CytoScan™ XON Assay Kit
CytoScan™ XON Assay Kit
Applied Biosystems™

CytoScan™ XON Assay Kit

The Applied Biosystems CytoScan XON Suite is an exon-level copy number solution that provides the sensitivity and flexibility required toRead more
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Catalog NumberQuantity
93131124 reactions
Catalog number 931311
Price (EUR)
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Quantity:
24 reactions
Delivery information
Standard Products - 1-2 business days for Beijing, Shanghai, Guangzhou, Shenzhen and provincial capitals, 2-3 business days for 2nd-tier cities, and 4 business days for 3rd-tier cities and remote areas.
Air Freight Restricted Products - 2-4 business days for Beijing, Shanghai, Guangzhou, Shenzhen and provincial capitals, 3-5 business days for 2nd-tier cities, and 6-10 business days for 3rd-tier cities and remote areas.
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The Applied Biosystems CytoScan XON Suite is an exon-level copy number solution that provides the sensitivity and flexibility required to improve and complement the analysis of important variants for clinical research. It is designed to cover the whole genome, with an increased focus on 7,000 clinically relevant genes. The CytoScan XON Suite is a full solution comprised of the assay, array, and analysis software. This CytoScan XON Assay Kit contains arrays and reagents sufficient for 24 reactions. Customer training is required for the CytoScan XON Assay. Different training programs are available based upon your experience level. Please contact your local distributor for details.

Sensitive exon-level copy number and superior coverage across the whole genome
Comprehensive and effective detection of deletions and duplications can be challenging from a cost perspective when using multiplex ligation-dependent probe amplification (MLPA) assays or exome arrays for medical research. Additionally, custom-made products lack the flexibility to include any new gene of interest that is relevant to a particular disease.The CytoScan XON Suite is a microarray solution that detects single-exon deletion and duplication events with high sensitivity in key relevant genes in addition to providing whole-genome coverage. The single-nucleotide polymorphism (SNP) probes allow sample tracking, duo/trio, and loss of heterozygosity (LOH) analysis.

Smart design improves resolution in key genes
The CytoScan XON Array content was designed through empirical selection from a pool of over 49 million probes for copy number responses across the genome. The best performing probes were selected to cover key genes and the exons within them. Any gaps were filled with additional probes flanking 500 bp from the targeted region ensuring that each exon contains enough probes to make a reliable call.

Reporting flexibility with gene panel or gene-level tier analysis
The flexibility of Chromosome Analysis Suite (ChAS) data analysis software enables easy viewing and summarizes the exon-level CNV results in various ways based on your specific clinical research needs.

Gene panel analysis
Simplify result reporting by using your preferred gene list or panel in the intuitive ChAS software. This analysis feature allows you to obtain exon-level CNV results limited to the gene panel you upload and view only the genes of interest.

Gene-level tier analysis
Gene-level tier analysis is incorporated into the user-friendly ChAS software, providing a novel and flexible approach where the software provides results by gene-level tiers based on clinical research relevance. This unique functionality allows visualization of CNVs for a targeted number of clinically relevant genes (level 1) or expands the gene-level tiers for a whole-genome view. Thus, the user determines the gene-level tiers of interest for analysis and reporting.

For Research Use Only. Not for use in diagnostic procedures.
Specifications
Number of Markers6.55 M CN probes, 300,000 SNP probes
Product LineApplied Biosystems™
Quantity24 reactions
Shipping ConditionApproved for shipment at Room Temperature or on Wet or Dry Ice
TypeXON Assay Kit
ArrayCytogenetics
Number of Arrays24 arrays
SpeciesHuman
Unit SizeEach
Contents & Storage
• Module 1 A: Amplification Kit, store at -20°C
• Module 1 B: DNA Prep Kit, store at 2°C to 8°C
• Module 2 A: Frag, Label, Hyb Kit, store at -20°C
• Module 2 B: Frag, QC, Stain Kit, store at 2°C to 8°C
• Module 2 C: Resuspension Kit, store at room temperature
• Fill Wash A, store at room temperature
• Fill Wash B, store at room temperature
• 4 x CytoScan XON Array 6-Pk., store (at 2°C to 8°C

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Frequently asked questions (FAQs)

Is the CytoScan XON Assay (Cat. No. 931311, 931312) validated for FFPE samples?

No, the CytoScan XON Assay has only been validated for blood samples.

Does Ref103 come in the CytoScan XON Assay Kit (Cat. No. 931311)?

Reference Genomic DNA 103 is not included in the kit, but is available for purchase separately (Cat. No. 901012).

Note: A positive control is recommended for the CytoScan XON assay.

Find additional tips, troubleshooting help, and resources within our Microarray Analysis Support Center.

Can the CytoScan XON assay differentiate between a gene and pseudogene by copy number analysis at the exon level?

Unfortunately, no, it is not possible to map to one or the other.

Find additional tips, troubleshooting help, and resources within our Microarray Analysis Support Center.

Has the CytoScan XON rehybridization assay been tested and verified?

Yes, the CytoScan XON rehybridization assay has been tested and the hybridization cocktail can be saved.

Find additional tips, troubleshooting help, and resources within our Microarray Analysis Support Center.

Which version of Chromosome Analysis Suite (ChAS) Software is required to analyze CytoScan XON arrays?

Chromosome Analysis Suite (ChAS) Software version 3.3 is required to analyze CytoScan XON arrays. 

Find additional tips, troubleshooting help, and resources within our Microarray Analysis Support Center.

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