Hydroxyurea, 98%, Thermo Scientific Chemicals
Hydroxyurea, 98%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Hydroxyurea, 98%, Thermo Scientific Chemicals

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Catalog number A10831.06
also known as A10831-06
Price (USD)/ Each
102.65
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114.00 
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Quantity:
5 g
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Price (USD)/ Each
102.65
Online exclusive
114.00 
Save 11.35 (10%)
Add to cart
Hydroxyurea, 98%, Thermo Scientific Chemicals
Catalog numberA10831.06
Price (USD)/ Each
102.65
Online exclusive
114.00 
Save 11.35 (10%)
-
Add to cart
Chemical Identifiers
CAS127-07-1
IUPAC Namehydroxyurea
Molecular FormulaCH4N2O2
InChI KeyVSNHCAURESNICA-UHFFFAOYSA-N
SMILESNC(=O)NO
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)White to cream or yellow
Assay (HPLC)≥97.5%
Identification (FTIR)Conforms
Proton NMRConforms to structure (non-U.S. specification)
FormCrystals or powder or crystalline powder
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Hydroxyurea is used as an inhibitor of DNA synthesis and an anti-cancer drug. It is used as a precursor to prepare 1-hydroxy-5,6-dimethyl-1H-pyrimidine-2,4-dione via reaction with 2-methyl-3-oxo-butyric acid ethyl ester. It is used in the treatment of melanoma, resistant chronic myelocytic leukemia and recurrent metastatic or inoperable ovarian. It is also involved in reducing the rate of painful attacks in sickle-cell disease and has anti-retroviral properties in diseases such as AIDS.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in water, hot alcohol and dimethyl sulfoxide. Insoluble in ethanol and benzene.

Notes
Moisture sensitive. Store in cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.
WARNING: Reproductive Harm - www.P65Warnings.ca.gov
RUO – Research Use Only

General References:

  1. Sheehan, V. A.; Nelson, S.; Yappan, C.; Dinu, B. R.; Guffey, D.; Minard, C. G.; Ware, R. E. Hydroxyurea Improves Oxygen Transport Effectiveness in Sickle Cell Anemia Patients. Blood 2014, 121 (24), 2716-2716.
  2. Anele, U. A.; Mack, A. K.; Resar, L. M.; Burnett, A. L. Hydroxyurea therapy for priapism prevention and erectile function recovery in sickle cell disease: a case report and review of the literature. Int Urol Nephrol 2014, 46 (9), 1733-1736.