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Indomethacin
Indomethacin, CAS # 53-86-1, is an indole-based nonsteroidal anti-inflammatory (NSAID).
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Catalog number 458030050
Price (USD)/ Each
33.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
39.80 Save 6.15 (15%)
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Quantity:
5 g
Price (USD)/ Each
33.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
39.80 Save 6.15 (15%)
Indomethacin
Catalog number458030050
Price (USD)/ Each
33.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
39.80 Save 6.15 (15%)
-
Chemical Identifiers
CAS53-86-1
IUPAC Name2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
Molecular FormulaC19H16ClNO4
InChI KeyCGIGDMFJXJATDK-UHFFFAOYSA-N
SMILESCOC1=CC=C2N(C(=O)C3=CC=C(Cl)C=C3)C(C)=C(CC(O)=O)C2=C1
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Specifications
Specification Sheet
Specification SheetMelting point156°C to 165°C
HPLC>=97.5 %
Loss on drying=<0.5 % (100°C, 2 h, 5 mm Hg)
Infrared spectrumConforms
Appearance (Color)White to yellow to light beige
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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Indomethacin is a synthetic NSAID of the indole family that inhibits cyclooxygenase and reduces prostaglandin and pyrogen release
• Indomethacin may suppress the multi-drug resistant transporter and thereby increase the efficacy of antineoplastics
• Indomethacin activates phosphatases that inhibit signaling pathways associated with cancer cell migration and proliferation
Applications
• Indomethacin may be used for the laboratory study of cancer cell proliferation, tumorigenesis and drug interactions
• Indomethacin may be used for laboratory study of the effect of inhibiting the multi-drug resistance transporter, or for downregulation of survival signaling in cells via survivin
RUO – Research Use Only
General References:
- Mitra, S.; Florez, I.D.; Tamayo, M.E.; Mbuagbaw, L.; Vanniyasingam, T.; Veroniki, A.A.; Zea, A.M.; Zhang, Y.; Sadeghirad, B.; Thabane, L. Association of Placebo, Indomethacin, Ibuprofen, and Acetaminophen With Closure of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-analysis. JAMA. 2018, 319(12), 1221-1238.
- El-Mashad, A.E.; El-Mahdy, H.; El Amrousy, D.; Elgendy, M. Comparative study of the efficacy and safety of paracetamol, ibuprofen, and indomethacin in closure of patent ductus arteriosus in preterm neonates. Eur J Pediatr. 2017, 176(2), 233-240.