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Ketoconazole, 98%
Catalog number: 455470250
25 g, Each
Thermo Scientific Chemicals
Ketoconazole, 98%
Catalog number: 455470250
25 g, Each
Quantity
Chemical Identifiers
CAS
65277-42-1
IUPAC Name
1-[4-(4-{[(2S,4R)-2-(2,4-dichlorophenyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one
Molecular Formula
C26H28Cl2N4O4
InChI Key
XMAYWYJOQHXEEK-ZEQKJWHPSA-N
SMILES
CC(=O)N1CCN(CC1)C1=CC=C(OC[C@@H]2CO[C@](CN3C=CN=C3)(O2)C2=CC=C(Cl)C=C2Cl)C=C1
Specifications
Specification SheetAppearance (Form)
Powder
HPLC
>=97.5 %
Infrared spectrum
Conforms
Appearance (Color)
White to light brown
Melting point
148°C to 152°C
Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Ketoconazole is an imidazole antifungal agent
• It functions by inhibiting synthesis of ergosterol, which is the fungal equivalent of cholesterol
Applications
• Ketoconazole shows fungicide activity against a variety of yeast infections
• It is an inhibitor of CYP3A4, which is necessary for the conversion of lanosterol to ergosterol
• It increases fungal cellular permeability
• It also inhibits endogenous respiration by disrupting membrane phospholipids
• Ketoconazole can also inhibit the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone
RUO – Research Use Only
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