Benzhydroxamic acid is used as precursor in the synthesis of novel mono-anionic and di-anionic hydroxamato complexes by reacting with BiPh
3 and Bi(O(t)Bu)
3, which has anti-bacterial activity against helicobacter pylori. It is used in the photometric determination of trace amounts of vanadium in alloy steels by making mixed-ligand vanadium chelates with ammonium thiocyanate. It is also involved in the palladium catalyzed synthesis of benzisoxazolones.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Benzhydroxamic acid is used as precursor in the synthesis of novel mono-anionic and di-anionic hydroxamato complexes by reacting with BiPh3 and Bi(O(t)Bu)3, which has anti-bacterial activity against helicobacter pylori. It is used in the photometric determination of trace amounts of vanadium in alloy steels by making mixed-ligand vanadium chelates with ammonium thiocyanate. It is also involved in the palladium catalyzed synthesis of benzisoxazolones.
Solubility
Soluble in alcohol. Slightly soluble in ether. Insoluble in benzene.
Notes
Store in cool place. Incompatible with strong oxidizing agents.
RUO – Research Use Only
Reaction with alkynes, catalyzed by NaH in DMSO, gives 2-phenyloxazoles: Can. J. Chem., 51, 1368 (1973).
Oxidation with tetraalkylammonium periodates generates the transient benzoylnitroso compound, which can react in situ with dienes to give good yields of cycloaddition products: Tetrahedron Lett., 4763 (1978); J. Chem. Soc., Perkin 1, 883, 887 (1985); J. Org. Chem., 50, 1911 (1985).
Gibson, G. E.; Kelebek, S.; Aghamirian, M.; Yu, B. Flotation of pyrochlore from low grade carbonatite gravity tailings with benzohydroxamic acid. Miner. Eng. 2015, 71, 97-104.
Yang, S.; Feng, Q.; Qiu, X.; Gao, Y.; Xie, Z. Relationship between flotation and Fe/Mn ratio of wolframite with benzohydroxamic acid and sodium oleate as collectors. Physicochem. Probl. Miner. Process. 2014, 50 (2), 747-758.