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Ofloxacin, 98%
Ofloxacin, CAS # 82419-36-1, is a fluoroquinolone antibiotic with broad antibacterial activity against gram-positive and -negative bacteria, as well as against mycobacteria.
Catalog number 455670250
Price (USD)/ Each
300.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
354.00 Save 53.35 (15%)
-
Quantity:
25 g
Price (USD)/ Each
300.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
354.00 Save 53.35 (15%)
Ofloxacin, 98%
Catalog number455670250
Price (USD)/ Each
300.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
354.00 Save 53.35 (15%)
-
Chemical Identifiers
CAS82419-36-1
IUPAC Name7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.0⁵,¹³]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
Molecular FormulaC18H20FN3O4
InChI KeyGSDSWSVVBLHKDQ-UHFFFAOYNA-N
SMILESCC1COC2=C3N1C=C(C(O)=O)C(=O)C3=CC(F)=C2N1CCN(C)CC1
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Specifications
Specification Sheet
Specification SheetHPLC>=97.5 %
Appearance (Form)Powder
Appearance (Color)White to yellow
Infrared spectrumConforms
Loss on drying=<0.2 %
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
Ofloxacin is a synthetic fluoroquinolone antibiotic that is an analog of nalidixic acid
Ofloxacin can directly interact with pneumococcal autolysin (LytA) at its choline binding domain, thus inhibiting the ability of LytA to degrade the pneumococcal cell wall
Ofloxacin is racemic and its (S)-enantiomer is levofloxacin
Applications
Ofloxacin may be used in pharmacokinetic laboratory studies and high-throughput drug screens
The DNA and protein-binding capabilities of ofloxacin have been studied in the laboratory
RUO – Research Use Only
Literature references
Fernández-Tornero, C.; García, E.; de Pascual-Teresa, B.; López, R.; Giménez-Gallego, G.; Romero, A. Ofloxacin-like antibiotics inhibit pneumococcal cell wall-degrading virulence factors. J Biol Chem. 2005, 280(20), 19948-57.
Maia, A.S.; Tiritan, M.E.; Castro, P.M.L. Enantioselective degradation of ofloxacin and levofloxacin by the bacterial strains Labrys portucalensis F11 and Rhodococcus sp. FP1. Ecotoxicol Environ Saf. 2018, 155, 144-151.