expression in murine tumour cells.
Tue Jan 01 00:00:00 UTC 2002
IL-12/IL-18-dependent IFN-gamma release by murine dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Stober D,Schirmbeck R,Reimann J
315-03 was used in In vitro experiments to study how dendritic cells (DCs) are a source of early IFN-gamma generated in response to a cascade of cytokine- and/or cell derived signals that can be positively and negatively regulated.
Sun Jul 15 00:00:00 UTC 2001
TNF-alpha-converting enzyme cleaves the macrophage colony-stimulating factor receptor in macrophages undergoing activation.
Journal of immunology (Baltimore, Md. : 1950)
Rovida E,Paccagnini A,Del Rosso M,Peschon J,Dello Sbarba P
315-03 was used in Cell Culture to study how M-CSFR is shed from macrophage surface and identify the protease responsible for M-CSFR cleavage and down-modulation and demonstrate how the proTNF-converting enzyme (TACE) protease is responsible for M-CSFR shedding and down-modulation in mononuclear phagocytes undergoing activation.
Thu Feb 01 00:00:00 UTC 2001
