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Diclofenac sodium, 98%
Diclofenac sodium, CAS # 15307-79-6, is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin synthesis.
Catalog number 445250100
Price (USD)/ Each
59.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
70.20 Save 10.55 (15%)
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Quantity:
10g
Packaging:
Glass bottle
Price (USD)/ Each
59.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
70.20 Save 10.55 (15%)
Diclofenac sodium, 98%
Catalog number445250100
Price (USD)/ Each
59.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
70.20 Save 10.55 (15%)
-
Chemical Identifiers
CAS15307-79-6
Specifications
Specification Sheet
Specification SheetAppearance (Color)White to off-white
Appearance (Form)Crystalline powder
Infrared spectrumConforms
HPLC>=97.5 %
Loss on drying=<0.5 %
View more
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
Diclofenac is a is a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties
Diclofenac has been shown to have anti-tumor capabilities through inhibition of MYC expression and glucose metabolism in models of melanoma and leukemia
Applications
Diclofenac sodium can be used as an antioxidant and free radical scavenger
It has been shown to have anti-bacterial activity against Listeria, E. coli, and M. tuberculosis partially through inhibition of bacterial DNA synthesis
It can be used for the study of metabolic activity as a CYP2C9 substrate
RUO – Research Use Only
Literature references
Altman, R; Bosch, B.; Brune, K.; Patrignani, P.; Young, C. Advances in NSAID development: evolution of diclofenac products using pharmaceutical technology. Drugs. 2015, 75(8), 859-77.
Tang, Y.Z.; Liu, Z.Q. Evaluation of the free-radical-scavenging activity of diclofenac acid on the free-radical-induced haemolysis of human erythrocytes. J Pharm Pharmacol. 2006, 58(5), 625-31.
Mazumdar K, Dastidar SG, Park JH, Dutta NK. The anti-inflammatory non-antibiotic helper compound diclofenac: an antibacterial drug target. Eur J Clin Microbiol Infect Dis. 2009, 28(8), 881-91.
Gottfried, E.; Lang, S.A.; Renner, K.; Bosserhoff, A.; Gronwald, W.; Rehli, M.; Einhell, S.; Gedig, I.; Singer, K.; Seilbeck, A.; Mackensen, A.; Grauer, O.; Hau, P.; Dettmer, K.; Andreesen, R.; Oefner, P.J.; Kreutz, M. New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells. PLoS One. 2013, 8(7), e66987.
Feng, S.; Wu, J.; Qiu, W.L.; Yang, L.; Deng, X.; Zhou, Y.; Chen, Y.; Li, X.; Yu, L.; Li, H.; Xu, Z.R.; Xiao, Y.; Ren, X.; Zhang, L.; Wang, C.; Sun, Z.; Wang, J.; Ding, X.; Chen, Y.; Gadue, P.; Pan, G.; Ogawa, M.; Ogawa S, Na J, Zhang P, Hui L, Yin H, Chen L, Xu CR, Cheng X. Large-scale Generation of Functional and Transplantable Hepatocytes and Cholangiocytes from Human Endoderm Stem Cells. Cell Rep. 2020, 33(10), 108455.
Cantoni, L.; Valaperta, R.; Ponsoda, X.; Castell, J.V.; Barelli, D., Rizzardini, M.; Mangolini, A.; Hauri, L.; Villa, P. Induction of hepatic heme oxygenase-1 by diclofenac in rodents: role of oxidative stress and cytochrome P-450 activity. J Hepatol. 2003, 38(6), 776-83.