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Melphalan, 94%, Thermo Scientific Chemicals
Melphalan, CAS # 148-82-3, belongs to the class of nitrogen mustards with anti-neoplastic activity.
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Catalog number 458650050
Price (USD)/ Each
590.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
695.00 Save 104.35 (15%)
-
Quantity:
5 g
Price (USD)/ Each
590.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
695.00 Save 104.35 (15%)
Melphalan, 94%, Thermo Scientific Chemicals
Catalog number458650050
Price (USD)/ Each
590.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
695.00 Save 104.35 (15%)
-
Chemical Identifiers
CAS148-82-3
IUPAC Name2-amino-3-{4-[bis(2-chloroethyl)amino]phenyl}propanoic acid
Molecular FormulaC13H18Cl2N2O2
InChI KeySGDBTWWWUNNDEQ-UHFFFAOYNA-N
SMILESNC(CC1=CC=C(C=C1)N(CCCl)CCCl)C(O)=O
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Specifications
Specification Sheet
Specification SheetAppearance (Form)Powder
Infrared spectrumConforms
Water=<5 %
HPLC>=93 %
Appearance (Color)White to light yellow
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
Melphalan is a phenylalanine derivative of nitrogen mustard with antineoplastic activity with the capacity to alkylate nucleic acids
Melphalan alkylates DNA at the N-7 position of guanine and induces DNA interstrand cross-linkages, resulting in the inhibition of DNA/RNA synthesis, inducing cytotoxicity against both dividing and non-dividing tumor cells
Applications
Melphalan has been used in in vitro experiments to treat multiple myeloma in cell lines and breast cancer cell lines
In in vivo experiments, using rats, it shows a potent therapeutic effect in cases of sarcomatous pulmonary metastases
WARNING: Cancer and Reproductive Harm – www.P65Warnings.ca.gov
RUO – Research Use Only
General References:
- Betcher, D.; Burnham, N. Melphalan. J Pediatr Oncol Nurs. 1990, 7 (1), 35-36.
- Nawata, S.; Abecasis, N.; Ross, H.M.; Abolhoda, A.; Cheng, H.; Sachar, K.S.; Burt, M.E. Isolated lung perfusion with melphalan for the treatment of metastatic pulmonary sarcoma. J Thorac Cardiovasc Surg. 1996, 112, (6), 1542-1547.
- Stühmer, T.; Arts, J.; Chatterjee, M.; Borawski,, J, Wolff A, King P, Einsele H, Leo E, Bargou RC. Preclinical anti-myeloma activity of the novel HDAC-inhibitor JNJ-26481585. Br J Haematol. 2010, 149, (4), 529-536.
- Bauer, G.B.; Povirk, L.F. Specificity and kinetics of interstrand and intrastrand bifunctional alkylation by nitrogen mustards at a G-G-C sequence. Nucleic Acids Res. 1997, 25, (6), 1211-1218.