Blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase and it inhibits folic acid synthesis in prokaryotes.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Sulfathiazole is a short-acting antimicrobial topical sulfa drug. It blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase and it Inhibits folic acid synthesis in prokaryotes. It will act against Gram positive, Gram negative and Chlamydial bacteria. It is also used as a common oral and topical antimicrobial agent.
Solubility
Slightly soluble in water, deuterated dimethyl sulfoxide and ethanol. Soluble in acetone, dilute mineral acids, potassium hydroxide solution, sodium hydroxide solution, ammonia water, dimethyl sulphoxide and methanol.
Notes
Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents.
RUO – Research Use Only
A. P. Simonelli.; S. C. Mehta.; W. I. Higuchi. Dissolution rates of high energy sulfathiazole-povidone coprecipitates II: Characterization of form of drug controlling its dissolution rate via solubility studies. Journal of Pharmaceutical Sciences. 1976, 65, (3), 355-361.
Keiji Sekiguchi.; Noboru Obi. Studies on Absorption of Eutectic Mixture. I. A Comparison of the Behavior of Eutectic Mixture of Sulfathiazole and that of Ordinary Sulfathiazole in Man. Chemical and Pharmaceutical Bulletin. 1961, 9 (11), 866-872.