Applications
N-Hydroxysuccinimide is used for improved amidations in the carbodiimide method. It is also used to activate a carboxyl group and reacts with amine to form amide. It is involved in the preparation of N-hydroxymaleimide-styrene copolymer. Further, it finds use in analytical chemistry. As an additive, it is used in the carbodiimide method for improved amidations and peptide couplings.

Solubility
Soluble in water, dimethyl formamide, alcohols and ethyl acetate. Insoluble in cold ether.

Notes
Hygroscopic. Moisture sensitive. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides and strong bases. Store in a cool place.