3-Aminobenzamide is used as an endogenous poly-ADP-ribosyltransferase inhibitor. Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It displays neuroprotective, anti-necrotic effects.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
3-Aminobenzamide is used as an endogenous poly-ADP-ribosyltransferase inhibitor. Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It displays neuroprotective, anti-necrotic effects.
Solubility
Soluble in dimethylformamide (∼30 mg/ml), dimethyl sulfoxide (∼30 mg/ml), phosphate buffered saline (pH7.2) (∼2 mg/ml), water (25 mg/ml), and ethanol (25 mg/ml).
Notes
Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents.
RUO – Research Use Only
General References:
- William F. Morgan.; James E. Cleaver.3-Aminobenzamide synergistically increases sister-chromatid exchanges in cells exposed to methyl methanesulfonate but not to ultraviolet light. Mutation Research Letters. 1982, 104, (6), 361-366.
- Zingarelli, B.; Cuzzocrea, S.; Zsengellér, Z.; Salzman, A. L.; Szabó, C. Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase. Soviet Powder Metallurgy and Metal Ceramics. 1997, 36 (2), 205-215.