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G418 sulfate, for biochemistry
G418 sulfate, geneticin, CAS # 108321-42-2, is an antibiotic closely related to Gentamicin B, the common aminoglycoside antibiotic.
| Catalog Number | Quantity | Packaging |
|---|---|---|
| 329400050 | 5 g | Glass Bottle |
Catalog number 329400050
Price (USD)Contact Us
-
Quantity:
5 g
Packaging:
Glass Bottle
Chemical Identifiers
CAS108321-42-2
IUPAC Name(2R,3S,4R,5R,6S)-5-amino-6-{[(1R,2S,3S,4R,6S)-4,6-diamino-3-{[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-2-(1-hydroxyethyl)oxane-3,4-diol; bis(sulfuric acid)
Molecular FormulaC20H44N4O18S2
InChI KeyUHEPSJJJMTWUCP-KETIWVBHNA-N
SMILESOS(O)(=O)=O.OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](C(C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)OC[C@]1(C)O
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Specifications
Specification Sheet
Specification SheetAppearance (Form)Powder
Water=<10 %
Potency>=650 µg/mg
Appearance (Color)White to off-white
Infrared spectrumConforms
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General description
• G418 sulfate (geneticin) is an aminoglycoside antibiotic isolated from Micromonospora rhodorangea
• G418 is a bacteriostatic that prevents polypeptide formation by inhibiting the elongation step of polypeptide synthesis
Applications
• G418 sulfate can be used for selection of genetically engineered cells in both eukaryotes and prokaryotes
• Laboratory grade for applications such as biochemistry
RUO – Research Use Only
Literature references
Arshad, H.; Patel, Z.; Mehrabian, M.; Bourkas, M.; Al-Azzawi, Z.; Schmitt-Ulms, G., & Watts, J. C. 2021. The aminoglycoside G418 hinders de novo prion infection in cultured cells. The Journal of biological chemistry, 297(3), 101073.
Ferguson, M. W.; Gerak, C.; Chow, C.; Rastelli, E. J.; Elmore, K. E.; Stahl, F.; Hosseini-Farahabadi, S.; Baradaran-Heravi, A.; Coltart, D. M., & Roberge, M. 2019. The antimalarial drug mefloquine enhances TP53 premature termination codon readthrough by aminoglycoside G418. PloS one, 14(5), e0216423.