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Melphalan, 94%, Thermo Scientific Chemicals
Catalog number: 458650010
1 g, Each
Thermo Scientific Chemicals
Melphalan, 94%, Thermo Scientific Chemicals
Catalog number: 458650010
1 g, Each
Quantity
Chemical Identifiers
CAS
148-82-3
IUPAC Name
2-amino-3-{4-[bis(2-chloroethyl)amino]phenyl}propanoic acid
Molecular Formula
C13H18Cl2N2O2
InChI Key
SGDBTWWWUNNDEQ-UHFFFAOYNA-N
SMILES
NC(CC1=CC=C(C=C1)N(CCCl)CCCl)C(O)=O
Specifications
Specification SheetAppearance (Form)
Powder
Infrared spectrum
Conforms
Water
=<5 %
HPLC
>=93 %
Appearance (Color)
White to light yellow
Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
Melphalan is a phenylalanine derivative of nitrogen mustard with antineoplastic activity with the capacity to alkylate nucleic acids
Melphalan alkylates DNA at the N-7 position of guanine and induces DNA interstrand cross-linkages, resulting in the inhibition of DNA/RNA synthesis, inducing cytotoxicity against both dividing and non-dividing tumor cells
Applications
Melphalan has been used in in vitro experiments to treat multiple myeloma in cell lines and breast cancer cell lines
In in vivo experiments, using rats, it shows a potent therapeutic effect in cases of sarcomatous pulmonary metastases
WARNING: Cancer and Reproductive Harm – www.P65Warnings.ca.gov
RUO – Research Use Only
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