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Indomethacin
Catalog number: 458030250
25 g, Each
Thermo Scientific Chemicals
Indomethacin
Catalog number: 458030250
25 g, Each
Quantity
Chemical Identifiers
CAS
53-86-1
IUPAC Name
2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
Molecular Formula
C19H16ClNO4
InChI Key
CGIGDMFJXJATDK-UHFFFAOYSA-N
SMILES
COC1=CC=C2N(C(=O)C3=CC=C(Cl)C=C3)C(C)=C(CC(O)=O)C2=C1
Specifications
Specification SheetHPLC
>=97.5 %
Loss on drying
=<0.5 % (100°C, 2 h, 5 mm Hg)
Infrared spectrum
Conforms
Appearance (Color)
White to yellow to light beige
Appearance (Form)
Crystalline powder
Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Indomethacin is a synthetic NSAID of the indole family that inhibits cyclooxygenase and reduces prostaglandin and pyrogen release
• Indomethacin may suppress the multi-drug resistant transporter and thereby increase the efficacy of antineoplastics
• Indomethacin activates phosphatases that inhibit signaling pathways associated with cancer cell migration and proliferation
Applications
• Indomethacin may be used for the laboratory study of cancer cell proliferation, tumorigenesis and drug interactions
• Indomethacin may be used for laboratory study of the effect of inhibiting the multi-drug resistance transporter, or for downregulation of survival signaling in cells via survivin
RUO – Research Use Only
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