Denatures and solubilizes proteins for electrophoresis.Sodium n-dodecyl sulfate is an anionic detergent used to function as a protein denaturant. It is mainly used in detergents for laundry with many cleaning applications. It finds application in the determination of protein molecular weight by polyacrylamide gel electrophoresis and in the analysis of hemoglobin. In food products, it is used as an emulsifying agent and a whipping aid. It is widely found in toothpastes, shampoos, shaving creams and bubble bath formulations due to its thickening effect and ability to create a lather.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Denatures and solubilizes proteins for electrophoresis.Sodium n-dodecyl sulfate is an anionic detergent used to function as a protein denaturant. It is mainly used in detergents for laundry with many cleaning applications. It finds application in the determination of protein molecular weight by polyacrylamide gel electrophoresis and in the analysis of hemoglobin. In food products, it is used as an emulsifying agent and a whipping aid. It is widely found in toothpastes, shampoos, shaving creams and bubble bath formulations due to its thickening effect and ability to create a lather.
Solubility
Slightly soluble in ethanol.
Notes
Incompatible with oxidizing agents.
RUO – Research Use Only
The reaction rate and endo:exo ratio in the Diels-Alder cycloadditions of acrylic acid derivatives to cyclopentadiene is increased in the presence of this surfactant: Tetrahedron Lett., 27, 1285 (1986).
Chen, J.; Gong, X.; Yang, H.; Yao, Y.; Xu, M.; Chen, Q.; Cheng, R. NMR study on the effects of sodium n-dodecyl sulfate on the coil-to-globule transition of poly (N-isopropylacrylamide) in aqueous solutions. Macromolecules 2011, 44 (15), 6227-6231.
Nwamba, C. O.; Chilaka, F. C.; Movahedi, A. A. M. Cation Modulation of Hemoglobin Interaction with Sodium n-Dodecyl Sulfate (SDS). III: Calcium Interaction with R-and Mixed Spin States of Hemoglobin S at pH 5.0: The Musical Chair Paradox. Cell Biochem. Biophys. 2013, 67, (2), 547-555.