L-Menthol is used as a cooling agent that strongly activates TRPM8.(Transient Receptor Potential Cation Channel, Subfamily M, Member 8 is a Protein Coding gene). It is used as analgesic (topical), antipruritic agent. It is used as: refreshing agent, food flavor, cool and antipruritic drug, carminative drug. Menthol crystals is used for pers onal care and cosmetics.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Solubility
Soluble in 100% ethanol, methanol (100 mg/ml), ether, and chloroform. Insoluble in water.
Notes
Store at room temperature. Incompatible with Strong oxidizing agents, phenols, potassium permanganate, chromium trioxide, chloral hydrate, thymol, pyrogallol, resorcinol, camphor, butylchloral hydrate, betanaphthol, exalgine.
RUO – Research Use Only
General References:
- UR Juergens, M Stöber, H Vetter. The anti-inflammatory activity of L-menthol compared to mint oil in human monocytes in vitro: a novel perspective for its therapeutic use in inflammatory diseases. European journal of medical research.1998, 3, (12) 539-545.
- The L-menthyl ester of succinic acid has been used in a chiral synthesis of (1S,2S)-cyclopropanedicarboxylic acid: Org. Synth. Coll., 8, 141 (1993):
- One recrystallization gives the pure enantiomer.