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Itraconazole, 99%
Itraconazole, or voriconazole, CAS # 84625-61-6, is an N-arylpiperazine that has antifungal properties.
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Catalog number 452870250
Price (USD)/ Each
396.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
466.00 Save 69.35 (15%)
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Quantity:
25 g
Price (USD)/ Each
396.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
466.00 Save 69.35 (15%)
Itraconazole, 99%
Catalog number452870250
Price (USD)/ Each
396.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
466.00 Save 69.35 (15%)
-
Chemical Identifiers
CAS84625-61-6
IUPAC Name1-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-4,5-dihydro-1H-1,2,4-triazol-5-one
Molecular FormulaC35H38Cl2N8O4
InChI KeyVHVPQPYKVGDNFY-ZPGVKDDISA-N
SMILESCCC(C)N1N=CN(C1=O)C1=CC=C(C=C1)N1CCN(CC1)C1=CC=C(OC[C@H]2CO[C@@](CN3C=NC=N3)(O2)C2=CC=C(Cl)C=C2Cl)C=C1
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Specifications
Specification Sheet
Specification SheetMelting point165°C to 169°C
Appearance (Color)White to almost white
Appearance (Form)Powder
Infrared spectrumConforms
HPLC>=98.5 %
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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Itraconazole is an aromatic ether that works as a strong inhibitor of P-glycoproteins and CYP3A4
• Itraconazole also acts as a hedgehog signaling inhibitor and P450 inhibitor
Applications
• Itraconazole can be exhibits antifungal activity against organisms including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis
• Itraconazole may be used to experimentally target the delivery of other molecules, such as plasmids, to cells
RUO – Research Use Only
General References:
- Sharma, P.; Bhalla, M.; Thami, G.P.; Chander, J. Evaluation of efficacy and safety of oral terbinafine and itraconazole combination therapy in the management of dermatophytosis. J Dermatolog Treat. 2020, 31(7), 749-753.
- Hamed Khater, M.; Khattab, F.M. Combined long-pulsed Nd-Yag laser and itraconazole versus itraconazole alone in the treatment of onychomycosis nails. J Dermatolog Treat. 2020, 31(4), 406-409.