Fumonisin B2, 96+%, Thermo Scientific Chemicals
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Fumonisin B2, 96+%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Fumonisin B2, 96+%, Thermo Scientific Chemicals

Fumonisin B2, CAS # 116355-84-1, is a diester of tricarballylic acid and is isolated from Fusarium.
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Catalog number 328260010
Price (USD)/ Each
334.65
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Ends: 31-Dec-2024
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Quantity:
1 mg
Request bulk or custom format
Price (USD)/ Each
334.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
393.00 
Save 58.35 (15%)
Add to cart
Fumonisin B2, 96+%, Thermo Scientific Chemicals
Catalog number328260010
Price (USD)/ Each
334.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
393.00 
Save 58.35 (15%)
-
Add to cart
Chemical Identifiers
CAS116355-84-1
SpecificationsSpecification SheetSpecification Sheet
HPLC>=96.0 %
Appearance (Color)White to light yellow to brown
Appearance (Form)Solid
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Fumonisin B2 is a fumonisin mycotoxin produced by the fungus Fusarium
• Fumonisin B2 is a structural analog of fumonisin B1 but it is more cytotoxic than B1 and can inhibit sphinganine-N-acetyltransferase (ceramide synthase)
Applications
• In vitro and in vivo studies have shown Fumonisin B2 can induce apoptosis
• It can inhibit de novo sphingolipid biosynthesis
• It is also considered an Aspergillus metabolite
• It shows cytotoxicity against a panel of seven rat hepatoma cell lines, and MDCK cell line
• It induces hepatocyte nodule formation, a marker of cancer initiation, in rats
WARNING: Cancer – www.P65Warnings.ca.gov
RUO – Research Use Only

General References:

  1. Gelderblom, W.C.A.; Jaskiewicz, K.; Marasas, W.F.O., et al. Fumonisins-novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Appl. Environ. Microbiol. 1988, 54, (7), 1806-1811.
  2. Shier, W.T.; Abbas, H.K.; and Mirocha, C.J. Toxicity of the mycotoxins fumonisins B1 and B2 and Alternaria alternata f. sp. lycopersici toxin (AAL) in cultured mammalian cells. Mycopathologia. 1991, 116, (2), 97-104.
  3. Gelderblom, W.C.A.; Cawood, M.E., Snyman, S.D., et al. Structure-activity relationships of fumonisins in short-term carcinogenesis and cytotoxicity assays. Food Chem. Toxicol. 1993, 31, (6), 407-414.